ATE50779T1 - N6-acenaphthyl-adenosine und analoga davon. - Google Patents

N6-acenaphthyl-adenosine und analoga davon.

Info

Publication number: ATE50779T1
Authority: AT; Austria
Prior art keywords: hydrogen; lower alkyl; alkyl; halogen; independently
Prior art date: 1984-10-26

Application number

AT85307544T

Other languages

English (en)

Inventor

James A Bristol

Bharat Trivedi

Walter Moos

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-10-26

Filing date

1985-10-18

Publication date

1990-03-15

1985-10-18 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

1990-03-15 Application granted granted Critical

1990-03-15 Publication of ATE50779T1 publication Critical patent/ATE50779T1/de

Links

229910052739 hydrogen Inorganic materials 0.000 abstract 7
239000001257 hydrogen Substances 0.000 abstract 7
125000000217 alkyl group Chemical group 0.000 abstract 6
150000002431 hydrogen Chemical class 0.000 abstract 5
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 3
229910052736 halogen Inorganic materials 0.000 abstract 3
150000002367 halogens Chemical class 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
125000004423 acyloxy group Chemical group 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 2
125000001231 benzoyloxy group Chemical group C(C1=CC=CC=C1)(=O)O* 0.000 abstract 2
125000001589 carboacyl group Chemical group 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Substances 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000001118 alkylidene group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
230000002526 effect on cardiovascular system Effects 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
229940124530 sulfonamide Drugs 0.000 abstract 1
150000003456 sulfonamides Chemical class 0.000 abstract 1
125000003396 thiol group Chemical group [H]S* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biotechnology (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

AT85307544T 1984-10-26 1985-10-18 N6-acenaphthyl-adenosine und analoga davon. ATE50779T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US06/665,219 US4593019A (en)	1984-10-26	1984-10-26	N6 -tricyclic adenosines
EP85307544A EP0179630B1 (de)	1984-10-26	1985-10-18	N6-Acenaphthyl-Adenosine und Analoga davon

Publications (1)

Publication Number	Publication Date
ATE50779T1 true ATE50779T1 (de)	1990-03-15

Family

ID=24669222

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT85307544T ATE50779T1 (de)	1984-10-26	1985-10-18	N6-acenaphthyl-adenosine und analoga davon.

Country Status (5)

Country	Link
US (1)	US4593019A (de)
EP (1)	EP0179630B1 (de)
JP (1)	JPS61103893A (de)
AT (1)	ATE50779T1 (de)
DE (1)	DE3576346D1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4683223A (en) *	1985-09-09	1987-07-28	Warner-Lambert Company	N6 -Benzopyrano-and benzothiopyrano adenosines and methods of use
US4755594A (en) *	1986-01-31	1988-07-05	Warner-Lambert Company	N6 -substituted adenosines
AU618723B2 (en) *	1986-10-06	1992-01-09	University Of Virginia Alumni Patents Foundation, The	Use of an adenosine, hypoxanthine and ribose-containing solution for improved protection of the heart during surgery
US4954504A (en) *	1986-11-14	1990-09-04	Ciba-Geigy Corporation	N9 -cyclopentyl-substituted adenine derivatives having adenosine-2 receptor stimulating activity
US5063233A (en) *	1986-11-14	1991-11-05	Ciba-Geigy Corporation	N9 -cyclopentyl-substituted adenine derivatives useful as adenosine receptor agonists
US4968697A (en) *	1987-02-04	1990-11-06	Ciba-Geigy Corporation	2-substituted adenosine 5'-carboxamides as antihypertensive agents
US5034381A (en) *	1988-01-07	1991-07-23	Ciba-Geigy Corporation	2-(substituted amino) adenosines as antihypertensives
JPH0725785B2 (ja) *	1989-01-11	1995-03-22	日本臓器製薬株式会社	アデノシン誘導体及び該化合物を有効成分として含有する医薬組成物
US5055569A (en) *	1989-10-19	1991-10-08	G. D. Searle & Co.	N-(6)-substituted adenosine compounds
US5561134A (en) *	1990-09-25	1996-10-01	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
ES2095960T3 (es) *	1990-09-25	1997-03-01	Rhone Poulenc Rorer Int	Compuestos que tienen propiedades antihipertensivas y antiisquemicas.
US6576619B2 (en)	1999-05-24	2003-06-10	Cv Therapeutics, Inc.	Orally active A1 adenosine receptor agonists
CN102812033B (zh) *	2009-12-10	2015-11-25	中国医学科学院药物研究所	N6-取代腺苷衍生物和n6-取代腺嘌呤衍生物及其用途
US9295423B2 (en) *	2013-04-03	2016-03-29	Toshiba America Electronic Components, Inc.	System and method for audio kymographic diagnostics

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL6717061A (de) *	1966-12-21	1968-06-24
DE1670265A1 (de) *	1967-08-25	1971-01-28	Boehringer Mannheim Gmbh	2-Amino-Adenosinderivate und Verfahren zu deren Herstellung
DE2139107A1 (de) *	1971-08-04	1973-02-15	Merck Patent Gmbh	Heterocyclisch substituierte adenosinverbindungen
BE788958A (fr) *	1971-09-18	1973-03-19	Schering Ag	Derives d'adenosine et leur procede de preparation
DE2230160A1 (de) *	1972-06-21	1974-01-31	Merck Patent Gmbh	Adenosinderivat
DE2406587A1 (de) *	1974-02-12	1975-08-21	Klinge Co Chem Pharm Fab	Hypolipaemisch wirksame adenosinderivate

1984
- 1984-10-26 US US06/665,219 patent/US4593019A/en not_active Expired - Fee Related
1985
- 1985-10-18 EP EP85307544A patent/EP0179630B1/de not_active Expired - Lifetime
- 1985-10-18 DE DE8585307544T patent/DE3576346D1/de not_active Expired - Fee Related
- 1985-10-18 AT AT85307544T patent/ATE50779T1/de not_active IP Right Cessation
- 1985-10-25 JP JP60237754A patent/JPS61103893A/ja active Pending

Also Published As

Publication number	Publication date
DE3576346D1 (de)	1990-04-12
EP0179630A2 (de)	1986-04-30
EP0179630B1 (de)	1990-03-07
JPS61103893A (ja)	1986-05-22
EP0179630A3 (en)	1987-05-20
US4593019A (en)	1986-06-03

Legal Events

Date	Code	Title	Description
1990-07-15	UEP	Publication of translation of european patent specification
1992-07-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE3576346D1 (de)	1990-04-12	N6-acenaphthyl-adenosine und analoga davon.
ES8403858A1 (es)	1984-04-01	Procedimiento para la preparacion de dipeptidos carboxialquilicos.
UA37178C2 (uk)	2001-05-15	Терапевтичні гетероциклічні сполуки, спосіб їх одержання, спосіб профілактики та лікування, лікарський засіб та спосіб його одержання
IL85988A (en)	1992-08-18	1-phenyl-3-naphthalenyloxy-propanamines,process for their preparation and pharmaceutical compositions containing them
ES8105298A1 (es)	1981-05-16	Un procedimiento para la preparacion de imidazol-cianoguani-dinas.
IL62110A (en)	1986-01-31	Pharmaceutical compositions containing(substituted)phenyl alkyl imidazole derivatives,some new such compounds and their preparation
ES547826A0 (es)	1986-12-16	Un procedimiento para preparar nuevos derivados de 6-(4-fenilo sustituido -3(2h) piradazinona.
ES557061A0 (es)	1988-01-01	Un procedimiento para preparar un derivado de 1,5-benzotiazepina
HUT39166A (en)	1986-08-28	Process for producing 2-/phenyl-alkyl/-3-/amino-alkyl/-4/3h/-quinazolinone derivatives and pharmaceutical compositions containing them
ATE26273T1 (de)	1987-04-15	3-indolcarboxamid-verbindungen.
ES548898A0 (es)	1987-04-16	Un procedimiento para la preparacion de derivados de 1,5-benzotiazepina'
AU554257B2 (en)	1986-08-14	6 - methyl - 1,4 dihydropyridine derivatives
ES8604185A1 (es)	1986-01-16	Un procedimiento para la preparacion de nuevos derivados de 1,5-benzotiazepina.
ES8607338A1 (es)	1986-05-16	Procedimiento para preparar n6-bicicloadenosinas
DK216186A (da)	1986-11-11	Hexensyrer
IL79928A (en)	1991-06-30	Spiro(benzofuran-2(3h),1'-cycloheptane)s,process for their preparation and pharmaceutical compositions containing them
IL81565A (en)	1991-09-16	Dihydropyridine-dicarboxylic acid esters,their preparation and pharmaceutical compositions containing them
TH13398A (th)	1993-11-15	เภสัชภัณฑ์