ATE507839T1 - Kombinationstherapie - Google Patents
KombinationstherapieInfo
- Publication number
- ATE507839T1 ATE507839T1 AT02719260T AT02719260T ATE507839T1 AT E507839 T1 ATE507839 T1 AT E507839T1 AT 02719260 T AT02719260 T AT 02719260T AT 02719260 T AT02719260 T AT 02719260T AT E507839 T1 ATE507839 T1 AT E507839T1
- Authority
- AT
- Austria
- Prior art keywords
- cells expressing
- combination therapy
- depletion
- treatment
- disorders characterized
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3061—Blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Iron Core Of Rotating Electric Machines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28080501P | 2001-04-02 | 2001-04-02 | |
| PCT/US2002/008057 WO2002078766A2 (en) | 2001-04-02 | 2002-03-14 | Combination therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE507839T1 true ATE507839T1 (de) | 2011-05-15 |
Family
ID=23074728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02719260T ATE507839T1 (de) | 2001-04-02 | 2002-03-14 | Kombinationstherapie |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US20020197256A1 (de) |
| EP (2) | EP1383532B1 (de) |
| JP (2) | JP4679035B2 (de) |
| AT (1) | ATE507839T1 (de) |
| AU (2) | AU2002250352C1 (de) |
| CA (1) | CA2440831C (de) |
| DE (1) | DE60239931D1 (de) |
| ES (1) | ES2364816T3 (de) |
| IL (3) | IL157946A0 (de) |
| WO (1) | WO2002078766A2 (de) |
Families Citing this family (83)
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| US8124630B2 (en) | 1999-01-13 | 2012-02-28 | Bayer Healthcare Llc | ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
| CA2359244C (en) | 1999-01-13 | 2013-10-08 | Bayer Healthcare Llc | .omega.-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors |
| US7183387B1 (en) | 1999-01-15 | 2007-02-27 | Genentech, Inc. | Polypeptide variants with altered effector function |
| US6737056B1 (en) * | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| ATE311199T1 (de) | 1999-05-07 | 2005-12-15 | Genentech Inc | Behandlung von autoimmunkrankheiten mit antagonisten die oberflächenmarker von b zellen binden |
| AU778863B2 (en) * | 1999-07-12 | 2004-12-23 | Genentech Inc. | Blocking immune response to a foreign antigen using an antagonist which binds to CD20 |
| AU2048501A (en) * | 2000-02-16 | 2001-08-27 | Genentech Inc. | Uses of agonists and antagonists to modulate activity of tnf-related molecules |
| JP2002016181A (ja) * | 2000-04-25 | 2002-01-18 | Torex Semiconductor Ltd | 半導体装置、その製造方法、及び電着フレーム |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| ES2364816T3 (es) * | 2001-04-02 | 2011-09-14 | Genentech, Inc. | Terapia de combinación. |
| FR2828104B1 (fr) * | 2001-08-01 | 2005-06-24 | Chu Montpellier | Utilisation d'inhibiteurs du facteur de croissance epidermique liant l'heparine ou d'inhibiteurs de ses recepteurs pour la preparation de medicaments utiles pour traiter le myelome |
| KR100988949B1 (ko) * | 2001-10-25 | 2010-10-20 | 제넨테크, 인크. | 당단백질 조성물 |
| EP2324825A1 (de) | 2002-02-11 | 2011-05-25 | Bayer Healthcare LLC | Arylharnstoffe mit Angiogenese hemmender Aktivität |
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| US20040191328A1 (en) * | 2002-12-31 | 2004-09-30 | Warrell Raymond P. | Combination of gallium compounds with nonchemotherapeutic anticancer agents in the treatment of neoplasia |
| UY28213A1 (es) | 2003-02-28 | 2004-09-30 | Bayer Pharmaceuticals Corp | Nuevos derivados de cianopiridina útiles en el tratamiento de cáncer y otros trastornos. |
| SI1613350T1 (sl) * | 2003-04-09 | 2009-08-31 | Genentech Inc | Zdravljenje avtoimunske bolezni pri bolniku z neustreznim odzivom na inhibitor TNF-alfa |
| KR101351122B1 (ko) * | 2003-05-09 | 2014-01-14 | 듀크 유니버시티 | Cd20-특이적 항체 및 이를 이용한 방법 |
| DE602004007382T2 (de) | 2003-05-20 | 2008-04-17 | Bayer Pharmaceuticals Corp., West Haven | Diaryl-harnstoffe für durch pdgfr vermittelte krankheiten |
| AR044388A1 (es) * | 2003-05-20 | 2005-09-07 | Applied Molecular Evolution | Moleculas de union a cd20 |
| PT2272868E (pt) | 2003-06-05 | 2015-07-07 | Genentech Inc | Terapêutica de combinação para distúrbios de células b |
| CA2532556A1 (en) * | 2003-07-29 | 2005-02-24 | Genentech, Inc. | Assay for human anti cd20 antibodies and uses therefor |
| BRPI0412629A (pt) * | 2003-08-29 | 2006-09-26 | Genentech Inc | método de tratamento de disfunção ocular em mamìferos |
| EP1689435A4 (de) * | 2003-10-22 | 2007-10-03 | Univ Rochester | Anti-thymozyten-antiserum und seine verwendung zur auslösung von b-zell-apoptose |
| US8277810B2 (en) | 2003-11-04 | 2012-10-02 | Novartis Vaccines & Diagnostics, Inc. | Antagonist anti-CD40 antibodies |
| PT1692182E (pt) | 2003-11-05 | 2010-05-13 | Roche Glycart Ag | Anticorpos de cd20 com uma afinidade de ligação acrescida ao receptor fc e uma função efectora acrescida |
| KR20060107555A (ko) * | 2003-12-19 | 2006-10-13 | 제넨테크, 인크. | 이식 거부에서 cd20의 검출 |
| US20050186206A1 (en) * | 2003-12-19 | 2005-08-25 | Genentech, Inc. | Detection of CD20 in therapy of autoimmune diseases |
| EP1735000A2 (de) * | 2004-04-16 | 2006-12-27 | Genentech, Inc. | Verfahren zur verstärkung des b-zellabbaus |
| EP1773393A2 (de) * | 2004-05-05 | 2007-04-18 | Genentech, Inc. | Verhütung von autoimmunerkrankungen mittels anti-cd20-antikörper |
| CA2568336A1 (en) * | 2004-06-04 | 2005-12-22 | Genentech, Inc. | Method for treating lupus |
| EP1753455A2 (de) | 2004-06-04 | 2007-02-21 | Genentech, Inc. | Verfahren zur behandlung von multipler sklerose |
| JP2008507555A (ja) * | 2004-07-22 | 2008-03-13 | ジェネンテック・インコーポレーテッド | シェーグレン症候群の治療方法 |
| EA012464B1 (ru) | 2004-08-04 | 2009-10-30 | Эпплайд Молекьюлар Эволюшн, Инк. | Антитело против cd20 и его применение |
| US8168222B2 (en) | 2004-09-07 | 2012-05-01 | Board Of Regents Of The University Of Nebraska | Amphiphilic polymer-protein conjugates and methods of use thereof |
| US8017151B2 (en) * | 2004-09-07 | 2011-09-13 | Board Of Regents Of The University Of Nebraska By And Behalf Of The University Of Nebraska Medical Center | Amphiphilic polymer-protein conjugates and methods of use thereof |
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| EP2295080A3 (de) | 2005-07-25 | 2011-06-22 | Emergent Product Development Seattle, LLC | B-Zell-Verringerung mit CD37-spezifischen und CD20-spezifischen Bindungsmolekülen |
| MY149159A (en) | 2005-11-15 | 2013-07-31 | Hoffmann La Roche | Method for treating joint damage |
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-
2002
- 2002-03-14 ES ES02719260T patent/ES2364816T3/es not_active Expired - Lifetime
- 2002-03-14 EP EP02719260A patent/EP1383532B1/de not_active Revoked
- 2002-03-14 CA CA2440831A patent/CA2440831C/en not_active Expired - Lifetime
- 2002-03-14 IL IL15794602A patent/IL157946A0/xx unknown
- 2002-03-14 EP EP10176041A patent/EP2359849A1/de not_active Withdrawn
- 2002-03-14 AT AT02719260T patent/ATE507839T1/de active
- 2002-03-14 WO PCT/US2002/008057 patent/WO2002078766A2/en not_active Ceased
- 2002-03-14 AU AU2002250352A patent/AU2002250352C1/en not_active Expired
- 2002-03-14 US US10/099,818 patent/US20020197256A1/en not_active Abandoned
- 2002-03-14 DE DE60239931T patent/DE60239931D1/de not_active Expired - Lifetime
- 2002-03-14 JP JP2002577030A patent/JP4679035B2/ja not_active Expired - Lifetime
-
2003
- 2003-09-16 IL IL157946A patent/IL157946A/en active IP Right Grant
-
2006
- 2006-09-29 US US11/537,559 patent/US20070178091A1/en not_active Abandoned
-
2008
- 2008-06-26 AU AU2008202838A patent/AU2008202838A1/en not_active Abandoned
-
2009
- 2009-10-28 JP JP2009247791A patent/JP5587589B2/ja not_active Expired - Lifetime
-
2010
- 2010-02-18 IL IL204031A patent/IL204031A/en active IP Right Grant
-
2011
- 2011-02-01 US US13/019,183 patent/US20110123531A1/en not_active Abandoned
-
2013
- 2013-11-05 US US14/072,703 patent/US20140065160A1/en not_active Abandoned
-
2016
- 2016-09-26 US US15/276,591 patent/US20170233482A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1383532B1 (de) | 2011-05-04 |
| EP1383532A2 (de) | 2004-01-28 |
| WO2002078766A2 (en) | 2002-10-10 |
| JP4679035B2 (ja) | 2011-04-27 |
| ES2364816T3 (es) | 2011-09-14 |
| WO2002078766A3 (en) | 2003-05-22 |
| AU2002250352B2 (en) | 2008-04-03 |
| US20070178091A1 (en) | 2007-08-02 |
| US20170233482A1 (en) | 2017-08-17 |
| IL204031A (en) | 2015-05-31 |
| DE60239931D1 (de) | 2011-06-16 |
| CA2440831C (en) | 2013-05-28 |
| JP5587589B2 (ja) | 2014-09-10 |
| EP1383532A4 (de) | 2004-10-06 |
| IL157946A (en) | 2013-11-28 |
| US20020197256A1 (en) | 2002-12-26 |
| AU2002250352C1 (en) | 2009-04-30 |
| AU2008202838A1 (en) | 2008-07-24 |
| JP2005508844A (ja) | 2005-04-07 |
| US20110123531A1 (en) | 2011-05-26 |
| EP2359849A1 (de) | 2011-08-24 |
| CA2440831A1 (en) | 2002-10-10 |
| JP2010077134A (ja) | 2010-04-08 |
| HK1062636A1 (en) | 2004-11-19 |
| IL157946A0 (en) | 2004-03-28 |
| US20140065160A1 (en) | 2014-03-06 |
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