ATE510532T1 - Arzneizusammensetzungen enthaltend rapamycinderivate - Google Patents

Arzneizusammensetzungen enthaltend rapamycinderivate

Info

Publication number: ATE510532T1
Authority: AT; Austria
Prior art keywords: compositions containing; phosphatidylglycerol; medicinal compositions; sub; salt
Prior art date: 1996-01-19

Application number

AT05018663T

Other languages

English (en)

Inventor

Harry Tiemessen

Original Assignee

Novartis Pharma Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-01-19

Filing date

1997-01-20

Publication date

2011-06-15

1997-01-20 Application filed by Novartis Pharma Gmbh filed Critical Novartis Pharma Gmbh

2011-06-15 Application granted granted Critical

2011-06-15 Publication of ATE510532T1 publication Critical patent/ATE510532T1/de

Links

239000000203 mixture Substances 0.000 title abstract 2
QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical class C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title 1
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 3
239000013543 active substance Substances 0.000 abstract 2
239000000839 emulsion Substances 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
239000003381 stabilizer Substances 0.000 abstract 2
HVCOBJNICQPDBP-UHFFFAOYSA-N 3-[3-[3,5-dihydroxy-6-methyl-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyoxan-2-yl]oxydecanoyloxy]decanoic acid;hydrate Chemical compound O.OC1C(OC(CC(=O)OC(CCCCCCC)CC(O)=O)CCCCCCC)OC(C)C(O)C1OC1C(O)C(O)C(O)C(C)O1 HVCOBJNICQPDBP-UHFFFAOYSA-N 0.000 abstract 1
229930186217 Glycolipid Natural products 0.000 abstract 1
ZDQSOHOQTUFQEM-PKUCKEGBSA-N ascomycin Chemical compound C/C([C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@@H](OC)C[C@@H](C)C\C(C)=C/[C@H](C(C[C@H](O)[C@H]1C)=O)CC)=C\[C@@H]1CC[C@@H](O)[C@H](OC)C1 ZDQSOHOQTUFQEM-PKUCKEGBSA-N 0.000 abstract 1
ZDQSOHOQTUFQEM-XCXYXIJFSA-N ascomycin Natural products CC[C@H]1C=C(C)C[C@@H](C)C[C@@H](OC)[C@H]2O[C@@](O)([C@@H](C)C[C@H]2OC)C(=O)C(=O)N3CCCC[C@@H]3C(=O)O[C@H]([C@H](C)[C@@H](O)CC1=O)C(=C[C@@H]4CC[C@@H](O)[C@H](C4)OC)C ZDQSOHOQTUFQEM-XCXYXIJFSA-N 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
239000012141 concentrate Substances 0.000 abstract 1
235000014113 dietary fatty acids Nutrition 0.000 abstract 1
229930195729 fatty acid Natural products 0.000 abstract 1
239000000194 fatty acid Substances 0.000 abstract 1
150000004665 fatty acids Chemical class 0.000 abstract 1
238000001990 intravenous administration Methods 0.000 abstract 1
239000002960 lipid emulsion Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
150000003904 phospholipids Chemical class 0.000 abstract 1
229940068196 placebo Drugs 0.000 abstract 1
239000000902 placebo Substances 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
150000003408 sphingolipids Chemical class 0.000 abstract 1

Classifications

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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
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- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Immunology (AREA)
Dermatology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Diabetes (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Communicable Diseases (AREA)
Physical Education & Sports Medicine (AREA)
Hematology (AREA)
Dispersion Chemistry (AREA)
Oncology (AREA)
Ophthalmology & Optometry (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurology (AREA)
Tropical Medicine & Parasitology (AREA)
Gastroenterology & Hepatology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Virology (AREA)
Neurosurgery (AREA)
Transplantation (AREA)
Biomedical Technology (AREA)

AT05018663T 1996-01-19 1997-01-20 Arzneizusammensetzungen enthaltend rapamycinderivate ATE510532T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB9601120.0A GB9601120D0 (en)	1996-01-19	1996-01-19	Organic compounds

Publications (1)

Publication Number	Publication Date
ATE510532T1 true ATE510532T1 (de)	2011-06-15

Family

ID=10787276

Family Applications (4)

Application Number	Title	Priority Date	Filing Date
AT02022256T ATE304842T1 (de)	1996-01-19	1997-01-20	Arzneizusammensetzungen enthaltend rapamycinderivate
AT02022257T ATE310504T1 (de)	1996-01-19	1997-01-20	Arzneizusammensetzungen enthaltend ascomycinderivate
AT05018663T ATE510532T1 (de)	1996-01-19	1997-01-20	Arzneizusammensetzungen enthaltend rapamycinderivate
AT97901563T ATE239449T1 (de)	1996-01-19	1997-01-20	(3'-desoxy-3-oxo-mebmt)1-(val)2-ciclosporin enthaltende arzneimittelemulsion

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
AT02022256T ATE304842T1 (de)	1996-01-19	1997-01-20	Arzneizusammensetzungen enthaltend rapamycinderivate
AT02022257T ATE310504T1 (de)	1996-01-19	1997-01-20	Arzneizusammensetzungen enthaltend ascomycinderivate

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT97901563T ATE239449T1 (de)	1996-01-19	1997-01-20	(3'-desoxy-3-oxo-mebmt)1-(val)2-ciclosporin enthaltende arzneimittelemulsion

Country Status (14)

Country	Link
US (2)	US6239102B1 (de)
EP (4)	EP0874621B1 (de)
JP (2)	JP4077386B2 (de)
KR (1)	KR100485146B1 (de)
AT (4)	ATE304842T1 (de)
AU (1)	AU1543497A (de)
CA (2)	CA2678707A1 (de)
DE (3)	DE69721729T2 (de)
DK (4)	DK0874621T3 (de)
ES (4)	ES2253483T3 (de)
GB (1)	GB9601120D0 (de)
HK (2)	HK1054183B (de)
PT (2)	PT1679064E (de)
WO (1)	WO1997025977A1 (de)

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US20030199425A1 (en) *	1997-06-27	2003-10-23	Desai Neil P.	Compositions and methods for treatment of hyperplasia
US20030220234A1 (en)	1998-11-02	2003-11-27	Selvaraj Naicker	Deuterated cyclosporine analogs and their use as immunodulating agents
US6284268B1 (en)	1997-12-10	2001-09-04	Cyclosporine Therapeutics Limited	Pharmaceutical compositions containing an omega-3 fatty acid oil
DE19810655A1 (de) *	1998-03-12	1999-09-16	Univ Eberhard Karls	Arzneimittel mit einem Gehalt an Ciclosporin
US6979456B1 (en)	1998-04-01	2005-12-27	Jagotec Ag	Anticancer compositions
TW537894B (en)	1998-05-26	2003-06-21	Novartis Ag	A spontaneously dispersible pharmaceutical composition comprising a piperidine substance P antagonist
US7265150B1 (en) *	1998-08-14	2007-09-04	Gpi Nil Holdings Inc.	Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds for vision and memory disorders
US6376517B1 (en) *	1998-08-14	2002-04-23	Gpi Nil Holdings, Inc.	Pipecolic acid derivatives for vision and memory disorders
US7063857B1 (en)	1999-04-30	2006-06-20	Sucampo Ag	Use of macrolide compounds for the treatment of dry eye
CZ20013769A3 (cs) *	1999-04-30	2002-03-13	Sucampo Ag	Činidlo pro léčbu suchého oka
WO2000067773A2 (en)	1999-05-10	2000-11-16	Novartis Ag	Combinations of immunosupressive agents for the treatment or prevention of graft rejections
US6720001B2 (en) *	1999-10-18	2004-04-13	Lipocine, Inc.	Emulsion compositions for polyfunctional active ingredients
US7473681B2 (en)	2000-10-31	2009-01-06	Pharma Mar, S.A.	Kahalalide F
CN1551767A (zh)	2001-02-19	2004-12-01	��˹��ŵ��	癌症的治疗
AU2002320407A1 (en) *	2001-07-10	2003-01-29	Trustees Of Boston University	Modified-fat nutritional products useful for preventing or treating obesity
US6641611B2 (en)	2001-11-26	2003-11-04	Swaminathan Jayaraman	Therapeutic coating for an intravascular implant
US20040137066A1 (en) *	2001-11-26	2004-07-15	Swaminathan Jayaraman	Rationally designed therapeutic intravascular implant coating
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1996
- 1996-01-19 GB GBGB9601120.0A patent/GB9601120D0/en active Pending
1997
- 1997-01-20 DK DK97901563T patent/DK0874621T3/da active
- 1997-01-20 KR KR10-1998-0704696A patent/KR100485146B1/ko not_active Expired - Lifetime
- 1997-01-20 DK DK02022257T patent/DK1273289T3/da active
- 1997-01-20 AT AT02022256T patent/ATE304842T1/de active
- 1997-01-20 CA CA002678707A patent/CA2678707A1/en not_active Abandoned
- 1997-01-20 AT AT02022257T patent/ATE310504T1/de active
- 1997-01-20 ES ES02022257T patent/ES2253483T3/es not_active Expired - Lifetime
- 1997-01-20 WO PCT/EP1997/000252 patent/WO1997025977A1/en not_active Ceased
- 1997-01-20 US US09/091,072 patent/US6239102B1/en not_active Ceased
- 1997-01-20 AT AT05018663T patent/ATE510532T1/de active
- 1997-01-20 DE DE69721729T patent/DE69721729T2/de not_active Expired - Lifetime
- 1997-01-20 EP EP97901563A patent/EP0874621B1/de not_active Expired - Lifetime
- 1997-01-20 ES ES97901563T patent/ES2199338T3/es not_active Expired - Lifetime
- 1997-01-20 DE DE69734253T patent/DE69734253T2/de not_active Expired - Lifetime
- 1997-01-20 DK DK02022256T patent/DK1273288T3/da active
- 1997-01-20 EP EP05018663A patent/EP1679064B1/de not_active Expired - Lifetime
- 1997-01-20 ES ES05018663T patent/ES2365734T3/es not_active Expired - Lifetime
- 1997-01-20 AT AT97901563T patent/ATE239449T1/de active
- 1997-01-20 DE DE69734742T patent/DE69734742T2/de not_active Expired - Lifetime
- 1997-01-20 PT PT05018663T patent/PT1679064E/pt unknown
- 1997-01-20 ES ES02022256T patent/ES2247245T3/es not_active Expired - Lifetime
- 1997-01-20 CA CA2240339A patent/CA2240339C/en not_active Expired - Lifetime
- 1997-01-20 AU AU15434/97A patent/AU1543497A/en not_active Abandoned
- 1997-01-20 DK DK05018663.4T patent/DK1679064T3/da active
- 1997-01-20 EP EP02022256A patent/EP1273288B1/de not_active Expired - Lifetime
- 1997-01-20 US US10/345,665 patent/USRE42014E1/en not_active Expired - Lifetime
- 1997-01-20 EP EP02022257A patent/EP1273289B1/de not_active Expired - Lifetime
- 1997-01-20 PT PT97901563T patent/PT874621E/pt unknown
1999
- 1999-02-05 HK HK03104827.8A patent/HK1054183B/en not_active IP Right Cessation
- 1999-02-05 HK HK03104828.7A patent/HK1053973B/en not_active IP Right Cessation
2003
- 2003-09-29 JP JP2003337458A patent/JP4077386B2/ja not_active Expired - Lifetime
2007
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Publication number	Publication date
JP2004107350A (ja)	2004-04-08
EP1679064B1 (de)	2011-05-25
DK1679064T3 (da)	2011-09-12
CA2240339C (en)	2010-11-16
HK1053973B (en)	2006-09-29
JP4077386B2 (ja)	2008-04-16
EP1273289A1 (de)	2003-01-08
EP1679064A2 (de)	2006-07-12
HK1054183A1 (en)	2003-11-21
PT874621E (pt)	2003-09-30
DK0874621T3 (da)	2003-09-01
ATE304842T1 (de)	2005-10-15
EP1273288A1 (de)	2003-01-08
DE69721729T2 (de)	2003-12-11
JP2000503655A (ja)	2000-03-28
CA2240339A1 (en)	1997-07-24
ES2247245T3 (es)	2006-03-01
EP1273289B1 (de)	2005-11-23
PT1679064E (pt)	2011-07-25
CA2678707A1 (en)	1997-07-24
ATE310504T1 (de)	2005-12-15
KR100485146B1 (ko)	2005-10-12
ES2365734T3 (es)	2011-10-10
HK1054183B (en)	2006-07-28
JP2007246543A (ja)	2007-09-27
AU1543497A (en)	1997-08-11
EP0874621A1 (de)	1998-11-04
DE69734253T2 (de)	2006-07-06
ATE239449T1 (de)	2003-05-15
DK1273289T3 (da)	2006-03-20
EP1679064A3 (de)	2009-10-07
JP3763581B2 (ja)	2006-04-05
HK1015277A1 (en)	1999-10-15
DE69734742D1 (de)	2005-12-29
EP0874621B1 (de)	2003-05-07
USRE42014E1 (en)	2010-12-28
DE69721729D1 (de)	2003-06-12
US6239102B1 (en)	2001-05-29
EP1273288B1 (de)	2005-09-21
DE69734742T2 (de)	2006-07-27
DK1273288T3 (da)	2005-11-21
HK1053973A1 (en)	2003-11-14
DE69734253D1 (de)	2006-02-02
GB9601120D0 (en)	1996-03-20
KR19990076603A (ko)	1999-10-15
ES2253483T3 (es)	2006-06-01
ES2199338T3 (es)	2004-02-16
WO1997025977A1 (en)	1997-07-24

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