ATE520713T1 - Identifizierung und veränderung von immundominanten polypeptidepitopen - Google Patents

Identifizierung und veränderung von immundominanten polypeptidepitopen

Info

Publication number
ATE520713T1
ATE520713T1 AT01988732T AT01988732T ATE520713T1 AT E520713 T1 ATE520713 T1 AT E520713T1 AT 01988732 T AT01988732 T AT 01988732T AT 01988732 T AT01988732 T AT 01988732T AT E520713 T1 ATE520713 T1 AT E520713T1
Authority
AT
Austria
Prior art keywords
polypeptides
immunodominant
alteration
identification
immunodominant epitopes
Prior art date
Application number
AT01988732T
Other languages
English (en)
Inventor
Eugen Koren
John Lowe
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Application granted granted Critical
Publication of ATE520713T1 publication Critical patent/ATE520713T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT01988732T 2000-10-27 2001-06-04 Identifizierung und veränderung von immundominanten polypeptidepitopen ATE520713T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24391300P 2000-10-27 2000-10-27
US09/872,702 US6673580B2 (en) 2000-10-27 2001-06-01 Identification and modification of immunodominant epitopes in polypeptides
PCT/US2001/040846 WO2002034779A1 (en) 2000-10-27 2001-06-04 Identification and modification of immunodominant epitopes in polypeptides

Publications (1)

Publication Number Publication Date
ATE520713T1 true ATE520713T1 (de) 2011-09-15

Family

ID=26936187

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01988732T ATE520713T1 (de) 2000-10-27 2001-06-04 Identifizierung und veränderung von immundominanten polypeptidepitopen

Country Status (7)

Country Link
US (2) US6673580B2 (de)
EP (1) EP1328547B1 (de)
AT (1) ATE520713T1 (de)
AU (1) AU2002245756A1 (de)
CA (1) CA2422953A1 (de)
DK (1) DK1328547T3 (de)
WO (1) WO2002034779A1 (de)

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EP2412816B1 (de) 2004-07-26 2014-12-03 Pfenex Inc. Verfahren zur verbesserten Proteinexpression durch Strain-Engineering
EP1789074A4 (de) * 2004-08-09 2009-08-12 Alios Biopharma Inc Synthetische hyperglycosylierte, protease-resistente polypeptid-varianten, orale formulierungen und anwendungsverfahren dafür
US7597884B2 (en) 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
AU2006231473B2 (en) 2005-04-04 2012-01-12 Idexx Laboratories, Inc. Ehrlichia canis DIVA (differentiate infected from vaccinated animals)
WO2006105993A2 (en) * 2005-04-05 2006-10-12 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Method for shielding functional sites or epitopes on proteins
EP1792996A1 (de) * 2005-12-01 2007-06-06 Consejo Superior de Investigaciones Cientificas Nukleinsäuren, kodierend für Impfstoffe gegen den reproduktiven und respiratorischen Syndrom Virus (prrsv)
WO2007109243A2 (en) * 2006-03-20 2007-09-27 Duramed Pharmaceuticals, Inc. Methods for comparing the immunogenicity of products and uses thereof
US9580719B2 (en) 2007-04-27 2017-02-28 Pfenex, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
EP2615172A1 (de) 2007-04-27 2013-07-17 Pfenex Inc. Schnellscreeningverfahren für Bakterienwirte zur Identifizierung bestimmter Stämme mit verbessertem Ertrag und/oder verbesserter Qualität bei der Expression heterologer Proteine
ES2720363T3 (es) 2007-10-31 2019-07-19 Idexx Lab Inc Ehrlichia canis DIVA (de diferenciación entre animales infectados y vacunados)
JP2012508014A (ja) * 2008-11-04 2012-04-05 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Ｃｒｈｒ２ペプチド作動薬及びその使用
BRPI1015424B1 (pt) 2009-06-22 2022-01-18 Burnham Institute For Medical Research Composição compreendendo um elemento cendr e uma co-composição e composição para uso no reforço da internalização, penetração, ou ambas, de uma co-composição
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WO2012118778A1 (en) 2011-02-28 2012-09-07 Sanford-Burnham Medical Research Institute Truncated car peptides and methods and compositions using truncated car peptides
WO2012166585A2 (en) 2011-05-31 2012-12-06 Airware, Inc. Re-calibration of ab ndir gas sensors
US10179801B2 (en) 2011-08-26 2019-01-15 Sanford-Burnham Medical Research Institute Truncated LYP-1 peptides and methods and compositions using truncated LYP-1 peptides
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EP3370065A1 (de) 2017-03-03 2018-09-05 Treos Bio Kft Immunogene peptide
MA53543A (fr) 2018-09-04 2021-07-14 Treos Bio Ltd Vaccins peptidiques
GB202004974D0 (en) 2020-04-03 2020-05-20 Treos Bio Ltd Coronavirus vaccine

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Also Published As

Publication number Publication date
EP1328547A1 (de) 2003-07-23
AU2002245756A1 (en) 2002-05-06
US20040209324A1 (en) 2004-10-21
US20030077756A1 (en) 2003-04-24
WO2002034779A1 (en) 2002-05-02
CA2422953A1 (en) 2002-05-02
US6673580B2 (en) 2004-01-06
DK1328547T3 (da) 2011-10-31
EP1328547B1 (de) 2011-08-17

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