ATE521611T1 - 1,4-dihydropyridin-kondensierte heterozyklen, herstellungsverfahren dafür, verwendung und zusammensetzungen damit - Google Patents

1,4-dihydropyridin-kondensierte heterozyklen, herstellungsverfahren dafür, verwendung und zusammensetzungen damit

Info

Publication number
ATE521611T1
ATE521611T1 AT06808922T AT06808922T ATE521611T1 AT E521611 T1 ATE521611 T1 AT E521611T1 AT 06808922 T AT06808922 T AT 06808922T AT 06808922 T AT06808922 T AT 06808922T AT E521611 T1 ATE521611 T1 AT E521611T1
Authority
AT
Austria
Prior art keywords
dihydropyridine
compositions
production method
condensed heterocycles
heterocycles
Prior art date
Application number
AT06808922T
Other languages
English (en)
Inventor
Jacques Mauger
Anil Nair
Nina Ma
Kirsten Bjergarde
Bruno Filoche-Romme
Odile Angouillant-Boniface
Serge Mignani
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Application granted granted Critical
Publication of ATE521611T1 publication Critical patent/ATE521611T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT06808922T 2005-07-20 2006-07-18 1,4-dihydropyridin-kondensierte heterozyklen, herstellungsverfahren dafür, verwendung und zusammensetzungen damit ATE521611T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05291558A EP1746097B1 (de) 2005-07-20 2005-07-20 1,4-Dihydropyridine-kondensierte Heterocyclen Verfahren zu deren Herstellung sowie Verwendung und Zusammensetzungen dergleichen
PCT/IB2006/002734 WO2007012972A2 (en) 2005-07-20 2006-07-18 1,4-dihydropyridine-fused heterocycles, process for preparing the same, use and compositions containing them

Publications (1)

Publication Number Publication Date
ATE521611T1 true ATE521611T1 (de) 2011-09-15

Family

ID=35510894

Family Applications (2)

Application Number Title Priority Date Filing Date
AT05291558T ATE455115T1 (de) 2005-07-20 2005-07-20 1,4-dihydropyridine-kondensierte heterocyclen verfahren zu deren herstellung sowie verwendung und zusammensetzungen dergleichen
AT06808922T ATE521611T1 (de) 2005-07-20 2006-07-18 1,4-dihydropyridin-kondensierte heterozyklen, herstellungsverfahren dafür, verwendung und zusammensetzungen damit

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT05291558T ATE455115T1 (de) 2005-07-20 2005-07-20 1,4-dihydropyridine-kondensierte heterocyclen verfahren zu deren herstellung sowie verwendung und zusammensetzungen dergleichen

Country Status (37)

Country Link
US (1) US8163768B2 (de)
EP (2) EP1746097B1 (de)
JP (2) JP2009501778A (de)
KR (1) KR101286796B1 (de)
CN (1) CN101243087B (de)
AR (1) AR054845A1 (de)
AT (2) ATE455115T1 (de)
AU (1) AU2006273692B8 (de)
BR (1) BRPI0614002A2 (de)
CA (1) CA2615700C (de)
CR (1) CR9663A (de)
CY (1) CY1109964T1 (de)
DE (1) DE602005018911D1 (de)
DK (1) DK1746097T3 (de)
DO (1) DOP2006000175A (de)
EA (1) EA016815B1 (de)
EC (1) ECSP078062A (de)
ES (1) ES2339676T3 (de)
HN (1) HN2008000088A (de)
HR (1) HRP20100195T1 (de)
IL (1) IL188861A0 (de)
MA (1) MA29634B1 (de)
MX (1) MX2008000902A (de)
MY (1) MY148617A (de)
NO (1) NO20080831L (de)
NZ (1) NZ592766A (de)
PE (2) PE20070212A1 (de)
PL (1) PL1746097T3 (de)
PT (1) PT1746097E (de)
RS (1) RS51351B (de)
SI (1) SI1746097T1 (de)
TN (1) TNSN08020A1 (de)
TW (1) TWI386411B (de)
UA (1) UA98928C2 (de)
UY (1) UY29685A1 (de)
WO (1) WO2007012972A2 (de)
ZA (1) ZA200800542B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2945535B1 (fr) * 2009-05-18 2011-06-10 Sanofi Aventis Compose anticancereux et composition pharmaceutique le contenant
FR2967413A1 (fr) * 2010-11-17 2012-05-18 Sanofi Aventis Compose 8-oxo-9-[3-(1h-benzimidazol-2-yloxy)-phenyl]-4,5,6,7,8,9-hexahydro-2h-pyrrolo[3,4-b]quinoline-3-carboxylate d'ethyle, sel, forme cristalline, co-cristal, formulation, procedes de preparation, application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteur des kinases aurora.
US9340537B2 (en) 2012-05-15 2016-05-17 Novatis Ag Benzamide derivatives for inhibiting the activity of ABL1, ABL2 and BCR-ABL1
US9278981B2 (en) 2012-05-15 2016-03-08 Novartis Ag Compounds and compositions for inhibiting the activity of ABL1, ABL2 and BCR-ABL1
JP6080947B2 (ja) 2012-05-15 2017-02-15 ノバルティス アーゲー Ａｂｌ１、ａｂｌ２およびｂｃｒ−ａｂｌ１の活性を阻害するための化合物および組成物
PT2861579T (pt) 2012-05-15 2018-04-27 Novartis Ag Derivados de benzamida para inibir a atividade de abl1, abl2 e bcr-abl
HUE043853T2 (hu) 2012-10-12 2019-09-30 Broad Inst Inc GSK3 inhibitorok és eljárások azok alkalmazására
CA2968884A1 (en) * 2014-12-10 2016-06-16 Massachusetts Institute Of Technology Fused 1,3-azole derivatives useful for the treatment of proliferative diseases
WO2016176657A1 (en) 2015-04-30 2016-11-03 Memorial Sloan-Kettering Cancer Center Mitragynine analogs and uses thereof
RU2619932C1 (ru) * 2015-11-25 2017-05-22 федеральное государственное бюджетное образовательное учреждение высшего образования "Воронежский государственный университет" (ФГБОУ ВО "ВГУ") ЗАМЕЩЕННЫЕ ПИРАЗОЛО[1,5-а]ПИРИДО[3,4-е]ПИРИМИДИНЫ И ИХ ИСПОЛЬЗОВАНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ ПРОТЕИНКИНАЗ
US11180492B2 (en) 2016-01-15 2021-11-23 University Of Central Florida Research Foundation, Inc. Anti-parasitic compounds and uses thereof
MX2018009913A (es) 2016-02-16 2018-11-29 Massachusetts Inst Technology Aglutinantes max como moduladores myc y sus usos.
WO2018187630A1 (en) 2017-04-05 2018-10-11 The Broad Institute, Inc. Tricyclic compounds as glycogen synthase kinase 3 (gsk3) inhibitors and uses thereof
EP3621951A4 (de) * 2017-05-12 2021-01-27 Research Triangle Institute Diarylharnstoffe als cb1-allosterische modulatoren

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69837282T2 (de) * 1997-12-13 2007-11-08 Bristol-Myers Squibb Co. VERWENDUNG VON PYRAZOLO Ä 3,4-bÜ PYRIDIN ALS CYCLIN-ABHÄNGIGE KINASE HEMMER
CA2391291A1 (en) 1999-11-19 2001-05-25 Abbott Laboratories Tricyclic dihydropyrimidine potassium channel openers
WO2001066544A2 (en) 2000-03-03 2001-09-13 Abbott Laboratories Tricyclic dihydropyrazolone and tricyclic dihydroisoxazolone potassium channel openers
US6538004B2 (en) 2000-03-03 2003-03-25 Abbott Laboratories Tricyclic dihydropyrazolone and tricyclic dihydroisoxazolone potassium channel openers
CA2437215A1 (en) 2001-02-02 2002-08-15 Mitsubishi Pharma Corporation Dihydropyrazolopyridine compounds and pharmaceutical use thereof
FR2823854A1 (fr) 2001-04-18 2002-10-25 Centre Nat Rech Scient Nouveau procede de criblage d'inhibiteurs de la liaison entre la proteine oxyde nitrique synthase neuronale et la proteine inhibitrice de l'oxyde nitrique synthase neuronale
FR2825091B1 (fr) * 2001-05-23 2003-07-04 Servier Lab Nouveaux derives tricycliques de dihydro-quinnoleines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US7037902B2 (en) * 2002-07-03 2006-05-02 Receptron, Inc. Affinity small molecules for the EPO receptor
SE0301371D0 (sv) 2003-05-09 2003-05-09 Astrazeneca Ab New Compounds
CA2528938A1 (en) * 2003-06-13 2005-02-24 Zentaris Gmbh Compounds having inhibitive activity of phosphatidylinositol 3-kinase and methods of use thereof

Also Published As

Publication number Publication date
CY1109964T1 (el) 2014-09-10
EA200800374A1 (ru) 2008-08-29
ZA200800542B (en) 2010-02-24
RS51351B (sr) 2011-02-28
CN101243087A (zh) 2008-08-13
SI1746097T1 (sl) 2010-05-31
HRP20100195T1 (hr) 2010-05-31
PT1746097E (pt) 2010-04-15
PE20070212A1 (es) 2007-03-21
CA2615700C (en) 2013-06-18
AU2006273692A1 (en) 2007-02-01
EA016815B1 (ru) 2012-07-30
KR20080026658A (ko) 2008-03-25
UA98928C2 (ru) 2012-07-10
JP2009501778A (ja) 2009-01-22
WO2007012972A3 (en) 2007-04-05
CR9663A (es) 2008-02-21
WO2007012972A2 (en) 2007-02-01
CN101243087B (zh) 2013-07-24
TWI386411B (zh) 2013-02-21
DK1746097T3 (da) 2010-05-25
BRPI0614002A2 (pt) 2011-03-01
CA2615700A1 (en) 2007-02-01
UY29685A1 (es) 2007-02-28
HN2008000088A (es) 2011-05-31
US8163768B2 (en) 2012-04-24
EP1746097B1 (de) 2010-01-13
AU2006273692B2 (en) 2012-11-22
KR101286796B1 (ko) 2013-07-17
AU2006273692A8 (en) 2012-12-13
DE602005018911D1 (de) 2010-03-04
EP1910366A2 (de) 2008-04-16
MY148617A (en) 2013-05-15
TW200740812A (en) 2007-11-01
NZ592766A (en) 2012-12-21
PE20100718A1 (es) 2010-10-20
EP1746097A1 (de) 2007-01-24
ECSP078062A (es) 2008-01-23
US20080261969A1 (en) 2008-10-23
AR054845A1 (es) 2007-07-18
PL1746097T3 (pl) 2010-06-30
MX2008000902A (es) 2008-03-26
AU2006273692B8 (en) 2012-12-13
TNSN08020A1 (en) 2009-07-14
MA29634B1 (fr) 2008-07-01
ES2339676T3 (es) 2010-05-24
JP2013063987A (ja) 2013-04-11
NO20080831L (no) 2008-04-03
IL188861A0 (en) 2008-04-13
DOP2006000175A (es) 2007-03-31
EP1910366B1 (de) 2011-08-24
ATE455115T1 (de) 2010-01-15

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