ATE507203T1 - Verbindungen für die modulation der proliferation von zellen - Google Patents
Verbindungen für die modulation der proliferation von zellenInfo
- Publication number
- ATE507203T1 ATE507203T1 AT03700255T AT03700255T ATE507203T1 AT E507203 T1 ATE507203 T1 AT E507203T1 AT 03700255 T AT03700255 T AT 03700255T AT 03700255 T AT03700255 T AT 03700255T AT E507203 T1 ATE507203 T1 AT E507203T1
- Authority
- AT
- Austria
- Prior art keywords
- 6alkyl
- compounds
- cell proliferation
- modulating cell
- 6alkoxy
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 230000004663 cell proliferation Effects 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/41—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by carboxyl groups, other than cyano groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/46—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
- C07D213/71—Sulfur atoms to which a second hetero atom is attached
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34921402P | 2002-01-18 | 2002-01-18 | |
| US34921602P | 2002-01-18 | 2002-01-18 | |
| US34921502P | 2002-01-18 | 2002-01-18 | |
| PCT/CA2003/000032 WO2003062190A1 (en) | 2002-01-18 | 2003-01-17 | Compounds for modulating cell proliferation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE507203T1 true ATE507203T1 (de) | 2011-05-15 |
Family
ID=27617577
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03700255T ATE507203T1 (de) | 2002-01-18 | 2003-01-17 | Verbindungen für die modulation der proliferation von zellen |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7563820B2 (de) |
| EP (1) | EP1467967B1 (de) |
| JP (1) | JP4383885B2 (de) |
| CN (1) | CN1633411A (de) |
| AT (1) | ATE507203T1 (de) |
| BR (1) | BR0307000A (de) |
| CA (1) | CA2473763A1 (de) |
| DE (1) | DE60336887D1 (de) |
| GB (1) | GB2401363B (de) |
| MX (1) | MXPA04006920A (de) |
| WO (1) | WO2003062190A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1467967B1 (de) | 2002-01-18 | 2011-04-27 | The Hospital For Sick Children | Verbindungen für die modulation der proliferation von zellen |
| AU2003273702A1 (en) * | 2002-10-11 | 2004-05-04 | The Hospital For Sick Children | Styrylacrylonitrile compounds for inhibition of vascular endothelial growth factor |
| CH696238A5 (de) * | 2003-06-30 | 2007-02-28 | Lymphosign Inc | Verfahren zur Herstellung von Zimtaldehydverbindungen. |
| WO2005012234A1 (en) * | 2003-07-30 | 2005-02-10 | The Hospital For Sick Children | Compounds for modulating cell proliferation |
| WO2005092904A1 (en) * | 2004-03-26 | 2005-10-06 | Hsc Research And Development Limited Partnership | Novel compounds for modulating cell proliferation |
| US7202383B2 (en) | 2004-09-14 | 2007-04-10 | The Hospital For Sick Children | Compounds useful for modulating abnormal cell proliferation |
| US7807719B2 (en) * | 2004-09-14 | 2010-10-05 | Chaim Roifman | Compounds useful for modulating abnormal cell proliferation |
| WO2007006143A1 (en) * | 2005-07-13 | 2007-01-18 | The Hospital For Sick Children | Compositions and methods for detecting transformed cells |
| ES2546063T3 (es) * | 2009-12-10 | 2015-09-18 | The Regents Of The University Of California | Agentes de enlace a amiloides |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3718472A (en) * | 1971-03-04 | 1973-02-27 | Eastman Kodak Co | Filter dyes for photographic elements |
| GB8421398D0 (en) | 1984-08-23 | 1984-09-26 | Minnesota Mining & Mfg | Sublimation transfer imaging system |
| US4632895A (en) * | 1984-08-23 | 1986-12-30 | Minnesota Mining And Manufacturing Company | Diffusion or sublimation transfer imaging system |
| US4617373A (en) * | 1985-02-15 | 1986-10-14 | Eastman Kodak Company | Condensation polymers and products therefrom |
| US5217999A (en) | 1987-12-24 | 1993-06-08 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Styryl compounds which inhibit EGF receptor protein tyrosine kinase |
| US5418245A (en) | 1990-04-16 | 1995-05-23 | Rhone-Poulenc Rorer International (Holdings) Inc. | Styryl-substituted monocyclic and bicyclic heteroaryl compounds which inhibit EGF receptor tyrosine kinase |
| WO1995024190A2 (en) | 1994-03-07 | 1995-09-14 | Sugen, Inc. | Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof |
| US5656655A (en) | 1994-03-17 | 1997-08-12 | Rhone-Poulenc Rorer Pharmaceuticals, Inc. | Styryl-substituted heteroaryl compounds which inhibit EGF receptor tyrosine kinase |
| AU6112896A (en) | 1995-06-07 | 1996-12-30 | Sugen, Inc. | Tyrphostin-like compounds for the treatment of cell prolifer ative disorders or cell differentiation disorders |
| JP2001066605A (ja) | 1999-08-30 | 2001-03-16 | Hayashi Telempu Co Ltd | 液晶配向膜およびその製造方法、液晶表示装置 |
| AU2001248201B2 (en) | 2000-04-13 | 2006-12-14 | Hsc Research And Development Limited Partnership | Compounds for modulating cell proliferation |
| EP1467967B1 (de) | 2002-01-18 | 2011-04-27 | The Hospital For Sick Children | Verbindungen für die modulation der proliferation von zellen |
-
2003
- 2003-01-17 EP EP03700255A patent/EP1467967B1/de not_active Expired - Lifetime
- 2003-01-17 BR BR0307000-0A patent/BR0307000A/pt not_active IP Right Cessation
- 2003-01-17 CA CA002473763A patent/CA2473763A1/en not_active Abandoned
- 2003-01-17 JP JP2003562074A patent/JP4383885B2/ja not_active Expired - Lifetime
- 2003-01-17 AT AT03700255T patent/ATE507203T1/de not_active IP Right Cessation
- 2003-01-17 GB GB0418331A patent/GB2401363B/en not_active Expired - Fee Related
- 2003-01-17 MX MXPA04006920A patent/MXPA04006920A/es active IP Right Grant
- 2003-01-17 CN CNA038040646A patent/CN1633411A/zh active Pending
- 2003-01-17 WO PCT/CA2003/000032 patent/WO2003062190A1/en not_active Ceased
- 2003-01-17 DE DE60336887T patent/DE60336887D1/de not_active Expired - Lifetime
- 2003-01-17 US US10/501,699 patent/US7563820B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7563820B2 (en) | 2009-07-21 |
| US20050085538A1 (en) | 2005-04-21 |
| JP4383885B2 (ja) | 2009-12-16 |
| CA2473763A1 (en) | 2003-07-31 |
| GB2401363B (en) | 2005-10-12 |
| EP1467967A1 (de) | 2004-10-20 |
| CN1633411A (zh) | 2005-06-29 |
| WO2003062190A1 (en) | 2003-07-31 |
| GB0418331D0 (en) | 2004-09-22 |
| MXPA04006920A (es) | 2005-06-17 |
| DE60336887D1 (de) | 2011-06-09 |
| BR0307000A (pt) | 2004-11-03 |
| EP1467967B1 (de) | 2011-04-27 |
| GB2401363A (en) | 2004-11-10 |
| JP2005515252A (ja) | 2005-05-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |