ATE517152T1 - Chirale indole als zwischenprodukte und daraus hergestellte cyaninfluoreszenzfarbstoffe mit funktionellen gruppen - Google Patents

Chirale indole als zwischenprodukte und daraus hergestellte cyaninfluoreszenzfarbstoffe mit funktionellen gruppen

Info

Publication number
ATE517152T1
ATE517152T1 AT03808367T AT03808367T ATE517152T1 AT E517152 T1 ATE517152 T1 AT E517152T1 AT 03808367 T AT03808367 T AT 03808367T AT 03808367 T AT03808367 T AT 03808367T AT E517152 T1 ATE517152 T1 AT E517152T1
Authority
AT
Austria
Prior art keywords
functional groups
fluorescent dyes
intermediate products
dyes produced
chiral
Prior art date
Application number
AT03808367T
Other languages
English (en)
Inventor
Ratnaker Mujumdar
Richard Martin West
Original Assignee
Univ Carnegie Mellon
Ge Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Carnegie Mellon, Ge Healthcare Ltd filed Critical Univ Carnegie Mellon
Application granted granted Critical
Publication of ATE517152T1 publication Critical patent/ATE517152T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0075—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of an heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/06—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups three >CH- groups, e.g. carbocyanines
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Food Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Indole Compounds (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT03808367T 2002-05-10 2003-05-09 Chirale indole als zwischenprodukte und daraus hergestellte cyaninfluoreszenzfarbstoffe mit funktionellen gruppen ATE517152T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37910702P 2002-05-10 2002-05-10
PCT/US2003/014632 WO2004039894A2 (en) 2002-05-10 2003-05-09 Chiral indole intermediates and their fluorescent cyanine dyes containing functional groups

Publications (1)

Publication Number Publication Date
ATE517152T1 true ATE517152T1 (de) 2011-08-15

Family

ID=32230083

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03808367T ATE517152T1 (de) 2002-05-10 2003-05-09 Chirale indole als zwischenprodukte und daraus hergestellte cyaninfluoreszenzfarbstoffe mit funktionellen gruppen

Country Status (7)

Country Link
US (2) US7615646B2 (de)
EP (2) EP1525265B1 (de)
JP (2) JP4749718B2 (de)
AT (1) ATE517152T1 (de)
AU (2) AU2003301687B2 (de)
CA (1) CA2484218A1 (de)
WO (1) WO2004039894A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2325263B1 (de) 2000-09-29 2013-01-23 Life Technologies Corporation Modifizierte Carbocyaninfarbstoffe und deren Konjugate
US7615646B2 (en) * 2002-05-10 2009-11-10 Carnegie Mellon University Chiral indole intermediates and their fluorescent cyanine dyes containing functional groups
EP1678258B1 (de) * 2003-10-31 2011-08-31 GE Healthcare Limited Cyaninfarbstoffe als markieragenzien
ATE480596T1 (de) 2005-12-05 2010-09-15 Dyomics Gmbh Hydrophile marker auf der basis von diastereomeren cyaninen
US7279296B2 (en) * 2005-12-16 2007-10-09 General Electric Company Compositions and methods for lipoprotein uptake assays
JP5475244B2 (ja) * 2007-03-30 2014-04-16 株式会社Ａｄｅｋａ シアニン化合物、該化合物を用いた光学フィルター及び光学記録材料
JP2010526859A (ja) * 2007-05-16 2010-08-05 ジーイー・ヘルスケア・アクスイェ・セルスカプ ペプチドイメージング剤
EP2148702A2 (de) * 2007-05-16 2010-02-03 GE Healthcare AS Pentamethincyaninfarbstoffe mit mindestens drei sulfonsäuregruppen
US7951959B2 (en) * 2008-09-17 2011-05-31 Thermo Fisher Scientific (Milwaukee) LLC Hydrophilic labels for biomolecules
GB201010878D0 (en) * 2010-06-29 2010-08-11 Ge Healthcare As Dye compositiion and dye syntheses
EP2734645A4 (de) * 2011-07-18 2014-12-17 Univ Georgia State Res Found Carbocyanine zur g-quadruplex-dna-stabilisierung und telomerase-hemmung
KR102688598B1 (ko) * 2015-07-14 2024-07-25 에스에프씨 주식회사 신규한 시아닌 염료
US10473666B2 (en) * 2015-07-16 2019-11-12 Sfc Co., Ltd. Dye compounds
EP3655408B1 (de) * 2017-08-24 2021-07-14 The U.S.A. As Represented By The Secretary, Department Of Health And Human Services Konformationale einschränkung von cyaninfluorophoren im fernrot- und nahinfrarotbereich
WO2019217583A1 (en) * 2018-05-09 2019-11-14 Board Of Trustees Of Michigan State University Near-infrared harvesting transparent luminescent solar concentrators with engineered stokes shift
CN116601238B (zh) 2020-12-17 2025-04-29 伯拉考成像股份公司 Ph响应性花青染料及其缀合物
WO2025144711A1 (en) * 2023-12-29 2025-07-03 Illumina, Inc. Tricyclic polymethine dyes for nucleic acid sequencing

Family Cites Families (20)

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JPS5911716B2 (ja) * 1976-06-11 1984-03-17 保土谷化学工業株式会社 酸性改質合成繊維の乾式転写捺染法
US5268486A (en) 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
US5569587A (en) 1986-04-18 1996-10-29 Carnegie Mellon University Method for labeling and detecting materials employing luminescent arysulfonate cyanine dyes
US6048982A (en) 1986-04-18 2000-04-11 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US5852191A (en) 1995-06-07 1998-12-22 Carnegie Mellon University Rigidized monomethine cyanines
US6008373A (en) 1995-06-07 1999-12-28 Carnegie Mellon University Fluorescent labeling complexes with large stokes shift formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer
US5986093A (en) 1995-06-07 1999-11-16 Carnegie Mellon University Monomethine cyanines rigidized by a two-carbon chain
EP1042407B1 (de) * 1997-12-17 2001-09-12 Carnegie-Mellon University Versteifte trimethin-cyaninfarbstoffe
US6133445A (en) * 1997-12-17 2000-10-17 Carnegie Mellon University Rigidized trimethine cyanine dyes
EP1212375A2 (de) 1999-06-09 2002-06-12 Carnegie-Mellon University Ph-sensitive cyaninfarbstoffe als reaktive fluoreszierende reagenzien
US6180085B1 (en) 2000-01-18 2001-01-30 Mallinckrodt Inc. Dyes
US6180087B1 (en) * 2000-01-18 2001-01-30 Mallinckrodt Inc. Tunable indocyanine dyes for biomedical applications
US6190641B1 (en) 2000-01-18 2001-02-20 Mallinckrodt Inc. Indocyanine dyes
US6183726B1 (en) 2000-01-18 2001-02-06 Mallinckrodt Inc. Versatile hydrophilic dyes
US6180086B1 (en) 2000-01-18 2001-01-30 Mallinckrodt Inc. Hydrophilic cyanine dyes
IL150948A0 (en) * 2000-02-02 2003-02-12 Amersham Biosciences Uk Ltd Detection reagent
JP4243028B2 (ja) * 2000-04-06 2009-03-25 富士フイルム株式会社 新規テトラシアノキノジメタン化合物、該化合物を対アニオンとしたシアニン色素化合物及び該シアニン色素化合物を含む光情報記録媒体
EP2325263B1 (de) 2000-09-29 2013-01-23 Life Technologies Corporation Modifizierte Carbocyaninfarbstoffe und deren Konjugate
US6673334B1 (en) 2000-10-16 2004-01-06 Mallinkcrodt, Inc. Light sensitive compounds for instant determination of organ function
US7615646B2 (en) * 2002-05-10 2009-11-10 Carnegie Mellon University Chiral indole intermediates and their fluorescent cyanine dyes containing functional groups

Also Published As

Publication number Publication date
JP4749718B2 (ja) 2011-08-17
EP1525265A2 (de) 2005-04-27
JP2010202876A (ja) 2010-09-16
AU2003301687A1 (en) 2004-05-25
CA2484218A1 (en) 2004-05-13
EP2258776A1 (de) 2010-12-08
WO2004039894A2 (en) 2004-05-13
AU2003301687B2 (en) 2010-05-13
US20100267008A1 (en) 2010-10-21
US7615646B2 (en) 2009-11-10
WO2004039894A3 (en) 2005-03-03
EP1525265B1 (de) 2011-07-20
US8044203B2 (en) 2011-10-25
EP1525265A4 (de) 2005-06-22
JP5179536B2 (ja) 2013-04-10
AU2010202052A1 (en) 2010-06-10
US20060051758A1 (en) 2006-03-09
AU2010202052B2 (en) 2011-09-08
JP2005536623A (ja) 2005-12-02

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