ATE543873T1 - Herstellung von 3-hydroxypropionsäure mittels beta-alanine-pyruvat-aminotrransferase - Google Patents

Herstellung von 3-hydroxypropionsäure mittels beta-alanine-pyruvat-aminotrransferase

Info

Publication number
ATE543873T1
ATE543873T1 AT04821820T AT04821820T ATE543873T1 AT E543873 T1 ATE543873 T1 AT E543873T1 AT 04821820 T AT04821820 T AT 04821820T AT 04821820 T AT04821820 T AT 04821820T AT E543873 T1 ATE543873 T1 AT E543873T1
Authority
AT
Austria
Prior art keywords
beta
hydroxypropionic acid
production
pyruvate aminotransferase
alanine
Prior art date
Application number
AT04821820T
Other languages
English (en)
Inventor
Hans Liao
Ravi Gokarn
Steven Gort
Holly Jessen
Olga Selifonova
Original Assignee
Novozymes As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novozymes As filed Critical Novozymes As
Application granted granted Critical
Publication of ATE543873T1 publication Critical patent/ATE543873T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C12P7/625—Polyesters of hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y206/00—Transferases transferring nitrogenous groups (2.6)
    • C12Y206/01—Transaminases (2.6.1)
    • C12Y206/01018—Beta-alanine-pyruvate transaminase (2.6.1.18)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT04821820T 2003-12-04 2004-12-06 Herstellung von 3-hydroxypropionsäure mittels beta-alanine-pyruvat-aminotrransferase ATE543873T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US52735703P 2003-12-04 2003-12-04
PCT/US2004/040827 WO2005118719A2 (en) 2003-12-04 2004-12-06 Production of 3-hydroxypropionic acid using beta-alanine/pyruvate aminotransferase

Publications (1)

Publication Number Publication Date
ATE543873T1 true ATE543873T1 (de) 2012-02-15

Family

ID=35463438

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04821820T ATE543873T1 (de) 2003-12-04 2004-12-06 Herstellung von 3-hydroxypropionsäure mittels beta-alanine-pyruvat-aminotrransferase

Country Status (6)

Country Link
US (3) US7700319B2 (de)
EP (1) EP1706457B1 (de)
AT (1) ATE543873T1 (de)
BR (1) BRPI0416546A (de)
DK (1) DK1706457T3 (de)
WO (1) WO2005118719A2 (de)

Families Citing this family (40)

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US7186541B2 (en) 2000-11-20 2007-03-06 Cargill, Incorporated 3-hydroxypropionic acid and other organic compounds
EP1575881B1 (de) * 2002-01-18 2009-05-27 Novozymes A/S Alanin-2,3-aminomutase
MX2007001195A (es) * 2004-07-30 2007-10-03 Cargill Inc Alanina 2,3-aminomutasas.
JP2008517607A (ja) 2004-10-25 2008-05-29 コデクシス， インコーポレイテッド 改良されたアラニン２，３−アミノムターゼおよび関連ポリヌクレオチド
WO2007047773A2 (en) 2005-10-14 2007-04-26 Codexis, Inc. Alanine 2,3-aminomutases and related polynucleotides
US7988883B2 (en) 2006-02-10 2011-08-02 Dupont Tate & Lyle Bio Products Company, Llc Heat transfer compositions comprising renewably-based biodegradable 1,3-propanediol
BRPI0709607B1 (pt) 2006-03-13 2018-05-08 Cargill Inc cédulas de levedura tendo via rompida de diidroxi acetona fosfato para glicerol e processo de fermentação"
EP2064321B1 (de) 2006-08-30 2016-03-09 Cargill, Incorporated Beta-alanin/alpha-ketoglutarat-aminotransferase zur herstellung von 3-hydroxypropionsäure
CA2675026A1 (en) * 2007-01-12 2008-07-24 The Regents Of The University Of Colorado, A Body Corporate Compositions and methods for enhancing tolerance for the production of organic chemicals produced by microorganisms
US8048624B1 (en) 2007-12-04 2011-11-01 Opx Biotechnologies, Inc. Compositions and methods for 3-hydroxypropionate bio-production from biomass
DE102008020688B3 (de) 2008-04-24 2009-11-05 Evonik Stockhausen Gmbh Verfahren zur Herstellung und Aufreinigung wässriger Phasen
BRPI0918882A2 (pt) * 2008-07-23 2019-02-26 Opx Biotechnologies Inc métodos, sistemas e composições para tolerância aumentada de microorganismo para produção de ácido 3-hidroxipropiônico (3-hp)
WO2010031083A2 (en) * 2008-09-15 2010-03-18 Opx Biotechnologies, Inc. Methods, systems and compositions related to reduction of conversions of microbially produced 3-hydroxypropionic acid (3-hp) to aldehyde metabolites
US8809027B1 (en) 2009-09-27 2014-08-19 Opx Biotechnologies, Inc. Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase
CA2775390C (en) 2009-09-27 2021-06-29 Opx Biotechnologies, Inc. Method for producing 3-hydroxypropionic acid and other products
CA2781400A1 (en) * 2009-11-20 2011-05-26 Opx Biotechnologies, Inc. Production of an organic acid and/or related chemicals
IN2012DN06617A (de) * 2010-01-27 2015-10-23 Opx Biotechnologies Inc
CN102781901B (zh) 2010-02-11 2016-08-03 梅塔玻利克斯公司 用于从经遗传修饰的聚羟基链烷酸酯生物质制备单体组分的方法
EP2588598B1 (de) 2010-07-02 2016-03-09 Metabolic Explorer Verfahren zur herstellung von hydroxysäuren
AU2011336923B2 (en) 2010-11-22 2017-02-16 Cargill, Incorporated Compositions and methods for 3-hydroxypropionic acid production
BR112014007647A2 (pt) * 2011-09-30 2017-04-18 Novozymes As “variante de 3-hpdh, polipeptídeo tendo atividade de 3-hpdh, polinucleotídeo isolado, célula hospedeira microbiana transgênica, e, método para produzir 3-hp
US20150159184A1 (en) * 2012-03-20 2015-06-11 Metabolix, Inc. Genetically Engineered Microorganisms for the Production of Poly-4-Hydroxybutyrate
WO2013173711A1 (en) 2012-05-18 2013-11-21 Novozymes A/S Bacterial mutants with improved transformation efficiency
CN104350034B (zh) 2012-06-08 2018-07-31 Cj 第一制糖株式会社 可再生丙烯酸生产和自其制备的产物
CN109182238A (zh) 2012-08-10 2019-01-11 嘉吉有限公司 用于生产脂肪酸和脂肪酸衍生产物的微生物及方法
CN104619721A (zh) 2012-09-27 2015-05-13 诺维信股份有限公司 具有改进的转化效率的细菌突变体
BR112015008111A2 (pt) * 2012-10-11 2017-11-28 Univ Denmark Tech Dtu célula de levedura geneticamente modificada, e , método para a produção de 3hp.
WO2014085330A1 (en) 2012-11-30 2014-06-05 Novozymes, Inc. 3-hydroxypropionic acid production by recombinant yeasts
WO2014145096A1 (en) 2013-03-15 2014-09-18 Cindy Hoppe Flash evaporation for production purification and recovery
WO2014146026A1 (en) 2013-03-15 2014-09-18 Opx Biotechnologies, Inc. Bioproduction of chemicals
JP2016518821A (ja) 2013-03-15 2016-06-30 カーギル・インコーポレイテッド ３−ヒドロキシプロピオン酸の回収
KR20160018568A (ko) * 2013-06-05 2016-02-17 란자테크 뉴질랜드 리미티드 발효 경로를 통한 플럭스의 증가를 나타내는 재조합 미생물
WO2014198841A1 (en) 2013-06-14 2014-12-18 Technical University Of Denmark 3hp tolerance
JP6603658B2 (ja) 2013-07-19 2019-11-06 カーギル インコーポレイテッド 脂肪酸及び脂肪酸誘導体の製造のための微生物及び方法
US11408013B2 (en) 2013-07-19 2022-08-09 Cargill, Incorporated Microorganisms and methods for the production of fatty acids and fatty acid derived products
EP2993228B1 (de) 2014-09-02 2019-10-09 Cargill, Incorporated Herstellung von fettsäureestern
KR101730035B1 (ko) * 2015-03-20 2017-04-26 한국과학기술원 L-아스파르트산 유도체를 생산하는 변이미생물 및 이를 이용한 l-아스파르트산 유도체의 제조방법
WO2018144701A2 (en) 2017-02-02 2018-08-09 Cargill Incorporated Genetically modified cells that produce c6-c10 fatty acid derivatives
JP7035024B2 (ja) * 2017-04-13 2022-03-14 協和発酵バイオ株式会社 テアニンの製造方法
WO2022170191A1 (en) * 2021-02-08 2022-08-11 Lanzatech, Inc. Recombinant microorganisms and uses therefor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU7093600A (en) 1999-08-30 2001-03-26 Wisconsin Alumni Research Foundation Production of 3-hydroxypropionic acid in recombinant organisms
US7186541B2 (en) * 2000-11-20 2007-03-06 Cargill, Incorporated 3-hydroxypropionic acid and other organic compounds
EP1575881B1 (de) 2002-01-18 2009-05-27 Novozymes A/S Alanin-2,3-aminomutase
MX2007001195A (es) 2004-07-30 2007-10-03 Cargill Inc Alanina 2,3-aminomutasas.

Also Published As

Publication number Publication date
DK1706457T3 (da) 2012-05-21
US20100267115A1 (en) 2010-10-21
US20070107080A1 (en) 2007-05-10
US20100136638A1 (en) 2010-06-03
WO2005118719A2 (en) 2005-12-15
US7700319B2 (en) 2010-04-20
BRPI0416546A (pt) 2007-01-09
US7785837B2 (en) 2010-08-31
EP1706457A2 (de) 2006-10-04
WO2005118719A3 (en) 2006-09-21
US8124388B2 (en) 2012-02-28
EP1706457B1 (de) 2012-02-01

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