ATE513800T1 - Verfahren zur herstellung pharmazeutischer zwischenprodukte - Google Patents

Verfahren zur herstellung pharmazeutischer zwischenprodukte

Info

Publication number: ATE513800T1
Authority: AT; Austria
Prior art keywords: formula; compound; intermediate products; pharmaceutical intermediate; producing pharmaceutical
Prior art date: 2007-11-27

Application number

AT08854421T

Other languages

English (en)

Inventor

Tibor Mezei

Cs Gyula Luk

R Enikoe Moln

Jozsef Barkaczy

Balazs Volk

Marta Porcs-Makkay

Gyi Janos Szul

Maria Vajjon

Original Assignee

Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-11-27

Filing date

2008-11-27

Publication date

2011-07-15

2008-11-27 Application filed by Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag filed Critical Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag

2011-07-15 Application granted granted Critical

2011-07-15 Publication of ATE513800T1 publication Critical patent/ATE513800T1/de

Links

238000004519 manufacturing process Methods 0.000 title 1
239000012450 pharmaceutical intermediate Substances 0.000 title 1
239000000047 product Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 3
229910052731 fluorine Inorganic materials 0.000 abstract 3
125000001153 fluoro group Chemical group F* 0.000 abstract 3
229910052801 chlorine Chemical group 0.000 abstract 2
125000001309 chloro group Chemical group Cl* 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
238000002360 preparation method Methods 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
RXZJHESCHPMWEK-UHFFFAOYSA-N 1-cyclopropyl-2-phenylethanone Chemical class C1CC1C(=O)CC1=CC=CC=C1 RXZJHESCHPMWEK-UHFFFAOYSA-N 0.000 abstract 1
239000005465 B01AC22 - Prasugrel Substances 0.000 abstract 1
239000007818 Grignard reagent Substances 0.000 abstract 1
239000000460 chlorine Substances 0.000 abstract 1
239000011737 fluorine Substances 0.000 abstract 1
150000004795 grignard reagents Chemical class 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
DTGLZDAWLRGWQN-UHFFFAOYSA-N prasugrel Chemical compound C1CC=2SC(OC(=O)C)=CC=2CN1C(C=1C(=CC=CC=1)F)C(=O)C1CC1 DTGLZDAWLRGWQN-UHFFFAOYSA-N 0.000 abstract 1
229960004197 prasugrel Drugs 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C233/58—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/004—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reaction with organometalhalides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT08854421T 2007-11-27 2008-11-27 Verfahren zur herstellung pharmazeutischer zwischenprodukte ATE513800T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU0700756A HU230262B1 (hu)	2007-11-27	2007-11-27	Eljárás gyógyszeripari intermedierek előállítására
PCT/HU2008/000138 WO2009068923A2 (en)	2007-11-27	2008-11-27	Process for the preparation of pharmaceutical intermediates

Publications (1)

Publication Number	Publication Date
ATE513800T1 true ATE513800T1 (de)	2011-07-15

Family

ID=89987891

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT08854421T ATE513800T1 (de)	2007-11-27	2008-11-27	Verfahren zur herstellung pharmazeutischer zwischenprodukte

Country Status (12)

Country	Link
US (1)	US8394993B2 (de)
EP (1)	EP2231575B1 (de)
CN (1)	CN101970391B (de)
AT (1)	ATE513800T1 (de)
EA (1)	EA017115B1 (de)
ES (1)	ES2368860T3 (de)
HU (1)	HU230262B1 (de)
PL (1)	PL2231575T3 (de)
PT (1)	PT2231575E (de)
RS (1)	RS52105B (de)
UA (1)	UA98023C2 (de)
WO (1)	WO2009068923A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN102241572B (zh) *	2010-05-12	2014-07-16	浙江九洲药业股份有限公司	芳香环丙基乙酮类化合物的制备方法及用途
CN102311325B (zh) *	2010-06-29	2014-12-31	山东新华制药股份有限公司	普拉格雷中间体环丙基-2-氟苄基酮的制备方法
EP2746260A1 (de)	2012-12-21	2014-06-25	Basf Se	Substituierte [1,2,4]Triazol- und Imidazolverbindungen
EP2746259A1 (de)	2012-12-21	2014-06-25	Basf Se	Substituierte [1,2,4]Triazol- und Imidazolverbindungen
HU230649B1 (hu)	2013-01-24	2017-05-29	Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság	Javított eljárás prasugrel gyógyszeripari hatóanyag és az 1-ciklopropil-2-(2-fluorofenil)-etanon intermedier előállítására
HU231079B1 (hu)	2016-06-23	2020-06-29	Richter Gedeon Nyrt.	Eljárás nagytisztaságú Prasugrel előállítására bromopentil szennyezés eltávolításával

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI101150B (fi) *	1991-09-09	1998-04-30	Sankyo Co	Menetelmä lääkeaineina käyttökelpoisten tetrahydrotienopyridiinin johd annaisten valmistamiseksi
EP1660183A2 (de) *	2003-05-05	2006-05-31	Eli Lilly and Company	Behandlung von kardiovaskulären erkrankungen mit einer substanz der formel 1 (cs 747 - prasugrel, rn 150322-43-4)

2007
- 2007-11-27 HU HU0700756A patent/HU230262B1/hu not_active IP Right Cessation
2008
- 2008-11-27 PT PT08854421T patent/PT2231575E/pt unknown
- 2008-11-27 US US12/742,484 patent/US8394993B2/en not_active Expired - Fee Related
- 2008-11-27 UA UAA201007992A patent/UA98023C2/ru unknown
- 2008-11-27 AT AT08854421T patent/ATE513800T1/de not_active IP Right Cessation
- 2008-11-27 WO PCT/HU2008/000138 patent/WO2009068923A2/en not_active Ceased
- 2008-11-27 EP EP08854421A patent/EP2231575B1/de active Active
- 2008-11-27 EA EA201000819A patent/EA017115B1/ru unknown
- 2008-11-27 CN CN2008801179350A patent/CN101970391B/zh not_active Expired - Fee Related
- 2008-11-27 ES ES08854421T patent/ES2368860T3/es active Active
- 2008-11-27 PL PL08854421T patent/PL2231575T3/pl unknown
- 2008-11-27 RS RS20110414A patent/RS52105B/sr unknown

Also Published As

Publication number	Publication date
WO2009068923A2 (en)	2009-06-04
EP2231575A2 (de)	2010-09-29
EP2231575B1 (de)	2011-06-22
WO2009068923A3 (en)	2009-08-20
CN101970391A (zh)	2011-02-09
ES2368860T3 (es)	2011-11-23
HUP0700756A2 (en)	2010-04-28
RS52105B (sr)	2012-08-31
US20100274020A1 (en)	2010-10-28
US8394993B2 (en)	2013-03-12
HU0700756D0 (en)	2008-02-28
CN101970391B (zh)	2013-09-18
HU230262B1 (hu)	2015-11-30
PL2231575T3 (pl)	2011-12-30
PT2231575E (pt)	2011-09-13
UA98023C2 (ru)	2012-04-10
EA201000819A1 (ru)	2010-10-29
EA017115B1 (ru)	2012-09-28

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Legal Events

Date	Code	Title	Description
2011-12-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties