HRP20110575T1 - Postupak pročišćavanja montelukasta i njegovih soli amina - Google Patents

Postupak pročišćavanja montelukasta i njegovih soli amina Download PDF

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Publication number
HRP20110575T1
HRP20110575T1 HR20110575T HRP20110575T HRP20110575T1 HR P20110575 T1 HRP20110575 T1 HR P20110575T1 HR 20110575 T HR20110575 T HR 20110575T HR P20110575 T HRP20110575 T HR P20110575T HR P20110575 T1 HRP20110575 T1 HR P20110575T1
Authority
HR
Croatia
Prior art keywords
montelukast
salt
purification process
process according
solvent
Prior art date
Application number
HR20110575T
Other languages
English (en)
Croatian (hr)
Inventor
Gasanz Guillen Yolanda
Monsalvatje Llagostera Montserrat
Talavera Escasany Pedro
Original Assignee
Esteve Quimica
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Esteve Quimica filed Critical Esteve Quimica
Publication of HRP20110575T1 publication Critical patent/HRP20110575T1/hr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4704—2-Quinolinones, e.g. carbostyril

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Quinoline Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HR20110575T 2006-08-09 2007-08-07 Postupak pročišćavanja montelukasta i njegovih soli amina HRP20110575T1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83685606P 2006-08-09 2006-08-09
EP06118690A EP1886998A1 (de) 2006-08-09 2006-08-09 Verfahren zur Reinigung von Montelukast und dessen Aminesalzen
PCT/EP2007/058180 WO2008017669A1 (en) 2006-08-09 2007-08-07 Purification process of montelukast and its amine salts

Publications (1)

Publication Number Publication Date
HRP20110575T1 true HRP20110575T1 (hr) 2011-09-30

Family

ID=37625598

Family Applications (1)

Application Number Title Priority Date Filing Date
HR20110575T HRP20110575T1 (hr) 2006-08-09 2007-08-07 Postupak pročišćavanja montelukasta i njegovih soli amina

Country Status (19)

Country Link
US (1) US8188285B2 (de)
EP (2) EP1886998A1 (de)
JP (1) JP5188501B2 (de)
KR (1) KR20090035696A (de)
CN (1) CN101501000B (de)
AT (1) ATE515498T1 (de)
AU (1) AU2007283615A1 (de)
CA (1) CA2657775A1 (de)
ES (1) ES2372414T3 (de)
HR (1) HRP20110575T1 (de)
IL (1) IL196303A (de)
MX (1) MX2009000524A (de)
NO (1) NO20091051L (de)
PL (1) PL2077996T3 (de)
PT (1) PT2077996E (de)
RU (1) RU2009108272A (de)
SI (1) SI2077996T1 (de)
WO (1) WO2008017669A1 (de)
ZA (1) ZA200900890B (de)

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CN101213177A (zh) 2005-07-05 2008-07-02 特瓦制药工业有限公司 孟鲁司特的纯化
KR101469015B1 (ko) * 2008-02-25 2014-12-05 주식회사 종근당 몬테루카스트의 제조방법 및 이에 사용되는 중간체
WO2009117381A2 (en) * 2008-03-17 2009-09-24 Dr. Reddy's Laboratories Ltd. Preparation of montelukast and its salts
KR101123292B1 (ko) * 2008-09-26 2012-03-19 주식회사 엘지생명과학 몬테루카스트 나트륨염의 제조방법
WO2011121091A1 (en) 2010-03-31 2011-10-06 Krka, D.D., Novo Mesto Efficient synthesis for the preparation of montelukast and novel crystalline form of intermediates therein
KR100990046B1 (ko) * 2010-07-30 2010-10-26 동국제약 주식회사 신규한 몬테루카스트 4-할로 벤질아민염 및 이를 이용한 몬테루카스트 나트륨염의 제조방법
HUP1000425A2 (en) 2010-08-11 2012-03-28 Richter Gedeon Nyrt Process for the production of montelukast sodium
WO2012077133A1 (en) * 2010-12-07 2012-06-14 Ind-Swift Laboratories Limited Processes for preparation of montelukast sodium and purification of diol intermediate
CN102060762B (zh) * 2011-01-28 2013-05-29 海南美大制药有限公司 孟鲁司特化合物及其新制法
CN103570618A (zh) * 2013-09-30 2014-02-12 浙江车头制药股份有限公司 一种孟鲁司特钠盐的制备方法
CN105585524B (zh) * 2016-02-29 2018-03-02 山东新时代药业有限公司 一种由孟鲁司特酸制备孟鲁司特钠的方法
CN105924392B (zh) * 2016-02-29 2018-03-02 山东新时代药业有限公司 一种孟鲁司特钠制备方法
CN105646344B (zh) * 2016-02-29 2018-08-14 山东新时代药业有限公司 一种孟鲁司特的纯化方法
ES2876292T3 (es) * 2017-07-24 2021-11-12 Interquim Sa Procedimiento de preparación y purificación del antagonista de LFA-1 lifitegrast
IT201800006337A1 (it) * 2018-06-14 2019-12-14 Procedimento per la preparazione di lifitegrast
US10966943B2 (en) 2018-09-06 2021-04-06 Innopharmascreen Inc. Methods and compositions for treatment of asthma or parkinson's disease

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NL8403224A (nl) * 1984-10-24 1986-05-16 Oce Andeno Bv Dioxafosforinanen, de bereiding ervan en de toepassing voor het splitsen van optisch actieve verbindingen.
CA2053209C (en) * 1990-10-12 1998-12-08 Michel L. Belley Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists
TW448160B (en) 1993-12-28 2001-08-01 Merck & Co Inc Novel dicyclohexylamine salt and process for the preparation of leukotriene antagonists
CN1420113A (zh) 2001-11-16 2003-05-28 北京上地新世纪生物医药研究所 孟鲁司特钠的制备方法及其制备中间体
CN1171873C (zh) 2001-12-26 2004-10-20 北京上地新世纪生物医药研究所 一种孟鲁司特钠的制备方法及其制备中间体
US20050107612A1 (en) * 2002-12-30 2005-05-19 Dr. Reddy's Laboratories Limited Process for preparation of montelukast and its salts
CA2528228C (en) * 2003-06-06 2011-09-20 Morepen Laboratories Limited A method for the preparation of montelukast acid and sodium salt thereof in amorphous form
AU2004283832B2 (en) * 2003-10-10 2011-04-07 Synthon B.V. Solid-state montelukast
CA2554572A1 (en) * 2004-01-30 2005-08-18 Teva Pharmaceutical Industries Ltd. Montelukast free acid polymorphs
US7189853B2 (en) * 2004-04-15 2007-03-13 Dr. Reddy's Laboratories Limited Process for the preparation of [R-(E)-1-[[[1-[3-[2-[7-chloro-2-quinolinyl]ethenyl]phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]thio]methyl]cyclopropaneacetic acid (Montelukast) and its pharmaceutically acceptable salts
EP1646612B1 (de) 2004-04-21 2009-07-01 Teva Pharmaceutical Industries Ltd Verfahren zur herstellung von montelukast-natrium
US7829716B2 (en) 2004-04-30 2010-11-09 Synthon Pharmaceuticals, Inc. Process for making montelukast and intermediates therefor
US7501517B2 (en) 2004-04-30 2009-03-10 Synthon Ip, Inc. Process for making montelukast and intermediates therefor
ATE500225T1 (de) * 2004-07-19 2011-03-15 Matrix Lab Ltd Verfahren zur herstellung von montelukast und salzen davon
PL205637B1 (pl) * 2004-10-22 2010-05-31 Inst Farmaceutyczny Sposób wytwarzania kwasu (R,E)-(1-{1-{3-[2-(7-chlorochinolin-2-ylo)etenylo]fenylo}-3-[2-(1-hydroksy-1-metyloetylo)fenylo] propylosulfanylometylo}cyklopropylo)octowego i/lub jego farmaceutycznie dopuszczalnych soli
WO2007004237A2 (en) 2005-07-05 2007-01-11 Matrix Laboratories Ltd A process for the preparation of montelukast
CN101213177A (zh) 2005-07-05 2008-07-02 特瓦制药工业有限公司 孟鲁司特的纯化
WO2007012075A2 (en) 2005-07-20 2007-01-25 Dr. Reddy's Laboratories Ltd. Preparation of montelukast
US8178680B2 (en) 2005-12-13 2012-05-15 Msn Laboratories Limited Process for the preparation of Montelukast and its pharmaceutically acceptable salts
EP1968942A4 (de) 2005-12-23 2010-06-02 Glade Organics Private Ltd Verbessertes verfahren zur herstellung von montelukast-natrium
WO2007096875A2 (en) 2006-02-21 2007-08-30 Chemagis Ltd. Novel polymorphs of montelukast ammonium salts and processes for preparation therefor
WO2007096889A2 (en) 2006-02-27 2007-08-30 Chemagis Ltd. Process for preparing montelukast and salts thereof
CN101432267A (zh) 2006-03-17 2009-05-13 斯索恩有限公司 孟鲁司特金刚烷胺盐
EP2004608B1 (de) 2006-04-12 2011-09-14 Glade Organics Private Limited Verbessertes verfahren zur herstellung von montelukast-natrium
WO2008001213A1 (en) 2006-06-26 2008-01-03 Aurobindo Pharma Limited An improved process for the preparation of leukotriene receptor antagonist (montelukast sodium)
GB0614485D0 (en) 2006-07-21 2006-09-27 Pliva Istrazivanje I Razvoj D Process
US20110092708A1 (en) 2006-08-04 2011-04-21 Seeta Ramanjaneyulu Gorantla Process for the preparation of montelukast and its salts thereof

Also Published As

Publication number Publication date
AU2007283615A1 (en) 2008-02-14
MX2009000524A (es) 2009-01-27
WO2008017669A1 (en) 2008-02-14
US20090247759A1 (en) 2009-10-01
EP1886998A1 (de) 2008-02-13
EP2077996B1 (de) 2011-07-06
JP2010500325A (ja) 2010-01-07
CA2657775A1 (en) 2008-02-14
KR20090035696A (ko) 2009-04-10
RU2009108272A (ru) 2010-09-20
NO20091051L (no) 2009-05-05
ATE515498T1 (de) 2011-07-15
IL196303A0 (en) 2009-09-22
ES2372414T3 (es) 2012-01-19
PT2077996E (pt) 2011-09-13
PL2077996T3 (pl) 2011-11-30
JP5188501B2 (ja) 2013-04-24
SI2077996T1 (sl) 2011-10-28
US8188285B2 (en) 2012-05-29
IL196303A (en) 2014-03-31
CN101501000A (zh) 2009-08-05
ZA200900890B (en) 2010-04-28
EP2077996A1 (de) 2009-07-15
CN101501000B (zh) 2012-04-04

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