DK2235017T3 - Spiroindolinonderivater som anticancermidler - Google Patents

Spiroindolinonderivater som anticancermidler

Info

Publication number: DK2235017T3
Authority: DK; Denmark
Prior art keywords: anticancer agents; spiroindolinone derivatives; spiroindolinone; derivatives; agents
Prior art date: 2007-12-19

Application number

DK08863724.4T

Other languages

English (en)

Inventor

Li Chen

Xingchun Han

Yun He

Zhuming Zhang

Song Yang

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-12-19

Filing date

2008-12-09

Publication date

2011-10-24

2008-12-09 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2011-10-24 Application granted granted Critical

2011-10-24 Publication of DK2235017T3 publication Critical patent/DK2235017T3/da

Links

239000002246 antineoplastic agent Substances 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
230000001028 anti-proliverative effect Effects 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Oncology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Indole Compounds (AREA)

DK08863724.4T 2007-12-19 2008-12-09 Spiroindolinonderivater som anticancermidler DK2235017T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US1488807P	2007-12-19	2007-12-19
US10738108P	2008-10-22	2008-10-22
PCT/EP2008/067061 WO2009080488A1 (en)	2007-12-19	2008-12-09	Spiroindolinone derivatives as anticancer agents

Publications (1)

Publication Number	Publication Date
DK2235017T3 true DK2235017T3 (da)	2011-10-24

Family

ID=40351961

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK08863724.4T DK2235017T3 (da)	2007-12-19	2008-12-09	Spiroindolinonderivater som anticancermidler

Country Status (16)

Country	Link
US (1)	US7776875B2 (da)
EP (1)	EP2235017B1 (da)
JP (1)	JP2011506524A (da)
KR (1)	KR20100076075A (da)
CN (1)	CN101903388A (da)
AT (1)	ATE524470T1 (da)
AU (1)	AU2008340473A1 (da)
BR (1)	BRPI0820699A2 (da)
CA (1)	CA2708312A1 (da)
DK (1)	DK2235017T3 (da)
ES (1)	ES2372903T3 (da)
IL (1)	IL205506A0 (da)
MX (1)	MX2010006332A (da)
PL (1)	PL2235017T3 (da)
PT (1)	PT2235017E (da)
WO (1)	WO2009080488A1 (da)

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US8629141B2 (en)	2011-05-11	2014-01-14	The Regents Of The University Of Michigan	Spiro-oxindole MDM2 antagonists
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US9604999B2 (en)	2013-03-15	2017-03-28	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
US8952171B2 (en)	2013-03-15	2015-02-10	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
CN105073728A (zh)	2013-03-15	2015-11-18	全球血液疗法股份有限公司	化合物及其用于调节血红蛋白的用途
US9422279B2 (en)	2013-03-15	2016-08-23	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
US10266551B2 (en)	2013-03-15	2019-04-23	Global Blood Therapeutics, Inc.	Compounds and uses thereof for the modulation of hemoglobin
MX379235B (es)	2013-03-15	2025-03-11	Global Blood Therapeutics Inc	Compuestos y sus usos para modular la hemoglobina.
CN105358530A (zh)	2013-06-10	2016-02-24	美国安进公司	制备mdm2抑制剂的方法及其结晶形式
EA201992707A1 (ru)	2013-11-18	2020-06-30	Глобал Блад Терапьютикс, Инк.	Соединения и их применения для модуляции гемоглобина
CN114181195A (zh)	2014-02-07	2022-03-15	全球血液疗法股份有限公司	一种化合物的结晶多晶型物
JP6503386B2 (ja)	2014-07-03	2019-04-17	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	ＭＤＭ２−ｐ５３阻害剤としての新しいスピロ［３Ｈ−インドール−３，２’−ピロリジン］−２（１Ｈ）−オン化合物および誘導体
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TWI663160B (zh)	2016-05-12	2019-06-21	全球血液治療公司	用於合成2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)-吡啶-3-基)甲氧基)苯甲醛之方法
EP3458101B1 (en)	2016-05-20	2020-12-30	H. Hoffnabb-La Roche Ag	Protac antibody conjugates and methods of use
TW202332423A (zh)	2016-10-12	2023-08-16	美商全球血液治療公司	包含2-羥基-6-((2-(1-異丙基-1h-吡唑-5-基)吡啶-3-基)甲氧基)-苯甲醛之片劑
US20190240210A1 (en)	2016-10-17	2019-08-08	Daiichi Sankyo Company, Limited	Treatment Method by Combined Use of MDM2 Inhibitor and DNA Methyltransferase Inhibitor
EP3511334A1 (en) *	2018-01-16	2019-07-17	Adamed sp. z o.o.	1,2,3',5'-tetrahydro-2'h-spiro[indole-3,1'-pyrrolo[3,4-c]pyrrole]-2,3'-dione compounds as therapeutic agents activating tp53
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2008
- 2008-11-18 US US12/273,035 patent/US7776875B2/en not_active Expired - Fee Related
- 2008-12-09 BR BRPI0820699A patent/BRPI0820699A2/pt not_active IP Right Cessation
- 2008-12-09 WO PCT/EP2008/067061 patent/WO2009080488A1/en not_active Ceased
- 2008-12-09 MX MX2010006332A patent/MX2010006332A/es active IP Right Grant
- 2008-12-09 CN CN2008801217831A patent/CN101903388A/zh active Pending
- 2008-12-09 PT PT08863724T patent/PT2235017E/pt unknown
- 2008-12-09 PL PL08863724T patent/PL2235017T3/pl unknown
- 2008-12-09 AU AU2008340473A patent/AU2008340473A1/en not_active Abandoned
- 2008-12-09 ES ES08863724T patent/ES2372903T3/es active Active
- 2008-12-09 JP JP2010538565A patent/JP2011506524A/ja active Pending
- 2008-12-09 DK DK08863724.4T patent/DK2235017T3/da active
- 2008-12-09 CA CA2708312A patent/CA2708312A1/en not_active Abandoned
- 2008-12-09 EP EP08863724A patent/EP2235017B1/en not_active Not-in-force
- 2008-12-09 AT AT08863724T patent/ATE524470T1/de active
- 2008-12-09 KR KR1020107013353A patent/KR20100076075A/ko not_active Abandoned
2010
- 2010-05-03 IL IL205506A patent/IL205506A0/en unknown

Also Published As

Publication number	Publication date
CN101903388A (zh)	2010-12-01
WO2009080488A1 (en)	2009-07-02
ES2372903T3 (es)	2012-01-27
BRPI0820699A2 (pt)	2019-09-24
AU2008340473A1 (en)	2009-07-02
EP2235017A1 (en)	2010-10-06
ATE524470T1 (de)	2011-09-15
EP2235017B1 (en)	2011-09-14
IL205506A0 (en)	2010-12-30
JP2011506524A (ja)	2011-03-03
PL2235017T3 (pl)	2012-02-29
US20090163512A1 (en)	2009-06-25
PT2235017E (pt)	2011-10-13
CA2708312A1 (en)	2009-07-02
US7776875B2 (en)	2010-08-17
MX2010006332A (es)	2010-07-05
KR20100076075A (ko)	2010-07-05

Publication	Publication Date	Title
DK2235017T3 (da)	2011-10-24	Spiroindolinonderivater som anticancermidler
ATE519764T1 (de)	2011-08-15	Spiroindolinon-derivate
ATE495176T1 (de)	2011-01-15	Spiroindolinon-derivate
TW200801000A (en)	2008-01-01	Spiroindolinone derivatives
MY160424A (en)	2017-03-15	Substituted pyrrolidine-2-carboxyamides.
MX2012009186A (es)	2012-08-23	Pirrolidina-2-carboxamidas sustituidas.
MX2011008176A (es)	2011-08-17	Derivados de 3,3'-espiroindolinona como agentes anticancerigenos.
IN2012DN02487A (da)	2015-08-28
CR9980A (es)	2008-06-18	Imidazolinas 4,4,5,5 tetrasustituidas
CR20170159A (es)	2017-06-26	Nuevos compuestos tricíclicos
WO2008005368A3 (en)	2009-02-26	Piperazines as p2x7 antagonists
HRP20120323T1 (en)	2012-05-31	Diarylhydantoin compounds
MX2011007886A (es)	2011-08-15	Derivado de espiroindolinona piridina.
EA201000544A1 (ru)	2010-10-29	Производные спирогетероциклического пирролидиндиона, применимые в качестве пестицидов
MX2014014229A (es)	2015-02-17	Pirrolidina-2-carboxamidas sustituidas.
MY156319A (en)	2016-02-15	Spiroheterocyclic n-oxypiperidines as pesticides
EA201270540A1 (ru)	2012-09-28	Макроциклические ингибиторы интегразы
WO2009057079A3 (en)	2009-12-03	Novel pyrimidine derivatives
WO2007084728A3 (en)	2008-01-17	2-imino-benzimidazoles
ATE528290T1 (de)	2011-10-15	Spiroindolinon-derivate
EP2581372A4 (en)	2013-12-04	CYANOCHINOLINDERIVATE
EP2578587A4 (en)	2013-12-04	PYRAZOLE DERIVATIVES
NO20084543L (no)	2008-10-21	Benzimidazolderivater
MX2014015345A (es)	2015-03-05	Inhibidores piranopiridona de tanquirasa.
MY152557A (en)	2014-10-31	3-aminocyclopentanecarboxamides as chemokine receptor modulators