ATE516290T1 - Verfahren zur herstellung von buprenorphin und derivaten von buprenorphin - Google Patents
Verfahren zur herstellung von buprenorphin und derivaten von buprenorphinInfo
- Publication number
- ATE516290T1 ATE516290T1 AT08862678T AT08862678T ATE516290T1 AT E516290 T1 ATE516290 T1 AT E516290T1 AT 08862678 T AT08862678 T AT 08862678T AT 08862678 T AT08862678 T AT 08862678T AT E516290 T1 ATE516290 T1 AT E516290T1
- Authority
- AT
- Austria
- Prior art keywords
- buprenorphine
- derivatives
- producing
- norhydromorphone
- production
- Prior art date
Links
- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 title abstract 6
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 229960001736 buprenorphine Drugs 0.000 title abstract 2
- SWIRXSKBBSJXGY-UIHHKEIPSA-N Norhydromorphone Chemical compound O=C([C@@H]1O2)CC[C@H]3[C@]4([H])NCC[C@]13C1=C2C(O)=CC=C1C4 SWIRXSKBBSJXGY-UIHHKEIPSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
- C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
- C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Addiction (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1409007P | 2007-12-17 | 2007-12-17 | |
| PCT/US2008/013772 WO2009078986A1 (en) | 2007-12-17 | 2008-12-17 | Process for the preparation of buprenorphine and derivatives of buprenorphine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE516290T1 true ATE516290T1 (de) | 2011-07-15 |
Family
ID=40429882
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08862678T ATE516290T1 (de) | 2007-12-17 | 2008-12-17 | Verfahren zur herstellung von buprenorphin und derivaten von buprenorphin |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US8017777B2 (de) |
| EP (1) | EP2222679B1 (de) |
| JP (1) | JP2011506601A (de) |
| CN (1) | CN101896489A (de) |
| AT (1) | ATE516290T1 (de) |
| AU (1) | AU2008338968A1 (de) |
| CA (1) | CA2709854A1 (de) |
| WO (1) | WO2009078986A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8829020B2 (en) | 2009-07-16 | 2014-09-09 | Mallinckrodt Llc | Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers |
| US10363251B2 (en) | 2009-07-16 | 2019-07-30 | Mallinckrodt Llc | (+)-morphinans as antagonists of toll-like receptor 9 and therapeutic uses thereof |
| US20110015219A1 (en) * | 2009-07-16 | 2011-01-20 | Mallinckrodt Inc. | (+)-Morphinans as Antagonists of Toll-Like Receptor 9 and Therapeutic Uses Thereof |
| PL2593095T3 (pl) | 2010-07-16 | 2019-12-31 | Mallinckrodt Llc | (+)-morfinany jako antagoniści receptora toll-podobnego 9 i ich terapeutyczne zastosowania |
| JP6181770B2 (ja) | 2012-12-31 | 2017-08-16 | ローズ テクノロジーズ | ７β−置換６α，１４α−エテノモルフィナンおよび７β−置換６α，１４α−エタノモルフィナンを調製するための方法 |
| EP3023427A1 (de) | 2014-11-19 | 2016-05-25 | Siegfried AG | Verfahren zur Herstellung von Buprenorphin und Analoga aus Oripavin |
| WO2021195209A1 (en) * | 2020-03-24 | 2021-09-30 | University Of Padova | Morphinan isomers and their structural modifications as nmdar antagonists and neuroplastogens |
| CN113956263B (zh) * | 2021-12-06 | 2023-06-20 | 四川大学 | 一种吗啡衍生物丁丙诺啡的合成方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007081506A1 (en) * | 2006-01-05 | 2007-07-19 | Mallinckrodt Inc. | The use of oripavine as a starting material for buprenorphine |
-
2008
- 2008-12-17 JP JP2010539458A patent/JP2011506601A/ja active Pending
- 2008-12-17 CN CN2008801207755A patent/CN101896489A/zh active Pending
- 2008-12-17 CA CA2709854A patent/CA2709854A1/en not_active Abandoned
- 2008-12-17 AT AT08862678T patent/ATE516290T1/de not_active IP Right Cessation
- 2008-12-17 EP EP08862678A patent/EP2222679B1/de active Active
- 2008-12-17 US US12/316,861 patent/US8017777B2/en active Active
- 2008-12-17 AU AU2008338968A patent/AU2008338968A1/en not_active Abandoned
- 2008-12-17 WO PCT/US2008/013772 patent/WO2009078986A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011506601A (ja) | 2011-03-03 |
| EP2222679A1 (de) | 2010-09-01 |
| US8017777B2 (en) | 2011-09-13 |
| CA2709854A1 (en) | 2009-06-25 |
| AU2008338968A1 (en) | 2009-06-25 |
| CN101896489A (zh) | 2010-11-24 |
| WO2009078986A1 (en) | 2009-06-25 |
| US20090156817A1 (en) | 2009-06-18 |
| EP2222679B1 (de) | 2011-07-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |