ATE509272T1 - Substrate mit hochliegendem oberflächenbereich für mikroarrays sowie verfahren zur herstellung davon - Google Patents

Substrate mit hochliegendem oberflächenbereich für mikroarrays sowie verfahren zur herstellung davon

Info

Publication number
ATE509272T1
ATE509272T1 AT02795610T AT02795610T ATE509272T1 AT E509272 T1 ATE509272 T1 AT E509272T1 AT 02795610 T AT02795610 T AT 02795610T AT 02795610 T AT02795610 T AT 02795610T AT E509272 T1 ATE509272 T1 AT E509272T1
Authority
AT
Austria
Prior art keywords
surface area
high surface
substrates
microarrays
producing same
Prior art date
Application number
AT02795610T
Other languages
English (en)
Inventor
Anoop Agrawal
John Cronin
Juan Carlos Lopez Tonazzi
A Goodyear
Robert Lecompte
Michael Hogan
David Galbraith
Original Assignee
3Dbiosurfaces Technologies Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3Dbiosurfaces Technologies Llc filed Critical 3Dbiosurfaces Technologies Llc
Application granted granted Critical
Publication of ATE509272T1 publication Critical patent/ATE509272T1/de

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B81MICROSTRUCTURAL TECHNOLOGY
    • B81CPROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C1/00Manufacture or treatment of devices or systems in or on a substrate
    • B81C1/00015Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems
    • B81C1/00206Processes for functionalising a surface, e.g. provide the surface with specific mechanical, chemical or biological properties
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508Rigid containers without fluid transport within
    • B01L3/5085Rigid containers without fluid transport within for multiple samples, e.g. microtitration plates
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508Rigid containers without fluid transport within
    • B01L3/5088Rigid containers without fluid transport within confining liquids at a location by surface tension, e.g. virtual wells on plates, wires
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B81MICROSTRUCTURAL TECHNOLOGY
    • B81BMICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B1/00Devices without movable or flexible elements, e.g. microcapillary devices
    • B81B1/006Microdevices formed as a single homogeneous piece, i.e. wherein the mechanical function is obtained by the use of the device, e.g. cutters
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00279Features relating to reactor vessels
    • B01J2219/00306Reactor vessels in a multiple arrangement
    • B01J2219/00313Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315Microtiter plates
    • B01J2219/00317Microwell devices, i.e. having large numbers of wells
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00351Means for dispensing and evacuation of reagents
    • B01J2219/00378Piezoelectric or ink jet dispensers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00351Means for dispensing and evacuation of reagents
    • B01J2219/00387Applications using probes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00497Features relating to the solid phase supports
    • B01J2219/00504Pins
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/00497Features relating to the solid phase supports
    • B01J2219/00527Sheets
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/0054Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572Chemical means
    • B01J2219/00574Chemical means radioactive
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277Apparatus
    • B01J2219/0054Means for coding or tagging the apparatus or the reagents
    • B01J2219/00572Chemical means
    • B01J2219/00576Chemical means fluorophore
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00585Parallel processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00596Solid-phase processes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/0061The surface being organic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614Delimitation of the attachment areas
    • B01J2219/00617Delimitation of the attachment areas by chemical means
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00614Delimitation of the attachment areas
    • B01J2219/00621Delimitation of the attachment areas by physical means, e.g. trenches, raised areas
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623Immobilisation or binding
    • B01J2219/00628Ionic
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632Introduction of reactive groups to the surface
    • B01J2219/00635Introduction of reactive groups to the surface by reactive plasma treatment
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00605Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632Introduction of reactive groups to the surface
    • B01J2219/00637Introduction of reactive groups to the surface by coating it with another layer
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00639Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium
    • B01J2219/00644Making arrays on substantially continuous surfaces the compounds being trapped in or bound to a porous medium the porous medium being present in discrete locations, e.g. gel pads
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00659Two-dimensional arrays
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583Features relative to the processes being carried out
    • B01J2219/00603Making arrays on substantially continuous surfaces
    • B01J2219/00677Ex-situ synthesis followed by deposition on the substrate
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718Type of compounds synthesised
    • B01J2219/0072Organic compounds
    • B01J2219/00722Nucleotides
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718Type of compounds synthesised
    • B01J2219/0072Organic compounds
    • B01J2219/00725Peptides
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718Type of compounds synthesised
    • B01J2219/0072Organic compounds
    • B01J2219/00734Lipids
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718Type of compounds synthesised
    • B01J2219/0072Organic compounds
    • B01J2219/0074Biological products
    • B01J2219/00743Cells
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/12Specific details about manufacturing devices
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0819Microarrays; Biochips
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/16Surface properties and coatings
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/16Surface properties and coatings
    • B01L2300/161Control and use of surface tension forces, e.g. hydrophobic, hydrophilic
    • B01L2300/165Specific details about hydrophobic, oleophobic surfaces
    • B01L2300/166Suprahydrophobic; Ultraphobic; Lotus-effect
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B81MICROSTRUCTURAL TECHNOLOGY
    • B81BMICROSTRUCTURAL DEVICES OR SYSTEMS, e.g. MICROMECHANICAL DEVICES
    • B81B2201/00Specific applications of microelectromechanical systems
    • B81B2201/02Sensors
    • B81B2201/0214Biosensors; Chemical sensors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Manufacturing & Machinery (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Computer Hardware Design (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
AT02795610T 2001-11-09 2002-11-08 Substrate mit hochliegendem oberflächenbereich für mikroarrays sowie verfahren zur herstellung davon ATE509272T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US34584801P 2001-11-09 2001-11-09
US36158802P 2002-03-02 2002-03-02
US39304402P 2002-07-01 2002-07-01
PCT/US2002/035952 WO2003046508A2 (en) 2001-11-09 2002-11-08 High surface area substrates for microarrays and methods to make same

Publications (1)

Publication Number Publication Date
ATE509272T1 true ATE509272T1 (de) 2011-05-15

Family

ID=27407715

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02795610T ATE509272T1 (de) 2001-11-09 2002-11-08 Substrate mit hochliegendem oberflächenbereich für mikroarrays sowie verfahren zur herstellung davon

Country Status (5)

Country Link
US (1) US7195872B2 (de)
EP (1) EP1451584B1 (de)
AT (1) ATE509272T1 (de)
AU (1) AU2002360361A1 (de)
WO (1) WO2003046508A2 (de)

Families Citing this family (319)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3555844B2 (ja) 1999-04-09 2004-08-18 三宅 正二郎 摺動部材およびその製造方法
US7420005B2 (en) * 2001-06-28 2008-09-02 Dai Nippon Printing Co., Ltd. Photocurable resin composition, finely embossed pattern-forming sheet, finely embossed transfer sheet, optical article, stamper and method of forming finely embossed pattern
US6908453B2 (en) * 2002-01-15 2005-06-21 3M Innovative Properties Company Microneedle devices and methods of manufacture
US6894712B2 (en) * 2002-04-10 2005-05-17 Fuji Photo Film Co., Ltd. Exposure head, exposure apparatus, and application thereof
FR2839660B1 (fr) * 2002-05-17 2005-01-21 Commissariat Energie Atomique Microreacteur,son procede de preparation,et procede pour realiser une reaction biochimique ou biologique
US20070275411A1 (en) 2006-05-25 2007-11-29 Mcgall Glenn H Silane mixtures
US7332273B2 (en) 2002-06-20 2008-02-19 Affymetrix, Inc. Antireflective coatings for high-resolution photolithographic synthesis of DNA arrays
MXPA05000597A (es) 2002-07-19 2005-04-28 3M Innovative Properties Co Dispositivos de microaguja y aparatos de administracion por microaguja.
FR2842826B1 (fr) 2002-07-25 2006-01-20 Centre Nat Rech Scient Procede de fabrication de puces biologiques
US7384742B2 (en) * 2002-08-16 2008-06-10 Decision Biomarkers, Inc. Substrates for isolating reacting and microscopically analyzing materials
ES2375724T3 (es) 2002-09-27 2012-03-05 The General Hospital Corporation Dispositivo microflu�?dico para seperación de células y sus usos.
JP2004138128A (ja) 2002-10-16 2004-05-13 Nissan Motor Co Ltd 自動車エンジン用摺動部材
DE60333715D1 (de) * 2002-10-30 2010-09-23 Hitachi Ltd Verfahren zur Herstellung funktioneller Substrate, die kolumnare Mikrosäulen aufweisen
US6969198B2 (en) 2002-11-06 2005-11-29 Nissan Motor Co., Ltd. Low-friction sliding mechanism
US7105809B2 (en) * 2002-11-18 2006-09-12 3M Innovative Properties Company Microstructured polymeric substrate
EP1420248A3 (de) * 2002-11-18 2004-05-26 Schott Glas Validiertes Design für Mikroarrays
JP2004354364A (ja) * 2002-12-02 2004-12-16 Nec Corp 微粒子操作ユニット、それを搭載したチップと検出装置、ならびにタンパク質の分離、捕獲、および検出方法
CN1745179A (zh) * 2003-01-02 2006-03-08 拜澳富斯毫微科学有限公司 在小样品体积中分子分析的方法和装置
DE10309201A1 (de) * 2003-02-25 2004-09-16 Siemens Ag Probenträger für einen Reaktor, Reaktor und Verfahren zur Herstellung des Probenträgers
JP2004279196A (ja) * 2003-03-14 2004-10-07 Dainippon Printing Co Ltd バイオマイクロアレイ用基板およびバイオマイクロアレイ
JP3891433B2 (ja) 2003-04-15 2007-03-14 日産自動車株式会社 燃料噴射弁
EP1479946B1 (de) 2003-05-23 2012-12-19 Nissan Motor Co., Ltd. Kolben für eine Brennkraftmaschine
JP2004360649A (ja) 2003-06-06 2004-12-24 Nissan Motor Co Ltd エンジン用ピストンピン
DE10326607A1 (de) * 2003-06-13 2005-01-05 Steag Microparts Gmbh Vorrichtung zum Handhaben von Flüssigkeiten
JP4464664B2 (ja) * 2003-06-13 2010-05-19 独立行政法人理化学研究所 生体分子マイクロアレイ用基板、生体分子マイクロアレイ、相互作用促進用装置および方法、ならびに、相互作用の検出方法
WO2005007796A2 (en) 2003-07-21 2005-01-27 Molecular Cytomics Ltd. Improved multiwell plate
US9200245B2 (en) 2003-06-26 2015-12-01 Seng Enterprises Ltd. Multiwell plate
US20040265171A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method for uniform application of fluid into a reactive reagent area
US20050048571A1 (en) * 2003-07-29 2005-03-03 Danielson Paul S. Porous glass substrates with reduced auto-fluorescence
JP4863152B2 (ja) 2003-07-31 2012-01-25 日産自動車株式会社 歯車
JP4973971B2 (ja) 2003-08-08 2012-07-11 日産自動車株式会社 摺動部材
JP2005054617A (ja) 2003-08-08 2005-03-03 Nissan Motor Co Ltd 動弁機構
JP4117553B2 (ja) 2003-08-13 2008-07-16 日産自動車株式会社 チェーン駆動装置
EP1507088B1 (de) 2003-08-13 2007-08-29 Nissan Motor Company, Limited Struktur zur Verbindung von einem Kolben mit einer Kurbelwelle
JP4539205B2 (ja) 2003-08-21 2010-09-08 日産自動車株式会社 冷媒圧縮機
EP1508611B1 (de) 2003-08-22 2019-04-17 Nissan Motor Co., Ltd. Getriebe enthaltend eine getriebeölzusammensetzung
TWI242466B (en) * 2003-08-29 2005-11-01 Prec Instr Dev Ct Nat Control device and method for controlling liquid droplets
US8124423B2 (en) * 2003-09-30 2012-02-28 Alcatel Lucent Method and apparatus for controlling the flow resistance of a fluid on nanostructured or microstructured surfaces
CN100568457C (zh) * 2003-10-02 2009-12-09 株式会社半导体能源研究所 半导体装置的制造方法
WO2005047904A2 (en) * 2003-11-06 2005-05-26 Sru Biosystems, Inc. High-density amine-functionalized surface
CN100334193C (zh) * 2003-11-17 2007-08-29 株式会社日立制作所 细胞培养容器、以及培养细胞
JP4507845B2 (ja) * 2003-11-17 2010-07-21 株式会社日立製作所 細胞培養容器、及び培養細胞
EP1541991A1 (de) * 2003-12-12 2005-06-15 STMicroelectronics S.r.l. Integrierter chemischer Reaktor aus Halbleitermaterial zur Echtzeit-Überwachung von biologischen Reaktionen
JP4237610B2 (ja) * 2003-12-19 2009-03-11 株式会社東芝 保守支援方法及びプログラム
US20070106374A1 (en) * 2004-01-22 2007-05-10 Isoflux, Inc. Radiopaque coating for biomedical devices
US20050170643A1 (en) * 2004-01-29 2005-08-04 Semiconductor Energy Laboratory Co., Ltd. Forming method of contact hole, and manufacturing method of semiconductor device, liquid crystal display device and EL display device
US20070191761A1 (en) * 2004-02-23 2007-08-16 3M Innovative Properties Company Method of molding for microneedle arrays
JP4539125B2 (ja) * 2004-03-08 2010-09-08 ブラザー工業株式会社 核酸単離部材
DE102004013388A1 (de) * 2004-03-17 2005-10-13 Schott Ag Anordnung zur Fluoreszensverstärkung
US7048889B2 (en) * 2004-03-23 2006-05-23 Lucent Technologies Inc. Dynamically controllable biological/chemical detectors having nanostructured surfaces
CA2561667C (en) * 2004-03-30 2010-04-06 Toyo Advanced Technologies Co., Ltd. Method for treating surface of material, surface-treated material, medical material, and medical instrument
US7354845B2 (en) * 2004-08-24 2008-04-08 Otb Group B.V. In-line process for making thin film electronic devices
US7416977B2 (en) 2004-04-28 2008-08-26 Semiconductor Energy Laboratory Co., Ltd. Method for manufacturing display device, liquid crystal television, and EL television
JP4507686B2 (ja) * 2004-04-28 2010-07-21 株式会社日立製作所 観察用容器及び培養用容器,培養細胞
US20070056898A1 (en) * 2004-05-13 2007-03-15 Keith Wesner Ablated predetermined surface geometric shaped boundary formed on porous material mounted on a substrate and methods of making same
WO2005113131A1 (en) 2004-05-13 2005-12-01 3M Innovative Properties Company Ablated predetermined surface geometric shaped boundary formed on porous material mounted on a substrate and methods of making same
JP3952042B2 (ja) * 2004-06-07 2007-08-01 ソニー株式会社 凹状部位を有する電極を備えるハイブリダイゼーション検出部と該検出部を備えるdnaチップ
EP1614460A1 (de) * 2004-07-08 2006-01-11 Yamatake Corporation Substrat für Biochips
DE102004034486B4 (de) * 2004-07-16 2007-08-23 Infineon Technologies Ag Verfahren zum Nachweis von Lumineszenzlicht aus einer porösen Trägerstruktur
US8563328B2 (en) * 2004-07-26 2013-10-22 University Of Louisville Research Foundation, Inc. Fiber-optic biosensor and biosensing methods
KR101354520B1 (ko) 2004-07-29 2014-01-21 퀄컴 엠이엠에스 테크놀로지스, 인크. 간섭 변조기의 미소기전 동작을 위한 시스템 및 방법
US7308164B1 (en) * 2004-09-16 2007-12-11 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Method for texturing surfaces of optical fiber sensors used for blood glucose monitoring
US20060108287A1 (en) * 2004-09-21 2006-05-25 Arnold Todd E Discrete zoned microporous nylon coated glass platform for use in microwell plates and methods of making and using same
US7327510B2 (en) 2004-09-27 2008-02-05 Idc, Llc Process for modifying offset voltage characteristics of an interferometric modulator
US8088321B2 (en) 2004-12-07 2012-01-03 3M Innovative Properties Company Method of molding a microneedle
US8158410B2 (en) * 2005-01-18 2012-04-17 Biocept, Inc. Recovery of rare cells using a microchannel apparatus with patterned posts
US20060252087A1 (en) * 2005-01-18 2006-11-09 Biocept, Inc. Recovery of rare cells using a microchannel apparatus with patterned posts
JP2008526251A (ja) 2005-01-18 2008-07-24 バイオセプト インコーポレイティッド パターン化されたポストを有するマイクロチャネルを用いた細胞分離
US20090136982A1 (en) * 2005-01-18 2009-05-28 Biocept, Inc. Cell separation using microchannel having patterned posts
WO2006088976A2 (en) * 2005-02-16 2006-08-24 University Of Louisville Research Foundation, Inc. Fiber-optic biosensor and biosensing methods
JP4570980B2 (ja) * 2005-02-21 2010-10-27 エスアイアイ・ナノテクノロジー株式会社 試料台及び試料加工方法
GB0505294D0 (en) * 2005-03-15 2005-04-20 Riso Nat Lab Transferring materials to polymer surfaces
EP1866646A1 (de) * 2005-03-29 2007-12-19 Inverness Medical Switzerland GmbH Hybride vorrichtung
US20090042736A1 (en) * 2005-04-18 2009-02-12 Johan Gerrit Bomer Biochip and process for the production of a biochip
US20060246218A1 (en) * 2005-04-29 2006-11-02 Guardian Industries Corp. Hydrophilic DLC on substrate with barrier discharge pyrolysis treatment
EP1882736A4 (de) * 2005-05-17 2012-05-02 Kuraray Co Zellkulturbehälter
JP4918755B2 (ja) * 2005-05-30 2012-04-18 株式会社日立製作所 細胞培養容器,細胞培養容器の製造方法、及び培養細胞
SE529254C2 (sv) * 2005-06-17 2007-06-12 Aamic Ab Optiskt testsystem
JP2008543528A (ja) 2005-06-27 2008-12-04 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルカートリッジアセンブリ及び適用方法
US8535616B2 (en) * 2005-08-02 2013-09-17 Moxtek, Inc. Sub-wavelength metallic apertures as light enhancement devices
JP2009503548A (ja) * 2005-08-02 2009-01-29 ユニバーシティ・オブ・ユタ・リサーチ・ファウンデイション 金属ナノキャビティを含むバイオセンサー
WO2007023413A2 (en) 2005-08-23 2007-03-01 Koninklijke Philips Electronics N.V. Method for manufacturing a component having a three-dimensional structure in a surface region and a ceramic component
US20070047388A1 (en) * 2005-08-25 2007-03-01 Rockwell Scientific Licensing, Llc Fluidic mixing structure, method for fabricating same, and mixing method
US7666665B2 (en) * 2005-08-31 2010-02-23 Alcatel-Lucent Usa Inc. Low adsorption surface
WO2007029101A2 (en) * 2005-09-06 2007-03-15 Bioinnovations Oy Vessel and method of manufacture thereof
US7556776B2 (en) * 2005-09-08 2009-07-07 President And Fellows Of Harvard College Microfluidic manipulation of fluids and reactions
US20100227770A1 (en) * 2005-09-13 2010-09-09 Randall True Brownian microbarcodes for bioassays
US8721161B2 (en) * 2005-09-15 2014-05-13 Alcatel Lucent Fluid oscillations on structured surfaces
US8287808B2 (en) * 2005-09-15 2012-10-16 Alcatel Lucent Surface for reversible wetting-dewetting
US8734003B2 (en) 2005-09-15 2014-05-27 Alcatel Lucent Micro-chemical mixing
US7412938B2 (en) * 2005-09-15 2008-08-19 Lucent Technologies Inc. Structured surfaces with controlled flow resistance
US20070059213A1 (en) * 2005-09-15 2007-03-15 Lucent Technologies Inc. Heat-induced transitions on a structured surface
US7572741B2 (en) 2005-09-16 2009-08-11 Cree, Inc. Methods of fabricating oxide layers on silicon carbide layers utilizing atomic oxygen
JP2009509786A (ja) 2005-09-30 2009-03-12 クォルコム・メムズ・テクノロジーズ・インコーポレーテッド Mems装置及びmems装置における相互接続
US20080308884A1 (en) * 2005-10-13 2008-12-18 Silex Microsystems Ab Fabrication of Inlet and Outlet Connections for Microfluidic Chips
GB0522461D0 (en) * 2005-11-03 2005-12-14 Immunoclin Ltd Dactyl detector
US20080262416A1 (en) * 2005-11-18 2008-10-23 Duan Daniel C Microneedle Arrays and Methods of Preparing Same
US20090301227A1 (en) * 2005-12-08 2009-12-10 Wataru Hattori Liquid Contact Structure, Structure for Controlling Movement of Liquid and Method of Controlling Movement of Liquid
US20070134784A1 (en) * 2005-12-09 2007-06-14 Halverson Kurt J Microreplicated microarrays
WO2007080761A1 (ja) 2006-01-10 2007-07-19 Murata Manufacturing Co., Ltd. プローブアレイ基体及びその製造方法、プローブアレイの製造方法
US7695956B2 (en) * 2006-01-12 2010-04-13 Biocept, Inc. Device for cell separation and analysis and method of using
US7648834B2 (en) * 2006-01-17 2010-01-19 Moore Wayne E Plasmon fluorescence augmentation for chemical and biological testing apparatus
JP5421588B2 (ja) * 2006-02-24 2014-02-19 株式会社クラレ 細胞培養容器およびその製造方法
JP2007298502A (ja) * 2006-04-04 2007-11-15 Fujifilm Corp 血球分離用フィルター
US7643203B2 (en) 2006-04-10 2010-01-05 Qualcomm Mems Technologies, Inc. Interferometric optical display system with broadband characteristics
US7623287B2 (en) * 2006-04-19 2009-11-24 Qualcomm Mems Technologies, Inc. Non-planar surface structures and process for microelectromechanical systems
US7527996B2 (en) 2006-04-19 2009-05-05 Qualcomm Mems Technologies, Inc. Non-planar surface structures and process for microelectromechanical systems
US7417784B2 (en) 2006-04-19 2008-08-26 Qualcomm Mems Technologies, Inc. Microelectromechanical device and method utilizing a porous surface
KR100772897B1 (ko) 2006-05-02 2007-11-05 삼성전자주식회사 향상된 잡음률을 나타내는 올리고머 프로브 어레이 및 그제조 방법
KR100772894B1 (ko) * 2006-05-02 2007-11-05 삼성전자주식회사 다기능 올리고머 프로브 어레이 및 그 제조 방법
KR100772893B1 (ko) * 2006-05-02 2007-11-05 삼성전자주식회사 향상된 잡음률과 검출 강도를 나타내는 올리고머 프로브어레이 및 그 제조 방법
JP2007330202A (ja) * 2006-06-16 2007-12-27 Ab Size:Kk 細胞配列用マイクロチップ及び細胞配列方法
EP1879214B1 (de) * 2006-07-11 2011-10-12 Canon Kabushiki Kaisha Substrat zur Massenspektrometrie und Herstellungsverfahren für das Substrat zur Massenspektrometrie
US7382944B1 (en) * 2006-07-14 2008-06-03 The United States Of America As Represented By The Administration Of The National Aeronautics And Space Administration Protective coating and hyperthermal atomic oxygen texturing of optical fibers used for blood glucose monitoring
KR100813262B1 (ko) * 2006-07-25 2008-03-13 삼성전자주식회사 광 촉매를 이용한 패터닝된 스팟 마이크로어레이의 제조방법 및 상기 방법에 의해 제조된 마이크로어레이
US7566664B2 (en) 2006-08-02 2009-07-28 Qualcomm Mems Technologies, Inc. Selective etching of MEMS using gaseous halides and reactive co-etchants
US20090047673A1 (en) 2006-08-22 2009-02-19 Cary Robert B Miniaturized lateral flow device for rapid and sensitive detection of proteins or nucleic acids
US8980561B1 (en) 2006-08-22 2015-03-17 Los Alamos National Security, Llc. Nucleic acid detection system and method for detecting influenza
JP5013584B2 (ja) * 2006-08-30 2012-08-29 株式会社日立製作所 軟骨細胞の培養方法および軟骨細胞
EP2076775B1 (de) * 2006-10-18 2015-08-19 President and Fellows of Harvard College Lateral-flow- und flow-through-bioassays, die auf porösen gemusterten substanzen beruhen, methoden, diese herzustellen und verwendung derselben
CN101578520B (zh) * 2006-10-18 2015-09-16 哈佛学院院长等 基于形成图案的多孔介质的横向流动和穿过生物测定装置、及其制备方法和使用方法
JP2010510247A (ja) * 2006-11-21 2010-04-02 アプライド バイオシステムズ インコーポレイテッド 酸化物層上に不動態化表面を形成するための中間体および方法およびこれにより製造される製品
WO2008062372A2 (en) * 2006-11-23 2008-05-29 Philips Intellectual Property & Standards Gmbh Device for separation and maldi analysis of an analyte in a sample
US9874501B2 (en) 2006-11-24 2018-01-23 Curiox Biosystems Pte Ltd. Use of chemically patterned substrate for liquid handling, chemical and biological reactions
WO2008063135A1 (en) 2006-11-24 2008-05-29 Agency For Science, Technology And Research Apparatus for processing a sample in a liquid droplet and method of using the same
US7867783B2 (en) * 2007-02-22 2011-01-11 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
TWI368082B (en) * 2007-03-15 2012-07-11 Au Optronics Corp Display panel
US7863037B1 (en) * 2007-04-04 2011-01-04 Maven Technologies, Llc Ligand binding assays on microarrays in closed multiwell plates
KR20100016195A (ko) 2007-04-04 2010-02-12 퀄컴 엠이엠스 테크놀로지스, 인크. 희생층의 계면 변형에 의한 해제 에칭 공격의 제거방법
KR100836827B1 (ko) * 2007-04-09 2008-06-10 전남대학교산학협력단 배아줄기세포의 배상체 형성용 배양용기
DE102007020544A1 (de) * 2007-04-25 2008-10-30 Siemens Ag Analysevorrichtung bzw. Verfahren zur Untersuchung der katalytischen Aktivität von Oberflächen
US20090041633A1 (en) * 2007-05-14 2009-02-12 Dultz Shane C Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US7799558B1 (en) * 2007-05-22 2010-09-21 Dultz Shane C Ligand binding assays on microarrays in closed multiwell plates
WO2008157640A2 (en) * 2007-06-18 2008-12-24 Illumina, Inc. Microfabrication methods for the optimal patterning of substrates
WO2009006340A2 (en) 2007-06-29 2009-01-08 Qualcomm Mems Technologies, Inc. Electromechanical device treatment with water vapor
WO2009013869A1 (ja) * 2007-07-25 2009-01-29 Panasonic Corporation バイオセンサ
US7570415B2 (en) 2007-08-07 2009-08-04 Qualcomm Mems Technologies, Inc. MEMS device and interconnects for same
EP2176395A2 (de) * 2007-08-13 2010-04-21 University of Utah Research Foundation Verfahren zur herstellung von für detektionen mit hohem durchsatz geeignete mikroarrays
KR20090028023A (ko) * 2007-09-13 2009-03-18 삼성전자주식회사 바이오칩 및 그 제조 방법
US8431508B2 (en) * 2007-10-30 2013-04-30 Cerahelix, Inc. Inorganic structure for molecular separations
US8431509B2 (en) 2007-10-30 2013-04-30 Cerahelix, Inc. Structure for molecular separations
WO2009061783A2 (en) * 2007-11-05 2009-05-14 University Of Rochester Dna microarray having hairpin probes tethered to nanostructured metal surface
US10725020B2 (en) 2007-11-14 2020-07-28 Curiox Biosystems Pte Ltd. High throughput miniaturized assay system and methods
WO2013114217A1 (en) 2012-02-05 2013-08-08 Curiox Biosystems Pte Ltd. Array plates and methods for making and using same
US9145540B1 (en) 2007-11-15 2015-09-29 Seng Enterprises Ltd. Device for the study of living cells
US9975118B2 (en) 2007-11-15 2018-05-22 Seng Enterprises Ltd. Device for the study of living cells
US20100215866A1 (en) * 2007-11-29 2010-08-26 Atomic Energy Council - Institute Of Nuclear Energy Research Method for coating an electrode on a wafer
US10302567B2 (en) 2007-12-19 2019-05-28 Berylliant, Inc. High throughput methods for analysis of contamination in environmental samples
GB0724736D0 (en) 2007-12-19 2008-01-30 Oxford Nanolabs Ltd Formation of layers of amphiphilic molecules
KR100971210B1 (ko) * 2007-12-26 2010-07-20 주식회사 동부하이텍 양자점 형성 및 그를 이용한 게이트 형성 방법
KR101435521B1 (ko) * 2008-01-23 2014-08-29 삼성전자 주식회사 바이오칩
US20090215050A1 (en) 2008-02-22 2009-08-27 Robert Delmar Jenison Systems and methods for point-of-care amplification and detection of polynucleotides
US8687189B2 (en) * 2008-03-03 2014-04-01 Ajjer, Llc Analysis of arrays by laser induced breakdown spectroscopy
US9829488B2 (en) * 2008-03-27 2017-11-28 President And Fellows Of Havard College Paper-based cellular arrays
CA2719322C (en) 2008-03-27 2018-11-27 President And Fellows Of Harvard College Cotton thread as a low-cost multi-assay diagnostic platform
CA2719320A1 (en) * 2008-03-27 2009-10-01 President And Fellows Of Harvard College Three-dimensional microfluidic devices
AU2009228012A1 (en) * 2008-03-27 2009-10-01 President And Fellows Of Harvard College Paper-based microfluidic systems
US9518288B2 (en) 2008-04-11 2016-12-13 University Of Utah Research Foundation Methods and compositions related to quantitative, array based methylation analysis
US9664619B2 (en) * 2008-04-28 2017-05-30 President And Fellows Of Harvard College Microfluidic device for storage and well-defined arrangement of droplets
WO2009137059A1 (en) 2008-05-05 2009-11-12 Los Alamos National Security, Llc Highly simplified lateral flow-based nucleic acid sample preparation and passive fluid flow control
US8039270B2 (en) * 2008-05-22 2011-10-18 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US7981664B1 (en) 2008-05-22 2011-07-19 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US8377390B1 (en) * 2008-05-29 2013-02-19 Stc.Unm Anisotropic wetting behavior on one-dimensional patterned surfaces for applications to microfluidic devices
US8632964B2 (en) * 2008-05-30 2014-01-21 University Of Strathclyde Detection system
CN102105578A (zh) * 2008-05-30 2011-06-22 康宁股份有限公司 具有可变表面形状的细胞培养装置
US7851239B2 (en) 2008-06-05 2010-12-14 Qualcomm Mems Technologies, Inc. Low temperature amorphous silicon sacrificial layer for controlled adhesion in MEMS devices
EP2300207A4 (de) * 2008-06-26 2012-05-09 Harvard College Mittels replikation hergestellte vielseitige betätigbare nanostrukturierte materialien
US8962248B2 (en) 2008-07-09 2015-02-24 Panasonic Corporation Sequencer
US8173198B2 (en) * 2008-07-23 2012-05-08 Life Technologies Corporation Deposition of metal oxides onto surfaces as an immobilization vehicle for carboxylated or phophated particles or polymers
WO2010034484A1 (en) * 2008-09-23 2010-04-01 Gilupi Gmbh Diagnostic analyte collection device based on flexible polymers with biological surface modification and microfluidic functionality
US8020314B2 (en) * 2008-10-31 2011-09-20 Corning Incorporated Methods and apparatus for drying ceramic green bodies with microwaves
KR101065077B1 (ko) * 2008-11-05 2011-09-15 삼성전자주식회사 시료 검출용 기판, 이를 채용한 바이오칩, 시료 검출용 기판의 제조방법 및 바이오 물질 검출장치
US8435387B2 (en) * 2008-11-14 2013-05-07 Massachusetts Institute Of Technology Small-scale method and apparatus for separating mixtures
US8784673B2 (en) * 2008-11-14 2014-07-22 Northeastern University Highly organized single-walled carbon nanotube networks and method of making using template guided fluidic assembly
WO2010085815A1 (en) * 2009-01-26 2010-07-29 Artemis Health, Inc. Methods and compositions for identifying a fetal cell
KR101433292B1 (ko) 2009-02-17 2014-08-22 더 보드 오브 트러스티즈 오브 더 유니버시티 오브 일리노이 마이크로구조 제조방법
US20120108787A1 (en) 2009-02-26 2012-05-03 Nubiome, Inc. Immobilization Particles for Removal of Microorganisms and/or Chemicals
CA2754577C (en) 2009-03-06 2018-07-10 President And Fellows Of Harvard College Microfluidic, electrochemical devices
EP2995953B1 (de) 2009-03-24 2017-11-29 Biocept, Inc. Vorrichtungen und verfahren für zellerfassung und -analyse
JPWO2010122720A1 (ja) * 2009-04-20 2012-10-25 パナソニック株式会社 流路デバイス
KR20180123190A (ko) * 2009-05-20 2018-11-14 질레코 인코포레이티드 바이오매스의 가공처리방법
EP2284534B1 (de) * 2009-08-13 2011-12-28 Roche Diagnostics GmbH Testelement zur Analyse einer Körperflüssigkeit
DE102009039777A1 (de) * 2009-09-02 2011-03-03 Forschungszentrum Jülich GmbH Verfahren zur Herstellung und Strukturierung einer Zinkoxidschicht und Zinkoxidschicht
TW201109285A (en) * 2009-09-10 2011-03-16 Applied Vacuum Coating Technologies Co Ltd Method of strengthening glass plate
US8355133B2 (en) * 2009-12-30 2013-01-15 Maven Technologies, Llc Biological testing with sawtooth-shaped prisms
WO2011097412A1 (en) 2010-02-03 2011-08-11 President And Fellows Of Harvard College Devices and methods for multiplexed assays
TWI426302B (zh) * 2010-02-12 2014-02-11 Au Optronics Corp 顯示裝置及其增光膜
US8547626B2 (en) 2010-03-25 2013-10-01 Qualcomm Mems Technologies, Inc. Mechanical layer and methods of shaping the same
SG185434A1 (en) * 2010-05-11 2012-12-28 Artelis S A Apparatus and methods for cell culture
JP5824646B2 (ja) * 2010-05-11 2015-11-25 パナソニックIpマネジメント株式会社 センサ基板及びそれを用いたアレイ基板
