ATE522523T1 - 1,3,5-trisubstituiertes triazolderivat - Google Patents
1,3,5-trisubstituiertes triazolderivatInfo
- Publication number
- ATE522523T1 ATE522523T1 AT08805280T AT08805280T ATE522523T1 AT E522523 T1 ATE522523 T1 AT E522523T1 AT 08805280 T AT08805280 T AT 08805280T AT 08805280 T AT08805280 T AT 08805280T AT E522523 T1 ATE522523 T1 AT E522523T1
- Authority
- AT
- Austria
- Prior art keywords
- triazole derivative
- trisubstituted
- trisubstituted triazole
- derivative
- triazole
- Prior art date
Links
- -1 1,3,5-TRISUBSTITUTED TRIAZOLE Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A61P25/10—Antiepileptics; Anticonvulsants for petit-mal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07118822 | 2007-10-18 | ||
| PCT/EP2008/063844 WO2009050185A1 (en) | 2007-10-18 | 2008-10-15 | 1,3,5-trisubstituted triazole derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE522523T1 true ATE522523T1 (de) | 2011-09-15 |
Family
ID=39047591
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08805280T ATE522523T1 (de) | 2007-10-18 | 2008-10-15 | 1,3,5-trisubstituiertes triazolderivat |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8404851B2 (de) |
| EP (1) | EP2205594B1 (de) |
| JP (1) | JP2011500624A (de) |
| CN (1) | CN101827839B (de) |
| AR (1) | AR068919A1 (de) |
| AT (1) | ATE522523T1 (de) |
| AU (1) | AU2008313775B2 (de) |
| CA (1) | CA2697982C (de) |
| CL (1) | CL2008003067A1 (de) |
| ES (1) | ES2371863T3 (de) |
| IL (1) | IL205102A (de) |
| JO (1) | JO2784B1 (de) |
| MX (1) | MX2010004176A (de) |
| PA (1) | PA8799901A1 (de) |
| PE (1) | PE20091080A1 (de) |
| RU (1) | RU2476433C2 (de) |
| TW (1) | TW200934491A (de) |
| WO (1) | WO2009050185A1 (de) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA97257C2 (en) * | 2006-10-19 | 2012-01-25 | Такеда Фармасьютикал Компани Лимитед | Indole derivatives |
| JP2011500625A (ja) * | 2007-10-18 | 2011-01-06 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | トリ置換された1,2,4−トリアゾール |
| MY152486A (en) * | 2008-03-19 | 2014-10-15 | Janssen Pharmaceutica Nv | Trisubstituted 1,2,4 - triazoles as nicotinic acetylcholine receptor modulators |
| WO2009135944A1 (en) * | 2008-05-09 | 2009-11-12 | Janssen Pharmaceutica Nv | Trisubstituted pyrazoles as acetylcholine receptor modulators |
| CA2825519A1 (en) | 2011-02-03 | 2012-09-08 | Lupin Limited | Pyrrole derivatives used as modulators of alpha7 nachr |
| RS55433B1 (sr) | 2011-02-23 | 2017-04-28 | Lupin Ltd | Derivati heteroarila kao modulatori nachr alfa7 |
| CN103402983B (zh) | 2011-02-25 | 2015-12-23 | 詹森药业有限公司 | 作为α7nAChR的别构调节剂的(吡啶-4-基)苄基酰胺 |
| AU2012235779B2 (en) | 2011-03-31 | 2017-03-02 | Lupin Limited | Pyrrole derivatives as nicotinic acetylcholine receptor modulators for use in the treatment of neurodegenerative disorders such as Alzheimer's and Parkinson's disease |
| US8946432B2 (en) | 2011-07-05 | 2015-02-03 | Lupin Limited | Biaryl derivatives as nAChR modulators |
| NZ629453A (en) | 2012-03-06 | 2016-04-29 | Lupin Ltd | Thiazole derivatives as alpha 7 nachr modulators |
| EP2945936A1 (de) | 2012-11-12 | 2015-11-25 | Lupin Limited | Thiazolderivate als alpha-7-nachr-modulatoren |
| EP2945941B1 (de) | 2013-01-16 | 2016-12-07 | Lupin Limited | Pyrrolderivate als alpha-7-nachr-modulatoren |
| US9617210B2 (en) | 2013-03-13 | 2017-04-11 | Lupin Limited | Pyrrole derivatives as alpha 7 NACHR modulators |
| TW201446243A (zh) | 2013-06-03 | 2014-12-16 | Lupin Ltd | 4-(5-(4-氯苯基)-2-(2-環丙基乙醯基)-1,4-二甲基-1氫-吡咯-3-基)苯磺醯胺作為α7尼古丁乙醯膽鹼受體調節劑 |
| WO2014203150A1 (en) | 2013-06-17 | 2014-12-24 | Lupin Limited | Pyrrole derivatives as alpha 7 nachr modulators |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE795907A (fr) * | 1972-02-25 | 1973-06-18 | Luso Farmaco Inst | 2-amino-4-arylthiazoles 5-substitues et leur preparation |
| DE3773746D1 (en) | 1986-05-07 | 1991-11-21 | Fisons Plc | Pyrazole. |
| JPS6339868A (ja) | 1986-08-04 | 1988-02-20 | Otsuka Pharmaceut Factory Inc | ジ低級アルキルフエノ−ル誘導体 |
| US4761422A (en) | 1986-11-20 | 1988-08-02 | Lusofarmaco Istituto Lusofarmaco D'italia Spa | (2-amino-4-aryl-thiazole-5-yl)ethanols and their derivatives having diuretic activity and methods for preparing the same |
| WO1996003392A1 (en) | 1994-07-27 | 1996-02-08 | G.D. Searle & Co. | Substituted thiazoles for the treatment of inflammation |
| BR9606546A (pt) | 1995-08-02 | 1998-07-14 | Uriach & Cia Sa J | Novas carboxamidas com atividade fungicida |
| FR2754258B1 (fr) | 1996-10-08 | 1998-12-31 | Sanofi Sa | Derives d'aminothiazole, leur procede de preparation et les compositions pharmaceutiques les contenant |
| US6187797B1 (en) * | 1996-12-23 | 2001-02-13 | Dupont Pharmaceuticals Company | Phenyl-isoxazoles as factor XA Inhibitors |
| ES2196396T3 (es) | 1996-12-23 | 2003-12-16 | Bristol Myers Squibb Pharma Co | Compuestos heteroaromaticos de 5 miembros conteniendo oxigeno o azufre como inhibidores del factor xa. |
| ATE257703T1 (de) | 1997-10-27 | 2004-01-15 | Takeda Chemical Industries Ltd | 1,3-thiazole als adenosine a3 rezeptor antagonisten zur behandlung von asthma, allergien und diabetes |
| FR2792314B1 (fr) | 1999-04-15 | 2001-06-01 | Adir | Nouveaux composes aminotriazoles, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| EP1070708B1 (de) * | 1999-07-21 | 2004-01-14 | F. Hoffmann-La Roche Ag | Triazolderivate |
| WO2001010865A1 (en) | 1999-08-06 | 2001-02-15 | Takeda Chemical Industries, Ltd. | p38MAP KINASE INHIBITORS |
| FR2802530B1 (fr) | 1999-12-17 | 2002-02-22 | Sanofi Synthelabo | Nouveaux derives amino substitues ramifies du 3-amino-1-phenyl-1h[1,2,4]triazole, procedes pour leur preparation et compositions pharmaceutiques les contenant |
| ATE414079T1 (de) | 2000-03-01 | 2008-11-15 | Janssen Pharmaceutica Nv | 2,4-disubstituierte thiazolyl derivate |
| AU2001249670A1 (en) | 2000-04-03 | 2001-10-15 | 3-Dimensional Pharmaceuticals, Inc. | Substituted thiazoles and the use thereof as inhibitors of plasminogen activatorinhibitor-1 |
| HUP0303038A2 (hu) | 2000-09-21 | 2003-12-29 | Bristol-Myers Squibb Co. | Szubsztituált azolszármazékok mint kortikotropin releasing faktor inhibitorok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk |
| GB0028383D0 (en) | 2000-11-21 | 2001-01-03 | Novartis Ag | Organic compounds |
| CA2432870A1 (en) | 2000-12-22 | 2002-07-25 | Ronghui Lin | Substituted triazole diamine derivatives as kinase inhibitors |
| EA007717B1 (ru) | 2001-08-13 | 2006-12-29 | Янссен Фармацевтика Н.В. | 2-амино-4,5-тризамещенные производные тиазолила |
| EP1441732A2 (de) * | 2001-11-08 | 2004-08-04 | Fujisawa Pharmaceutical Co., Ltd. | Thiazolderivat und seine pharmazeutische anwendung |
| CA2474322A1 (en) | 2002-01-25 | 2003-07-31 | Kylix Pharmaceuticals B.V. | 4(hetero-) aryl substituted (thia-/oxa-/pyra) zoles for inhibition of tie-2 |
| MXPA04004037A (es) * | 2002-01-28 | 2004-07-23 | Fuji Yakuhin Co Ltd | Compuestos novedosos de 1, 2, 4-de triazol. |
| ATE348831T1 (de) | 2002-05-07 | 2007-01-15 | Neurosearch As | Diazabicyclische biarylderivate |
| MXPA05000962A (es) * | 2002-07-29 | 2005-05-16 | Hoffmann La Roche | Nuevos benzodioxoles. |
| AR042052A1 (es) * | 2002-11-15 | 2005-06-08 | Vertex Pharma | Diaminotriazoles utiles como inhibidores de proteinquinasas |
| US20070191267A1 (en) | 2003-04-28 | 2007-08-16 | Ab Science | Use of tyrosine kinase inhibitors for treating cerebral ischemia |
| EP1628666B1 (de) | 2003-05-14 | 2015-09-23 | NeuroGenetic Pharmaceuticals, Inc. | Verbindungen und ihre verwendungen zur modulierung von amyloid beta |
| AU2004251668B2 (en) * | 2003-06-03 | 2008-03-20 | Triad Therapeutics, Inc | 5-membered heterocycle-based p-38 inhibitors |
| EP1648876A1 (de) * | 2003-07-24 | 2006-04-26 | Pharmagene Laboratories Ltd | 5-ht sb 2b/sb rezeptor-antagonisten |
| FR2862647B1 (fr) | 2003-11-25 | 2008-07-04 | Aventis Pharma Sa | Derives de pyrazolyle, procede de preparation et intermediaires de ce procede a titre de medicaments et de compositions pharmaceutiques les renfermant |
| GB0401336D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
| CN1942450A (zh) * | 2004-02-11 | 2007-04-04 | 詹森药业有限公司 | 取代三唑化合物的制备方法 |
| MX2007003154A (es) * | 2004-09-17 | 2007-05-15 | Vertex Pharma | Compuestos de diaminotriazol de utilidad como inhibidores de proteina quinasa. |
| ATE485042T1 (de) | 2004-10-21 | 2010-11-15 | Vertex Pharma | Triazole als hemmer von proteinkinasen |
| WO2006064375A2 (en) | 2004-12-16 | 2006-06-22 | Ab Science | Aminoaryl substituted five-membered ring heterocyclic compounds for the treatment of diseases |
| AU2006206611A1 (en) * | 2005-01-19 | 2006-07-27 | Bristol-Myers Squibb Company | 2-phenoxy-N- (1, 3 , 4-thiadizol-2-yl) pyridin-3-amine derivatives and related compounds as P2Y1 receptor inhibitors for the treatment of thromboembolic disorders |
| NZ566036A (en) * | 2005-09-13 | 2010-06-25 | Janssen Pharmaceutica Nv | 2-Aniline-4-aryl substituted thiazole derivatives that modulate the alpha7 nicotinic receptor |
| JO3019B1 (ar) * | 2006-04-19 | 2016-09-05 | Janssen Pharmaceutica Nv | ثلاثي مستبدل 4،2،1-ثلاثي زولات |
| JP2011500625A (ja) * | 2007-10-18 | 2011-01-06 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | トリ置換された1,2,4−トリアゾール |
| MY152486A (en) * | 2008-03-19 | 2014-10-15 | Janssen Pharmaceutica Nv | Trisubstituted 1,2,4 - triazoles as nicotinic acetylcholine receptor modulators |
