EE200700052A - Antikeha he v?i mitme apo-lipoproteiin B fragmendi vastu - Google Patents

Antikeha he v?i mitme apo-lipoproteiin B fragmendi vastu

Info

Publication number
EE200700052A
EE200700052A EEP200700052A EEP200700052A EE200700052A EE 200700052 A EE200700052 A EE 200700052A EE P200700052 A EEP200700052 A EE P200700052A EE P200700052 A EEP200700052 A EE P200700052A EE 200700052 A EE200700052 A EE 200700052A
Authority
EE
Estonia
Prior art keywords
fragments
apo
lipoprotein
antibody against
against several
Prior art date
Application number
EEP200700052A
Other languages
English (en)
Inventor
Nilsson Jan
K. Shah Prediman
Original Assignee
Forskarpatent I Syd Ab
Cedars Sinai Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE0101232A external-priority patent/SE0101232D0/xx
Application filed by Forskarpatent I Syd Ab, Cedars Sinai Medical Center filed Critical Forskarpatent I Syd Ab
Publication of EE200700052A publication Critical patent/EE200700052A/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Zoology (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Toxicology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
EEP200700052A 2001-04-05 2002-04-05 Antikeha he v?i mitme apo-lipoproteiin B fragmendi vastu EE200700052A (et)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0101232A SE0101232D0 (sv) 2001-04-05 2001-04-05 Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based elisa for determination of immune responses against oxidized low density liprotein
SE0103754A SE0103754L (sv) 2001-04-05 2001-11-09 Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid
EEP200300487A EE200300487A (et) 2001-04-05 2002-04-05 Peptiid-põhine immunoteraapia ateroskleroosi raviks ja peptiid-põhise määramise arendamine immuunvastuste määramiseks oksüdeeritud madala tihedusega lipoproteiini vastu

Publications (1)

Publication Number Publication Date
EE200700052A true EE200700052A (et) 2008-08-15

Family

ID=26655437

Family Applications (2)

Application Number Title Priority Date Filing Date
EEP200700052A EE200700052A (et) 2001-04-05 2002-04-05 Antikeha he v?i mitme apo-lipoproteiin B fragmendi vastu
EEP200300487A EE200300487A (et) 2001-04-05 2002-04-05 Peptiid-põhine immunoteraapia ateroskleroosi raviks ja peptiid-põhise määramise arendamine immuunvastuste määramiseks oksüdeeritud madala tihedusega lipoproteiini vastu

Family Applications After (1)

Application Number Title Priority Date Filing Date
EEP200300487A EE200300487A (et) 2001-04-05 2002-04-05 Peptiid-põhine immunoteraapia ateroskleroosi raviks ja peptiid-põhise määramise arendamine immuunvastuste määramiseks oksüdeeritud madala tihedusega lipoproteiini vastu

Country Status (18)

Country Link
EP (42) EP2295461A1 (et)
JP (6) JP2004529143A (et)
CN (4) CN103122031B (et)
AT (2) ATE510851T1 (et)
AU (1) AU2002246484B8 (et)
BR (1) BR0208685A (et)
CA (3) CA2827167A1 (et)
CY (1) CY1108817T1 (et)
DE (1) DE60230029D1 (et)
DK (3) DK1383526T3 (et)
EE (2) EE200700052A (et)
ES (2) ES2317999T3 (et)
IL (4) IL158285A0 (et)
PL (4) PL217858B1 (et)
PT (1) PT1383526E (et)
RU (1) RU2296582C2 (et)
SE (1) SE0103754L (et)
WO (1) WO2002080954A1 (et)

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US20030105003A1 (en) 2001-04-05 2003-06-05 Jan Nilsson Peptide-based immunization therapy for treatment of atherosclerosis and development of peptide-based assay for determination of immune responses against oxidized low density lipoprotein
SE0103754L (sv) * 2001-04-05 2002-10-06 Forskarpatent I Syd Ab Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid
AU2002362612B2 (en) 2001-09-28 2007-11-15 Cedars-Sinai Medical Center Prevention and treatment of restenosis by local administration of drug
SE0302312D0 (sv) * 2002-10-04 2003-08-27 Forskarpatent I Syd Ab Peptide-based passive immunization therapy for treatment of atherosclerosis
CA2500895A1 (en) * 2002-10-04 2004-04-15 Forskarpatent I Syd Ab Peptide-based passive immunization therapy for treatment of atherosclerosis
SE0302422D0 (sv) 2003-09-11 2003-09-11 Forskarpatent I Syd Ab Peptide-based immunization therapy for treatment of atherosclerosis
SE0400683D0 (sv) * 2004-03-19 2004-03-19 Forskarpatent I Syd Ab Use of modified extracellular matrix proteins in diagnosis and treatment of a atherosclerosis
JP2007531537A (ja) 2004-04-06 2007-11-08 セダーズ−シナイ　メディカル　センター アポリポタンパク質ａ−ｉおよびアポリポタンパク質ａ−ｉｍｉｌａｎｏをコードする組換えアデノ随伴ウイルスベクターによる血管疾患の予防および処置
DE602005023428D1 (de) * 2004-04-15 2010-10-21 Athera Biotechnologies Ab Verfahren zur Feststellung der Gefahren von ischemischen Herzgefässerkrankungen mit PhosphorylcholinKonjugaten
EP1676602A1 (en) * 2005-01-04 2006-07-05 Institut National De La Sante Et De La Recherche Medicale (Inserm) Continuous administration of epitopes derived from protein present in atherosclerotic plaque for the treatment of atherosclerosis
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WO2008104194A1 (en) * 2007-02-28 2008-09-04 Bioinvent International Ab Oxidized ldl and antibodies thereto for the treatment of atheroscleroti c plaques
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US9359633B2 (en) * 2007-11-05 2016-06-07 Nordic Bioscience A/S Biochemical markers for CVD risk assessment
US20100041663A1 (en) 2008-07-18 2010-02-18 Novartis Ag Organic Compounds as Smo Inhibitors
EP3021121B1 (en) * 2008-08-15 2018-06-06 Fujikura Kasei Co., Ltd. Polypeptide marker for diagnosis of arteriosclerosis, method for detection of arteriosclerosis by using the maker or the like, and kit for diagnosis of arteriosclerosis
JP2013510586A (ja) * 2009-11-14 2013-03-28 チュウ、カン−ユウ アテローム性動脈硬化を治療及び／又は予防するための免疫調節方法及びシステム
US8506964B2 (en) * 2010-02-05 2013-08-13 Cardiovax, Llc Fusion proteins and related compositions, methods and systems for treatment and/or prevention of atherosclerosis
US20130142760A1 (en) 2010-08-18 2013-06-06 Cedars-Sinai Medical Center Atherosclerosis inhibition via modulation of monocyte-macrophage phenotype using apo a-i milano gene transfer
WO2012065135A2 (en) 2010-11-12 2012-05-18 Cedars-Sinai Medical Center Immunomodulatory compositions, methods and systems comprising immunogenic fragments of apob100
RU2013126628A (ru) 2010-11-12 2014-12-20 Седарс-Синаи Медикал Сентер Иммуномодулирующие способы и системы для лечения и/или предотвращения аневризм
CA2817543A1 (en) * 2010-11-12 2012-06-07 Cedars-Sinai Medical Center Immunomodulatory methods and systems for treatment and/or prevention of hypertension
AU2012294431B2 (en) 2011-08-09 2017-03-30 Athera Biotechnologies Ab Antibodies binding to phosphorylcholine (PC) and/or PC conjugates
TR201909072T4 (tr) 2011-08-09 2019-08-21 Athera Biotechnologies Ab Fosforilkoline karşı yeni antikorlar.
RU2495048C1 (ru) * 2012-04-18 2013-10-10 Андрей Валентинович Исаев Пептид, обладающий антиатеросклеротическим действием и композиция для профилактики и лечения атеросклероза сосудов
BR112015010276A2 (pt) * 2012-11-06 2019-10-15 Hoffmann La Roche peptídeos miméticos
CN103520713B (zh) * 2013-10-16 2015-10-28 西北农林科技大学 一种ApoB100酵母重组疫苗及其制备方法和应用
CN103860470A (zh) * 2014-03-05 2014-06-18 贵州中泰生物科技有限公司 一种口服高密度脂蛋白脂质体的制备方法
CN105315364B (zh) * 2014-06-17 2018-09-18 广州文瑞生物科技有限公司 胶原蛋白vi疫苗预防动脉粥样硬化
CN108135973B (zh) * 2015-05-19 2021-10-19 拉·约拉过敏反应及免疫医学研究所 调节炎症应答及治疗不良心血管事件、病和粥样硬化的人apob100表位、方法和用途
US10858422B2 (en) 2016-05-31 2020-12-08 Abcentra, Llc Methods for treating systemic lupus erythematosus with an anti-apolipoprotein B antibody
CN108478817B (zh) * 2018-03-16 2020-10-27 北京大学 一种动脉粥样硬化检测试剂及其制备方法
US11690912B2 (en) 2018-05-29 2023-07-04 Abcentra, Llc Methods for treatment of rheumatoid arthritis and accelerated atherosclerosis with an anti-Apo B100 antibody
US12016921B2 (en) 2018-05-29 2024-06-25 Abcentra, Llc Methods for treatment of psoriasis with an anti-Apo B100 antibody
CN115025210B (zh) * 2021-03-05 2025-09-05 香港中文大学 减少动脉粥样硬化进展的肽疫苗组合物和药物制剂
CN115025211A (zh) * 2021-11-02 2022-09-09 南京理工大学 用于动脉粥样硬化治疗的纳米疫苗及其制备方法

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SE0103754L (sv) * 2001-04-05 2002-10-06 Forskarpatent I Syd Ab Peptider från apolipoprotein B, användning därav immunisering, diagnosmetod eller terapeutisk behandling av ischemiska kardiovaskulära sjukdomar, samt farmaceutisk komposition och vaccin innehållande sådan peptid
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Also Published As

Publication number Publication date
EP2295464A1 (en) 2011-03-16
DK2295464T3 (en) 2015-08-17
EP2289917A1 (en) 2011-03-02
AU2002246484A1 (en) 2002-10-21
EP2289914A1 (en) 2011-03-02
JP2008169215A (ja) 2008-07-24
JP5613890B2 (ja) 2014-10-29
EP1383526A1 (en) 2004-01-28
JP2004529143A (ja) 2004-09-24
CN103122031A (zh) 2013-05-29
ES2317999T3 (es) 2009-05-01
EP2289933A1 (en) 2011-03-02
EP2289931A1 (en) 2011-03-02
IL158285A (en) 2009-12-24
JP2011068654A (ja) 2011-04-07
CA2443223A1 (en) 2002-10-17
EP2289926A1 (en) 2011-03-02
EP2289913A1 (en) 2011-03-02
EP2147929A2 (en) 2010-01-27
EP2289916A1 (en) 2011-03-02
EP2289929A1 (en) 2011-03-02
AU2002246484B2 (en) 2007-04-19
EP2289920A1 (en) 2011-03-02
DE60230029D1 (de) 2009-01-08
EP2295458A1 (en) 2011-03-16
IL158285A0 (en) 2004-05-12
JP2009191078A (ja) 2009-08-27
JP5300820B2 (ja) 2013-09-25
EP2289915A1 (en) 2011-03-02
PL367301A1 (en) 2005-02-21
EP2295463A1 (en) 2011-03-16
EP2147680A2 (en) 2010-01-27
EP2289912A1 (en) 2011-03-02
EP2305706A1 (en) 2011-04-06
CN1505525B (zh) 2012-11-07
EP2295461A1 (en) 2011-03-16
EP2006301B1 (en) 2011-05-25
EP2305707A1 (en) 2011-04-06
EP2305708A1 (en) 2011-04-06
EP2289922A1 (en) 2011-03-02
ATE415423T1 (de) 2008-12-15
CY1108817T1 (el) 2014-04-09
EP2295460B1 (en) 2015-06-03
RU2296582C2 (ru) 2007-04-10
EP2289918A1 (en) 2011-03-02
JP2011063598A (ja) 2011-03-31
JP5270456B2 (ja) 2013-08-21
PL215401B1 (pl) 2013-12-31
EP2289935A1 (en) 2011-03-02
ES2546293T3 (es) 2015-09-22
EP1918300A3 (en) 2009-06-17
EP2147930A3 (en) 2010-04-14
EP2295464B1 (en) 2015-06-03
PT1383526E (pt) 2009-02-27
RU2003132443A (ru) 2005-02-27
DK2006301T3 (da) 2011-09-12
IL195356A0 (en) 2009-08-03
EP1383526B1 (en) 2008-11-26
CA2606839A1 (en) 2002-10-17
EP2289919A1 (en) 2011-03-02
PL217858B1 (pl) 2014-08-29
CN101284874B (zh) 2012-10-03
EP2289934B1 (en) 2013-11-13
EP2006301A1 (en) 2008-12-24
EP2289932A1 (en) 2011-03-02
EP2289928A1 (en) 2011-03-02
ATE510851T1 (de) 2011-06-15
BR0208685A (pt) 2004-03-30
CA2827167A1 (en) 2002-10-17
WO2002080954A1 (en) 2002-10-17
CN103122031B (zh) 2015-07-22
EP2289923A1 (en) 2011-03-02
EP2295460A1 (en) 2011-03-16
EP2295459A1 (en) 2011-03-16
JP5300819B2 (ja) 2013-09-25
CN101284874A (zh) 2008-10-15
CA2443223C (en) 2013-11-26
EP2289921A1 (en) 2011-03-02
EP2295457A1 (en) 2011-03-16
EP2289925A1 (en) 2011-03-02
EP2147928A3 (en) 2010-04-14
CN101486766A (zh) 2009-07-22
EP2147929A3 (en) 2010-04-14
EP2295462A1 (en) 2011-03-16
EP2147680A3 (en) 2010-04-14
JP2013144687A (ja) 2013-07-25
SE0103754D0 (sv) 2001-11-09
EP2289924A1 (en) 2011-03-02
EP2289934A1 (en) 2011-03-02
AU2002246484B8 (en) 2007-06-14
EP1918300A2 (en) 2008-05-07
IL188286A0 (en) 2008-03-20
EP2289930A1 (en) 2011-03-02
SE0103754L (sv) 2002-10-06
CA2606839C (en) 2015-06-09
PL400308A1 (pl) 2012-12-17
CN1505525A (zh) 2004-06-16
EP2147928A2 (en) 2010-01-27
EP2289927A1 (en) 2011-03-02
EE200300487A (et) 2004-02-16
EP2147930A2 (en) 2010-01-27
DK1383526T3 (da) 2009-03-30

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