ATE513056T1 - Stabilisierte proteine - Google Patents

Stabilisierte proteine

Info

Publication number
ATE513056T1
ATE513056T1 AT00973574T AT00973574T ATE513056T1 AT E513056 T1 ATE513056 T1 AT E513056T1 AT 00973574 T AT00973574 T AT 00973574T AT 00973574 T AT00973574 T AT 00973574T AT E513056 T1 ATE513056 T1 AT E513056T1
Authority
AT
Austria
Prior art keywords
polypeptide
tyrosine
cross
tyrosine cross
linking
Prior art date
Application number
AT00973574T
Other languages
English (en)
Inventor
Christopher Marshall
Alexander Hoffman
Joseph Errico
Paul Marshall
Original Assignee
Avatar Medical L L C
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avatar Medical L L C filed Critical Avatar Medical L L C
Application granted granted Critical
Publication of ATE513056T1 publication Critical patent/ATE513056T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • C12N9/54—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea bacteria being Bacillus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Gyroscopes (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Optical Head (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
AT00973574T 1999-10-15 2000-10-16 Stabilisierte proteine ATE513056T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15976399P 1999-10-15 1999-10-15
PCT/US2000/028595 WO2001029247A1 (en) 1999-10-15 2000-10-16 Stabilized proteins

Publications (1)

Publication Number Publication Date
ATE513056T1 true ATE513056T1 (de) 2011-07-15

Family

ID=22573921

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00973574T ATE513056T1 (de) 1999-10-15 2000-10-16 Stabilisierte proteine

Country Status (7)

Country Link
US (3) US7037894B2 (de)
EP (1) EP1282722B1 (de)
AT (1) ATE513056T1 (de)
AU (1) AU1207301A (de)
CA (1) CA2387870C (de)
ES (1) ES2367475T3 (de)
WO (1) WO2001029247A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001029247A1 (en) 1999-10-15 2001-04-26 Avatar Medical, Llc Stabilized proteins
DE10059720A1 (de) 2000-11-30 2002-06-06 Roche Diagnostics Gmbh Verwendung intramolekular kovalent vernetzter Proteine als Bindepartner in Immunoassays
AU2004293371A1 (en) * 2003-07-03 2005-06-09 Avatar Biotechnologies, Inc. Methods for obtaining molecules with reduced immunogenicity
GB0317304D0 (en) * 2003-07-24 2003-08-27 Hewlett Packard Development Co An analysis apparatus arranged to analyse data and detect change and related methods
US20060275780A1 (en) * 2005-06-06 2006-12-07 Beckman Coulter, Inc. Cross-linking reagents and uses thereof
US8333722B2 (en) * 2005-10-24 2012-12-18 Paul Ewing Communications during rehabilitation
DK1957118T3 (da) * 2005-10-28 2013-09-08 Indian Oil Corp Ltd Fremgangsmåde til bio-oxidativ afsvovling af flydende carbonhydridbrændsler og produkt deraf
US8759044B2 (en) 2011-03-23 2014-06-24 Butamax Advanced Biofuels Llc In situ expression of lipase for enzymatic production of alcohol esters during fermentation
US8765425B2 (en) 2011-03-23 2014-07-01 Butamax Advanced Biofuels Llc In situ expression of lipase for enzymatic production of alcohol esters during fermentation
WO2013049614A1 (en) * 2011-09-30 2013-04-04 Microlink Devices, Inc. Light emitting diode fabricated by epitaxial lift-off
US20130273585A1 (en) * 2012-04-11 2013-10-17 Gangagen, Inc. Soluble cytoplasmic expression of heterologous proteins in escherichia coli
US20130302366A1 (en) * 2012-05-09 2013-11-14 Christopher Marshall Conformationally Specific Viral Immunogens
BR112015031277A2 (pt) 2013-06-14 2017-09-19 Harvard College Moduladores do receptor de insulina de polipeptídeos estabilizados, análogos de insulina, composições farmacêuticas compreendendo os referidos polipeptídeos e métodos de preparação e usos dos mesmos
US10125172B2 (en) 2013-07-25 2018-11-13 Calder Biosciences Inc. Conformationally stabilized RSV pre-fusion F proteins
EP3395826B1 (de) * 2013-08-03 2020-10-14 Calder Biosciences Inc. Verfahren zur herstellung und verwendung von influenza virus hämagglutinin komplexen
WO2015051030A2 (en) * 2013-10-01 2015-04-09 President And Fellows Of Harvard College Stabilized polypeptides and uses thereof
EP3145523A4 (de) 2014-05-21 2018-02-21 President and Fellows of Harvard College Ras-hemmerpeptide und verwendungen davon
LU92906B1 (en) 2015-12-14 2017-06-20 Luxembourg Inst Science & Tech List Method for enzymatically modifying the tri-dimensional structure of a protein
AU2018313000B2 (en) 2017-08-07 2025-07-03 Calder Biosciences Inc. Conformationally stabilized RSV pre-fusion F proteins
EA202090513A1 (ru) 2017-09-07 2020-08-24 Фог Фармасьютикалз, Инк. Агенты, модулирующие функции бета-катенина, и связанные способы
US11623004B2 (en) 2018-03-16 2023-04-11 University Of Pittsburgh Of The Commonwealth System Of Higher Education Compositions and methods for vaccination against respiratory syncytial virus infection

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4650758A (en) * 1984-09-21 1987-03-17 Cetus Corporation Stabilization of enzymes useful in the production of glucosone and other enzymatic processes
IL83451A (en) * 1987-08-06 1991-06-10 Univ Ramot Stabilized water soluble enzymes and a method for their preparation
US5238831A (en) * 1989-04-28 1993-08-24 Gist-Brocades Stabilization of carboxyl esterase
US5747654A (en) * 1993-06-14 1998-05-05 The United States Of America As Represented By The Department Of Health And Human Services Recombinant disulfide-stabilized polypeptide fragments having binding specificity
WO2001029247A1 (en) 1999-10-15 2001-04-26 Avatar Medical, Llc Stabilized proteins
EP1251730A4 (de) 2000-01-26 2004-10-20 Univ Kansas State Herstellung und verwendung von polymeren, welche mit tyrosin enthaltenden peptiden vernetzt sind

Also Published As

Publication number Publication date
CA2387870A1 (en) 2001-04-26
CA2387870C (en) 2012-02-14
US7037894B2 (en) 2006-05-02
US20050123530A1 (en) 2005-06-09
AU1207301A (en) 2001-04-30
US20070184518A1 (en) 2007-08-09
US7445912B2 (en) 2008-11-04
EP1282722A1 (de) 2003-02-12
ES2367475T3 (es) 2011-11-03
EP1282722A4 (de) 2004-04-07
US20020061549A1 (en) 2002-05-23
WO2001029247A1 (en) 2001-04-26
EP1282722B1 (de) 2011-06-15

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