| CL2009000916A1 (es) | 2008-04-17 | 2010-12-31 | Glaxo Group Ltd | Compuestos derivados de 2-trifluorometil-1h-indol-5-metilcarboxamida, moduladores del receptor nicotinico de acetilcolina alfa7 (nachr); composicon farmaceutica; y uso para el tratamiento del deterioro cognitivo y de un trastorno psicotico como esquizofrenia. |
| WO2009135944A1 (en) * | 2008-05-09 | 2009-11-12 | Janssen Pharmaceutica Nv | Trisubstituted pyrazoles as acetylcholine receptor modulators |
| CN102574832B (zh) * | 2009-09-17 | 2014-09-24 | 詹森药业有限公司 | 取代的n-苯基-1-(4-吡啶基)-1h-吡唑-3-胺 |
| JO3078B1 (ar) * | 2009-11-27 | 2017-03-15 | Janssen Pharmaceutica Nv | مورفولينوثيازولات بصفتها منظمات الوستيرية نوع الفا 7 موجبة |
| CN103402983B (zh) | 2011-02-25 | 2015-12-23 | 詹森药业有限公司 | 作为α7nAChR的别构调节剂的(吡啶-4-基)苄基酰胺 |
-
2008
- 2008-09-15 JO JO2008412A patent/JO2784B1/en active
- 2008-10-15 JP JP2010529360A patent/JP2011500624A/ja active Pending
- 2008-10-15 ES ES08805280T patent/ES2371863T3/es active Active
- 2008-10-15 RU RU2010119458/04A patent/RU2476433C2/ru active
- 2008-10-15 AU AU2008313775A patent/AU2008313775B2/en not_active Ceased
- 2008-10-15 WO PCT/EP2008/063844 patent/WO2009050185A1/en not_active Ceased
- 2008-10-15 CN CN2008801119538A patent/CN101827839B/zh not_active Expired - Fee Related
- 2008-10-15 AT AT08805280T patent/ATE522523T1/de not_active IP Right Cessation
- 2008-10-15 US US12/738,725 patent/US8404851B2/en not_active Expired - Fee Related
- 2008-10-15 EP EP08805280A patent/EP2205594B1/de active Active
- 2008-10-15 CA CA2697982A patent/CA2697982C/en not_active Expired - Fee Related
- 2008-10-15 MX MX2010004176A patent/MX2010004176A/es active IP Right Grant
- 2008-10-16 CL CL2008003067A patent/CL2008003067A1/es unknown
- 2008-10-17 PE PE2008001789A patent/PE20091080A1/es active IP Right Grant
- 2008-10-17 AR ARP080104545A patent/AR068919A1/es not_active Application Discontinuation
- 2008-10-17 TW TW097139807A patent/TW200934491A/zh unknown
- 2008-10-17 PA PA20088799901A patent/PA8799901A1/es unknown
-
2010
- 2010-04-15 IL IL205102A patent/IL205102A/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| PE20091080A1 (es) | 2009-08-03 |
| TW200934491A (en) | 2009-08-16 |
| RU2476433C2 (ru) | 2013-02-27 |
| AU2008313775B2 (en) | 2012-12-13 |
| IL205102A0 (en) | 2010-11-30 |
| CA2697982C (en) | 2015-09-22 |
| EP2205594B1 (de) | 2011-08-31 |
| EP2205594A1 (de) | 2010-07-14 |
| JP2011500624A (ja) | 2011-01-06 |
| CN101827839A (zh) | 2010-09-08 |
| CN101827839B (zh) | 2012-10-24 |
| PA8799901A1 (es) | 2009-05-15 |
| MX2010004176A (es) | 2010-05-03 |
| CL2008003067A1 (es) | 2009-11-27 |
| AU2008313775A1 (en) | 2009-04-23 |
| RU2010119458A (ru) | 2011-11-27 |
| US20100240707A1 (en) | 2010-09-23 |
| US8404851B2 (en) | 2013-03-26 |
| ES2371863T3 (es) | 2012-01-10 |
| WO2009050185A1 (en) | 2009-04-23 |
| CA2697982A1 (en) | 2009-04-23 |
| IL205102A (en) | 2015-04-30 |
| AR068919A1 (es) | 2009-12-16 |
| JO2784B1 (en) | 2014-03-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |