ATE510851T1 - Auf peptiden basierende immunisierungstherapie zur behandlung von atherosklerose - Google Patents

Auf peptiden basierende immunisierungstherapie zur behandlung von atherosklerose

Info

Publication number
ATE510851T1
ATE510851T1 AT08151489T AT08151489T ATE510851T1 AT E510851 T1 ATE510851 T1 AT E510851T1 AT 08151489 T AT08151489 T AT 08151489T AT 08151489 T AT08151489 T AT 08151489T AT E510851 T1 ATE510851 T1 AT E510851T1
Authority
AT
Austria
Prior art keywords
atherosclerosis
peptide
treatment
immunization therapy
based immunization
Prior art date
Application number
AT08151489T
Other languages
English (en)
Inventor
Jan Nilsson
Shah K Prediman
Original Assignee
Forskarpatent I Syd Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0101232A external-priority patent/SE0101232D0/xx
Application filed by Forskarpatent I Syd Ab filed Critical Forskarpatent I Syd Ab
Application granted granted Critical
Publication of ATE510851T1 publication Critical patent/ATE510851T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Zoology (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
AT08151489T 2001-04-05 2002-04-05 Auf peptiden basierende immunisierungstherapie zur behandlung von atherosklerose ATE510851T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0101232A SE0101232D0 (sv) 2001-04-05 2001-04-05 Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based elisa for determination of immune responses against oxidized low density liprotein
SE0103754A SE0103754L (sv) 2001-04-05 2001-11-09 Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid

Publications (1)

Publication Number Publication Date
ATE510851T1 true ATE510851T1 (de) 2011-06-15

Family

ID=26655437

Family Applications (2)

Application Number Title Priority Date Filing Date
AT08151489T ATE510851T1 (de) 2001-04-05 2002-04-05 Auf peptiden basierende immunisierungstherapie zur behandlung von atherosklerose
AT02714667T ATE415423T1 (de) 2001-04-05 2002-04-05 Immunisierungstherapie zur behandlung von atherosklerose

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT02714667T ATE415423T1 (de) 2001-04-05 2002-04-05 Immunisierungstherapie zur behandlung von atherosklerose

Country Status (18)

Country Link
EP (42) EP2295461A1 (de)
JP (6) JP2004529143A (de)
CN (4) CN103122031B (de)
AT (2) ATE510851T1 (de)
AU (1) AU2002246484B8 (de)
BR (1) BR0208685A (de)
CA (3) CA2827167A1 (de)
CY (1) CY1108817T1 (de)
DE (1) DE60230029D1 (de)
DK (3) DK1383526T3 (de)
EE (2) EE200700052A (de)
ES (2) ES2317999T3 (de)
IL (4) IL158285A0 (de)
PL (4) PL217858B1 (de)
PT (1) PT1383526E (de)
RU (1) RU2296582C2 (de)
SE (1) SE0103754L (de)
WO (1) WO2002080954A1 (de)

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US20030105003A1 (en) 2001-04-05 2003-06-05 Jan Nilsson Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein
SE0103754L (sv) * 2001-04-05 2002-10-06 Forskarpatent I Syd Ab Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid
AU2002362612B2 (en) 2001-09-28 2007-11-15 Cedars-Sinai Medical Center Prevention and treatment of restenosis by local administration of drug
SE0302312D0 (sv) * 2002-10-04 2003-08-27 Forskarpatent I Syd Ab Peptide-based passive immunization therapy for treatment of atherosclerosis
CA2500895A1 (en) * 2002-10-04 2004-04-15 Forskarpatent I Syd Ab Peptide-based passive immunization therapy for treatment of atherosclerosis
SE0302422D0 (sv) 2003-09-11 2003-09-11 Forskarpatent I Syd Ab Peptide-based immunization therapy for treatment of atherosclerosis
SE0400683D0 (sv) * 2004-03-19 2004-03-19 Forskarpatent I Syd Ab Use of modified extracellular matrix proteins in diagnosis and treatment of a atherosclerosis
JP2007531537A (ja) 2004-04-06 2007-11-08 セダーズ−シナイ　メディカル　センター アポリポタンパク質ａ−ｉおよびアポリポタンパク質ａ−ｉｍｉｌａｎｏをコードする組換えアデノ随伴ウイルスベクターによる血管疾患の予防および処置
DE602005023428D1 (de) * 2004-04-15 2010-10-21 Athera Biotechnologies Ab Verfahren zur Feststellung der Gefahren von ischemischen Herzgefässerkrankungen mit PhosphorylcholinKonjugaten
EP1676602A1 (de) * 2005-01-04 2006-07-05 Institut National De La Sante Et De La Recherche Medicale (Inserm) Kontinuierlicheverabreichung von Epitope aus dem atherosklerotischem Belag zur Behandlung von Atheriosklerose
GB0517878D0 (en) 2005-09-02 2005-10-12 Bioinvent Int Ab Immunotherapeutic treatment
WO2008080030A2 (en) * 2006-12-22 2008-07-03 Abbott Laboratories Cardiovascular autoimmune disease panel and methods of using same
WO2008104194A1 (en) * 2007-02-28 2008-09-04 Bioinvent International Ab Oxidized ldl and antibodies thereto for the treatment of atheroscleroti c plaques
PE20090188A1 (es) 2007-03-15 2009-03-20 Novartis Ag Compuestos heterociclicos como moduladores de la senda de hedgehog
US9359633B2 (en) * 2007-11-05 2016-06-07 Nordic Bioscience A/S Biochemical markers for CVD risk assessment
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
EP3021121B1 (de) * 2008-08-15 2018-06-06 Fujikura Kasei Co., Ltd. Polypeptidmarker zur diagnose von arteriosklerose, verfahren für den nachweis von arteriosklerose anhand des markers oder dergleichen und kit für die diagnose von arteriosklerose
JP2013510586A (ja) * 2009-11-14 2013-03-28 チュウ、カン−ユウ アテローム性動脈硬化を治療及び／又は予防するための免疫調節方法及びシステム
US8506964B2 (en) * 2010-02-05 2013-08-13 Cardiovax, Llc Fusion proteins and related compositions, methods and systems for treatment and/or prevention of atherosclerosis
US20130142760A1 (en) 2010-08-18 2013-06-06 Cedars-Sinai Medical Center Atherosclerosis inhibition via modulation of monocyte-macrophage phenotype using apo a-i milano gene transfer
WO2012065135A2 (en) 2010-11-12 2012-05-18 Cedars-Sinai Medical Center Immunomodulatory compositions, methods and systems comprising immunogenic fragments of apob100
RU2013126628A (ru) 2010-11-12 2014-12-20 Седарс-Синаи Медикал Сентер Иммуномодулирующие способы и системы для лечения и/или предотвращения аневризм
CA2817543A1 (en) * 2010-11-12 2012-06-07 Cedars-Sinai Medical Center Immunomodulatory methods and systems for treatment and/or prevention of hypertension
AU2012294431B2 (en) 2011-08-09 2017-03-30 Athera Biotechnologies Ab Antibodies binding to phosphorylcholine (PC) and/or PC conjugates
TR201909072T4 (tr) 2011-08-09 2019-08-21 Athera Biotechnologies Ab Fosforilkoline karşı yeni antikorlar.
RU2495048C1 (ru) * 2012-04-18 2013-10-10 Андрей Валентинович Исаев Пептид, обладающий антиатеросклеротическим действием и композиция для профилактики и лечения атеросклероза сосудов
BR112015010276A2 (pt) * 2012-11-06 2019-10-15 Hoffmann La Roche peptídeos miméticos
CN103520713B (zh) * 2013-10-16 2015-10-28 西北农林科技大学 一种ApoB100酵母重组疫苗及其制备方法和应用
CN103860470A (zh) * 2014-03-05 2014-06-18 贵州中泰生物科技有限公司 一种口服高密度脂蛋白脂质体的制备方法
CN105315364B (zh) * 2014-06-17 2018-09-18 广州文瑞生物科技有限公司 胶原蛋白vi疫苗预防动脉粥样硬化
CN108135973B (zh) * 2015-05-19 2021-10-19 拉·约拉过敏反应及免疫医学研究所 调节炎症应答及治疗不良心血管事件、病和粥样硬化的人apob100表位、方法和用途
US10858422B2 (en) 2016-05-31 2020-12-08 Abcentra, Llc Methods for treating systemic lupus erythematosus with an anti-apolipoprotein B antibody
CN108478817B (zh) * 2018-03-16 2020-10-27 北京大学 一种动脉粥样硬化检测试剂及其制备方法
US11690912B2 (en) 2018-05-29 2023-07-04 Abcentra, Llc Methods for treatment of rheumatoid arthritis and accelerated atherosclerosis with an anti-Apo B100 antibody
US12016921B2 (en) 2018-05-29 2024-06-25 Abcentra, Llc Methods for treatment of psoriasis with an anti-Apo B100 antibody
CN115025210B (zh) * 2021-03-05 2025-09-05 香港中文大学 减少动脉粥样硬化进展的肽疫苗组合物和药物制剂
CN115025211A (zh) * 2021-11-02 2022-09-09 南京理工大学 用于动脉粥样硬化治疗的纳米疫苗及其制备方法

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ATE506615T1 (de) * 1999-10-26 2011-05-15 Univ California Reagenzien und verfahren für diagnose, 'imaging' und behandlung von atherosklerotischen krankheiten
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EP1186299A1 (de) * 2000-09-12 2002-03-13 Universitair Medisch Centrum Utrecht Diagnose, Verbeugung und/oder Behandlung von Atherosklerose, Infectionen und Störungen des Immunsystems
CA2425513A1 (en) * 2000-10-25 2002-06-20 Vincent Agnello Method of inhibiting infection by hcv, other flaviviridae viruses, and any other virus that complexes to low density lipoprotein or to very low density lipoprotein in blood preventing viral entry into a cell
AU2002241603A1 (en) * 2000-11-10 2002-06-03 University Of Utah Research Foundation Carrier system for specific artery wall gene delivery
SE0103754L (sv) * 2001-04-05 2002-10-06 Forskarpatent I Syd Ab Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid
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Also Published As

Publication number Publication date
EP2295464A1 (de) 2011-03-16
DK2295464T3 (en) 2015-08-17
EP2289917A1 (de) 2011-03-02
AU2002246484A1 (en) 2002-10-21
EP2289914A1 (de) 2011-03-02
JP2008169215A (ja) 2008-07-24
JP5613890B2 (ja) 2014-10-29
EP1383526A1 (de) 2004-01-28
JP2004529143A (ja) 2004-09-24
CN103122031A (zh) 2013-05-29
ES2317999T3 (es) 2009-05-01
EP2289933A1 (de) 2011-03-02
EP2289931A1 (de) 2011-03-02
IL158285A (en) 2009-12-24
JP2011068654A (ja) 2011-04-07
CA2443223A1 (en) 2002-10-17
EP2289926A1 (de) 2011-03-02
EP2289913A1 (de) 2011-03-02
EP2147929A2 (de) 2010-01-27
EP2289916A1 (de) 2011-03-02
EP2289929A1 (de) 2011-03-02
AU2002246484B2 (en) 2007-04-19
EP2289920A1 (de) 2011-03-02
DE60230029D1 (de) 2009-01-08
EP2295458A1 (de) 2011-03-16
IL158285A0 (en) 2004-05-12
JP2009191078A (ja) 2009-08-27
JP5300820B2 (ja) 2013-09-25
EP2289915A1 (de) 2011-03-02
PL367301A1 (en) 2005-02-21
EP2295463A1 (de) 2011-03-16
EP2147680A2 (de) 2010-01-27
EP2289912A1 (de) 2011-03-02
EP2305706A1 (de) 2011-04-06
CN1505525B (zh) 2012-11-07
EP2295461A1 (de) 2011-03-16
EP2006301B1 (de) 2011-05-25
EP2305707A1 (de) 2011-04-06
EP2305708A1 (de) 2011-04-06
EP2289922A1 (de) 2011-03-02
ATE415423T1 (de) 2008-12-15
CY1108817T1 (el) 2014-04-09
EP2295460B1 (de) 2015-06-03
RU2296582C2 (ru) 2007-04-10
EP2289918A1 (de) 2011-03-02
JP2011063598A (ja) 2011-03-31
JP5270456B2 (ja) 2013-08-21
PL215401B1 (pl) 2013-12-31
EP2289935A1 (de) 2011-03-02
ES2546293T3 (es) 2015-09-22
EP1918300A3 (de) 2009-06-17
EP2147930A3 (de) 2010-04-14
EP2295464B1 (de) 2015-06-03
PT1383526E (pt) 2009-02-27
RU2003132443A (ru) 2005-02-27
DK2006301T3 (da) 2011-09-12
IL195356A0 (en) 2009-08-03
EP1383526B1 (de) 2008-11-26
CA2606839A1 (en) 2002-10-17
EP2289919A1 (de) 2011-03-02
PL217858B1 (pl) 2014-08-29
CN101284874B (zh) 2012-10-03
EP2289934B1 (de) 2013-11-13
EP2006301A1 (de) 2008-12-24
EP2289932A1 (de) 2011-03-02
EP2289928A1 (de) 2011-03-02
BR0208685A (pt) 2004-03-30
CA2827167A1 (en) 2002-10-17
WO2002080954A1 (en) 2002-10-17
CN103122031B (zh) 2015-07-22
EP2289923A1 (de) 2011-03-02
EP2295460A1 (de) 2011-03-16
EP2295459A1 (de) 2011-03-16
JP5300819B2 (ja) 2013-09-25
CN101284874A (zh) 2008-10-15
CA2443223C (en) 2013-11-26
EP2289921A1 (de) 2011-03-02
EP2295457A1 (de) 2011-03-16
EP2289925A1 (de) 2011-03-02
EP2147928A3 (de) 2010-04-14
CN101486766A (zh) 2009-07-22
EP2147929A3 (de) 2010-04-14
EP2295462A1 (de) 2011-03-16
EP2147680A3 (de) 2010-04-14
JP2013144687A (ja) 2013-07-25
SE0103754D0 (sv) 2001-11-09
EP2289924A1 (de) 2011-03-02
EP2289934A1 (de) 2011-03-02
AU2002246484B8 (en) 2007-06-14
EP1918300A2 (de) 2008-05-07
IL188286A0 (en) 2008-03-20
EP2289930A1 (de) 2011-03-02
EE200700052A (et) 2008-08-15
SE0103754L (sv) 2002-10-06
CA2606839C (en) 2015-06-09
PL400308A1 (pl) 2012-12-17
CN1505525A (zh) 2004-06-16
EP2147928A2 (de) 2010-01-27
EP2289927A1 (de) 2011-03-02
EE200300487A (et) 2004-02-16
EP2147930A2 (de) 2010-01-27
DK1383526T3 (da) 2009-03-30

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