ATE508128T1 - Cyclopropaheterocyclen als nicht-nukleosidische hemmer der reversen transkriptase - Google Patents

Cyclopropaheterocyclen als nicht-nukleosidische hemmer der reversen transkriptase

Info

Publication number
ATE508128T1
ATE508128T1 AT02748329T AT02748329T ATE508128T1 AT E508128 T1 ATE508128 T1 AT E508128T1 AT 02748329 T AT02748329 T AT 02748329T AT 02748329 T AT02748329 T AT 02748329T AT E508128 T1 ATE508128 T1 AT E508128T1
Authority
AT
Austria
Prior art keywords
cyclopropaheterocycles
reverse transcriptase
nucleosidic inhibitors
nucleosidic
inhibitors
Prior art date
Application number
AT02748329T
Other languages
English (en)
Inventor
Stefan Lindstroem
Christer Sahlberg
Hans Wallberg
Genaidy Kalyanov
Lourdes Oden
Lotta Naeslund
Original Assignee
Medivir Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medivir Ab filed Critical Medivir Ab
Application granted granted Critical
Publication of ATE508128T1 publication Critical patent/ATE508128T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/12—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom
    • C07C245/14—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C245/18—Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT02748329T 2001-03-05 2002-03-04 Cyclopropaheterocyclen als nicht-nukleosidische hemmer der reversen transkriptase ATE508128T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0100733A SE0100733D0 (sv) 2001-03-05 2001-03-05 Non-nucleoside reverse transcriptase inhibitors
PCT/EP2002/002328 WO2002070516A2 (en) 2001-03-05 2002-03-04 Cyclopropaheterocycles as non-nucleoside reverse transcriptase inhibitors

Publications (1)

Publication Number Publication Date
ATE508128T1 true ATE508128T1 (de) 2011-05-15

Family

ID=20283208

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02748329T ATE508128T1 (de) 2001-03-05 2002-03-04 Cyclopropaheterocyclen als nicht-nukleosidische hemmer der reversen transkriptase

Country Status (21)

Country Link
US (3) US6716850B2 (de)
EP (1) EP1373261B1 (de)
JP (2) JP4463478B2 (de)
KR (1) KR100884494B1 (de)
CN (2) CN101081843B (de)
AR (1) AR035941A1 (de)
AT (1) ATE508128T1 (de)
AU (1) AU2002308231B2 (de)
BR (1) BR0207886A (de)
CA (1) CA2438524C (de)
DE (1) DE60239924D1 (de)
DK (1) DK1373261T3 (de)
ES (1) ES2364926T3 (de)
IL (2) IL157543A0 (de)
MX (1) MXPA03008040A (de)
MY (1) MY137083A (de)
PL (1) PL207392B1 (de)
RU (1) RU2281284C2 (de)
SE (1) SE0100733D0 (de)
TW (1) TWI228990B (de)
WO (1) WO2002070516A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003260492B2 (en) * 2002-09-05 2007-03-01 Medivir Ab Non-nucleoside reverse transcriptase inhibitors
EP1680431A1 (de) * 2003-10-17 2006-07-19 Rigel Pharmaceuticals, Inc. Benzothiazol- und thiazol[5,5-b]pyridinzusammensetzungen und deren verwendung als ubiquitinligaseinhibitoren
JP4762917B2 (ja) * 2004-01-08 2011-08-31 メディヴィル・アクチボラグ 非ヌクレオシド逆転写酵素インヒビター
SE0400021D0 (sv) * 2004-01-08 2004-01-08 Medivir Ab Non-nucleoside reverse transcriptase inhibitors
GB0608876D0 (en) * 2006-05-05 2006-06-14 Medivir Ab Combination therapy
WO2007136572A2 (en) 2006-05-15 2007-11-29 Merck & Co., Inc. Antidiabetic bicyclic compounds
EP3013797B1 (de) 2013-06-28 2018-01-03 BeiGene, Ltd. Kondensierte tricyclische amidverbindungen als multiple kinaseinhibitoren
NZ716392A (en) 2013-06-28 2017-03-31 Beigene Ltd Fused tricyclic urea compounds as raf kinase and/or raf kinase dimer inhibitors
WO2015089842A1 (en) * 2013-12-20 2015-06-25 Merck Sharp & Dohme Corp. Novel tricyclic calcium sensing receptor antagonists for the treatment of osteoporosis
TWI849043B (zh) 2019-01-25 2024-07-21 英屬開曼群島商百濟神州有限公司 B-raf激酶二聚體抑制劑之穩定固體分散體、製備方法及其用途

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3803175A (en) 1969-08-22 1974-04-09 Universal Oil Prod Co Preparation of coumarin compounds
GB1311171A (en) * 1969-08-22 1973-03-21 Universal Oil Prod Co Vinylation of aromatic compounds
US4931221A (en) * 1988-12-30 1990-06-05 Ppg Industries, Inc. Photochromic spiropyran compounds
IL102548A (en) 1991-08-02 1998-08-16 Medivir Ab Thiourea derivatives for use in the preparation of medicaments for the inhibition of hiv and the treatment of aids and some such novel compounds
HUT70029A (en) * 1991-08-14 1995-09-28 Procter & Gamble Pharma Novel cyclic urea derivatives and antiarrhythmic and antifibrillatory compositions containing them
EP0598061B1 (de) * 1991-08-14 2002-07-17 Procter & Gamble Pharmaceuticals 4-oxozyklische harnstoffe mit antiarrhythmische und entfibrillatorische wirkung
EP0706514B1 (de) * 1993-08-24 1998-11-18 Medivir Ab Verbindungen und methoden zur inhibition von hiv und verwandten viren
AR016169A1 (es) * 1998-01-16 2001-06-20 Medivir Ab Compuesto, composicion farmaceutica que lo comprende y uso del mismo en la fabricacion de un medicamento para el tratamiento o profilaxis del vih.
US5998411A (en) 1998-03-17 1999-12-07 Hughes Institute Heterocyclic nonnucleoside inhibitors of reverse transcriptase
WO1999051613A1 (en) 1998-04-03 1999-10-14 Medivir Ab Prodrugs of phosphorous-containing pharmaceuticals
US6136335A (en) 1998-12-31 2000-10-24 Hughes Institute Phenethyl-5-bromopyridylthiourea (PBT) and dihydroalkoxybenzyloxopyrimidine (DABO) derivatives exhibiting spermicidal activity
US7186736B1 (en) 1999-03-20 2007-03-06 Parker Hughes Institute NNI for treatment of multi-drug resistant HIV
US6469034B1 (en) 1999-06-23 2002-10-22 Parker Hughes Institute Cyclohexenyl-ethyl-thiourea compounds for inhibiting HIV reverse transcriptase
US6207688B1 (en) 1999-06-23 2001-03-27 Parker Hughes Institute Phenethyl-thiourea compounds and use
US6124324A (en) 1999-06-23 2000-09-26 Hughes Institute Thiophene-ethyl thiourea compounds and use

Also Published As

Publication number Publication date
JP4463478B2 (ja) 2010-05-19
US20030069224A1 (en) 2003-04-10
IL157543A0 (en) 2004-03-28
EP1373261A2 (de) 2004-01-02
DE60239924D1 (de) 2011-06-16
HK1063784A1 (en) 2005-01-14
MXPA03008040A (es) 2004-05-24
US20050240035A1 (en) 2005-10-27
WO2002070516A3 (en) 2003-02-06
KR100884494B1 (ko) 2009-02-18
KR20030086601A (ko) 2003-11-10
CN1494545A (zh) 2004-05-05
CN101081843A (zh) 2007-12-05
WO2002070516A2 (en) 2002-09-12
SE0100733D0 (sv) 2001-03-05
TWI228990B (en) 2005-03-11
RU2281284C2 (ru) 2006-08-10
US20030187266A1 (en) 2003-10-02
DK1373261T3 (da) 2011-08-29
CN101081843B (zh) 2010-10-13
JP2009102436A (ja) 2009-05-14
IL157543A (en) 2010-11-30
ES2364926T3 (es) 2011-09-16
BR0207886A (pt) 2004-08-17
PL364414A1 (en) 2004-12-13
AR035941A1 (es) 2004-07-28
EP1373261B1 (de) 2011-05-04
RU2003129513A (ru) 2005-03-20
PL207392B1 (pl) 2010-12-31
US6894177B2 (en) 2005-05-17
AU2002308231B2 (en) 2007-05-10
MY137083A (en) 2008-12-31
CA2438524A1 (en) 2002-09-12
US6716850B2 (en) 2004-04-06
JP2004529112A (ja) 2004-09-24
CA2438524C (en) 2011-11-29
US7405310B2 (en) 2008-07-29
HK1111155A1 (en) 2008-08-01
CN1264839C (zh) 2006-07-19

Similar Documents

Publication Publication Date Title
DE60135087D1 (de) Dipeptidnitrile als inhibitoren von cathepsin k
SE0000540D0 (sv) New compounds
NO20033593D0 (no) Kinazoliner som MMP-13 inhibitorer
NO20043158L (no) Substituerte kinazolinderivater som inhibitorer av aurorakinaser
DK1438306T3 (da) Derivater af UK-2A
EP1622569A4 (de) Aza-spiro-alkan-derivate als hemmer von metallproteasen
ATE308316T1 (de) Neue zusammensetzungen von minoxidil
DE60218138D1 (de) Rho-kinase inhibitoren
DE60321324D1 (de) Sulfonylaminoderivate als neue inhibitoren von histondeacetylase
ATE370938T1 (de) Pro-pharmakon von cox-2-inhibitoren
DE60305061D1 (de) 2-pyridonderivate als inhibitoren von neutrophiler elastase
BR0213981A (pt) Fotoiniciadores difuncionais
EP1496894A4 (de) Angiogenese-hemmer
ATE370137T1 (de) 4-(6-gliedriger)-heteroaryl-acyl-pyrrolidin derivate als hcv-inhibitoren
DOP2001000151A (es) Derivados de imidazopirimidina y derivados de triazolopimidina.
DE60236226D1 (de) Verbesserung der Altersweitsichtigkeit
DE60330362D1 (de) Neue pyrazol-verbindungen als hemmer des transformierenden wachstumsfaktors (tgf)
NO20042534L (no) Forbedringer vedrorende optiske lysgjoringsmidler
DK1458447T3 (da) Kombination af cytokrom-p450-beroende proteasinhibitorer
EP1534268A4 (de) Tyrosin-kinase-hemmer
NO20041235L (no) Kinolinderivater som neuropeptid Y antagonister
ATE412653T1 (de) Nicht-nukleosidische inhibitoren der reversen transkriptase
FI20010558L (fi) Kappaleiden paikannus
ATE411287T1 (de) Neue metallproteinaseinhibitoren
ATE508128T1 (de) Cyclopropaheterocyclen als nicht-nukleosidische hemmer der reversen transkriptase

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties