DK0973806T3 - Sted-beskyttet proteinmodificering - Google Patents
Sted-beskyttet proteinmodificeringInfo
- Publication number
- DK0973806T3 DK0973806T3 DK98911482T DK98911482T DK0973806T3 DK 0973806 T3 DK0973806 T3 DK 0973806T3 DK 98911482 T DK98911482 T DK 98911482T DK 98911482 T DK98911482 T DK 98911482T DK 0973806 T3 DK0973806 T3 DK 0973806T3
- Authority
- DK
- Denmark
- Prior art keywords
- protein
- polyethylene glycol
- site
- activity
- conjugating
- Prior art date
Links
- 230000009145 protein modification Effects 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 6
- 108090000623 proteins and genes Proteins 0.000 abstract 6
- 238000000034 method Methods 0.000 abstract 4
- 239000002202 Polyethylene glycol Substances 0.000 abstract 3
- 229920001223 polyethylene glycol Polymers 0.000 abstract 3
- 230000001268 conjugating effect Effects 0.000 abstract 2
- 230000021615 conjugation Effects 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 230000014759 maintenance of location Effects 0.000 abstract 1
- 102000035118 modified proteins Human genes 0.000 abstract 1
- 108091005573 modified proteins Proteins 0.000 abstract 1
- 230000004952 protein activity Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/642—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the peptide or protein in the drug conjugate being a cytokine, e.g. IL2, chemokine, growth factors or interferons being the inactive part of the conjugate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/814,305 US6548644B1 (en) | 1997-03-10 | 1997-03-10 | Site protected protein modification |
| EP98911482A EP0973806B1 (en) | 1997-03-10 | 1998-03-05 | Site protected protein modification |
| PCT/US1998/004301 WO1998040409A1 (en) | 1997-03-10 | 1998-03-05 | Site protected protein modification |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0973806T3 true DK0973806T3 (da) | 2005-01-31 |
Family
ID=25214667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98911482T DK0973806T3 (da) | 1997-03-10 | 1998-03-05 | Sted-beskyttet proteinmodificering |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6548644B1 (da) |
| EP (1) | EP0973806B1 (da) |
| JP (1) | JP3708134B2 (da) |
| AT (1) | ATE277084T1 (da) |
| AU (1) | AU6542598A (da) |
| DE (1) | DE69826452T2 (da) |
| DK (1) | DK0973806T3 (da) |
| ES (1) | ES2229485T3 (da) |
| PT (1) | PT973806E (da) |
| WO (1) | WO1998040409A1 (da) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100353392B1 (ko) * | 2000-03-13 | 2002-09-18 | 선바이오(주) | 높은 생체 활성도를 갖는 생체 활성 단백질과 peg의결합체 제조방법 |
| JP2003535208A (ja) | 2000-06-08 | 2003-11-25 | ラ ホヤ ファーマシューティカル カンパニー | 高分子量ポリエチレン・オキシドを含む多価プラットホーム分子 |
| MXPA04008149A (es) * | 2002-02-21 | 2005-06-17 | Wyeth Corp | Proteinas que contienen dominios de folistatina. |
| DE102004005710A1 (de) * | 2004-02-05 | 2006-05-04 | Siemens Ag | Biosensor und Verfahren zu dessen Betrieb |
| DE102004005711A1 (de) * | 2004-02-05 | 2006-05-11 | Siemens Ag | Biosensor zur Bestimmung eines Allergenes mit Betriebsverfahren |
| AU2005275108B2 (en) * | 2004-07-16 | 2011-05-12 | Nektar Therapeutics | Conjugates of a GM-CSF moiety and a polymer |
| KR100754667B1 (ko) | 2005-04-08 | 2007-09-03 | 한미약품 주식회사 | 비펩타이드성 중합체로 개질된 면역글로불린 Fc 단편 및이를 포함하는 약제학적 조성물 |
| US7833979B2 (en) * | 2005-04-22 | 2010-11-16 | Amgen Inc. | Toxin peptide therapeutic agents |
| US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
| US8168592B2 (en) * | 2005-10-21 | 2012-05-01 | Amgen Inc. | CGRP peptide antagonists and conjugates |
| US7531341B1 (en) | 2006-06-12 | 2009-05-12 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof |
| US7534595B2 (en) | 2006-06-12 | 2009-05-19 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of using compositions thereof |
| US8043829B2 (en) * | 2006-10-25 | 2011-10-25 | Amgen Inc. | DNA encoding chimeric toxin peptide fusion proteins and vectors and mammalian cells for recombinant expression |
| EP2738257A1 (en) | 2007-05-22 | 2014-06-04 | Amgen Inc. | Compositions and methods for producing bioactive fusion proteins |
