ATE519764T1 - Spiroindolinon-derivate - Google Patents
Spiroindolinon-derivateInfo
- Publication number
- ATE519764T1 ATE519764T1 AT08861848T AT08861848T ATE519764T1 AT E519764 T1 ATE519764 T1 AT E519764T1 AT 08861848 T AT08861848 T AT 08861848T AT 08861848 T AT08861848 T AT 08861848T AT E519764 T1 ATE519764 T1 AT E519764T1
- Authority
- AT
- Austria
- Prior art keywords
- spiroindolinone derivatives
- spiroindolinone
- derivatives
- compounds
- esters
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1369107P | 2007-12-14 | 2007-12-14 | |
| US10743108P | 2008-10-22 | 2008-10-22 | |
| PCT/EP2008/066874 WO2009077357A1 (en) | 2007-12-14 | 2008-12-05 | Spiroindolinone derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE519764T1 true ATE519764T1 (de) | 2011-08-15 |
Family
ID=40289301
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08861848T ATE519764T1 (de) | 2007-12-14 | 2008-12-05 | Spiroindolinon-derivate |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8134001B2 (de) |
| EP (1) | EP2229396B1 (de) |
| JP (1) | JP2011506380A (de) |
| KR (1) | KR20100076037A (de) |
| CN (1) | CN101896486A (de) |
| AT (1) | ATE519764T1 (de) |
| AU (1) | AU2008337651A1 (de) |
| BR (1) | BRPI0821255A2 (de) |
| CA (1) | CA2707456A1 (de) |
| IL (1) | IL205354A0 (de) |
| MX (1) | MX2010006107A (de) |
| WO (1) | WO2009077357A1 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7776875B2 (en) * | 2007-12-19 | 2010-08-17 | Hoffman-La Roche Inc. | Spiroindolinone derivatives |
| US8354444B2 (en) * | 2008-09-18 | 2013-01-15 | Hoffmann-La Roche Inc. | Substituted pyrrolidine-2-carboxamides |
| CN104876938A (zh) | 2009-11-12 | 2015-09-02 | 密歇根大学董事会 | 螺-吲哚酮mdm2拮抗剂 |
| US8288431B2 (en) * | 2010-02-17 | 2012-10-16 | Hoffmann-La Roche Inc. | Substituted spiroindolinones |
| PE20140408A1 (es) | 2010-11-12 | 2014-04-10 | Univ Michigan | Derivados espiro-oxindol como antagonistas de mdm2 |
| CN102584835B (zh) * | 2011-01-17 | 2014-08-27 | 苏州大学 | 一种含吲哚结构的螺杂环化合物及其制备方法 |
| TR201807311T4 (tr) | 2011-03-10 | 2018-06-21 | Daiichi Sankyo Co Ltd | Dispiropirolidin derivesi. |
| MX346375B (es) | 2011-05-11 | 2017-03-16 | Univ Michigan Regents | Antagonistas de espiro-oxindol de mdm2. |
| CN102321095B (zh) * | 2011-05-26 | 2014-09-10 | 兰州大学 | 手性螺环吲哚-吡喃嘧啶碱类化合物及其制备和应用 |
| MX352672B (es) * | 2011-09-27 | 2017-12-04 | Amgen Inc | Compuestos heterocíclicos como inhibidores de mdm2 para el tratamiento del cáncer. |
| CN102627650B (zh) * | 2012-03-08 | 2015-07-08 | 徐州师范大学 | 手性四氢吡咯-3,2′-氧化吲哚螺环化合物及其合成方法 |
| TWI586668B (zh) | 2012-09-06 | 2017-06-11 | 第一三共股份有限公司 | 二螺吡咯啶衍生物之結晶 |
| WO2015027067A2 (en) * | 2013-08-23 | 2015-02-26 | Virginia Commonwealth University | Ester nitrates derivatives of aromatic aldehydes with multiple pharmalogic properties to treat sickle cell disease |
| WO2016001376A1 (en) | 2014-07-03 | 2016-01-07 | Boehringer Ingelheim International Gmbh | New spiro[3h-indole-3,2´-pyrrolidin]-2(1h)-one compounds and derivatives as mdm2-p53 inhibitors |
| JP6591532B2 (ja) | 2014-08-21 | 2019-10-16 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | ＭＤＭ２−ｐ５３阻害剤としての新しいスピロ［３Ｈ−インドール−３，２’−ピロリジン］−２（１Ｈ）−オン化合物および誘導体 |
| JP6564449B2 (ja) | 2015-02-20 | 2019-08-21 | 第一三共株式会社 | がんの併用治療法 |
| KR20170134462A (ko) | 2015-04-13 | 2017-12-06 | 다이이찌 산쿄 가부시키가이샤 | Mdm2 저해제와 btk 저해제의 병용 치료법 |
| HUE054985T2 (hu) | 2015-10-09 | 2021-11-29 | Boehringer Ingelheim Int | Spiro[3H-indol-3,2'-pirrolidin]-2(1H)-on vegyületek és számrazékok, mint MDM2-P53 inhibitorok |
| CN109152843A (zh) | 2016-05-20 | 2019-01-04 | 豪夫迈·罗氏有限公司 | Protac抗体缀合物及其使用方法 |
| US20190240210A1 (en) | 2016-10-17 | 2019-08-08 | Daiichi Sankyo Company, Limited | Treatment Method by Combined Use of MDM2 Inhibitor and DNA Methyltransferase Inhibitor |
| US12240855B2 (en) | 2019-03-06 | 2025-03-04 | Daiichi Sankyo Company, Limited | Pyrrolopyrazole derivative |
| WO2022183006A1 (en) | 2021-02-25 | 2022-09-01 | Mayo Foundation For Medical Education And Research | Compounds for programmable protein degradation and methods of use for the disease treatment |
| WO2023056069A1 (en) | 2021-09-30 | 2023-04-06 | Angiex, Inc. | Degrader-antibody conjugates and methods of using same |
| CN116253736B (zh) * | 2023-01-06 | 2024-06-18 | 中山大学 | 一种吡唑β-内酰胺类衍生物及其制备方法和应用 |
| WO2024240858A1 (en) | 2023-05-23 | 2024-11-28 | Valerio Therapeutics | Protac molecules directed against dna damage repair system and uses thereof |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7495007B2 (en) | 2006-03-13 | 2009-02-24 | Hoffmann-La Roche Inc. | Spiroindolinone derivatives |
| US20070213341A1 (en) * | 2006-03-13 | 2007-09-13 | Li Chen | Spiroindolinone derivatives |
| DE602007011902D1 (de) | 2006-03-13 | 2011-02-24 | Hoffmann La Roche | Spiroindolinon-derivate |
| US7638548B2 (en) | 2006-11-09 | 2009-12-29 | Hoffmann-La Roche Inc. | Spiroindolinone derivatives |
-
2008
- 2008-11-18 US US12/272,870 patent/US8134001B2/en not_active Expired - Fee Related
- 2008-12-05 JP JP2010537394A patent/JP2011506380A/ja active Pending
- 2008-12-05 KR KR1020107011040A patent/KR20100076037A/ko not_active Ceased
- 2008-12-05 AU AU2008337651A patent/AU2008337651A1/en not_active Abandoned
- 2008-12-05 EP EP08861848A patent/EP2229396B1/de not_active Not-in-force
- 2008-12-05 CN CN2008801198987A patent/CN101896486A/zh active Pending
- 2008-12-05 MX MX2010006107A patent/MX2010006107A/es unknown
- 2008-12-05 BR BRPI0821255-4A patent/BRPI0821255A2/pt not_active IP Right Cessation
- 2008-12-05 AT AT08861848T patent/ATE519764T1/de not_active IP Right Cessation
- 2008-12-05 WO PCT/EP2008/066874 patent/WO2009077357A1/en not_active Ceased
- 2008-12-05 CA CA2707456A patent/CA2707456A1/en not_active Abandoned
-
2010
- 2010-04-26 IL IL205354A patent/IL205354A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009077357A1 (en) | 2009-06-25 |
| CN101896486A (zh) | 2010-11-24 |
| EP2229396B1 (de) | 2011-08-10 |
| JP2011506380A (ja) | 2011-03-03 |
| BRPI0821255A2 (pt) | 2015-06-16 |
| IL205354A0 (en) | 2010-12-30 |
| AU2008337651A1 (en) | 2009-06-25 |
| EP2229396A1 (de) | 2010-09-22 |
| CA2707456A1 (en) | 2009-06-25 |
| MX2010006107A (es) | 2010-06-25 |
| US20090156610A1 (en) | 2009-06-18 |
| KR20100076037A (ko) | 2010-07-05 |
| US8134001B2 (en) | 2012-03-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |