ATE337296T1 - Verbindungen für die modulation der proliferation von zellen - Google Patents

Verbindungen für die modulation der proliferation von zellen

Info

Publication number
ATE337296T1
ATE337296T1 AT01921087T AT01921087T ATE337296T1 AT E337296 T1 ATE337296 T1 AT E337296T1 AT 01921087 T AT01921087 T AT 01921087T AT 01921087 T AT01921087 T AT 01921087T AT E337296 T1 ATE337296 T1 AT E337296T1
Authority
AT
Austria
Prior art keywords
compounds
cell proliferation
modulating cell
modulating
styrylacrylonitrile
Prior art date
Application number
AT01921087T
Other languages
English (en)
Inventor
Chaim M Roifman
Thomas Grunberger
Olga Rounova
Peter Demin
Nigel Sharfe
Original Assignee
Hsc Res Dev Lp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hsc Res Dev Lp filed Critical Hsc Res Dev Lp
Application granted granted Critical
Publication of ATE337296T1 publication Critical patent/ATE337296T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
    • C07C255/41—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by carboxyl groups, other than cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00—Thiocarboxylic acids
    • C07C327/38—Amides of thiocarboxylic acids
    • C07C327/40—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C327/44—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/292—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with chromium derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT01921087T 2000-04-13 2001-04-12 Verbindungen für die modulation der proliferation von zellen ATE337296T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19693600P 2000-04-13 2000-04-13

Publications (1)

Publication Number Publication Date
ATE337296T1 true ATE337296T1 (de) 2006-09-15

Family

ID=22727358

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01921087T ATE337296T1 (de) 2000-04-13 2001-04-12 Verbindungen für die modulation der proliferation von zellen

Country Status (17)

Country Link
US (3) US7012095B2 (de)
EP (1) EP1272457B9 (de)
JP (1) JP2003531133A (de)
CN (1) CN100413845C (de)
AT (1) ATE337296T1 (de)
AU (2) AU2001248201B2 (de)
BR (1) BR0110087A (de)
CA (1) CA2406160A1 (de)
CY (1) CY1106447T1 (de)
DE (1) DE60122484T2 (de)
DK (1) DK1272457T3 (de)
ES (1) ES2267747T3 (de)
GB (1) GB2378948B (de)
MX (1) MXPA02010089A (de)
PT (1) PT1272457E (de)
RU (1) RU2277531C9 (de)
WO (1) WO2001079158A2 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001248201B2 (en) 2000-04-13 2006-12-14 Hsc Research And Development Limited Partnership Compounds for modulating cell proliferation
US20050014690A1 (en) * 2001-10-11 2005-01-20 Chaim Roifman Styryl acrylonitrile compounds and their use to promote myelopoiesis
EP1467967B1 (de) * 2002-01-18 2011-04-27 The Hospital For Sick Children Verbindungen für die modulation der proliferation von zellen
AU2003273702A1 (en) * 2002-10-11 2004-05-04 The Hospital For Sick Children Styrylacrylonitrile compounds for inhibition of vascular endothelial growth factor
CH696238A5 (de) * 2003-06-30 2007-02-28 Lymphosign Inc Verfahren zur Herstellung von Zimtaldehydverbindungen.
WO2005012234A1 (en) * 2003-07-30 2005-02-10 The Hospital For Sick Children Compounds for modulating cell proliferation
WO2005092904A1 (en) * 2004-03-26 2005-10-06 Hsc Research And Development Limited Partnership Novel compounds for modulating cell proliferation
US7202383B2 (en) 2004-09-14 2007-04-10 The Hospital For Sick Children Compounds useful for modulating abnormal cell proliferation
US7807719B2 (en) * 2004-09-14 2010-10-05 Chaim Roifman Compounds useful for modulating abnormal cell proliferation
CA2585125C (en) 2004-10-25 2014-04-22 Lee Morgan Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents
WO2007006143A1 (en) * 2005-07-13 2007-01-18 The Hospital For Sick Children Compositions and methods for detecting transformed cells
US7964583B2 (en) 2006-02-17 2011-06-21 Ziopharm Oncology, Inc. Salts of isophosphoramide mustard and analogs thereof as anti-tumor agents
CA2654909A1 (en) * 2006-06-13 2007-12-21 Elan Pharma International Ltd. Nanoparticulate kinase inhibitor formulations
KR20150139620A (ko) 2007-04-06 2015-12-11 지오팜 온콜로지 인코포레이티드 이소포스포르아미드 머스타드의 염 및 이의 동족체
US8450337B2 (en) * 2008-09-30 2013-05-28 Moleculin, Llc Methods of treating skin disorders with caffeic acid analogs
JPWO2013027694A1 (ja) * 2011-08-24 2015-03-19 国立大学法人京都大学 コンフォメーション病診断用分子イメージングプローブ

Family Cites Families (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3125597A (en) 1964-03-17 chj oh
US2798881A (en) * 1954-11-12 1957-07-09 Du Pont 4-(aminoaryl)-1, 3-butadiene-2-carbonitriles and their preparation
US3047606A (en) * 1958-12-01 1962-07-31 Rohm & Haas Dialkyl 1-cyanovinylphosphonates, their preparation, and polymers and copolymers thereof
US3852683A (en) 1971-10-18 1974-12-03 Eastman Kodak Co Arylidene dye lasers
GB1572441A (en) * 1975-12-23 1980-07-30 Vickers Ltd Photopolymerisable polymers with free carboxyl groups and printing plates therefrom
US4601532A (en) 1983-05-09 1986-07-22 Minnesota Mining And Manufacturing Company Narrow band light absorbing filter
US4554238A (en) 1984-03-20 1985-11-19 Minnesota Mining And Manufacturing Company Spectrally-sensitized imaging system
JPS60244595A (ja) 1984-05-18 1985-12-04 Ricoh Co Ltd 感熱記録材料
US4632895A (en) * 1984-08-23 1986-12-30 Minnesota Mining And Manufacturing Company Diffusion or sublimation transfer imaging system
US4617373A (en) * 1985-02-15 1986-10-14 Eastman Kodak Company Condensation polymers and products therefrom
CA1275538C (en) 1985-08-16 1990-10-23 Wayne P. Pruett Colored unsaturated polyester material containing copolymerized methine dyes, and products therefrom
US4950467A (en) 1986-11-14 1990-08-21 Ici Americas Inc. Ultraviolet radiation absorbing compositions
AU632992B2 (en) 1987-12-24 1993-01-21 Yissum Research Development Company Of The Hebrew University Of Jerusalem Pharmaceutical compositions comprising benzylidene- and cinnamylidene-malononitrile derivatives for the inhibition of proliferative processes in mammalian cells, certain such novel compounds and their preparation
US5217999A (en) 1987-12-24 1993-06-08 Yissum Research Development Company Of The Hebrew University Of Jerusalem Styryl compounds which inhibit EGF receptor protein tyrosine kinase
US5196147A (en) 1988-03-28 1993-03-23 Teijin Limited Organic nonlinear optical substance
EP0335641B1 (de) * 1988-03-28 1994-01-05 Teijin Limited Organischer nichtlinearer optischer Stoff
JPH02193954A (ja) 1989-01-23 1990-07-31 Teijin Ltd 薄膜規則性構造体
JP2672363B2 (ja) 1989-03-29 1997-11-05 帝人株式会社 有機非線形光学材料
JPH03230127A (ja) 1990-02-05 1991-10-14 Teijin Ltd 芳香族非線形光学材料
JPH03259126A (ja) 1990-03-09 1991-11-19 Teijin Ltd 新規な芳香族非線形光学材料
US5196446A (en) 1990-04-16 1993-03-23 Yissum Research Development Company Of The Hebrew University Of Jerusalem Certain indole compounds which inhibit EGF receptor tyrosine kinase
US5418245A (en) * 1990-04-16 1995-05-23 Rhone-Poulenc Rorer International (Holdings) Inc. Styryl-substituted monocyclic and bicyclic heteroaryl compounds which inhibit EGF receptor tyrosine kinase
JPH0436731A (ja) 1990-06-01 1992-02-06 Teijin Ltd 新規な芳香族系非線形光学材料
JPH0496026A (ja) 1990-08-13 1992-03-27 Teijin Ltd 非線形光学材料
EP0477140B1 (de) * 1990-09-17 1995-12-13 Ciba-Geigy Ag Druck- oder wärmeempfindliches Aufzeichnungsmaterial
JPH04198924A (ja) 1990-11-29 1992-07-20 Teijin Ltd 芳香族共役基を有する非線形光学材料
JPH04214387A (ja) 1990-12-12 1992-08-05 Teijin Ltd 記録媒体及び記録方法
DE69221290T2 (de) 1991-12-10 1998-01-15 Shionogi & Co Auf aromatischen sulfonamiden basierende hydroxamsäurederivate
JPH05173206A (ja) 1991-12-20 1993-07-13 Teijin Ltd 配向非線形光学素子
JPH0695186A (ja) 1992-09-14 1994-04-08 Teijin Ltd 耐久性を有する非線形光学素子
JPH06135948A (ja) 1992-10-30 1994-05-17 Taiho Yakuhin Kogyo Kk スチレン誘導体又はその塩
US5792771A (en) * 1992-11-13 1998-08-11 Sugen, Inc. Quinazoline compounds and compositions thereof for the treatment of disease
US6177401B1 (en) * 1992-11-13 2001-01-23 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis
US5763441A (en) 1992-11-13 1998-06-09 Sugen, Inc. Compounds for the treatment of disorders related to vasculogenesis and/or angiogenesis
US5712395A (en) * 1992-11-13 1998-01-27 Yissum Research Development Corp. Compounds for the treatment of disorders related to vasculogenesis and/or angiogenesis
JPH06186599A (ja) 1992-12-16 1994-07-08 Teijin Ltd 配向安定性を有する非線形光学素子
IL107736A (en) 1993-11-24 2001-01-11 Yissum Res Dev Co Pharmaceutical composition for the prevention of septic shock and for the treatment of chronic inflammatory diseases
US5700823A (en) * 1994-01-07 1997-12-23 Sugen, Inc. Treatment of platelet derived growth factor related disorders such as cancers
WO1995024190A2 (en) * 1994-03-07 1995-09-14 Sugen, Inc. Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof
US5656655A (en) * 1994-03-17 1997-08-12 Rhone-Poulenc Rorer Pharmaceuticals, Inc. Styryl-substituted heteroaryl compounds which inhibit EGF receptor tyrosine kinase
GB9406137D0 (en) * 1994-03-28 1994-05-18 Erba Carlo Spa N-substituted beta-aryl- and betaheteroaryl-alpha-cyanoacrylamide derivatives and process for their preparation
JP3230127B2 (ja) 1994-06-09 2001-11-19 三菱マテリアル株式会社 チップ材が高い接合強度を有する内燃機関タペット部材
US5789448A (en) * 1994-07-27 1998-08-04 Mitsubishi Chemical Corporation Benzoylethylene derivative
JPH09230585A (ja) 1995-02-01 1997-09-05 Toray Ind Inc 水なし平版印刷版原版
AU6112896A (en) 1995-06-07 1996-12-30 Sugen, Inc. Tyrphostin-like compounds for the treatment of cell prolifer ative disorders or cell differentiation disorders
JP3259126B2 (ja) 1995-09-26 2002-02-25 富士通株式会社 リング伝送システム及び該システムのスケルチ方法
US5578416A (en) * 1995-11-20 1996-11-26 Eastman Kodak Company Cinnamal-nitrile dyes for laser recording element
US5990193A (en) * 1995-12-12 1999-11-23 University Of Pittsburgh Polymers for reversible photoinduced sol gel transitions
US5932580A (en) * 1997-12-01 1999-08-03 Yissum Research And Development Company Of The Hebrew University Of Jerusalem PDGF receptor kinase inhibitory compounds their preparation and compositions
DE69918950T2 (de) * 1998-02-06 2005-07-28 De Montfort University Durch hydroxylierung aktivierte medikamentvorstufen
AU2001248201B2 (en) 2000-04-13 2006-12-14 Hsc Research And Development Limited Partnership Compounds for modulating cell proliferation

Also Published As

Publication number Publication date
US7012095B2 (en) 2006-03-14
CN100413845C (zh) 2008-08-27
RU2277531C9 (ru) 2006-11-20
AU2001248201B2 (en) 2006-12-14
CN1429202A (zh) 2003-07-09
GB0226316D0 (en) 2002-12-18
US20030109502A1 (en) 2003-06-12
HK1052496A1 (en) 2003-09-19
CA2406160A1 (en) 2001-10-25
RU2277531C2 (ru) 2006-06-10
WO2001079158A3 (en) 2002-01-31
DE60122484D1 (de) 2006-10-05
DE60122484T2 (de) 2006-12-21
MXPA02010089A (es) 2004-08-19
WO2001079158A2 (en) 2001-10-25
GB2378948B (en) 2004-11-10
PT1272457E (pt) 2007-01-31
AU4820101A (en) 2001-10-30
BR0110087A (pt) 2004-02-17
US20040209845A1 (en) 2004-10-21
RU2002127415A (ru) 2004-02-27
JP2003531133A (ja) 2003-10-21
GB2378948A (en) 2003-02-26
DK1272457T3 (da) 2007-01-08
EP1272457A2 (de) 2003-01-08
ES2267747T3 (es) 2007-03-16
CY1106447T1 (el) 2011-10-12
EP1272457B9 (de) 2006-12-20
US20040072803A1 (en) 2004-04-15
EP1272457B1 (de) 2006-08-23
US6800659B2 (en) 2004-10-05

Similar Documents

Publication Publication Date Title
DE60122484D1 (de) Verbindungen für die modulation der proliferation von zellen
EP1487428A4 (de) Amino-substituierte (e)-2,6-dialkoxystyryl 4-substituierte benzylsulfone zur behandlung von proliferierenden erkrankungen
DK1836201T3 (da) Pyrrolidininhibitorer af IAP
NZ506329A (en) Inhibitors of phospholipase enzymes
CY1121314T1 (el) Παραγωγο ραπαμυκινης για την θεραπευτικη αντιμετωπιση του καρκινου του πνευμονα
MXPA05001354A (es) Piperidina-ftalazonas sustituidas por pirrolidinodiona como inhibidores pde4.
HRP20050228A2 (en) Novel phenanthridines
MXPA03006093A (es) Derivados de n(fenilsulfonil)glicina y su uso terapeutico.
BR0112857A (pt) Compostos 2-(4-piridil)amino-6-dialcoxifenil-pirido-[2,3-d]pirimidin- 7-onas
ATE409035T1 (de) Substituierte pyrroline als kinase inhibitoren
CY1108567T1 (el) Αντιθρομβωτικες ενωσεις
BR0207278A (pt) Derivados de ftalazinona-piperidina como inibidores de pde4
BR0209149A (pt) Ftalazinonas
ATE359283T1 (de) Substituierte pyrazinonverbindungen zur behandlung von entzündungen
DE602005026962D1 (de) Arylcarboxamide und ihre verwendung als antitumormittel
IL138688A0 (en) Certain heteroaryl substituted thiol inhibitors of endothelin-converting enzyme
BR0109512A (pt) Imidazopiridinas tricìclicas
ATE507203T1 (de) Verbindungen für die modulation der proliferation von zellen
DE60217651D1 (de) Zur modulation der krebszellenproliferation geeignetes polynukleotid
ATE269313T1 (de) Tryptase-inhibitoren
ATE276259T1 (de) Dihydroporphyrinderivate und ihre verwendung
ATE529108T1 (de) Zellmigrationsmodulierende verbindungen
SI1244614T1 (en) Tryptase inhibitors
TR200000555T2 (tr) Malonik asit esaslı matriks metaloproteinaz inhibitörleri.
AU2003222426A1 (en) Methods and compositions for modulating beta-catenin phosphorylation

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1272457

Country of ref document: EP

REN Ceased due to non-payment of the annual fee