| US7537923B2 (en) * | 2007-08-17 | 2009-05-26 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase and methods of treating cancer using compositions thereof |
| EP2285350B1 (en) * | 2008-06-16 | 2017-11-15 | Pfizer Inc | Methods for the preparation of targeting agent functionalized diblock copolymers for use in fabrication of therapeutic nanoparticles |
| US20110201022A1 (en) | 2008-07-30 | 2011-08-18 | Biomarin Pharmaceutical Inc. | Assays for detection of phenylalanine ammonia-lyase and antibodies to phenylalanine ammonia-lyase |
| PL2349341T3 (pl) * | 2008-10-15 | 2014-03-31 | Baxalta Inc | Pegylacja rekombinowanych czynników krzepnięcia krwi w obecności przeciwciał zwierzęcych |
| WO2010096394A2 (en) * | 2009-02-17 | 2010-08-26 | Redwood Biosciences, Inc. | Aldehyde-tagged protein-based drug carriers and methods of use |
| EP2507267B1 (en) * | 2009-12-02 | 2016-09-14 | Acceleron Pharma, Inc. | Compositions and methods for increasing serum half-life of fc fusion proteins |
| AU2011212929B2 (en) | 2010-02-04 | 2016-10-27 | Biomarin Pharmaceutical Inc. | Compositions of prokaryotic phenylalanine ammonia-lyase variants and methods of using compositions thereof |
| AU2012205301B2 (en) | 2011-01-14 | 2017-01-05 | Redwood Bioscience, Inc. | Aldehyde-tagged immunoglobulin polypeptides and method of use thereof |
| AU2012228990B2 (en) | 2011-03-16 | 2017-04-06 | Amgen Inc. | Potent and selective inhibitors of Nav1.3 and Nav1.7 |
| WO2012170938A1 (en) | 2011-06-08 | 2012-12-13 | Acceleron Pharma Inc. | Compositions and methods for increasing serum half-life |
| ES2875957T3 (es) | 2012-12-20 | 2021-11-11 | Amgen Inc | Agonistas del receptor APJ y usos de los mismos |
| TW201446792A (zh) | 2013-03-12 | 2014-12-16 | Amgen Inc | Nav1.7之強效及選擇性抑制劑 |
| MX370689B (es) | 2014-06-10 | 2019-12-19 | Amgen Inc | Polipeptidos apelina. |
| CA3019398A1 (en) | 2016-04-26 | 2017-11-02 | R.P. Scherer Technologies, Llc | Antibody conjugates and methods of making and using the same |
| CN111378026A (zh) * | 2018-12-27 | 2020-07-07 | 天津键凯科技有限公司 | 一种制备结合位点可控的peg化生物分子的方法 |
| US20230102464A1 (en) * | 2020-01-15 | 2023-03-30 | Jenkem Technology Co., Ltd. (Tianjin) | Method for preparing pegylated biomolecule with controllable binding sites |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US5235028A (en) * | 1990-08-31 | 1993-08-10 | University Of Minnesota | Polyethylene glycol derivatives for solid-phase applications |
| US6565841B1 (en) * | 1991-03-15 | 2003-05-20 | Amgen, Inc. | Pulmonary administration of granulocyte colony stimulating factor |
| IT1260468B (it) * | 1992-01-29 | 1996-04-09 | Metodo per mantenere l'attivita' di enzimi proteolitici modificati con polietilenglicole | |
| GB9225448D0 (en) * | 1992-12-04 | 1993-01-27 | Erba Carlo Spa | Improved synthesis of polymer bioactive conjugates |
| AU3830895A (en) * | 1994-10-07 | 1996-05-02 | Amgen Boulder Inc. | Dimeric il-4 inhibitors |
-
1997
- 1997-03-10 US US08/814,305 patent/US6548644B1/en not_active Expired - Lifetime
-
1998
- 1998-03-05 WO PCT/US1998/004301 patent/WO1998040409A1/en not_active Ceased
- 1998-03-05 ES ES98911482T patent/ES2229485T3/es not_active Expired - Lifetime
- 1998-03-05 JP JP53962998A patent/JP3708134B2/ja not_active Expired - Fee Related
- 1998-03-05 PT PT98911482T patent/PT973806E/pt unknown
- 1998-03-05 AT AT98911482T patent/ATE277084T1/de active
- 1998-03-05 EP EP98911482A patent/EP0973806B1/en not_active Expired - Lifetime
- 1998-03-05 DK DK98911482T patent/DK0973806T3/da active
- 1998-03-05 DE DE69826452T patent/DE69826452T2/de not_active Expired - Lifetime
- 1998-03-05 AU AU65425/98A patent/AU6542598A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001506670A (ja) | 2001-05-22 |
| DE69826452T2 (de) | 2006-02-16 |
| EP0973806B1 (en) | 2004-09-22 |
| JP3708134B2 (ja) | 2005-10-19 |
| DE69826452D1 (de) | 2004-10-28 |
| AU6542598A (en) | 1998-09-29 |
| EP0973806A1 (en) | 2000-01-26 |
| US6548644B1 (en) | 2003-04-15 |
| WO1998040409A1 (en) | 1998-09-17 |
| ES2229485T3 (es) | 2005-04-16 |
| ATE277084T1 (de) | 2004-10-15 |
| PT973806E (pt) | 2005-01-31 |
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