ATE514677T1 - Als serotonintransporterinhibitoren und neurokinin-1-rezeptorantagonisten geeignete piperidinderivate - Google Patents
Als serotonintransporterinhibitoren und neurokinin-1-rezeptorantagonisten geeignete piperidinderivateInfo
- Publication number
- ATE514677T1 ATE514677T1 AT07727325T AT07727325T ATE514677T1 AT E514677 T1 ATE514677 T1 AT E514677T1 AT 07727325 T AT07727325 T AT 07727325T AT 07727325 T AT07727325 T AT 07727325T AT E514677 T1 ATE514677 T1 AT E514677T1
- Authority
- AT
- Austria
- Prior art keywords
- serotonin transporter
- neurokinin
- receptor antagonists
- treatment
- inhibitors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 4
- 102000019208 Serotonin Plasma Membrane Transport Proteins Human genes 0.000 title abstract 2
- 108010012996 Serotonin Plasma Membrane Transport Proteins Proteins 0.000 title abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title 1
- 239000002742 neurokinin 1 receptor antagonist Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000020401 Depressive disease Diseases 0.000 abstract 1
- 102000002002 Neurokinin-1 Receptors Human genes 0.000 abstract 1
- 108010040718 Neurokinin-1 Receptors Proteins 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 230000009977 dual effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
- C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4465—Non condensed piperidines, e.g. piperocaine only substituted in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06112170 | 2006-04-03 | ||
| PCT/EP2007/052852 WO2007113153A1 (en) | 2006-04-03 | 2007-03-26 | Piperidine derivatives useful as serotonin transporter inhibitors and neurokinin-1 receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE514677T1 true ATE514677T1 (de) | 2011-07-15 |
Family
ID=36923892
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07727325T ATE514677T1 (de) | 2006-04-03 | 2007-03-26 | Als serotonintransporterinhibitoren und neurokinin-1-rezeptorantagonisten geeignete piperidinderivate |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7872022B2 (de) |
| EP (1) | EP2004605B1 (de) |
| JP (1) | JP5027208B2 (de) |
| KR (1) | KR101101107B1 (de) |
| CN (1) | CN101460460B (de) |
| AT (1) | ATE514677T1 (de) |
| AU (1) | AU2007233812B2 (de) |
| BR (1) | BRPI0709742A2 (de) |
| CA (1) | CA2648065C (de) |
| ES (1) | ES2367219T3 (de) |
| IL (1) | IL194392A (de) |
| MX (1) | MX2008012634A (de) |
| WO (1) | WO2007113153A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7872022B2 (en) * | 2006-04-03 | 2011-01-18 | Hoffmann-La Roche Inc. | Serotonin transporter (SERT) inhibitors for the treatment of depression and anxiety |
| TWI773657B (zh) * | 2015-12-18 | 2022-08-11 | 美商亞德利克斯公司 | 作爲非全身ｔｇｒ５促效劑之經取代之4-苯基吡啶化合物 |
| US12084472B2 (en) | 2015-12-18 | 2024-09-10 | Ardelyx, Inc. | Substituted 4-phenyl pyridine compounds as non-systemic TGR5 agonists |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL98757A (en) * | 1990-07-18 | 1997-01-10 | Novo Nordisk As | Piperidine derivatives their preparation and pharmaceutical compositions containing them |
| EP0977573A1 (de) | 1997-04-24 | 2000-02-09 | MERCK SHARP & DOHME LTD. | Verwendung einer kombination aus einem nk-1 rezeptor antagonist und einem ssri zur behandlung von obesitas |
| GB9904786D0 (en) | 1999-03-02 | 1999-04-28 | Merck Sharp & Dohme | Therapeutic agents |
| PT1035115E (pt) | 1999-02-24 | 2005-01-31 | Hoffmann La Roche | Derivados de 4-fenilpiridina e a sua utilizacao como antagonistas do receptor nk-1 |
| GB9924855D0 (en) | 1999-10-20 | 1999-12-22 | Smithkline Beecham Plc | Novel processes |
| JP3860445B2 (ja) * | 2001-04-19 | 2006-12-20 | 独立行政法人科学技術振興機構 | Ｃｕ−Ｂｅ基非晶質合金 |
| GB0119797D0 (en) | 2001-08-14 | 2001-10-03 | Glaxo Group Ltd | Chemical compounds |
| WO2003023790A1 (en) * | 2001-09-06 | 2003-03-20 | Noritake Co.,Limited | Conductor composition and method for production thereof |
| GB0203020D0 (en) | 2002-02-08 | 2002-03-27 | Glaxo Group Ltd | Chemical compounds |
| JP3963802B2 (ja) * | 2002-08-30 | 2007-08-22 | 独立行政法人科学技術振興機構 | Ｃｕ基非晶質合金 |
| KR100677805B1 (ko) * | 2003-07-23 | 2007-02-02 | 샤프 가부시키가이샤 | 은 합금 재료, 회로 기판, 전자 장치 및 회로 기판의 제조방법 |
| AU2004277932B2 (en) | 2003-09-30 | 2009-07-16 | Merck & Co., Inc. | Phenyl pyrrolidine ether tachykinin receptor antagonists |
| KR100583230B1 (ko) * | 2004-03-29 | 2006-05-25 | 한국과학기술연구원 | 구리계 비정질 합금 조성물 |
| US7872022B2 (en) * | 2006-04-03 | 2011-01-18 | Hoffmann-La Roche Inc. | Serotonin transporter (SERT) inhibitors for the treatment of depression and anxiety |
| KR101485304B1 (ko) * | 2006-06-30 | 2015-01-23 | 미쓰비시 마테리알 가부시키가이샤 | 태양 전지의 전극 형성용 조성물 및 그 전극의 형성 방법, 그리고 그 형성 방법에 의해 얻어진 전극을 사용한 태양 전지 |
| WO2008078374A1 (ja) * | 2006-12-25 | 2008-07-03 | Namics Corporation | 太陽電池用導電性ペースト |
| US20080196794A1 (en) * | 2007-02-20 | 2008-08-21 | Centre National De La Recherche Scientifique Institut National Polytechnique De Grenoble | Bulk metallic glass/metal composites produced by codeformation |
| TWI477332B (zh) * | 2007-02-27 | 2015-03-21 | Mitsubishi Materials Corp | 金屬奈米粒子分散液及其製造方法及金屬奈米粒子之合成方法 |
| TWI423462B (zh) * | 2008-10-22 | 2014-01-11 | Ind Tech Res Inst | 矽晶太陽電池之背面電極製造方法 |
| KR101741683B1 (ko) * | 2010-08-05 | 2017-05-31 | 삼성전자주식회사 | 도전성 페이스트, 상기 도전성 페이스트를 사용하여 형성된 전극을 포함하는 전자 소자 및 태양 전지 |
| EP2448003A3 (de) * | 2010-10-27 | 2012-08-08 | Samsung Electronics Co., Ltd. | Leitfähige Paste enthaltend ein leitfähiges Pulver und ein metallisches Glas zur Herstellung einer Solarzellenelektrode |
-
2007
- 2007-03-23 US US11/726,931 patent/US7872022B2/en not_active Expired - Fee Related
- 2007-03-26 MX MX2008012634A patent/MX2008012634A/es active IP Right Grant
- 2007-03-26 CN CN2007800205495A patent/CN101460460B/zh not_active Expired - Fee Related
- 2007-03-26 KR KR1020087024162A patent/KR101101107B1/ko not_active Expired - Fee Related
- 2007-03-26 WO PCT/EP2007/052852 patent/WO2007113153A1/en not_active Ceased
- 2007-03-26 CA CA2648065A patent/CA2648065C/en not_active Expired - Fee Related
- 2007-03-26 BR BRPI0709742-5A patent/BRPI0709742A2/pt not_active Application Discontinuation
- 2007-03-26 ES ES07727325T patent/ES2367219T3/es active Active
- 2007-03-26 AU AU2007233812A patent/AU2007233812B2/en not_active Ceased
- 2007-03-26 EP EP07727325A patent/EP2004605B1/de not_active Not-in-force
- 2007-03-26 JP JP2009503526A patent/JP5027208B2/ja not_active Expired - Fee Related
- 2007-03-26 AT AT07727325T patent/ATE514677T1/de active
-
2008
- 2008-09-25 IL IL194392A patent/IL194392A/en not_active IP Right Cessation
-
2011
- 2011-01-10 US US12/987,186 patent/US8580821B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0709742A2 (pt) | 2011-07-26 |
| KR20080100383A (ko) | 2008-11-17 |
| KR101101107B1 (ko) | 2012-01-03 |
| CA2648065C (en) | 2015-06-02 |
| MX2008012634A (es) | 2008-10-13 |
| IL194392A (en) | 2013-10-31 |
| JP2009532409A (ja) | 2009-09-10 |
| ES2367219T3 (es) | 2011-10-31 |
| AU2007233812B2 (en) | 2013-03-21 |
| EP2004605A1 (de) | 2008-12-24 |
| AU2007233812A1 (en) | 2007-10-11 |
| US8580821B2 (en) | 2013-11-12 |
| US20070232652A1 (en) | 2007-10-04 |
| CN101460460A (zh) | 2009-06-17 |
| CA2648065A1 (en) | 2007-10-11 |
| WO2007113153A1 (en) | 2007-10-11 |
| US7872022B2 (en) | 2011-01-18 |
| JP5027208B2 (ja) | 2012-09-19 |
| IL194392A0 (en) | 2009-08-03 |
| EP2004605B1 (de) | 2011-06-29 |
| US20110105561A1 (en) | 2011-05-05 |
| CN101460460B (zh) | 2011-07-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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