ATE515498T1 - Verfahren zur aufreinigung von montelukast und dessen aminsalzen - Google Patents

Verfahren zur aufreinigung von montelukast und dessen aminsalzen

Info

Publication number: ATE515498T1
Authority: AT; Austria
Prior art keywords: montelukast; purification; salts; amine salts; treo
Prior art date: 2006-08-09

Application number

AT07788281T

Other languages

English (en)

Inventor

Guillen Yolanda Gasanz

Llagostera Montserrat Monsalvatje

Escasany Pedro Talavera

Original Assignee

Esteve Quimica Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-08-09

Filing date

2007-08-07

Publication date

2011-07-15

2007-08-07 Application filed by Esteve Quimica Sa filed Critical Esteve Quimica Sa

2011-07-15 Application granted granted Critical

2011-07-15 Publication of ATE515498T1 publication Critical patent/ATE515498T1/de

Links

UCHDWCPVSPXUMX-TZIWLTJVSA-N Montelukast Chemical compound CC(C)(O)C1=CC=CC=C1CC[C@H](C=1C=C(\C=C\C=2N=C3C=C(Cl)C=CC3=CC=2)C=CC=1)SCC1(CC(O)=O)CC1 UCHDWCPVSPXUMX-TZIWLTJVSA-N 0.000 title abstract 4
229960005127 montelukast Drugs 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 2
238000000746 purification Methods 0.000 title abstract 2
PAFZNILMFXTMIY-UHFFFAOYSA-N cyclohexylamine Chemical compound NC1CCCCC1 PAFZNILMFXTMIY-UHFFFAOYSA-N 0.000 abstract 4
239000000203 mixture Substances 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
239000012453 solvate Substances 0.000 abstract 2
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
-1 amine salt Chemical class 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/18—Halogen atoms or nitro radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4704—2-Quinolinones, e.g. carbostyril

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Quinoline Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT07788281T 2006-08-09 2007-08-07 Verfahren zur aufreinigung von montelukast und dessen aminsalzen ATE515498T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US83685606P	2006-08-09	2006-08-09
EP06118690A EP1886998A1 (de)	2006-08-09	2006-08-09	Verfahren zur Reinigung von Montelukast und dessen Aminesalzen
PCT/EP2007/058180 WO2008017669A1 (en)	2006-08-09	2007-08-07	Purification process of montelukast and its amine salts

Publications (1)

Publication Number	Publication Date
ATE515498T1 true ATE515498T1 (de)	2011-07-15

Family

ID=37625598

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07788281T ATE515498T1 (de)	2006-08-09	2007-08-07	Verfahren zur aufreinigung von montelukast und dessen aminsalzen

Country Status (19)

Country	Link
US (1)	US8188285B2 (de)
EP (2)	EP1886998A1 (de)
JP (1)	JP5188501B2 (de)
KR (1)	KR20090035696A (de)
CN (1)	CN101501000B (de)
AT (1)	ATE515498T1 (de)
AU (1)	AU2007283615A1 (de)
CA (1)	CA2657775A1 (de)
ES (1)	ES2372414T3 (de)
HR (1)	HRP20110575T1 (de)
IL (1)	IL196303A (de)
MX (1)	MX2009000524A (de)
NO (1)	NO20091051L (de)
PL (1)	PL2077996T3 (de)
PT (1)	PT2077996E (de)
RU (1)	RU2009108272A (de)
SI (1)	SI2077996T1 (de)
WO (1)	WO2008017669A1 (de)
ZA (1)	ZA200900890B (de)

Families Citing this family (16)

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US7812168B2 (en)	2005-07-05	2010-10-12	Teva Pharmaceutical Industries Ltd.	Purification of montelukast
KR101469015B1 (ko) *	2008-02-25	2014-12-05	주식회사 종근당	몬테루카스트의 제조방법 및 이에 사용되는 중간체
WO2009117381A2 (en) *	2008-03-17	2009-09-24	Dr. Reddy's Laboratories Ltd.	Preparation of montelukast and its salts
KR101123292B1 (ko)	2008-09-26	2012-03-19	주식회사 엘지생명과학	몬테루카스트 나트륨염의 제조방법
WO2011121091A1 (en)	2010-03-31	2011-10-06	Krka, D.D., Novo Mesto	Efficient synthesis for the preparation of montelukast and novel crystalline form of intermediates therein
KR100990046B1 (ko) *	2010-07-30	2010-10-26	동국제약 주식회사	신규한 몬테루카스트 4-할로 벤질아민염 및 이를 이용한 몬테루카스트 나트륨염의 제조방법
HUP1000425A2 (en)	2010-08-11	2012-03-28	Richter Gedeon Nyrt	Process for the production of montelukast sodium
WO2012077133A1 (en) *	2010-12-07	2012-06-14	Ind-Swift Laboratories Limited	Processes for preparation of montelukast sodium and purification of diol intermediate
CN102060762B (zh) *	2011-01-28	2013-05-29	海南美大制药有限公司	孟鲁司特化合物及其新制法
CN103570618A (zh) *	2013-09-30	2014-02-12	浙江车头制药股份有限公司	一种孟鲁司特钠盐的制备方法
CN105924392B (zh) *	2016-02-29	2018-03-02	山东新时代药业有限公司	一种孟鲁司特钠制备方法
CN105585524B (zh) *	2016-02-29	2018-03-02	山东新时代药业有限公司	一种由孟鲁司特酸制备孟鲁司特钠的方法
CN105646344B (zh) *	2016-02-29	2018-08-14	山东新时代药业有限公司	一种孟鲁司特的纯化方法
WO2019020580A1 (en) *	2017-07-24	2019-01-31	Interquim, S.A.	PROCESS FOR PREPARING AND PURIFYING LIFITEGRAST ANTAGONIST OF LFA-1
IT201800006337A1 (it) *	2018-06-14	2019-12-14		Procedimento per la preparazione di lifitegrast
AU2019334202A1 (en)	2018-09-06	2021-03-25	Innopharmascreen, Inc.	Methods and compositions for treatment of asthma or parkinson's disease

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NL8403224A (nl) *	1984-10-24	1986-05-16	Oce Andeno Bv	Dioxafosforinanen, de bereiding ervan en de toepassing voor het splitsen van optisch actieve verbindingen.
HU222344B1 (hu) *	1990-10-12	2003-06-28	Merck Frosst Canada & Co.	Eljárás telítetlen hidroxi-alkil-kinolinsavak, és ezeket tartalmazó gyógyszerkészítmények előállítására
TW448160B (en)	1993-12-28	2001-08-01	Merck & Co Inc	Novel dicyclohexylamine salt and process for the preparation of leukotriene antagonists
CN1420113A (zh)	2001-11-16	2003-05-28	北京上地新世纪生物医药研究所	孟鲁司特钠的制备方法及其制备中间体
CN1171873C (zh)	2001-12-26	2004-10-20	北京上地新世纪生物医药研究所	一种孟鲁司特钠的制备方法及其制备中间体
US20050107612A1 (en) *	2002-12-30	2005-05-19	Dr. Reddy's Laboratories Limited	Process for preparation of montelukast and its salts
AU2003253247A1 (en) *	2003-06-06	2005-01-04	Morepen Laboratories Limited	An improved method for the preparation of montelukast acid and sodium salt thereof in amorphous form
JP2007508271A (ja) *	2003-10-10	2007-04-05	シントン・ベスローテン・フェンノートシャップ	固体状態のモンテルカスト
MXPA06008584A (es) *	2004-01-30	2007-04-16	Teva Pharma	Polimorfos de acido libre de montelukast.
US7189853B2 (en) *	2004-04-15	2007-03-13	Dr. Reddy's Laboratories Limited	Process for the preparation of [R-(E)-1-[[[1-[3-[2-[7-chloro-2-quinolinyl]ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid (Montelukast) and its pharmaceutically acceptable salts
MXPA06012220A (es)	2004-04-21	2007-07-18	Teva Pharma	Procesos para preparar sodio de montelukast.
US7501517B2 (en)	2004-04-30	2009-03-10	Synthon Ip, Inc.	Process for making montelukast and intermediates therefor
US7829716B2 (en)	2004-04-30	2010-11-09	Synthon Pharmaceuticals, Inc.	Process for making montelukast and intermediates therefor
WO2006008751A2 (en) *	2004-07-19	2006-01-26	Matrix Laboratories Ltd	Process for the preparation of montelukast and its salts
PL205637B1 (pl) *	2004-10-22	2010-05-31	Inst Farmaceutyczny	Sposób wytwarzania kwasu (R,E)-(1-{1-{3-[2-(7-chlorochinolin-2-ylo)etenylo]fenylo}-3-[2-(1-hydroksy-1-metyloetylo)fenylo] propylosulfanylometylo}cyklopropylo)octowego i/lub jego farmaceutycznie dopuszczalnych soli
US7812168B2 (en)	2005-07-05	2010-10-12	Teva Pharmaceutical Industries Ltd.	Purification of montelukast
US20100168432A1 (en)	2005-07-05	2010-07-01	Matrix Laboratories Ltd	Process for the Preparation of Montelukast
KR20080033425A (ko)	2005-07-20	2008-04-16	닥터 레디스 래보러토리즈, 인코포레이티드	몬테루캐스트의 제조 공정
US8178680B2 (en)	2005-12-13	2012-05-15	Msn Laboratories Limited	Process for the preparation of Montelukast and its pharmaceutically acceptable salts
CA2632954A1 (en)	2005-12-23	2007-06-28	Glade Organics Private Limited	An improved process for the manufacture of montelukast sodium
IL181485A0 (en)	2006-02-21	2007-07-04	Chemagis Ltd	Processes for preparing novel montelukast salts
WO2007096889A2 (en)	2006-02-27	2007-08-30	Chemagis Ltd.	Process for preparing montelukast and salts thereof
WO2007107297A1 (en)	2006-03-17	2007-09-27	Synthon B.V.	Montelukast amantadine salt
EP2004608B1 (de)	2006-04-12	2011-09-14	Glade Organics Private Limited	Verbessertes verfahren zur herstellung von montelukast-natrium
US20090326232A1 (en)	2006-06-26	2009-12-31	Uttam Kumar Ray	Process for the Preparation of Leukotriene Receptor Antagonist (Montelukast Sodium)
GB0614485D0 (en)	2006-07-21	2006-09-27	Pliva Istrazivanje I Razvoj D	Process
EP2069307A4 (de)	2006-08-04	2010-03-03	Matrix Lab Ltd	Verfahren zur herstellung von montelukast und salzen daraus

