ATE518960T1 - Gentechnisch hergestellte zinkfingerproteine zur regulation der genexpression - Google Patents
Gentechnisch hergestellte zinkfingerproteine zur regulation der genexpressionInfo
- Publication number
- ATE518960T1 ATE518960T1 AT04784464T AT04784464T ATE518960T1 AT E518960 T1 ATE518960 T1 AT E518960T1 AT 04784464 T AT04784464 T AT 04784464T AT 04784464 T AT04784464 T AT 04784464T AT E518960 T1 ATE518960 T1 AT E518960T1
- Authority
- AT
- Austria
- Prior art keywords
- gene expression
- zinc finger
- finger proteins
- regulate gene
- produced zinc
- Prior art date
Links
- 230000014509 gene expression Effects 0.000 title abstract 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 239000011701 zinc Substances 0.000 title 1
- 229910052725 zinc Inorganic materials 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50450203P | 2003-09-19 | 2003-09-19 | |
| PCT/US2004/030606 WO2005028630A2 (en) | 2003-09-19 | 2004-09-17 | Engineered zinc finger proteins for regulation of gene expression |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE518960T1 true ATE518960T1 (de) | 2011-08-15 |
Family
ID=34375508
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04784464T ATE518960T1 (de) | 2003-09-19 | 2004-09-17 | Gentechnisch hergestellte zinkfingerproteine zur regulation der genexpression |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7407776B2 (de) |
| EP (1) | EP1678315B1 (de) |
| AT (1) | ATE518960T1 (de) |
| AU (1) | AU2004274957B2 (de) |
| CA (1) | CA2539439C (de) |
| WO (1) | WO2005028630A2 (de) |
Families Citing this family (31)
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| EP1459065B1 (de) * | 2001-12-04 | 2010-07-28 | Teva Pharmaceutical Industries, Ltd. | Verfahren zur messung der wirkstärke von glatirameracetat |
| US20080311095A1 (en) * | 2007-05-23 | 2008-12-18 | Sangamo Biosciences, Inc. | Methods and compositions for increased transgene expression |
| JP5147692B2 (ja) * | 2005-07-13 | 2013-02-20 | ノボ ノルディスク ヘルス ケア アーゲー | 治療用タンパク質生成のための宿主細胞タンパク質ノックアウト細胞 |
| WO2008060510A2 (en) | 2006-11-13 | 2008-05-22 | Sangamo Biosciences, Inc. | Zinc finger nuclease for targeting the human glucocorticoid receptor locus |
| CA2669746C (en) * | 2006-12-14 | 2017-05-16 | Dow Agrosciences Llc | Optimized non-canonical zinc finger proteins |
| CN102782140B (zh) * | 2009-10-22 | 2016-04-13 | 陶氏农业科学有限公司 | 靶向参与脂肪酸生物合成的植物基因的工程改造锌指蛋白 |
| EP2566972B1 (de) | 2010-05-03 | 2020-01-15 | Sangamo Therapeutics, Inc. | Zusammensetzungen zur verknüpfung von zinkfingermodulen |
| CN105658792B (zh) | 2012-02-28 | 2020-11-10 | 西格马-奥尔德里奇有限责任公司 | 靶向组蛋白乙酰化 |
| EP2841572B1 (de) | 2012-04-27 | 2019-06-19 | Duke University | Genetische korrektur mutierter gene |
| UA118090C2 (uk) | 2012-09-07 | 2018-11-26 | ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі | Спосіб інтегрування послідовності нуклеїнової кислоти, що представляє інтерес, у ген fad2 у клітині сої та специфічний для локусу fad2 білок, що зв'язується, здатний індукувати спрямований розрив |
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| US9828582B2 (en) | 2013-03-19 | 2017-11-28 | Duke University | Compositions and methods for the induction and tuning of gene expression |
| WO2015164228A1 (en) | 2014-04-21 | 2015-10-29 | Cellular Dynamics International, Inc. | Hepatocyte production via forward programming by combined genetic and chemical engineering |
| GB201418965D0 (de) | 2014-10-24 | 2014-12-10 | Ospedale San Raffaele And Fond Telethon | |
| US10676726B2 (en) | 2015-02-09 | 2020-06-09 | Duke University | Compositions and methods for epigenome editing |
| WO2017066497A2 (en) | 2015-10-13 | 2017-04-20 | Duke University | Genome engineering with type i crispr systems in eukaryotic cells |
| US12214054B2 (en) | 2015-11-30 | 2025-02-04 | Duke University | Therapeutic targets for the correction of the human dystrophin gene by gene editing and methods of use |
| EP3443081A4 (de) | 2016-04-13 | 2019-10-30 | Duke University | Crispr/cas9-basierte repressoren zur in-vivo-ausschaltung von gen-targets und verfahren zur verwendung |
| JP7490211B2 (ja) | 2016-07-19 | 2024-05-27 | デューク ユニバーシティ | Ｃｐｆ１に基づくゲノム編集の治療適用 |
| US12509492B2 (en) | 2018-01-19 | 2025-12-30 | Duke University | Genome engineering with CRISPR-Cas systems in eukaryotes |
| US11649455B2 (en) | 2018-03-30 | 2023-05-16 | University Of Geneva | Micro RNA expression constructs and uses thereof |
| TWI887234B (zh) | 2019-04-14 | 2025-06-21 | 美國公爵大學 | 治療杜興氏（ｄｕｃｈｅｎｎｅ）肌肉失養症之大型突變熱點之ａａｖ載體介導之刪除 |
| CN110791523B (zh) * | 2019-12-13 | 2022-05-10 | 南京农业大学 | 一种棉花抗旱相关基因GhRCHY1及其应用 |
| AU2021278356A1 (en) | 2020-05-27 | 2022-11-03 | Antion Biosciences Sa | Adapter molecules to re-direct CAR T cells to an antigen of interest |
| GB202010075D0 (en) * | 2020-07-01 | 2020-08-12 | Imp College Innovations Ltd | Therapeutic nucleic acids, peptides and uses |
| WO2022170117A1 (en) * | 2021-02-04 | 2022-08-11 | New York University | Seamless integration of engineered zinc fingers into endogenous transcription factors to commandeer their natural functions |
| IL311610A (en) | 2021-09-21 | 2024-05-01 | Scribe Therapeutics Inc | Engineered CASX suppressor systems |
| WO2023114887A2 (en) * | 2021-12-15 | 2023-06-22 | The Trustees Of Indiana University | Cell targeting compositions and methods |
| CN119998446A (zh) | 2022-06-07 | 2025-05-13 | 斯克里贝治疗公司 | 用于靶向pcsk9的组合物和方法 |
| CA3260237A1 (en) | 2022-06-24 | 2023-12-28 | Tune Therapeutics, Inc. | Compositions, systems and methods for reducing low-density lipoprotein by targeted gene repression |
| WO2024040254A2 (en) | 2022-08-19 | 2024-02-22 | Tune Therapeutics, Inc. | Compositions, systems, and methods for regulation of hepatitis b virus through targeted gene repression |
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| KR100857125B1 (ko) | 2004-05-25 | 2008-09-11 | 주식회사 툴젠 | 단일클론 항체 생산을 증가시키는 폴리펩타이드, 이를코드하는 핵산 및 이의 용도 |
-
2004
- 2004-09-17 CA CA2539439A patent/CA2539439C/en not_active Expired - Lifetime
- 2004-09-17 US US10/572,886 patent/US7407776B2/en not_active Expired - Lifetime
- 2004-09-17 EP EP04784464A patent/EP1678315B1/de not_active Expired - Lifetime
- 2004-09-17 AT AT04784464T patent/ATE518960T1/de not_active IP Right Cessation
- 2004-09-17 WO PCT/US2004/030606 patent/WO2005028630A2/en not_active Ceased
- 2004-09-17 AU AU2004274957A patent/AU2004274957B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005028630A2 (en) | 2005-03-31 |
| AU2004274957B2 (en) | 2009-02-05 |
| CA2539439C (en) | 2012-10-23 |
| WO2005028630A3 (en) | 2005-06-09 |
| EP1678315B1 (de) | 2011-08-03 |
| US7407776B2 (en) | 2008-08-05 |
| EP1678315A2 (de) | 2006-07-12 |
| EP1678315A4 (de) | 2006-11-08 |
| US20070059795A1 (en) | 2007-03-15 |
| AU2004274957A1 (en) | 2005-03-31 |
| CA2539439A1 (en) | 2005-03-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |