ATE543873T1 - Herstellung von 3-hydroxypropionsäure mittels beta-alanine-pyruvat-aminotrransferase - Google Patents

Herstellung von 3-hydroxypropionsäure mittels beta-alanine-pyruvat-aminotrransferase

Info

Publication number
ATE543873T1
ATE543873T1 AT04821820T AT04821820T ATE543873T1 AT E543873 T1 ATE543873 T1 AT E543873T1 AT 04821820 T AT04821820 T AT 04821820T AT 04821820 T AT04821820 T AT 04821820T AT E543873 T1 ATE543873 T1 AT E543873T1
Authority
AT
Austria
Prior art keywords
beta
hydroxypropionic acid
production
pyruvate aminotransferase
alanine
Prior art date
Application number
AT04821820T
Other languages
English (en)
Inventor
Hans Liao
Ravi Gokarn
Steven Gort
Holly Jessen
Olga Selifonova
Original Assignee
Novozymes As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes As filed Critical Novozymes As
Application granted granted Critical
Publication of ATE543873T1 publication Critical patent/ATE543873T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C12P7/625—Polyesters of hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)
    • C12Y206/01018—Beta-alanine-pyruvate transaminase (2.6.1.18)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT04821820T 2003-12-04 2004-12-06 Herstellung von 3-hydroxypropionsäure mittels beta-alanine-pyruvat-aminotrransferase ATE543873T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52735703P 2003-12-04 2003-12-04
PCT/US2004/040827 WO2005118719A2 (en) 2003-12-04 2004-12-06 Production of 3-hydroxypropionic acid using beta-alanine/pyruvate aminotransferase

Publications (1)

Publication Number Publication Date
ATE543873T1 true ATE543873T1 (de) 2012-02-15

Family

ID=35463438

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04821820T ATE543873T1 (de) 2003-12-04 2004-12-06 Herstellung von 3-hydroxypropionsäure mittels beta-alanine-pyruvat-aminotrransferase

Country Status (6)

Country Link
US (3) US7700319B2 (de)
EP (1) EP1706457B1 (de)
AT (1) ATE543873T1 (de)
BR (1) BRPI0416546A (de)
DK (1) DK1706457T3 (de)
WO (1) WO2005118719A2 (de)

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AR031480A1 (es) 2000-11-20 2003-09-24 Cargill Inc Acido 3-hidroxipropionico y otros compuestos organicos
US7309597B2 (en) * 2002-01-18 2007-12-18 Cargill, Incorporated Alanine 2,3-Aminomutase
JP2008507970A (ja) * 2004-07-30 2008-03-21 カーギル インコーポレイテッド アラニン２，３アミノムターゼ
JP2008517607A (ja) 2004-10-25 2008-05-29 コデクシス， インコーポレイテッド 改良されたアラニン２，３−アミノムターゼおよび関連ポリヌクレオチド
WO2007047773A2 (en) 2005-10-14 2007-04-26 Codexis, Inc. Alanine 2,3-aminomutases and related polynucleotides
US20070203276A1 (en) 2006-02-10 2007-08-30 Gyorgyi Fenyvesi Plasticizers comprising biologically-based mono and di esters
EP2001992B1 (de) 2006-03-13 2016-07-20 Cargill Inc. Hefezellen mit unterbrochenem weg von dihydroxyaceton-phosphate bis glycerin
BRPI0716212A2 (pt) 2006-08-30 2013-10-15 Cargill Inc Beta-alanina/alfa-cetoglutarato aminotransferase para produção de ácido 3-hidroxipropiônico
CA2675026A1 (en) * 2007-01-12 2008-07-24 The Regents Of The University Of Colorado, A Body Corporate Compositions and methods for enhancing tolerance for the production of organic chemicals produced by microorganisms
US8048624B1 (en) 2007-12-04 2011-11-01 Opx Biotechnologies, Inc. Compositions and methods for 3-hydroxypropionate bio-production from biomass
DE102008020688B3 (de) 2008-04-24 2009-11-05 Evonik Stockhausen Gmbh Verfahren zur Herstellung und Aufreinigung wässriger Phasen
AU2009273953B2 (en) * 2008-07-23 2013-08-29 Opx Biotechnologies, Inc Methods, systems and compositions for increased microorganism tolerance to and production of 3-hydroxypropionic acid (3-HP)
EP2326709A4 (de) * 2008-09-15 2013-01-23 Opx Biotechnologies Inc Verfahren, systeme und zusammensetzungen in zusammenhang mit reduzierter umwandlung mikrobiell erzeugter 3-hydroxypropionsäure (3-hp) in aldehydmetabolite
US8809027B1 (en) 2009-09-27 2014-08-19 Opx Biotechnologies, Inc. Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase
KR20140015136A (ko) 2009-09-27 2014-02-06 더 리젠츠 오브 더 유니버시티 오브 콜로라도, 어 바디 코포레이트 3-히드록시프로피온산 및 다른 생성물의 제조 방법
US20110125118A1 (en) * 2009-11-20 2011-05-26 Opx Biotechnologies, Inc. Production of an Organic Acid and/or Related Chemicals
CA2788045A1 (en) * 2010-01-27 2011-08-04 Opx Biotechnologies, Inc. Microorganism production of high-valve chemical products, and related compositions, methods and systems
CN102781901B (zh) 2010-02-11 2016-08-03 梅塔玻利克斯公司 用于从经遗传修饰的聚羟基链烷酸酯生物质制备单体组分的方法
WO2012001003A1 (en) 2010-07-02 2012-01-05 Metabolic Explorer Method for the preparation of hydroxy acids
JP6061862B2 (ja) 2010-11-22 2017-01-18 カーギル，インコーポレイティド ３‐ヒドロキシプロピオン酸生産用の組成物及び方法
EP2751261B1 (de) 2011-09-30 2018-08-29 Novozymes, Inc. Dehydrogenasevarianten und dafür kodierende polynukleotide
WO2013142033A1 (en) * 2012-03-20 2013-09-26 Metabolix, Inc. Genetically engineered microorganisms for the production of poly-4-hydroxybutyrate
US9803209B2 (en) 2012-05-18 2017-10-31 Novozymes A/S Bacterial mutants with improved transformation efficiency
CN104350034B (zh) 2012-06-08 2018-07-31 Cj 第一制糖株式会社 可再生丙烯酸生产和自其制备的产物
KR20150040359A (ko) 2012-08-10 2015-04-14 오피엑스 바이오테크놀로지스, 인크. 지방산 및 지방산 유도된 산물의 생산을 위한 미생물 및 방법
EP2900689B1 (de) 2012-09-27 2017-08-02 Novozymes, Inc. Bakterielle mutanten mit verbesserter transformationseffizienz
WO2014057036A1 (en) 2012-10-11 2014-04-17 Technical University Of Denmark Genetically engineered yeast
JP2015536669A (ja) 2012-11-30 2015-12-24 ノボザイムス，インコーポレイティド 組換え酵母による３−ヒドロキシプロピオン酸の生産
US20150057465A1 (en) 2013-03-15 2015-02-26 Opx Biotechnologies, Inc. Control of growth-induction-production phases
US9512057B2 (en) 2013-03-15 2016-12-06 Cargill, Incorporated 3-hydroxypropionic acid compositions
EP2970085B1 (de) 2013-03-15 2018-11-07 Cargill, Incorporated Rückgewinnung von 3-hydroxypropionsäure
CA2914003C (en) * 2013-06-05 2018-01-02 Lanzatech New Zealand Limited Recombinant microorganisms exhibiting increased flux through a fermentation pathway
WO2014198841A1 (en) 2013-06-14 2014-12-18 Technical University Of Denmark 3hp tolerance
US10337038B2 (en) 2013-07-19 2019-07-02 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
EP2993228B1 (de) 2014-09-02 2019-10-09 Cargill, Incorporated Herstellung von fettsäureestern
KR101730035B1 (ko) * 2015-03-20 2017-04-26 한국과학기술원 L-아스파르트산 유도체를 생산하는 변이미생물 및 이를 이용한 l-아스파르트산 유도체의 제조방법
EP3577227A4 (de) 2017-02-02 2020-12-30 Cargill Inc. Genetisch veränderte zellen, die c6-c10-fettsäurederivate produzieren
CN110494553B (zh) 2017-04-13 2023-07-04 协和发酵生化株式会社 茶氨酸的制造方法
AU2022218205A1 (en) * 2021-02-08 2023-05-25 Lanzatech, Inc. Recombinant microorganisms and uses therefor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001016346A1 (en) 1999-08-30 2001-03-08 Wisconsin Alumni Research Foundation Production of 3-hydroxypropionic acid in recombinant organisms
AR031480A1 (es) * 2000-11-20 2003-09-24 Cargill Inc Acido 3-hidroxipropionico y otros compuestos organicos
US7309597B2 (en) 2002-01-18 2007-12-18 Cargill, Incorporated Alanine 2,3-Aminomutase
JP2008507970A (ja) 2004-07-30 2008-03-21 カーギル インコーポレイテッド アラニン２，３アミノムターゼ

Also Published As

Publication number Publication date
EP1706457B1 (de) 2012-02-01
US20100136638A1 (en) 2010-06-03
US20100267115A1 (en) 2010-10-21
US7785837B2 (en) 2010-08-31
DK1706457T3 (da) 2012-05-21
WO2005118719A2 (en) 2005-12-15
US7700319B2 (en) 2010-04-20
US8124388B2 (en) 2012-02-28
EP1706457A2 (de) 2006-10-04
WO2005118719A3 (en) 2006-09-21
US20070107080A1 (en) 2007-05-10
BRPI0416546A (pt) 2007-01-09

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