DK1373261T3 - Cyklopropaheterocykler som non-nukleotid revers transkriptase-hæmmer - Google Patents

Cyklopropaheterocykler som non-nukleotid revers transkriptase-hæmmer

Info

Publication number
DK1373261T3
DK1373261T3 DK02748329.6T DK02748329T DK1373261T3 DK 1373261 T3 DK1373261 T3 DK 1373261T3 DK 02748329 T DK02748329 T DK 02748329T DK 1373261 T3 DK1373261 T3 DK 1373261T3
Authority
DK
Denmark
Prior art keywords
cyclopropaheterocycles
reverse transcriptase
transcriptase inhibitor
nucleotide reverse
nucleotide
Prior art date
Application number
DK02748329.6T
Other languages
English (en)
Inventor
Stefan Lindstroem
Christer Sahlberg
Hans Wallberg
Genaidy Kalyanov
Lourdes Oden
Lotta Naeslund
Original Assignee
Medivir Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medivir Ab filed Critical Medivir Ab
Application granted granted Critical
Publication of DK1373261T3 publication Critical patent/DK1373261T3/da

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/12Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom
    • C07C245/14Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C245/18Diazo compounds, i.e. compounds having the free valencies of >N2 groups attached to the same carbon atom having diazo groups bound to acyclic carbon atoms of a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/02Ethers
    • C07C43/20Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/23Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing hydroxy or O-metal groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
DK02748329.6T 2001-03-05 2002-03-04 Cyklopropaheterocykler som non-nukleotid revers transkriptase-hæmmer DK1373261T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0100733A SE0100733D0 (sv) 2001-03-05 2001-03-05 Non-nucleoside reverse transcriptase inhibitors
PCT/EP2002/002328 WO2002070516A2 (en) 2001-03-05 2002-03-04 Cyclopropaheterocycles as non-nucleoside reverse transcriptase inhibitors

Publications (1)

Publication Number Publication Date
DK1373261T3 true DK1373261T3 (da) 2011-08-29

Family

ID=20283208

Family Applications (1)

Application Number Title Priority Date Filing Date
DK02748329.6T DK1373261T3 (da) 2001-03-05 2002-03-04 Cyklopropaheterocykler som non-nukleotid revers transkriptase-hæmmer

Country Status (21)

Country Link
US (3) US6716850B2 (da)
EP (1) EP1373261B1 (da)
JP (2) JP4463478B2 (da)
KR (1) KR100884494B1 (da)
CN (2) CN1264839C (da)
AR (1) AR035941A1 (da)
AT (1) ATE508128T1 (da)
AU (1) AU2002308231B2 (da)
BR (1) BR0207886A (da)
CA (1) CA2438524C (da)
DE (1) DE60239924D1 (da)
DK (1) DK1373261T3 (da)
ES (1) ES2364926T3 (da)
IL (2) IL157543A0 (da)
MX (1) MXPA03008040A (da)
MY (1) MY137083A (da)
PL (1) PL207392B1 (da)
RU (1) RU2281284C2 (da)
SE (1) SE0100733D0 (da)
TW (1) TWI228990B (da)
WO (1) WO2002070516A2 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1534276B1 (en) * 2002-09-05 2008-11-05 Medivir AB Non-nucleoside reverse transcriptase inhibitors
US20050130974A1 (en) * 2003-10-17 2005-06-16 Rigel Pharmaceuticals, Inc. Benzothiazole compositions and their use as ubiquitin ligase inhibitors
SE0400021D0 (sv) * 2004-01-08 2004-01-08 Medivir Ab Non-nucleoside reverse transcriptase inhibitors
JP4762917B2 (ja) * 2004-01-08 2011-08-31 メディヴィル・アクチボラグ 非ヌクレオシド逆転写酵素インヒビター
GB0608876D0 (en) 2006-05-05 2006-06-14 Medivir Ab Combination therapy
ATE552245T1 (de) 2006-05-15 2012-04-15 Merck Sharp & Dohme Antidiabetische bicyclische verbindungen
US9670203B2 (en) * 2013-06-28 2017-06-06 Beigene, Ltd. Fused tricyclic urea compounds as Raf kinase and/or Raf kinase dimer inhibitors
US9670231B2 (en) 2013-06-28 2017-06-06 Beigene, Ltd. Fused tricyclic amide compounds as multiple kinase inhibitors
WO2015089842A1 (en) * 2013-12-20 2015-06-25 Merck Sharp & Dohme Corp. Novel tricyclic calcium sensing receptor antagonists for the treatment of osteoporosis
TWI909513B (zh) 2019-01-25 2025-12-21 英屬開曼群島商百濟神州有限公司 作為b-raf激酶二聚體抑制劑之化合物及其製備方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA973885A (en) * 1969-08-22 1975-09-02 Universal Oil Products Company Vinylation of aromatic compounds
US3803175A (en) 1969-08-22 1974-04-09 Universal Oil Prod Co Preparation of coumarin compounds
US4931221A (en) * 1988-12-30 1990-06-05 Ppg Industries, Inc. Photochromic spiropyran compounds
IL102548A (en) 1991-08-02 1998-08-16 Medivir Ab Thiourea derivatives for use in the preparation of medicaments for the inhibition of hiv and the treatment of aids and some such novel compounds
CA2115427C (en) * 1991-08-14 2000-05-02 Stanford Salvatore Pelosi Jr. Novel 4-oxocyclic ureas useful as antiarrhythmic and antifibrillatory agents
CZ286265B6 (cs) * 1991-08-14 2000-03-15 Procter And Gamble Pharmaceuticals Cyklické sloučeniny močoviny a farmaceutický prostředek, který je obsahuje
CA2168447C (en) * 1993-08-24 2006-07-11 Peter Thomas Lind Compounds and methods for inhibition of hiv and related viruses
BR9906933A (pt) * 1998-01-16 2001-11-27 Medivir Ab Antiviróticos
US5998411A (en) 1998-03-17 1999-12-07 Hughes Institute Heterocyclic nonnucleoside inhibitors of reverse transcriptase
WO1999051613A1 (en) 1998-04-03 1999-10-14 Medivir Ab Prodrugs of phosphorous-containing pharmaceuticals
US6136335A (en) 1998-12-31 2000-10-24 Hughes Institute Phenethyl-5-bromopyridylthiourea (PBT) and dihydroalkoxybenzyloxopyrimidine (DABO) derivatives exhibiting spermicidal activity
US7186736B1 (en) 1999-03-20 2007-03-06 Parker Hughes Institute NNI for treatment of multi-drug resistant HIV
US6207688B1 (en) 1999-06-23 2001-03-27 Parker Hughes Institute Phenethyl-thiourea compounds and use
US6469034B1 (en) 1999-06-23 2002-10-22 Parker Hughes Institute Cyclohexenyl-ethyl-thiourea compounds for inhibiting HIV reverse transcriptase
US6124324A (en) 1999-06-23 2000-09-26 Hughes Institute Thiophene-ethyl thiourea compounds and use

Also Published As

Publication number Publication date
RU2003129513A (ru) 2005-03-20
HK1063784A1 (en) 2005-01-14
MY137083A (en) 2008-12-31
EP1373261B1 (en) 2011-05-04
BR0207886A (pt) 2004-08-17
US6716850B2 (en) 2004-04-06
PL364414A1 (en) 2004-12-13
JP4463478B2 (ja) 2010-05-19
JP2009102436A (ja) 2009-05-14
CA2438524C (en) 2011-11-29
CN101081843A (zh) 2007-12-05
WO2002070516A2 (en) 2002-09-12
US6894177B2 (en) 2005-05-17
IL157543A (en) 2010-11-30
JP2004529112A (ja) 2004-09-24
PL207392B1 (pl) 2010-12-31
ATE508128T1 (de) 2011-05-15
US20030069224A1 (en) 2003-04-10
MXPA03008040A (es) 2004-05-24
KR20030086601A (ko) 2003-11-10
US20030187266A1 (en) 2003-10-02
RU2281284C2 (ru) 2006-08-10
CA2438524A1 (en) 2002-09-12
US20050240035A1 (en) 2005-10-27
IL157543A0 (en) 2004-03-28
CN1494545A (zh) 2004-05-05
CN101081843B (zh) 2010-10-13
KR100884494B1 (ko) 2009-02-18
AR035941A1 (es) 2004-07-28
ES2364926T3 (es) 2011-09-16
HK1111155A1 (en) 2008-08-01
US7405310B2 (en) 2008-07-29
TWI228990B (en) 2005-03-11
EP1373261A2 (en) 2004-01-02
AU2002308231B2 (en) 2007-05-10
CN1264839C (zh) 2006-07-19
DE60239924D1 (de) 2011-06-16
WO2002070516A3 (en) 2003-02-06
SE0100733D0 (sv) 2001-03-05

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