ATE510839T1 - Benzofuropyrimidinone als proteinkinase-hemmer - Google Patents

Benzofuropyrimidinone als proteinkinase-hemmer

Info

Publication number
ATE510839T1
ATE510839T1 AT08832770T AT08832770T ATE510839T1 AT E510839 T1 ATE510839 T1 AT E510839T1 AT 08832770 T AT08832770 T AT 08832770T AT 08832770 T AT08832770 T AT 08832770T AT E510839 T1 ATE510839 T1 AT E510839T1
Authority
AT
Austria
Prior art keywords
benzofuropyrimidinone
protein kinase
kinase inhibitor
inhibitor
protein
Prior art date
Application number
AT08832770T
Other languages
English (en)
Inventor
S Brown
Hongwang Du
Maurizio Franzini
Adam Galan
Ping Huang
Patrick Kearney
Moon Kim
Elena Koltun
Steven Richards
Amy Tsuhako
Cristiana Zaharia
Original Assignee
Exelixis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40383673&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE510839(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Exelixis Inc filed Critical Exelixis Inc
Application granted granted Critical
Publication of ATE510839T1 publication Critical patent/ATE510839T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT08832770T 2007-12-21 2008-12-22 Benzofuropyrimidinone als proteinkinase-hemmer ATE510839T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US890707P 2007-12-21 2007-12-21
US7097108P 2008-03-25 2008-03-25
PCT/US2008/087939 WO2009086264A1 (en) 2007-12-21 2008-12-22 Benzofuropyrimidinones as protein kinase inhibitors

Publications (1)

Publication Number Publication Date
ATE510839T1 true ATE510839T1 (de) 2011-06-15

Family

ID=40383673

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08832770T ATE510839T1 (de) 2007-12-21 2008-12-22 Benzofuropyrimidinone als proteinkinase-hemmer

Country Status (20)

Country Link
US (1) US20090247559A1 (de)
EP (1) EP2097419B1 (de)
JP (1) JP2011507908A (de)
KR (1) KR20100098714A (de)
CN (1) CN101965351A (de)
AR (1) AR069869A1 (de)
AT (1) ATE510839T1 (de)
AU (1) AU2008345560A1 (de)
BR (1) BRPI0821573A2 (de)
CA (1) CA2712358A1 (de)
CL (1) CL2008003873A1 (de)
CO (1) CO6321258A2 (de)
EA (1) EA019785B1 (de)
IL (1) IL206416A0 (de)
MX (1) MX2010006799A (de)
NZ (1) NZ586936A (de)
PE (1) PE20091669A1 (de)
TW (1) TW200930375A (de)
WO (1) WO2009086264A1 (de)
ZA (1) ZA201004243B (de)

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DE102007026341A1 (de) 2007-06-06 2008-12-11 Merck Patent Gmbh Benzoxazolonderivate
DE102007032507A1 (de) 2007-07-12 2009-04-02 Merck Patent Gmbh Pyridazinonderivate
DE102007061963A1 (de) 2007-12-21 2009-06-25 Merck Patent Gmbh Pyridazinonderivate
DE102008019907A1 (de) 2008-04-21 2009-10-22 Merck Patent Gmbh Pyridazinonderivate
DE102008028905A1 (de) 2008-06-18 2009-12-24 Merck Patent Gmbh 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate
SG171914A1 (en) 2008-12-02 2011-07-28 Chiralgen Ltd Method for the synthesis of phosphorus atom modified nucleic acids
MX2011006682A (es) 2008-12-22 2011-07-13 Merck Patent Gmbh Nuevas formas polimorficas de dihidrogeno-fosfato de 6-(1-metil-1h-pirazol-4-il)-2-{3-[5-(2-morfolin-4-il-etoxi)-pirim idin-2-il]-bencil}-2h-piridazin-3-ona y procesos para su preparacion.
EP2451461A4 (de) 2009-07-06 2013-05-29 Ontorii Inc Neuartige nukleinsäure-prodrugs und verwendungsverfahren dafür
DK2620428T3 (da) * 2010-09-24 2019-07-01 Wave Life Sciences Ltd Asymmetrisk hjælpegruppe
US9605019B2 (en) 2011-07-19 2017-03-28 Wave Life Sciences Ltd. Methods for the synthesis of functionalized nucleic acids
DK2872485T3 (da) 2012-07-13 2021-03-08 Wave Life Sciences Ltd Asymmetrisk hjælpegruppe
CN112007045B (zh) 2012-07-13 2026-01-06 波涛生命科学有限公司 手性控制
JP6246121B2 (ja) 2012-07-13 2017-12-13 株式会社新日本科学 キラル核酸アジュバント
CN102875558A (zh) * 2012-11-05 2013-01-16 贵州大学 2-氯-4-取代-8-硝基苯并呋喃[3,2-d]嘧啶类化合物及其制备方法和用途
CN103044370A (zh) * 2012-12-28 2013-04-17 山东邹平大展新材料有限公司 一种5-（哌嗪-1-基）苯并呋喃-2-甲酰胺的制备方法
CN104045642B (zh) * 2013-03-14 2016-08-24 上海医药工业研究院 含嘧啶或吡啶的稠环化合物及其作为抗肿瘤药物的应用
WO2015108048A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
EP3095461A4 (de) 2014-01-15 2017-08-23 Shin Nippon Biomedical Laboratories, Ltd. Chirales nukleinsäure-adjuvans mit immunitätsinduktionswirkung und immunitätsinduktionsaktivator
US10322173B2 (en) 2014-01-15 2019-06-18 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
KR102423317B1 (ko) 2014-01-16 2022-07-22 웨이브 라이프 사이언시스 리미티드 키랄 디자인
JP6569908B2 (ja) 2014-01-31 2019-09-04 カルナバイオサイエンス株式会社 抗がん剤組成物
EP3110794A1 (de) 2014-02-27 2017-01-04 Merck Patent GmbH Heterocyclische verbindungen als nav-kanalinhibitoren und verwendungen davon
WO2015152319A1 (ja) * 2014-04-02 2015-10-08 株式会社 三和化学研究所 ５，７－無置換－ピラゾロ［１，５－ａ］ピリミジン－６－カルボン酸の製造方法
KR101837565B1 (ko) 2014-08-06 2018-03-12 삼성에스디아이 주식회사 유기 화합물, 유기 광전자 소자 및 표시 장치
JP6840931B2 (ja) * 2015-03-09 2021-03-10 東ソー株式会社 縮環芳香族化合物の製造方法
WO2018087527A1 (en) 2016-11-08 2018-05-17 Cancer Research Technology Limited Pyrimidinone derivatives as cdc7 inhibitors
NL2021185B1 (en) 2018-06-26 2020-01-06 Stichting Het Nederlands Kanker Inst Antoni Van Leeuwenhoek Ziekenhuis Combination Therapy and Use Thereof for Treating Cancer
JP7579781B2 (ja) 2018-09-24 2024-11-08 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー Ｃｄｃ７阻害剤を含む癌の治療方法
ES2973117T3 (es) 2018-09-25 2024-06-18 Incyte Corp Compuestos de pirazolo[4,3-d]pirimidina como moduladores de ALK2 y/o FGFR
CN111689947B (zh) * 2019-03-13 2023-07-14 鲁南制药集团股份有限公司 替加氟-l-脯氨酸共晶体及其制备方法
US20230140216A1 (en) * 2020-02-03 2023-05-04 Gain Therapeutics Sa Combination therapy for treating mps1
WO2021198191A1 (en) 2020-03-30 2021-10-07 Enyo Pharma Quinazolinone derivatives and uses thereof for treating a cancer
MX2023003932A (es) * 2020-10-05 2023-04-26 Japan Tobacco Inc Compuesto de tetrahidrobenzofurodiazepinona y uso farmaceutico del mismo.
CN117120447A (zh) * 2021-03-18 2023-11-24 薛定谔公司 环状化合物和其使用方法
KR20230158657A (ko) 2021-03-18 2023-11-21 메르크 파텐트 게엠베하 유기 전계 발광 디바이스용 헤테로방향족 화합물
IL314895A (en) * 2022-02-16 2024-10-01 Duke Street Bio Ltd Pharmaceutical compound
CN116731025B (zh) * 2023-05-24 2025-06-24 曲阜师范大学 一种具有2-芳基苯并呋喃并[2,3-d]嘧啶酮类结构的荧光材料及其制备方法和应用
CN120114459B (zh) * 2025-05-14 2025-07-29 南京工业大学 苯并呋喃嘧啶酮或苯并噻吩嘧啶酮类化合物的应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL112248A0 (en) * 1994-01-25 1995-03-30 Warner Lambert Co Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them
JPWO2002051849A1 (ja) 2000-12-26 2004-04-22 第一製薬株式会社 Ｃｄｋ４活性阻害剤
JP2005504730A (ja) * 2001-04-20 2005-02-17 バーテックス　ファーマシューティカルズ　インコーポレイテッド Ｇｓｋ−３インヒビターとして有用な組成物
US7345046B2 (en) 2003-05-30 2008-03-18 Chiron Corporation Heteroaryl-fused pyrimidinyl compounds as anticancer agents
WO2006023381A1 (en) * 2004-08-16 2006-03-02 Taigen Biotechnology Pyrimidinone compounds
JP2008519794A (ja) 2004-11-11 2008-06-12 アージェンタ・ディスカバリー・リミテッド ピリミジン化合物
EP1776982A1 (de) * 2005-10-18 2007-04-25 Argenta Discovery Limited Pyrimidine Derivate als Modulator der Histamine Rezeptor

Also Published As

Publication number Publication date
TW200930375A (en) 2009-07-16
CN101965351A (zh) 2011-02-02
CO6321258A2 (es) 2011-09-20
NZ586936A (en) 2012-07-27
MX2010006799A (es) 2010-10-05
ZA201004243B (en) 2011-03-30
IL206416A0 (en) 2010-12-30
WO2009086264A1 (en) 2009-07-09
EP2097419B1 (de) 2011-05-25
BRPI0821573A2 (pt) 2016-08-09
EA019785B1 (ru) 2014-06-30
CL2008003873A1 (es) 2009-06-26
EA201070786A1 (ru) 2011-02-28
CA2712358A1 (en) 2009-07-09
AR069869A1 (es) 2010-02-24
AU2008345560A1 (en) 2009-07-09
JP2011507908A (ja) 2011-03-10
US20090247559A1 (en) 2009-10-01
PE20091669A1 (es) 2009-12-06
EP2097419A1 (de) 2009-09-09
KR20100098714A (ko) 2010-09-08

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