2006
- 2006-08-09 EP EP06118690A patent/EP1886998A1/de not_active Withdrawn
2007
- 2007-08-07 WO PCT/EP2007/058180 patent/WO2008017669A1/en not_active Ceased
- 2007-08-07 EP EP07788281A patent/EP2077996B1/de active Active
- 2007-08-07 JP JP2009523276A patent/JP5188501B2/ja not_active Expired - Fee Related
- 2007-08-07 CN CN2007800295684A patent/CN101501000B/zh not_active Expired - Fee Related
- 2007-08-07 RU RU2009108272/04A patent/RU2009108272A/ru not_active Application Discontinuation
- 2007-08-07 HR HR20110575T patent/HRP20110575T1/hr unknown
- 2007-08-07 KR KR1020097002477A patent/KR20090035696A/ko not_active Withdrawn
- 2007-08-07 US US12/376,779 patent/US8188285B2/en not_active Expired - Fee Related
- 2007-08-07 MX MX2009000524A patent/MX2009000524A/es active IP Right Grant
- 2007-08-07 AU AU2007283615A patent/AU2007283615A1/en not_active Abandoned
- 2007-08-07 ZA ZA200900890A patent/ZA200900890B/xx unknown
- 2007-08-07 PL PL07788281T patent/PL2077996T3/pl unknown
- 2007-08-07 CA CA002657775A patent/CA2657775A1/en not_active Abandoned
- 2007-08-07 PT PT07788281T patent/PT2077996E/pt unknown
- 2007-08-07 ES ES07788281T patent/ES2372414T3/es active Active
- 2007-08-07 AT AT07788281T patent/ATE515498T1/de not_active IP Right Cessation
- 2007-08-07 SI SI200730709T patent/SI2077996T1/sl unknown
2008
- 2008-12-31 IL IL196303A patent/IL196303A/en not_active IP Right Cessation
2009
- 2009-03-09 NO NO20091051A patent/NO20091051L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
EP2077996B1 (de)	2011-07-06
US20090247759A1 (en)	2009-10-01
JP2010500325A (ja)	2010-01-07
IL196303A (en)	2014-03-31
PT2077996E (pt)	2011-09-13
EP2077996A1 (de)	2009-07-15
PL2077996T3 (pl)	2011-11-30
CN101501000B (zh)	2012-04-04
CA2657775A1 (en)	2008-02-14
HRP20110575T1 (hr)	2011-09-30
NO20091051L (no)	2009-05-05
KR20090035696A (ko)	2009-04-10
IL196303A0 (en)	2009-09-22
RU2009108272A (ru)	2010-09-20
SI2077996T1 (sl)	2011-10-28
US8188285B2 (en)	2012-05-29
JP5188501B2 (ja)	2013-04-24
AU2007283615A1 (en)	2008-02-14
CN101501000A (zh)	2009-08-05
ZA200900890B (en)	2010-04-28
MX2009000524A (es)	2009-01-27
EP1886998A1 (de)	2008-02-13
ES2372414T3 (es)	2012-01-19
WO2008017669A1 (en)	2008-02-14

Legal Events

Date	Code	Title	Description
2012-01-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
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