FR2960799A1 (fr) 2010-06-07 2011-12-09 Commissariat Energie Atomique Procede de formation d'un depot localise et de forme definie d'un materiau a la surface d'un substrat
WO2012011877A2 (en) * 2010-07-23 2012-01-26 Curiox Biosystems Pte Ltd Apparatus and method for multiple reactions in small volumes
ES2351495B1 (es) * 2010-08-05 2011-09-08 Nanoate S.L. Procedimiento de obtención de biosensores.
US9492952B2 (en) 2010-08-30 2016-11-15 Endo-Surgery, Inc. Super-hydrophilic structures
US20120143228A1 (en) 2010-08-30 2012-06-07 Agency For Science Technology And Research Adhesive structure with stiff protrusions on adhesive surface
US8963159B2 (en) 2011-04-04 2015-02-24 Qualcomm Mems Technologies, Inc. Pixel via and methods of forming the same
US9134527B2 (en) 2011-04-04 2015-09-15 Qualcomm Mems Technologies, Inc. Pixel via and methods of forming the same
JP5879667B2 (ja) 2011-04-20 2016-03-08 メサ バイオテック,インク. 核酸の検出および同定のための一体型デバイス
US20120302465A1 (en) 2011-05-26 2012-11-29 Agency For Science Technology And Research Polymeric structures for adsorbing biological material and their method of preparation
US20140193900A1 (en) * 2011-06-09 2014-07-10 Ivar Meyvantsson Device for washing suspended cells or particles
US20140162351A1 (en) * 2011-08-29 2014-06-12 Hitachi, Ltd. Culturing sheet, culturing equipment material and manufacturing method
US9117967B2 (en) * 2011-08-30 2015-08-25 El-Seed Corporation Method of manufacturing glass substrate with concave-convex film using dry etching, glass substrate with concave-convex film, solar cell, and method of manufacturing solar cell
NL2007382C2 (en) * 2011-09-09 2013-03-12 Univ Leiden Method to coat an active agent to a surface.
KR101407605B1 (ko) * 2011-11-24 2014-06-16 포항공과대학교 산학협력단 나노 구조를 갖는 세포 배양용 용기와 그 제조 방법
US20130149500A1 (en) * 2011-12-06 2013-06-13 Nazanin Bassiri-Gharb Soft-template infiltration manufacturing of nanomaterials
CN104220079B (zh) 2011-12-29 2018-01-12 伊西康公司 在其表面上具有组织穿刺突起的粘合结构
CA3191015A1 (en) 2012-02-07 2013-08-15 Vibrant Holdings, Llc Substrates, peptide arrays, and methods
JP6017793B2 (ja) * 2012-02-09 2016-11-02 ローム株式会社 マイクロチップ
GB201202519D0 (en) 2012-02-13 2012-03-28 Oxford Nanopore Tech Ltd Apparatus for supporting an array of layers of amphiphilic molecules and method of forming an array of layers of amphiphilic molecules
IN2014DN08160A (de) 2012-03-30 2015-05-01 Ethicon Endo Surgery Inc
US8926881B2 (en) 2012-04-06 2015-01-06 DePuy Synthes Products, LLC Super-hydrophobic hierarchical structures, method of forming them and medical devices incorporating them
US8969648B2 (en) * 2012-04-06 2015-03-03 Ethicon, Inc. Blood clotting substrate and medical device
JP6071318B2 (ja) * 2012-08-09 2017-02-01 キヤノン株式会社 光学部材および光学部材の製造方法
CN103630953B (zh) * 2012-08-22 2016-08-03 北京京东方光电科技有限公司 一种棱镜膜及其制备方法及装置
US10006909B2 (en) 2012-09-28 2018-06-26 Vibrant Holdings, Llc Methods, systems, and arrays for biomolecular analysis
WO2014052989A2 (en) 2012-09-28 2014-04-03 Vibrant Holdings, Llc Methods, systems, and arrays for biomolecular analysis
US20140093953A1 (en) * 2012-10-01 2014-04-03 The Regents Of The University Of Michigan Non-adherent cell support and manufacturing method
GB201313121D0 (en) * 2013-07-23 2013-09-04 Oxford Nanopore Tech Ltd Array of volumes of polar medium
US10286376B2 (en) 2012-11-14 2019-05-14 Vibrant Holdings, Llc Substrates, systems, and methods for array synthesis and biomolecular analysis
US20140141503A1 (en) * 2012-11-20 2014-05-22 Corning Incorporated Cell culture substrate having uniform surface coating
WO2014116813A1 (en) * 2013-01-25 2014-07-31 Douglas Scientific Silica-based biological material isolation
US8995658B2 (en) 2013-02-13 2015-03-31 Honeywell International Inc. Physics-based key generation
CA2923379C (en) 2013-02-15 2023-01-03 Vibrant Holdings, Llc Methods and compositions for amplified electrochemiluminescence detection
US9290219B2 (en) 2013-03-14 2016-03-22 The Boeing Company Locomotion system and method of controlling a robotic device
US20140260688A1 (en) * 2013-03-14 2014-09-18 The Boeing Company Sensor assembly using micropillars and method of use
US9352256B2 (en) 2013-03-14 2016-05-31 The Boeing Company Filtration systems and methods for filtering particles of a predetermined substance
JP5991426B2 (ja) * 2013-03-25 2016-09-14 株式会社村田製作所 空隙配置構造体およびそれを用いた測定方法
EP4610368B1 (de) 2013-08-05 2026-02-04 Twist Bioscience Corporation De-novo-synthetisierte genbibliotheken
US9946033B2 (en) 2013-08-07 2018-04-17 Corning Optical Communications LLC Fiber optic connector with adhesive management
JP6281834B2 (ja) * 2013-08-21 2018-02-21 国立大学法人 東京大学 高密度微小チャンバーアレイおよびその製造方法
US9683937B2 (en) * 2013-08-23 2017-06-20 Semiconductor Components Industries, Llc Imaging devices for molecule detection
DE102013111759A1 (de) * 2013-10-25 2015-04-30 Bürkert Werke GmbH Vorrichtung und Verfahren zur Untersuchung von Probenflüssigkeit
US9465960B2 (en) 2013-12-04 2016-10-11 Honeywell International Inc. Physics-based authentication
US9969964B2 (en) * 2013-12-23 2018-05-15 Purdue Research Foundation Disease-on-a-chip
US20170166853A1 (en) * 2014-02-12 2017-06-15 Kristian EKEROTH Dividable surfaces for cell culturing
DE102014008369A1 (de) * 2014-06-05 2015-12-17 Rosenberger-Osi Gmbh & Co. Ohg Endflächenbeschichtung eines Wellenleiters
TWI512292B (zh) * 2014-09-04 2015-12-11 Taiwan Green Point Entpr Co 薄膜式生物晶片之製作方法
CA2960655C (en) 2014-09-10 2024-03-19 Vibrant Holdings, Llc Peptide microarrays and novel biomarkers for celiac disease
GB201418512D0 (en) 2014-10-17 2014-12-03 Oxford Nanopore Tech Ltd Electrical device with detachable components
WO2016126882A1 (en) * 2015-02-04 2016-08-11 Twist Bioscience Corporation Methods and devices for de novo oligonucleic acid assembly
US10712356B2 (en) 2015-04-21 2020-07-14 General Automation Lab Technologies Inc. Apparatus and method for picking biological sample
US9981239B2 (en) 2015-04-21 2018-05-29 Twist Bioscience Corporation Devices and methods for oligonucleic acid library synthesis
CA3184363C (en) 2015-04-21 2024-01-02 Isolation Bio Inc. High resolution systems, kits, apparatus, and methods for high throughput microbiology applications
WO2016172724A1 (en) 2015-04-24 2016-10-27 Mesa Biotech, Inc. Fluidic test cassette
US10545139B2 (en) 2015-06-16 2020-01-28 Curiox Biosystems Pte Ltd. Methods and devices for performing biological assays using magnetic components
IL258164B (en) 2015-09-18 2022-09-01 Twist Bioscience Corp Methods for modulating protein and cellular activity and method for nucleic acid synthesis
CN108698012A (zh) 2015-09-22 2018-10-23 特韦斯特生物科学公司 用于核酸合成的柔性基底
WO2017070570A1 (en) * 2015-10-22 2017-04-27 Alan Gordon Goodyear Textured compositions, systems, and methods for enhanced fluorescence
WO2017070577A1 (en) * 2015-10-22 2017-04-27 Alan Gordon Goodyear Textured compositions, methods, and systems for capturing and retaining biomolecules
US20180298436A1 (en) * 2015-10-30 2018-10-18 Universal Sequencing Technology Corporation Methods and Systems for Controlling DNA, RNA and Other Biological Molecules Passing Through Nanopores
GB201520341D0 (en) * 2015-11-18 2015-12-30 Randox Lab Ltd And Randox Teoranta Improvements relating to substrates for the attachment of molecules
US10000732B2 (en) * 2015-11-20 2018-06-19 National Health Research Institutes Microfluidic dual-well device for highthroughput single-cell capture and culture
KR20180088722A (ko) * 2015-12-02 2018-08-06 베링거잉겔하임베트메디카게엠베하 칩 상에 다수의 측정 영역들을 제조하는 방법 및 다수의 측정 영역들을 갖는 칩
US20170191912A1 (en) 2016-01-06 2017-07-06 International Business Machines Corporation Semiconductor manufactured nano-structures for microbe or virus trapping or destruction
WO2017156308A1 (en) * 2016-03-09 2017-09-14 3Dbiosurfaces Technologies, Llc Textured compositions, methods, and systems for retaining biomolecules
EP3377226B1 (de) * 2016-03-28 2021-02-17 Illumina, Inc. Mikroarrays in mehreren ebenen
US10177001B2 (en) * 2016-05-31 2019-01-08 Taiwan Semiconductor Manufacturing Co., Ltd. Surface modifying material for semiconductor device fabrication
GB201611770D0 (en) 2016-07-06 2016-08-17 Oxford Nanopore Tech Microfluidic device
CN110088281A (zh) * 2016-08-03 2019-08-02 特韦斯特生物科学公司 用于多核苷酸合成的纹理化表面
JP6746436B2 (ja) * 2016-08-30 2020-08-26 日本電子株式会社 分析方法
JP6871364B2 (ja) 2016-09-21 2021-05-12 ツイスト バイオサイエンス コーポレーション 核酸に基づくデータ保存
JP6767257B2 (ja) * 2016-12-22 2020-10-14 東京エレクトロン株式会社 基板処理装置及び基板処理方法
US10814493B2 (en) * 2017-01-12 2020-10-27 Robotiq Inc. Tactile sensor and a method of manufacturing thereof
EP4556433A3 (de) 2017-02-22 2025-08-06 Twist Bioscience Corporation Nukleinsäurebasierte datenspeicherung
WO2018185554A1 (en) 2017-04-05 2018-10-11 Curiox Biosystems Pte Ltd. Methods, devices, and apparatus for washing samples on array plates
WO2018200916A1 (en) * 2017-04-28 2018-11-01 Corning Incorporated Glass structure, glass structure forming system, and method of making glass structure
US10538808B2 (en) 2017-05-26 2020-01-21 Vibrant Holdings, Llc Photoactive compounds and methods for biomolecule detection and sequencing
WO2018231864A1 (en) 2017-06-12 2018-12-20 Twist Bioscience Corporation Methods for seamless nucleic acid assembly
CN111566209B (zh) 2017-06-12 2024-08-30 特韦斯特生物科学公司 无缝核酸装配方法
AU2018306306B2 (en) 2017-07-25 2023-09-14 Magnomer Llc Methods and compositions for magnetizable plastics
JP6931943B2 (ja) * 2017-08-30 2021-09-08 イムプリメド インコーポレイティッドImprimed,Inc. 化学的及び生化学的化合物の高処理量選別のための製品
CN107775285B (zh) * 2017-09-08 2019-11-22 西安理工大学 一种提高砂芯造型机导轨耐磨性的表面织构化方法
EP3681906A4 (de) 2017-09-11 2021-06-09 Twist Bioscience Corporation Gpcr-bindende proteine und deren synthese
KR102889470B1 (ko) 2017-10-20 2025-11-21 트위스트 바이오사이언스 코포레이션 폴리뉴클레오타이드 합성을 위한 가열된 나노웰
CN111386363A (zh) * 2017-10-30 2020-07-07 康宁股份有限公司 核酸固定制品及其方法
GB2568895B (en) 2017-11-29 2021-10-27 Oxford Nanopore Tech Ltd Microfluidic device
US10920376B2 (en) * 2017-12-26 2021-02-16 The Procter & Gamble Company Fibrous structures with shaped polymer particles
US11207874B2 (en) 2017-12-26 2021-12-28 The Procter & Gamble Company Methods of making fibrous structures with shaped polymer particles
CA3088911A1 (en) 2018-01-04 2019-07-11 Twist Bioscience Corporation Dna-based storage device and method for synthesizing polynucleotides using the device
EP3511292A1 (de) * 2018-01-10 2019-07-17 SABIC Global Technologies B.V. Strukturierte oberfläche mit hydrophoben auswirkungen und verfahren zur herstellung davon
CN111684273B (zh) * 2018-02-09 2023-09-05 浜松光子学株式会社 试样支撑体、电离法以及质量分析方法
EP3759213A4 (de) * 2018-03-02 2022-03-16 Quantumcyte, Inc. Verfahren, zusammensetzungen und vorrichtungen zur isolierung und expressionsanalyse von interessierenden regionen aus einem gewebe
US11926091B2 (en) 2018-03-27 2024-03-12 UNITED STATES OF AMERICA has certain rights in the invention from DOE Grant No. DE-SC0008581 In situ partially degradable separation interface for fabrication of complex near net shape objects by pressure assisted sintering
US12319712B2 (en) 2018-05-09 2025-06-03 Vibrant Holdings, Llc Methods of synthesizing a polynucleotide array using photoactivated agents
US12465902B2 (en) * 2018-05-15 2025-11-11 Biocopy Gmbh Microarray transformer
WO2019222706A1 (en) 2018-05-18 2019-11-21 Twist Bioscience Corporation Polynucleotides, reagents, and methods for nucleic acid hybridization
GB2574048B (en) 2018-05-24 2021-06-16 Oxford Nanopore Tech Ltd Nanopore sensor component with electrostatic discharge protection
US11192110B2 (en) 2018-07-06 2021-12-07 Liu Lian Methods and systems for cell-based non-invasive prenatal testing
DE102018132120B4 (de) * 2018-12-13 2024-04-18 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Probenaufnahmeeinrichtung für biologische Proben mit einer Probenaufnahme aus Kohlenstoff-basiertem Werkstoff
CA3124980A1 (en) 2018-12-26 2020-07-02 Twist Bioscience Corporation Highly accurate de novo polynucleotide synthesis
WO2020160260A1 (en) 2019-01-30 2020-08-06 Magnomer Llc Methods and compositions for magnetizable plastics
JP2022521551A (ja) 2019-02-26 2022-04-08 ツイスト バイオサイエンス コーポレーション Glp1受容体の変異体核酸ライブラリ
CN113785057A (zh) 2019-02-26 2021-12-10 特韦斯特生物科学公司 用于抗体优化的变异核酸文库
CN109810895B (zh) * 2019-02-27 2021-12-03 西北工业大学 基于等高微柱的开放式三维细胞培养芯片及其制备技术
EP4336182A3 (de) * 2019-03-11 2024-06-12 Redbud Labs, Inc. Verfahren zur oberflächenmodifizierung von silikonen für spezifisches target und hocheffiziente bindung
US11789006B2 (en) 2019-03-12 2023-10-17 Oxford Nanopore Technologies Plc Nanopore sensing device, components and method of operation
JP2022527124A (ja) 2019-04-09 2022-05-30 コーニング インコーポレイテッド 防眩特性および増加した耐引掻性を提供するために特定の高さ対幅比を有する表面特徴を備えたテクスチャ表面を有するガラス基板
JP6886668B2 (ja) * 2019-04-23 2021-06-16 住友ゴム工業株式会社 医療用検査装置及び細胞検査方法
AU2020298294A1 (en) 2019-06-21 2022-02-17 Twist Bioscience Corporation Barcode-based nucleic acid sequence assembly
US12091777B2 (en) 2019-09-23 2024-09-17 Twist Bioscience Corporation Variant nucleic acid libraries for CRTH2
WO2021061842A1 (en) 2019-09-23 2021-04-01 Twist Bioscience Corporation Variant nucleic acid libraries for single domain antibodies
CN110902646B (zh) * 2019-11-21 2023-08-22 厦门大学 一种阵列结构硅基靶板及其应用
WO2022013551A1 (en) 2020-07-17 2022-01-20 Oxford Nanopore Technologies Limited Nanopore sensing device
US12371743B2 (en) 2022-03-04 2025-07-29 Element Biosciences, Inc. Double-stranded splint adaptors and methods of use
US12359193B2 (en) 2022-03-04 2025-07-15 Element Biosciences, Inc. Single-stranded splint strands and methods of use
US12280540B2 (en) 2020-09-27 2025-04-22 San Diego State University Research Foundation In situ partially degradable separation interface for fabrication of complex near net shape objects by pressure assisted sintering
CN113264498A (zh) * 2021-04-08 2021-08-17 哈尔滨工业大学(深圳) 金属氧化物界面装置及其制备方法与应用
CN113219164B (zh) * 2021-05-18 2024-01-02 北京京东方技术开发有限公司 生物芯片及其制备方法、检测装置
CN113277123B (zh) * 2021-06-18 2023-06-27 中国人民解放军军事科学院国防科技创新研究院 板式表面张力贮箱管理装置表面处理方法及管理装置
DE102021206851A1 (de) 2021-06-30 2023-01-05 Karlsruher Institut für Technologie Strukturvorlage zur Fertigung eines Prägewerkzeuges zum Prägen eines dünnschichtigen Elements, Verwendung einer Strukturvorlage und Verfahren zur Bereitstellung einer Strukturvorlage
EP4344443A1 (de) 2021-08-31 2024-04-03 Illumina, Inc. Durchflusszelle mit verbesserter bohrlochabbildungsauflösung
CN113730042B (zh) * 2021-09-09 2022-10-11 北京理工大学 具有多级微纳结构的骨科植入体及其制造方法
CN114832595B (zh) * 2022-04-11 2023-02-03 福建德尔科技股份有限公司 电子级六氟化硫碱洗装置及其控制方法
CN115429940B (zh) * 2022-08-30 2024-01-26 电子科技大学 一种增强生物活性涂层稳定性的方法
CN115323019B (zh) * 2022-08-31 2024-07-26 深圳市曙芯生物科技有限公司 一种高通量基因合成方法
JP2025530259A (ja) 2022-09-12 2025-09-11 エレメント バイオサイエンシズ,インコーポレイティド ユニバーサル長スプリント鎖を有する二本鎖スプリントアダプター及び使用方法
WO2024105470A1 (en) * 2022-11-15 2024-05-23 Solventum Intellectual Properties Company Microstructured substrate including connected wells
CN116002758B (zh) * 2023-02-09 2024-06-25 北京信息科技大学 一种二维掺铵六角相氧化钨的制备方法
CN119438563B (zh) * 2024-11-04 2025-06-03 江苏荣盛嘉美生物试剂有限公司 一种乳胶增强免疫比浊检测试剂及其应用

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4483700A (en) 1983-08-15 1984-11-20 Corning Glass Works Chemical strengthening method
US6228116B1 (en) * 1987-12-22 2001-05-08 Walter J. Ledergerber Tissue expander
US5700637A (en) 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US6054270A (en) 1988-05-03 2000-04-25 Oxford Gene Technology Limited Analying polynucleotide sequences
US5252294A (en) * 1988-06-01 1993-10-12 Messerschmitt-Bolkow-Blohm Gmbh Micromechanical structure
GB8822228D0 (en) 1988-09-21 1988-10-26 Southern E M Support-bound oligonucleotides
US5744101A (en) 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5700636A (en) * 1990-10-19 1997-12-23 Becton Dickinson And Company Methods for selectively detecting microorganisms associated with vaginal infections in complex biological samples
US5412087A (en) 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
US5277986A (en) 1992-07-15 1994-01-11 Donnelly Corporation Method for depositing high performing electrochromic layers
JP3488465B2 (ja) 1993-10-28 2004-01-19 ヒューストン・アドバンスド・リサーチ・センター 結合反応を別々に検出する微細加工フロースルー多孔性装置
US5610287A (en) 1993-12-06 1997-03-11 Molecular Tool, Inc. Method for immobilizing nucleic acid molecules
US5451260A (en) 1994-04-15 1995-09-19 Cornell Research Foundation, Inc. Method and apparatus for CVD using liquid delivery system with an ultrasonic nozzle
US5629186A (en) 1994-04-28 1997-05-13 Lockheed Martin Corporation Porous matrix and method of its production
US5807522A (en) 1994-06-17 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods for fabricating microarrays of biological samples
US5922534A (en) * 1995-03-28 1999-07-13 Hewlett-Packard Company Dry biochemical assay plate and method for making the same
US5951295A (en) 1996-02-08 1999-09-14 Materials Evolution And Development Usa, Inc. Ceramic fused fiber enhanced dental materials
US5858309A (en) * 1996-03-22 1999-01-12 Corning Incorporated Microplates with UV permeable bottom wells
US5788814A (en) 1996-04-09 1998-08-04 David Sarnoff Research Center Chucks and methods for positioning multiple objects on a substrate
CA2389358C (en) 1996-12-31 2008-07-15 Genometrix Incorporated Multiplexed molecular analysis apparatus and method
US5827748A (en) 1997-01-24 1998-10-27 The United States Of America As Represented By The Secretary Of The Navy Chemical sensor using two-dimensional lens array
US5859937A (en) * 1997-04-04 1999-01-12 Neomecs Incorporated Minimally invasive sensor
EP0998347A1 (de) 1997-07-22 2000-05-10 Rapigene, Inc. Matrizen von biomolekülen auf einem träger mit polyäthylenbasis
JP4313861B2 (ja) * 1997-08-01 2009-08-12 キヤノン株式会社 プローブアレイの製造方法
US5922617A (en) * 1997-11-12 1999-07-13 Functional Genetics, Inc. Rapid screening assay methods and devices
US6232066B1 (en) 1997-12-19 2001-05-15 Neogen, Inc. High throughput assay system
GB9800933D0 (en) 1998-01-17 1998-03-11 Central Research Lab Ltd A dispenser
US6262216B1 (en) * 1998-10-13 2001-07-17 Affymetrix, Inc. Functionalized silicon compounds and methods for their synthesis and use
JP3946921B2 (ja) 1998-12-11 2007-07-18 富士フイルム株式会社 画像読取方法及び画像読取装置
US6151973A (en) 1999-01-29 2000-11-28 Glaxo Wellcome Inc. Bead picking apparatus and method
WO2000061282A1 (en) 1999-04-08 2000-10-19 Affymetrix, Inc. Porous silica substrates for polymers synthesis and assays
AU7090600A (en) 1999-09-02 2001-03-26 Corning Incorporated Porous substrates for dna arrays
US6257011B1 (en) 1999-09-16 2001-07-10 U T Battelle Llc Personal cooling apparatus and method
US6297016B1 (en) * 1999-10-08 2001-10-02 Applera Corporation Template-dependent ligation with PNA-DNA chimeric probes
DE19950452A1 (de) 1999-10-20 2001-04-26 Creavis Tech & Innovation Gmbh Strukturierte Oberflächen mit zelladhäsions- und zellproliferationshemmenden Eigenschaften
CA2399163A1 (en) 2000-02-18 2001-08-23 Pall Corporation Composite membranes for assaying biomolecules
AU2000269393A1 (en) 2000-03-09 2001-09-17 Genometrix Genomix, Inc. Integrated nucleic acid hybridization devices
EP1272439A2 (de) 2000-03-24 2003-01-08 Lyles, Mark B. Poröses material enthaltende diagnostische vorrichtung
US6861214B1 (en) * 2000-10-23 2005-03-01 Beckman Coulter, Inc. Immobilization of biopolymers to aminated substrates by direct adsorption

Also Published As

Publication number Publication date
EP1451584A2 (de) 2004-09-01
US20030148401A1 (en) 2003-08-07
US7195872B2 (en) 2007-03-27
AU2002360361A8 (en) 2003-06-10
AU2002360361A1 (en) 2003-06-10
EP1451584B1 (de) 2011-05-11
EP1451584A4 (de) 2005-06-29
WO2003046508A3 (en) 2004-04-08
WO2003046508A2 (en) 2003-06-05

Similar Documents

Publication Publication Date Title
ATE509272T1 (de) Substrate mit hochliegendem oberflächenbereich für mikroarrays sowie verfahren zur herstellung davon
ATE301623T1 (de) Verfahren zur herstellung von randbearbeitungfähigem glas, hergestelltes glas und verfahren zur randbearbeitung von einem solchen glas
DE602004026725D1 (de) Verfahren zur bereitstellung einer eingegrenzten flüssigkeit für die immersionslithographie
ATE275441T1 (de) Verfahren zur herstellung eines mikrostrukturierten oberflächenreliefs durch prägen thixotroper schichten und mikrostrukturiertes oberflächenrelief
DE60214513D1 (de) Verfahren zur oberflächenmodifizierung
DE60324868D1 (de) Träger für elektronische Vorrichtungen, dessen Verfahren zur Herstellung, und elektronische Vorrichtung
ATE531077T1 (de) Belastungsfreies zusammengesetztes substrat und verfahren zur herstellung eines solchen zusammengesetzten substrats
ATE491225T1 (de) Verfahren zur herstellung dünner schichten, die mikrokomponenten enthalten
ATE368095T1 (de) Verfahren zur herstellung von mitteldistillaten
DE60334747D1 (de) Verfahren und Vorrichtung zur Herstellung von Microarrays
DE50203798D1 (de) Verfahren zur beschichtung von gegenständen
DE69717805D1 (de) Verfahren und Vorrichtung zur Herstellung von porösen keramischen Beschichtungen, insbesondere wärmedämmende Beschichtungen, auf metallische Substrate
ATE504353T1 (de) Verfahren zur verbindung von mikrostrukturierten substraten
DE10197137T1 (de) Verfahren zur Herstellung von Mikrostrukturen
DE602006003463D1 (de) Verfahren zur Herstellung von einkristallinem Diamantsubstrat und dadurch hergestelltes Substrat
DE60137044D1 (de) Verfahren zur herstellung von scheiben für variatoren
ATE375260T1 (de) Verfahren zur herstellung von beschichtungen mit strukturierter oberfläche, verwendet insbesondere für stifte, und gegenstand mit strukturierter oberfläche
DE60225751D1 (de) Verfahren zur Herstellung von einer Mehrkomponenten-Dünnschicht
DE60231466D1 (de) Verfahren zur Wiederherstellung von Diffusions-Aluminid-Beschichtung
DE50310646D1 (de) Verfahren zur beschichtung von metalloberflächen
DE60138861D1 (de) Verfahren zur Erzeugung von feinen Linien auf einem Substrat
DE60225148D1 (de) Verfahren zur herstellung von flüssigen kohlenwasserstoffen
DE60218750D1 (de) Verfahren zur herstellung von oxidschichten mit unterschiedlicher dicke auf einer substratoberfläche
DE60229316D1 (de) Dünnfilmbeschichtung eines geschlitzen Substrates und Verfahren zur Herstellung von geschlitzten Substraten
DE60231084D1 (de) Verfahren zur selektiven Abscheidung einer MCrAlY-Beschichtung

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties