DK2235017T3 - Spiroindolinonderivater som anticancermidler - Google Patents

Spiroindolinonderivater som anticancermidler

Info

Publication number: DK2235017T3
Authority: DK; Denmark
Prior art keywords: anticancer agents; spiroindolinone derivatives; spiroindolinone; derivatives; agents
Prior art date: 2007-12-19

Application number

DK08863724.4T

Other languages

English (en)

Inventor

Li Chen

Xingchun Han

Yun He

Zhuming Zhang

Song Yang

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-12-19

Filing date

2008-12-09

Publication date

2011-10-24

2008-12-09 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2011-10-24 Application granted granted Critical

2011-10-24 Publication of DK2235017T3 publication Critical patent/DK2235017T3/da

Links

239000002246 antineoplastic agent Substances 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
230000001028 anti-proliverative effect Effects 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Oncology (AREA)
Urology & Nephrology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)

DK08863724.4T 2007-12-19 2008-12-09 Spiroindolinonderivater som anticancermidler DK2235017T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US1488807P	2007-12-19	2007-12-19
US10738108P	2008-10-22	2008-10-22
PCT/EP2008/067061 WO2009080488A1 (en)	2007-12-19	2008-12-09	Spiroindolinone derivatives as anticancer agents

Publications (1)

Publication Number	Publication Date
DK2235017T3 true DK2235017T3 (da)	2011-10-24

Family

ID=40351961

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK08863724.4T DK2235017T3 (da)	2007-12-19	2008-12-09	Spiroindolinonderivater som anticancermidler

Country Status (16)

Country	Link
US (1)	US7776875B2 (da)
EP (1)	EP2235017B1 (da)
JP (1)	JP2011506524A (da)
KR (1)	KR20100076075A (da)
CN (1)	CN101903388A (da)
AT (1)	ATE524470T1 (da)
AU (1)	AU2008340473A1 (da)
BR (1)	BRPI0820699A2 (da)
CA (1)	CA2708312A1 (da)
DK (1)	DK2235017T3 (da)
ES (1)	ES2372903T3 (da)
IL (1)	IL205506A0 (da)
MX (1)	MX2010006332A (da)
PL (1)	PL2235017T3 (da)
PT (1)	PT2235017E (da)
WO (1)	WO2009080488A1 (da)

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ES2624808T3 (es)	2011-05-11	2017-07-17	The Regents Of The University Of Michigan	Antagonistas de MDM2 espirooxindólicos
AU2012316055B2 (en)	2011-09-27	2016-05-12	Amgen Inc.	Heterocyclic compounds as MDM2 inhibitors for the treatment of cancer
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US9802900B2 (en)	2013-03-15	2017-10-31	Global Blood Therapeutics, Inc.	Bicyclic heteroaryl compounds and uses thereof for the modulation of hemoglobin
US8952171B2 (en)	2013-03-15	2015-02-10	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
US9604999B2 (en)	2013-03-15	2017-03-28	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
US9422279B2 (en)	2013-03-15	2016-08-23	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en)	2013-03-15	2019-04-23	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
AU2014237330A1 (en)	2013-03-15	2015-09-17	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
MA53572A1 (fr)	2013-06-10	2021-10-29	Amgen Inc	Procédés de production et formes cristallines d'un inhibiteur mdm2
EA201992707A1 (ru)	2013-11-18	2020-06-30	Глобал Блад Терапьютикс, Инк.	Соединения и их применения для модуляции гемоглобина
SI3102208T2 (sl)	2014-02-07	2024-10-30	Global Blood Therapeutics, Inc.	Kristalinični polimorf proste baze 2-hidroksi-6-((2-(1-izopropil-1H-pirazol-5-IL)piridin-3-IL)metoksi)- benzaldehida
JP6503386B2 (ja)	2014-07-03	2019-04-17	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	ＭＤＭ２−ｐ５３阻害剤としての新しいスピロ［３Ｈ−インドール−３，２’−ピロリジン］−２（１Ｈ）−オン化合物および誘導体
ES2739697T3 (es)	2014-08-21	2020-02-03	Boehringer Ingelheim Int	Nuevos compuestos y derivados de espiro[3H-indol-3,2-pirrolidin]-2(1H)-ona como inhibidores de MDM2-p53
EP3260119B1 (en)	2015-02-20	2023-11-15	Daiichi Sankyo Company, Limited	Combination method for treating cancer
MA41841A (fr)	2015-03-30	2018-02-06	Global Blood Therapeutics Inc	Composés aldéhyde pour le traitement de la fibrose pulmonaire, de l'hypoxie, et de maladies auto-immunes et des tissus conjonctifs
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AR108435A1 (es)	2016-05-12	2018-08-22	Global Blood Therapeutics Inc	Proceso para sintetizar 2-hidroxi-6-((2-(1-isopropil-1h-pirazol-5-il)-piridin-3-il)metoxi)benzaldehído
CN118436801A (zh)	2016-05-20	2024-08-06	豪夫迈·罗氏有限公司	Protac抗体缀合物及其使用方法
TWI778983B (zh)	2016-10-12	2022-10-01	美商全球血液治療公司	包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
EP3527226A4 (en)	2016-10-17	2020-06-17	Daiichi Sankyo Company, Limited	COMBINATION THERAPY PROCEDURE WITH MDM2 INHIBITOR AND DNA METHYL TRANSFERASE INHIBITOR
EP3511334A1 (en) *	2018-01-16	2019-07-17	Adamed sp. z o.o.	1,2,3',5'-tetrahydro-2'h-spiro[indole-3,1'-pyrrolo[3,4-c]pyrrole]-2,3'-dione compounds as therapeutic agents activating tp53
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JP2022514253A (ja) *	2018-12-18	2022-02-10	ノバルティスアーゲー	Ｎ－（ピリジン－２－イルスルホニル）シクロプロパンカルボキサミド誘導体及びｃｆｔｒ媒介疾患の処置におけるその使用
WO2020163689A1 (en)	2019-02-08	2020-08-13	University Of Pittsburgh - Of The Commonwealth System Of Higher Education	20-hete formation inhibitors
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2008
- 2008-11-18 US US12/273,035 patent/US7776875B2/en not_active Expired - Fee Related
- 2008-12-09 PL PL08863724T patent/PL2235017T3/pl unknown
- 2008-12-09 ES ES08863724T patent/ES2372903T3/es active Active
- 2008-12-09 AT AT08863724T patent/ATE524470T1/de active
- 2008-12-09 KR KR1020107013353A patent/KR20100076075A/ko not_active Abandoned
- 2008-12-09 CA CA2708312A patent/CA2708312A1/en not_active Abandoned
- 2008-12-09 AU AU2008340473A patent/AU2008340473A1/en not_active Abandoned
- 2008-12-09 WO PCT/EP2008/067061 patent/WO2009080488A1/en not_active Ceased
- 2008-12-09 CN CN2008801217831A patent/CN101903388A/zh active Pending
- 2008-12-09 PT PT08863724T patent/PT2235017E/pt unknown
- 2008-12-09 MX MX2010006332A patent/MX2010006332A/es active IP Right Grant
- 2008-12-09 BR BRPI0820699A patent/BRPI0820699A2/pt not_active IP Right Cessation
- 2008-12-09 DK DK08863724.4T patent/DK2235017T3/da active
- 2008-12-09 EP EP08863724A patent/EP2235017B1/en not_active Not-in-force
- 2008-12-09 JP JP2010538565A patent/JP2011506524A/ja active Pending
2010
- 2010-05-03 IL IL205506A patent/IL205506A0/en unknown

Also Published As

Publication number	Publication date
PL2235017T3 (pl)	2012-02-29
WO2009080488A1 (en)	2009-07-02
MX2010006332A (es)	2010-07-05
JP2011506524A (ja)	2011-03-03
KR20100076075A (ko)	2010-07-05
EP2235017A1 (en)	2010-10-06
EP2235017B1 (en)	2011-09-14
CA2708312A1 (en)	2009-07-02
ATE524470T1 (de)	2011-09-15
US20090163512A1 (en)	2009-06-25
US7776875B2 (en)	2010-08-17
CN101903388A (zh)	2010-12-01
BRPI0820699A2 (pt)	2019-09-24
IL205506A0 (en)	2010-12-30
ES2372903T3 (es)	2012-01-27
AU2008340473A1 (en)	2009-07-02
PT2235017E (pt)	2011-10-13

Publication	Publication Date	Title
BRPI0820699A2 (pt)	2019-09-24	derivados de espieoindolina
ATE519764T1 (de)	2011-08-15	Spiroindolinon-derivate
ATE495176T1 (de)	2011-01-15	Spiroindolinon-derivate
TW200801000A (en)	2008-01-01	Spiroindolinone derivatives
MY160424A (en)	2017-03-15	Substituted pyrrolidine-2-carboxyamides.
MX2012009186A (es)	2012-08-23	Pirrolidina-2-carboxamidas sustituidas.
MX2011008176A (es)	2011-08-17	Derivados de 3,3'-espiroindolinona como agentes anticancerigenos.
IN2012DN02487A (da)	2015-08-28
CR9980A (es)	2008-06-18	Imidazolinas 4,4,5,5 tetrasustituidas
CR20170159A (es)	2017-06-26	Nuevos compuestos tricíclicos
HRP20120323T1 (en)	2012-05-31	Diarylhydantoin compounds
MX2011007886A (es)	2011-08-15	Derivado de espiroindolinona piridina.
EA201000544A1 (ru)	2010-10-29	Производные спирогетероциклического пирролидиндиона, применимые в качестве пестицидов
MX2014014229A (es)	2015-02-17	Pirrolidina-2-carboxamidas sustituidas.
EA201270540A1 (ru)	2012-09-28	Макроциклические ингибиторы интегразы
WO2007117465A3 (en)	2008-08-28	Indazole compounds
WO2007084728A3 (en)	2008-01-17	2-imino-benzimidazoles
ATE528290T1 (de)	2011-10-15	Spiroindolinon-derivate
EP2581372A4 (en)	2013-12-04	CYANOCHINOLINDERIVATE
EA201170132A1 (ru)	2011-08-30	5-гетероциклилалкил-3-гидрокси-2-фенилциклопент-2-еноны в качестве гербицидов
EP2578587A4 (en)	2013-12-04	PYRAZOLE DERIVATIVES
NO20084543L (no)	2008-10-21	Benzimidazolderivater
MX2014015345A (es)	2015-03-05	Inhibidores piranopiridona de tanquirasa.
MY152557A (en)	2014-10-31	3-aminocyclopentanecarboxamides as chemokine receptor modulators
ATE469647T1 (de)	2010-06-15	Thienoä3,2-cüpyridin-7-carbonsäure-derivate