DK1458447T3 - Kombination af cytokrom-p450-beroende proteasinhibitorer - Google Patents

Kombination af cytokrom-p450-beroende proteasinhibitorer

Info

Publication number: DK1458447T3
Authority: DK; Denmark
Prior art keywords: cytochrome; combination; protease inhibitors; dependent protease; dependent
Prior art date: 2001-12-12

Application number

DK02793018.9T

Other languages

English (en)

Inventor

Der Geest Ronald Van

Paul Stoffels

Cornelis Groen

Dirk Edward Desire Jochmans

Original Assignee

Tibotec Pharm Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-12

Filing date

2002-12-12

Publication date

2010-01-18

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8181408&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1458447(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-12-12 Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd

2010-01-18 Application granted granted Critical

2010-01-18 Publication of DK1458447T3 publication Critical patent/DK1458447T3/da

Links

102000002004 Cytochrome P-450 Enzyme System Human genes 0.000 title 1
108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 title 1
230000001419 dependent effect Effects 0.000 title 1
229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
239000000137 peptide hydrolase inhibitor Substances 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
- A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Virology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
AIDS & HIV (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Ultra Sonic Daignosis Equipment (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DK02793018.9T 2001-12-12 2002-12-12 Kombination af cytokrom-p450-beroende proteasinhibitorer DK1458447T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP01204841		2001-12-12
PCT/EP2002/014277 WO2003049746A2 (en)	2001-12-12	2002-12-12	Combination of cytochome p450 dependent protease inhibitors

Publications (1)

Publication Number	Publication Date
DK1458447T3 true DK1458447T3 (da)	2010-01-18

Family

ID=8181408

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02793018.9T DK1458447T3 (da)	2001-12-12	2002-12-12	Kombination af cytokrom-p450-beroende proteasinhibitorer

Country Status (27)

Country	Link
US (1)	US20050119338A1 (da)
EP (1)	EP1458447B1 (da)
JP (1)	JP2005511723A (da)
KR (1)	KR100974921B1 (da)
CN (1)	CN100335060C (da)
AR (1)	AR037797A1 (da)
AT (1)	ATE442189T1 (da)
AU (1)	AU2002358713B2 (da)
BR (1)	BR0215043A (da)
CA (1)	CA2469343C (da)
CY (1)	CY1110604T1 (da)
DE (1)	DE60233677D1 (da)
DK (1)	DK1458447T3 (da)
ES (1)	ES2333206T3 (da)
HR (1)	HRP20040619A2 (da)
HU (1)	HUP0402644A3 (da)
IL (1)	IL162353A0 (da)
MX (1)	MXPA04005755A (da)
NO (1)	NO20042666L (da)
NZ (1)	NZ533826A (da)
PL (1)	PL373072A1 (da)
PT (1)	PT1458447E (da)
RU (1)	RU2329050C2 (da)
SI (1)	SI1458447T1 (da)
TW (1)	TWI286476B (da)
WO (1)	WO2003049746A2 (da)
ZA (1)	ZA200404633B (da)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PL1670773T3 (pl) *	2003-09-30	2007-06-29	Tibotec Pharm Ltd	Sposób wytwarzania sulfonamidów benzoksazolu i ich związków pośrednich
AU2004308712A1 (en) *	2003-12-23	2005-07-14	Tibotec Pharmaceuticals Ltd.	Self-microemulsifying drug delivery systems of a HIV protease inhibitor
MXPA06012909A (es) *	2004-05-07	2007-09-06	Sequoia Pharmaceuticals Inc	Inhibidores de proteasa retroviral repelente de resistencia.
CN1984654A (zh) *	2004-07-08	2007-06-20	泰博特克药品有限公司	抗－hiv逆转录酶和蛋白酶抑制剂的组合
AU2006217922B2 (en)	2005-02-25	2012-04-05	Janssen Sciences Ireland Uc	Protease inhibitor precursor synthesis
JP2008538354A (ja) *	2005-04-08	2008-10-23	キメリクス，インコーポレイテッド	ウイルス感染症およびその他の内科疾患を治療するための化合物、組成物および方法
AR053845A1 (es) *	2005-04-15	2007-05-23	Tibotec Pharm Ltd	5-tiazolilmetil[(1s,2r)-3-[[(2-amino-6-benzoxazolil)sulfonil)](2-metilpropil)amino]-2-hidroxi-1-(fenilmetil)propil]carbamato como mejorador de farmacos metabolizados por el citocromo p450
AR058238A1 (es) *	2005-11-28	2008-01-23	Tibotec Pharm Ltd	Compuestos y derivados de aminofenilsulfonamida sustituida como inhibidores de proteasa del vih
TWI385173B (zh) *	2005-11-28	2013-02-11	Tibotec Pharm Ltd	作為ｈｉｖ蛋白酶抑制劑之經取代的胺基苯基磺醯胺化合物
BRPI0620865A2 (pt) *	2005-12-30	2011-11-29	Gilead Sciences Inc	métodos para melhorar a farmacocinética de inibidores das integrases do hiv
JO2841B1 (en) *	2006-06-23	2014-09-15	تيبوتيك فارماسيوتيكالز ليمتد	2-(substituted-amino) -benzothiazole sulfonamide as protease inhibitors HIV (HIV)
US8048871B2 (en)	2006-08-18	2011-11-01	Sequoia Pharmaceuticals, Inc.	Compositions and methods for inhibiting cytochrome P450
EP2139883A4 (en) *	2007-03-23	2011-06-22	Univ Massachusetts	HIV-1 protease inhibitor
UA103013C2 (uk)	2007-12-06	2013-09-10	Тиботек Фармасьютикелз	Амідні сполуки як активатори противірусних препаратів
GT200800303A (es) *	2007-12-24	2009-09-18		Combinacion anti-retroviral
CN101977610B (zh)	2008-01-25	2012-05-16	奇默里克斯公司	治疗病毒感染的方法
US8664391B2 (en)	2008-10-07	2014-03-04	Janssen R&D Ireland Ltd	Amide compounds as boosters of antivirals
US8921349B2 (en)	2009-05-11	2014-12-30	Purdue Research Foundation	Compounds and methods for treating AIDS and HIV infections
JO3090B1 (ar) *	2009-12-11	2017-03-15	Janssen Sciences Ireland Uc	5- امينو-4- هيدروكسي-بنتويل اميدات
PT2534150T (pt)	2010-02-12	2017-05-02	Chimerix Inc	Métodos para tratar uma infecção viral
US9278135B2 (en)	2010-04-26	2016-03-08	Chimerix Inc.	Methods of treating retroviral infections and related dosage regimes
EP2576544A4 (en) *	2010-06-01	2013-09-11	Angion Biomedica Corp	INHIBITORS OF CYTOCHROMES P450 AND USES THEREOF
HUE030341T2 (en)	2011-07-07	2017-05-29	Janssen Sciences Ireland Uc	Darunavir preparations
SI2729130T1 (en)	2011-07-07	2018-03-30	Janssen Sciences Ireland Uc	Combined formulations of darunavir

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1995010281A1 (en) *	1993-10-13	1995-04-20	Merck & Co., Inc.	Combination therapy for hiv infection
US6037157A (en) *	1995-06-29	2000-03-14	Abbott Laboratories	Method for improving pharmacokinetics
ES2262184T3 (es) *	1996-08-05	2006-11-16	Myriad Genetics, Inc.	Utilizacion de mimeticos de hojas beta como inhibidores de proteasa y de kinasa o como inhibidores de factores de transcripcion.
US6180634B1 (en) *	1997-11-13	2001-01-30	Merck & Co., Inc.	Combination therapy for the treatment of AIDS
US6436989B1 (en) *	1997-12-24	2002-08-20	Vertex Pharmaceuticals, Incorporated	Prodrugs of aspartyl protease inhibitors
JP4776775B2 (ja) *	1998-06-23	2011-09-21	アメリカ合衆国	Ｈｉｖ感染哺乳動物を治療するための医薬組成物
WO1999067254A2 (en) *	1998-06-23	1999-12-29	The United States Of America Represented By The Secretary, Department Of Health And Human Services	Multi-drug resistant retroviral protease inhibitors and use thereof
MY145265A (en) *	1998-07-20	2012-01-13	Abbott Lab	Amorphous ritonavir
EP1159278B1 (en) *	1999-02-12	2005-11-30	Vertex Pharmaceuticals Incorporated	Inhibitors of aspartyl protease
TWI260322B (en) *	1999-02-12	2006-08-21	Vertex Pharma	Inhibitors of aspartyl protease

2002
- 2002-12-11 AR ARP020104805A patent/AR037797A1/es unknown
- 2002-12-11 TW TW091135882A patent/TWI286476B/zh not_active IP Right Cessation
- 2002-12-12 PL PL02373072A patent/PL373072A1/xx not_active IP Right Cessation
- 2002-12-12 KR KR1020047008830A patent/KR100974921B1/ko not_active Ceased
- 2002-12-12 IL IL16235302A patent/IL162353A0/xx unknown
- 2002-12-12 NZ NZ533826A patent/NZ533826A/en not_active IP Right Cessation
- 2002-12-12 HR HR20040619A patent/HRP20040619A2/hr not_active Application Discontinuation
- 2002-12-12 PT PT02793018T patent/PT1458447E/pt unknown
- 2002-12-12 CA CA002469343A patent/CA2469343C/en not_active Expired - Fee Related
- 2002-12-12 EP EP02793018A patent/EP1458447B1/en not_active Revoked
- 2002-12-12 AU AU2002358713A patent/AU2002358713B2/en not_active Revoked
- 2002-12-12 SI SI200230865T patent/SI1458447T1/sl unknown
- 2002-12-12 BR BR0215043-3A patent/BR0215043A/pt not_active Application Discontinuation
- 2002-12-12 CN CNB028249119A patent/CN100335060C/zh not_active Expired - Fee Related
- 2002-12-12 ES ES02793018T patent/ES2333206T3/es not_active Expired - Lifetime
- 2002-12-12 DK DK02793018.9T patent/DK1458447T3/da active
- 2002-12-12 US US10/498,024 patent/US20050119338A1/en not_active Abandoned
- 2002-12-12 WO PCT/EP2002/014277 patent/WO2003049746A2/en not_active Ceased
- 2002-12-12 RU RU2004121144/15A patent/RU2329050C2/ru not_active IP Right Cessation
- 2002-12-12 HU HU0402644A patent/HUP0402644A3/hu unknown
- 2002-12-12 JP JP2003550795A patent/JP2005511723A/ja active Pending
- 2002-12-12 DE DE60233677T patent/DE60233677D1/de not_active Expired - Lifetime
- 2002-12-12 AT AT02793018T patent/ATE442189T1/de not_active IP Right Cessation
2004
- 2004-06-10 ZA ZA200404633A patent/ZA200404633B/en unknown
- 2004-06-14 MX MXPA04005755A patent/MXPA04005755A/es active IP Right Grant
- 2004-06-24 NO NO20042666A patent/NO20042666L/no not_active Application Discontinuation
2009
- 2009-12-09 CY CY20091101283T patent/CY1110604T1/el unknown

Also Published As

Publication number	Publication date
CA2469343A1 (en)	2003-06-19
ZA200404633B (en)	2005-09-01
WO2003049746A3 (en)	2003-12-31
TWI286476B (en)	2007-09-11
CN100335060C (zh)	2007-09-05
SI1458447T1 (sl)	2010-01-29
NO20042666L (no)	2004-09-09
HRP20040619A2 (en)	2005-08-31
RU2329050C2 (ru)	2008-07-20
IL162353A0 (en)	2005-11-20
RU2004121144A (ru)	2005-04-20
WO2003049746A2 (en)	2003-06-19
NZ533826A (en)	2006-04-28
HK1070008A1 (en)	2005-06-10
PT1458447E (pt)	2009-12-16
HUP0402644A3 (en)	2008-04-28
HUP0402644A2 (en)	2007-02-28
CY1110604T1 (el)	2015-04-29
ES2333206T3 (es)	2010-02-18
CA2469343C (en)	2008-05-13
AU2002358713B2 (en)	2009-01-29
MXPA04005755A (es)	2004-09-10
TW200409624A (en)	2004-06-16
KR20040071182A (ko)	2004-08-11
JP2005511723A (ja)	2005-04-28
EP1458447B1 (en)	2009-09-09
BR0215043A (pt)	2004-11-03
CN1604803A (zh)	2005-04-06
DE60233677D1 (de)	2009-10-22
AU2002358713A1 (en)	2003-06-23
EP1458447A2 (en)	2004-09-22
KR100974921B1 (ko)	2010-08-09
PL373072A1 (en)	2005-08-08
AR037797A1 (es)	2004-12-01
US20050119338A1 (en)	2005-06-02
ATE442189T1 (de)	2009-09-15

Publication	Publication Date	Title
NO20034042D0 (no)	2003-09-12	Metallproteinase-inhibitorer
DE60234125D1 (de)	2009-12-03	E inhibitoren
CY2015028I2 (el)	2016-07-27	Ενας αναστολεας ν-ακυλοσφιγγοσινο γλυκοζυλοτρανσφερασης
EE200300439A (et)	2003-12-15	Metalloproteinaasi inhibiitorid
DK1438306T3 (da)	2014-06-23	Derivater af UK-2A
CY2012007I2 (el)	2014-07-02	Πεπτιδομιμητικοι αναστολεις πρωτεασης
DK1567529T4 (da)	2021-05-10	Pseudopolymorfe former af en hiv-proteaseinhibitor
PT1370553E (pt)	2006-09-29	Inibidores de rhoquinase
ATE286049T1 (de)	2005-01-15	Pyridazinonaldose reductase inhibitoren
NO20034032D0 (no)	2003-09-11	Metallproteinase-inhibitorer
EP1499336A4 (en)	2005-06-01	PROTEASE INHIBITORS
DK1686113T3 (da)	2012-02-20	Inhibitorer af aspartylprotease
DE60233677D1 (de)	2009-10-22	Kombination von cytochrom-p450-abhängigen protease-inhibitoren
FI20010558L (fi)	2002-09-20	Kappaleiden paikannus
DK1451154T3 (da)	2008-05-19	Inhibitorer af cytosolisk phospholipase A2
DK1536796T3 (da)	2008-06-09	N-arylpiperidinsubstituerede biphenylcarboxamider som inhibitorer af apolipoprotein B-sektion
ATE429431T1 (de)	2009-05-15	2-amino-benzoxazol-suphonamide als breitspektrum- hiv-protease-inhibitoren
NO20025786L (no)	2003-02-12	Protaseinhibitorer
NO20025005L (no)	2002-12-06	Proteaseinhibitorer
EP1463521A4 (en)	2009-06-24	INHIBITOR OF GP41
NO20032328D0 (no)	2003-05-22	Proteaseinhibitorer
DK1373898T3 (da)	2006-10-30	Påvisning af inflammationer
SE0100694D0 (sv)	2001-02-28	DHFR inhibitors
DK1319049T3 (da)	2005-03-21	Grunding af stål
DOP2001000307A (es)	2002-11-30	Inhibidores de thrombin