ATE514424T1 - Pharmazeutische zubereitungen von taxanen - Google Patents

Pharmazeutische zubereitungen von taxanen

Info

Publication number: ATE514424T1
Authority: AT; Austria
Prior art keywords: taxans; pharmaceutical preparations; formulation; methylpyrrolidin; docetaxel
Prior art date: 1999-01-08

Application number

AT00903178T

Other languages

English (en)

Inventor

Frederick Hausheer

Dhanabalan Murali

Original Assignee

Bionumerik Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-01-08

Filing date

2000-01-07

Publication date

2011-07-15

2000-01-07 Application filed by Bionumerik Pharmaceuticals Inc filed Critical Bionumerik Pharmaceuticals Inc

2011-07-15 Application granted granted Critical

2011-07-15 Publication of ATE514424T1 publication Critical patent/ATE514424T1/de

Links

239000000825 pharmaceutical preparation Substances 0.000 title 1
SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 abstract 4
ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
229930012538 Paclitaxel Natural products 0.000 abstract 1
229940123237 Taxane Drugs 0.000 abstract 1
229940034982 antineoplastic agent Drugs 0.000 abstract 1
239000002246 antineoplastic agent Substances 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
239000003085 diluting agent Substances 0.000 abstract 1
229960003668 docetaxel Drugs 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
229960001592 paclitaxel Drugs 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
239000000546 pharmaceutical excipient Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 1
RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Oil, Petroleum & Natural Gas (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Dermatology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Epoxy Compounds (AREA)

AT00903178T 1999-01-08 2000-01-07 Pharmazeutische zubereitungen von taxanen ATE514424T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US09/226,968 US6040330A (en)	1999-01-08	1999-01-08	Pharmaceutical formulations of taxanes
PCT/US2000/000442 WO2000040238A1 (en)	1999-01-08	2000-01-07	Pharmaceutical formulations of taxanes

Publications (1)

Publication Number	Publication Date
ATE514424T1 true ATE514424T1 (de)	2011-07-15

Family

ID=22851219

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT00903178T ATE514424T1 (de)	1999-01-08	2000-01-07	Pharmazeutische zubereitungen von taxanen

Country Status (9)

Country	Link
US (1)	US6040330A (de)
EP (1)	EP1061915B1 (de)
JP (2)	JP5642913B2 (de)
CN (1)	CN1169525C (de)
AT (1)	ATE514424T1 (de)
AU (1)	AU764626B2 (de)
CA (1)	CA2321826C (de)
DK (1)	DK1061915T3 (de)
WO (1)	WO2000040238A1 (de)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6040330A (en) *	1999-01-08	2000-03-21	Bionumerik Pharmaceuticals, Inc.	Pharmaceutical formulations of taxanes
US7919119B2 (en) *	1999-05-27	2011-04-05	Acusphere, Inc.	Porous drug matrices and methods of manufacture thereof
JP4776843B2 (ja)	1999-10-01	2011-09-21	イムノゲンインコーポレーティッド	免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
JP2004536026A (ja)	2000-11-28	2004-12-02	トランスフォームファーマシューティカルズ，インコーポレーティッド．	パクリタキセル、その誘導体、および薬剤として許容される塩を含む医薬品製剤
EP1418945A2 (de) *	2001-03-13	2004-05-19	Angiotech Pharmaceuticals, Inc.	Mizellare arzneimittelabgabe vehikel und ihre anwendungen
US20030157170A1 (en) *	2001-03-13	2003-08-21	Richard Liggins	Micellar drug delivery vehicles and precursors thereto and uses thereof
DE10115740A1 (de) *	2001-03-26	2002-10-02	Ulrich Speck	Zubereitung für die Restenoseprophylaxe
JP2004532847A (ja)	2001-04-20	2004-10-28	ザユニヴァーシティオヴブリティッシュコロンビア	疎水性薬物のためのミセル薬物送達システム
JP2005507874A (ja) *	2001-08-29	2005-03-24	ユーエムディー，インコーポレイテッド	癌治療のための化学療法剤及び膜流出システム阻害剤の経膣送達
CA2466851C (en) *	2001-11-26	2012-09-11	Supergen, Inc.	Method for preparing and using polyoxyethylated castor oil in pharmaceutical compositions
AU2002357012A1 (en) *	2001-11-27	2003-06-10	Transform Pharmaceuticals, Inc.	Oral pharmaceutical formulations comprising paclitaxel, derivatives and methods of administration thereof
CN1303994C (zh) *	2003-03-03	2007-03-14	浙江海正药业股份有限公司	紫杉醇囊泡注射剂及其制备方法
WO2005007129A2 (en) *	2003-07-17	2005-01-27	Angiotech International Ag	Topical formulations with bioactive components
EP1947094A3 (de) *	2003-12-12	2009-02-18	Quiral Quimica Do Brasil	Herstellungsverfahren für Taxanderivate
US20050129719A1 (en) *	2003-12-15	2005-06-16	Yu-Fang Hu	Concentrated emulsion formulation for silatecan
US7491263B2 (en) *	2004-04-05	2009-02-17	Technology Innovation, Llc	Storage assembly
US7345093B2 (en)	2004-04-27	2008-03-18	Formatech, Inc.	Methods of enhancing solubility of compounds
US7659310B2 (en)	2004-04-27	2010-02-09	Formatech, Inc.	Methods of enhancing solubility of agents
US8312836B2 (en) *	2004-09-28	2012-11-20	Atrium Medical Corporation	Method and apparatus for application of a fresh coating on a medical device
US9012506B2 (en)	2004-09-28	2015-04-21	Atrium Medical Corporation	Cross-linked fatty acid-based biomaterials
US20090011116A1 (en) *	2004-09-28	2009-01-08	Atrium Medical Corporation	Reducing template with coating receptacle containing a medical device to be coated
US9801913B2 (en) *	2004-09-28	2017-10-31	Atrium Medical Corporation	Barrier layer
US9592324B2 (en) *	2006-11-06	2017-03-14	Atrium Medical Corporation	Tissue separating device with reinforced support for anchoring mechanisms
US9801982B2 (en) *	2004-09-28	2017-10-31	Atrium Medical Corporation	Implantable barrier device
WO2006036982A2 (en)	2004-09-28	2006-04-06	Atrium Medical Corporation	Drug delivery coating for use with a stent
US9000040B2 (en)	2004-09-28	2015-04-07	Atrium Medical Corporation	Cross-linked fatty acid-based biomaterials
US8367099B2 (en)	2004-09-28	2013-02-05	Atrium Medical Corporation	Perforated fatty acid films
EP1888137A2 (de) *	2005-04-29	2008-02-20	Atrium Medical Corporation	Arzneistoffzuführungsbeschichtung zur verwendung mit einer medizinischen vorrichtung sowie verfahren zur behandlung von gefässverletzung
EP2308467A3 (de) *	2005-06-17	2011-06-22	Hospira Australia Pty Ltd	Flüssige Pharmazeutische Docetaxel Zubereitungen
US9278161B2 (en)	2005-09-28	2016-03-08	Atrium Medical Corporation	Tissue-separating fatty acid adhesion barrier
US9427423B2 (en) *	2009-03-10	2016-08-30	Atrium Medical Corporation	Fatty-acid based particles
EP1933991A4 (de) *	2005-10-15	2012-05-02	Atrium Medical Corp	Hydrophobe vernetzte gele für bioabsorbierbare arzneimittelträgerüberzüge
WO2007134354A1 (de) *	2006-05-23	2007-11-29	Ebewe Pharma Ges.M.B.H. Nfg. Kg	Pharmazeutische formulierung
LT2056675T (lt)	2006-10-12	2019-05-27	Galera Labs, Llc	Burnos gleivinės mukozito gydymo būdai
US9492596B2 (en) *	2006-11-06	2016-11-15	Atrium Medical Corporation	Barrier layer with underlying medical device and one or more reinforcing support structures
FR2917088B1 (fr) *	2007-06-08	2009-09-04	Aventis Pharma Sa	Dissolution directe du docetaxel dans un solvant dans le polysorbate 80
WO2009047794A2 (en) *	2007-10-01	2009-04-16	Intas Pharmaceuticals Limited	Taxane derivative composition
US20110038910A1 (en)	2009-08-11	2011-02-17	Atrium Medical Corporation	Anti-infective antimicrobial-containing biomaterials
US10143652B2 (en)	2009-09-23	2018-12-04	Curirx Inc.	Methods for the preparation of liposomes
CA2781529C (en)	2009-09-23	2017-10-24	Indu Javeri	Methods for the preparation of liposomes comprising docetaxel
WO2011160170A1 (en) *	2010-06-21	2011-12-29	Peter Maccallum Cancer Institute	Stimulating immune response
US10322213B2 (en)	2010-07-16	2019-06-18	Atrium Medical Corporation	Compositions and methods for altering the rate of hydrolysis of cured oil-based materials
US20120172796A1 (en) *	2010-12-30	2012-07-05	Chappa Ralph A	Composition for intravascular delivery of therapeutic composition
JP2013032332A (ja) *	2011-07-01	2013-02-14	Lintec Corp	免疫賦活剤
CA3120505C (en)	2011-09-26	2024-11-12	Galera Labs, Llc	METHODS OF TREATING DISEASES
US9867880B2 (en)	2012-06-13	2018-01-16	Atrium Medical Corporation	Cured oil-hydrogel biomaterial compositions for controlled drug delivery
EP2777691A1 (de) *	2013-03-14	2014-09-17	Pharmachemie B.V.	Taxoid - Reinigung der flüssigen Hilfsstoffen
UA126788C2 (uk)	2015-08-11	2023-02-08	Ґалера Лебз, Елелсі	Комплексні сполуки, що містять макроциклічне кільце пентаази, які мають пероральну біодоступність
MX393974B (es)	2016-05-03	2025-03-24	Galera Labs Llc	Terapia de combinacion para tratamiento de cancer.
JP7166634B2 (ja)	2016-09-01	2022-11-08	ガレラ・ラブス・リミテッド・ライアビリティ・カンパニー	ペンタアザ大環状環複合体およびアスコルビン酸化合物による組み合わせ癌療法
CN107157926B (zh) *	2017-07-20	2020-08-21	四川汇宇制药股份有限公司	一种多西他赛注射剂的制备方法
EA201992431A1 (ru)	2017-10-13	2020-03-13	ГАЛЕРА ЛЭБЗ, ЭлЭлСи	Комбинированная иммунотерапия рака с использованием пента-аза-макроциклического кольцевого комплекса

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5399363A (en) *	1991-01-25	1995-03-21	Eastman Kodak Company	Surface modified anticancer nanoparticles
US5614549A (en) *	1992-08-21	1997-03-25	Enzon, Inc.	High molecular weight polymer-based prodrugs
CA2149150C (en) *	1992-11-27	2000-08-01	David R. Carver	Injectable taxol composition with improved stability
WO1999000113A1 (en) *	1997-06-27	1999-01-07	Vivorx Pharmaceuticals, Inc.	Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
CA2155947C (en) *	1993-02-22	2007-08-21	Mark W. Grinstaff	Methods for in vivo delivery of biologics and compositions useful therefor
US5554382A (en) *	1993-05-28	1996-09-10	Aphios Corporation	Methods and apparatus for making liposomes
TW406020B (en) *	1993-09-29	2000-09-21	Bristol Myers Squibb Co	Stabilized pharmaceutical composition and its method for preparation and stabilizing solvent
US5447936A (en) *	1993-12-22	1995-09-05	Bionumerik Pharmaceuticals, Inc.	Lactone stable formulation of 10-hydroxy 7-ethyl camptothecin and methods for uses thereof
US5726181A (en) *	1995-06-05	1998-03-10	Bionumerik Pharmaceuticals, Inc.	Formulations and compositions of poorly water soluble camptothecin derivatives
US5877205A (en) *	1996-06-28	1999-03-02	Board Of Regents, The University Of Texas System	Parenteral paclitaxel in a stable non-toxic formulation
US6630168B1 (en) *	1997-02-20	2003-10-07	Biomedicines, Inc.	Gel delivery vehicles for anticellular proliferative agents
SI0999826T1 (en) *	1997-07-29	2004-12-31	Pharmacia & Upjohn Company	Self-emulsifying formulation for lipophilic compounds
IL131217A0 (en) *	1998-03-10	2001-01-28	Napro Biotherapeutics Inc	Novel methods and compositions for delivery of taxanes
US6017948A (en) *	1998-10-30	2000-01-25	Supergen, Inc.	Water-miscible pharmaceutical compositions
US6040330A (en) *	1999-01-08	2000-03-21	Bionumerik Pharmaceuticals, Inc.	Pharmaceutical formulations of taxanes

1999
- 1999-01-08 US US09/226,968 patent/US6040330A/en not_active Expired - Lifetime
2000
- 2000-01-07 JP JP2000591995A patent/JP5642913B2/ja not_active Expired - Fee Related
- 2000-01-07 EP EP00903178A patent/EP1061915B1/de not_active Expired - Lifetime
- 2000-01-07 AU AU24963/00A patent/AU764626B2/en not_active Ceased
- 2000-01-07 CA CA002321826A patent/CA2321826C/en not_active Expired - Fee Related
- 2000-01-07 WO PCT/US2000/000442 patent/WO2000040238A1/en not_active Ceased
- 2000-01-07 CN CNB008000182A patent/CN1169525C/zh not_active Expired - Fee Related
- 2000-01-07 AT AT00903178T patent/ATE514424T1/de active
- 2000-01-07 DK DK00903178.2T patent/DK1061915T3/da active
2010
- 2010-07-15 JP JP2010160404A patent/JP5285663B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DK1061915T3 (da)	2011-10-03
CN1293570A (zh)	2001-05-02
JP5285663B2 (ja)	2013-09-11
JP2002534382A (ja)	2002-10-15
EP1061915A4 (de)	2009-09-09
CA2321826C (en)	2007-12-04
US6040330A (en)	2000-03-21
EP1061915B1 (de)	2011-06-29
WO2000040238A1 (en)	2000-07-13
JP2010235636A (ja)	2010-10-21
EP1061915A1 (de)	2000-12-27
JP5642913B2 (ja)	2014-12-17
AU764626B2 (en)	2003-08-28
CN1169525C (zh)	2004-10-06
CA2321826A1 (en)	2000-07-13
AU2496300A (en)	2000-07-24

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EP1061915A4 (de)	2009-09-09	Pharmazeutische zubereitungen von taxanen
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ECSP045411A (es)	2005-01-03	Derivados de quinolinona
CA2301057A1 (en)	2000-01-13	A method of administering liposomal encapsulated taxane
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HUP0301334A2 (hu)	2003-08-28	Szubsztituált akriloil-disztamicin-származékokat és taxánokat és/vagy antimetabolitokat tartalmazó kombinált tumorellenes kompozíciók