BRPI0916363A2 - derivados de 4,5-di-hidro-oxazol-2-ila - Google Patents

derivados de 4,5-di-hidro-oxazol-2-ila

Info

Publication number: BRPI0916363A2
Authority: BR; Brazil
Prior art keywords: oxazol; dihydro; derivatives
Prior art date: 2008-07-24

Application number

BRPI0916363A

Other languages

English (en)

Inventor

Goergler Annick

Galley Guido

Groebke Zbinden Katrin

Norcross Roger

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-07-24

Filing date

2009-07-15

Publication date

2018-05-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41066683&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BRPI0916363(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2009-07-15 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2018-05-29 Publication of BRPI0916363A2 publication Critical patent/BRPI0916363A2/pt

Links

-1 4,5-dihydro-oxazol-2-yl Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/28—Nitrogen atoms not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/421—1,3-Oxazoles, e.g. pemoline, trimethadione
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Diabetes (AREA)
Obesity (AREA)
Hematology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Psychology (AREA)
Child & Adolescent Psychology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Hospice & Palliative Care (AREA)
Addiction (AREA)
Nutrition Science (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

BRPI0916363A 2008-07-24 2009-07-15 derivados de 4,5-di-hidro-oxazol-2-ila BRPI0916363A2 (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP08161060		2008-07-24
PCT/EP2009/059026 WO2010010014A1 (en)	2008-07-24	2009-07-15	4,5-dihydro-oxazol-2-yl derivatives

Publications (1)

Publication Number	Publication Date
BRPI0916363A2 true BRPI0916363A2 (pt)	2018-05-29

Family

ID=41066683

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BRPI0916363A BRPI0916363A2 (pt)	2008-07-24	2009-07-15	derivados de 4,5-di-hidro-oxazol-2-ila

Country Status (22)

Country	Link
US (2)	US20100041686A1 (pt)
EP (1)	EP2321287B1 (pt)
JP (1)	JP5547187B2 (pt)
KR (1)	KR101307007B1 (pt)
CN (1)	CN102083805A (pt)
AR (1)	AR072876A1 (pt)
AU (1)	AU2009273324A1 (pt)
BR (1)	BRPI0916363A2 (pt)
CA (1)	CA2728480A1 (pt)
CL (1)	CL2011000137A1 (pt)
CO (1)	CO6331336A2 (pt)
CR (1)	CR11843A (pt)
EC (1)	ECSP11010782A (pt)
ES (1)	ES2556633T3 (pt)
IL (1)	IL209423A0 (pt)
MA (1)	MA32486B1 (pt)
MX (1)	MX2011000464A (pt)
PE (1)	PE20110215A1 (pt)
RU (1)	RU2513086C2 (pt)
TW (1)	TW201008916A (pt)
WO (1)	WO2010010014A1 (pt)
ZA (1)	ZA201008657B (pt)

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US8426447B2 (en)	2008-09-11	2013-04-23	Amgen Inc.	Spiro-tricyclic ring compounds as beta-secretase modulators and methods of use
US8354441B2 (en) *	2009-11-11	2013-01-15	Hoffmann-La Roche Inc.	Oxazoline derivatives
US9452980B2 (en)	2009-12-22	2016-09-27	Hoffmann-La Roche Inc.	Substituted benzamides
US8883782B2 (en)	2010-03-15	2014-11-11	Amgen Inc.	Spiro-tetracyclic ring compounds as beta-secretase modulators and methods of use
JP5584352B2 (ja)	2010-03-15	2014-09-03	アムジエン・インコーポレーテツド	β−セクレターゼ調節剤としてのアミノ−ジヒドロオキサジン系およびアミノ−ジヒドロチアジン系スピロ化合物ならびにそれらの医学的用途
US9132136B2 (en)	2010-08-02	2015-09-15	Hoffmann-La Roche Inc.	Pharmaceutical combination
US8673950B2 (en) *	2010-11-02	2014-03-18	Hoffmann-Laroche Inc.	Dihydrooxazol-2-amine derivatives
US9346827B2 (en)	2011-02-07	2016-05-24	Amgen Inc.	5-amino-oxazepine and 5-amino-thiazepane compounds as beta secretase antagonists and methods of use
JP2014526560A (ja)	2011-09-21	2014-10-06	アムジエン・インコーポレーテツド	β‐セクレターゼ調節因子としてのアミノオキサジン化合物およびアミノジヒドロチアジン化合物および使用方法
WO2014078314A1 (en)	2012-11-15	2014-05-22	Amgen Inc.	Amino-oxazine and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use
JP6814814B2 (ja)	2016-03-17	2021-01-20	エフ．ホフマン−ラロシュアーゲーＦ．Ｈｏｆｆｍａｎｎ−ＬａＲｏｃｈｅＡｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ	Ｔａａｒのアゴニストとしての活性を有する５−エチル−４−メチル−ピラゾール−３−カルボキサミド誘導体
US10858326B2 (en)	2016-05-04	2020-12-08	Purdue Pharma L.P.	Oxazoline pseudodimers, pharmaceutical compositions and the use thereof
EP3463359A4 (en) *	2016-06-02	2020-08-26	Purdue Pharma LP	TRACE AMINE RECEPTOR 1 AGONISTS AND PARTIAL PAIN AGONISTS

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US4665095A (en) *	1985-12-11	1987-05-12	Abbott Laboratories	Use of 2-[(3,5-dihalo-4-aminobenzyl)]imidazolines to stimulate alpha-1 adrenergic receptors and to treat nasal congestion
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DE19514579A1 (de) *	1995-04-20	1996-10-24	Boehringer Ingelheim Kg	Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz
US5610174A (en) *	1995-06-02	1997-03-11	Synaptic Pharmaceutical Corporation	Use of α1A -selective adrenoceptor agonists for the treatment of urinary incontinence
US5866579A (en) *	1997-04-11	1999-02-02	Synaptic Pharmaceutical Corporation	Imidazole and imidazoline derivatives and uses thereof
CA2328973A1 (en) *	1998-04-23	1999-10-28	Akio Ojida	Naphthalene derivatives, their production and use
IL147921A0 (en) *	2002-01-31	2002-08-14	Abdulrazik Mohammad	A method for treating central nervous system disorders by ocular dosing
AU2005290008A1 (en) *	2004-09-24	2006-04-06	Allergan, Inc.	4-(heteroaryl-methyl and substituted heteroaryl-methyl)-imidazole-2-thiones acting as alpha2 adrenergic agonists
CN101374832B (zh) *	2006-01-27	2013-03-06	弗·哈夫曼-拉罗切有限公司	4-咪唑衍生物用于cns病症的用途
MX2009008255A (es) *	2007-02-02	2009-08-12	Hoffmann La Roche	Nuevas 2-aminooxazolinas como ligandos taar1.

2009
- 2009-07-15 CN CN200980125666.7A patent/CN102083805A/zh active Pending
- 2009-07-15 JP JP2011519122A patent/JP5547187B2/ja not_active Expired - Fee Related
- 2009-07-15 EP EP09780600.4A patent/EP2321287B1/en active Active
- 2009-07-15 CA CA2728480A patent/CA2728480A1/en not_active Abandoned
- 2009-07-15 ES ES09780600.4T patent/ES2556633T3/es active Active
- 2009-07-15 KR KR1020117001611A patent/KR101307007B1/ko not_active Expired - Fee Related
- 2009-07-15 RU RU2011104433/04A patent/RU2513086C2/ru not_active IP Right Cessation
- 2009-07-15 AU AU2009273324A patent/AU2009273324A1/en not_active Abandoned
- 2009-07-15 PE PE2011000063A patent/PE20110215A1/es not_active Application Discontinuation
- 2009-07-15 BR BRPI0916363A patent/BRPI0916363A2/pt not_active IP Right Cessation
- 2009-07-15 WO PCT/EP2009/059026 patent/WO2010010014A1/en not_active Ceased
- 2009-07-15 MX MX2011000464A patent/MX2011000464A/es not_active Application Discontinuation
- 2009-07-17 US US12/504,702 patent/US20100041686A1/en not_active Abandoned
- 2009-07-22 TW TW098124766A patent/TW201008916A/zh unknown
- 2009-07-23 AR ARP090102799A patent/AR072876A1/es unknown
2010
- 2010-11-18 IL IL209423A patent/IL209423A0/en unknown
- 2010-11-25 CO CO10148408A patent/CO6331336A2/es not_active Application Discontinuation
- 2010-12-01 ZA ZA2010/08657A patent/ZA201008657B/en unknown
- 2010-12-13 CR CR11843A patent/CR11843A/es not_active Application Discontinuation
2011
- 2011-01-18 MA MA33533A patent/MA32486B1/fr unknown
- 2011-01-21 CL CL2011000137A patent/CL2011000137A1/es unknown
- 2011-01-24 EC EC2011010782A patent/ECSP11010782A/es unknown
2012
- 2012-03-02 US US13/410,315 patent/US20120165294A1/en not_active Abandoned

Also Published As

Publication number	Publication date
JP5547187B2 (ja)	2014-07-09
MX2011000464A (es)	2011-03-01
RU2011104433A (ru)	2012-08-27
WO2010010014A1 (en)	2010-01-28
ZA201008657B (en)	2011-10-26
RU2513086C2 (ru)	2014-04-20
EP2321287A1 (en)	2011-05-18
ECSP11010782A (es)	2011-02-28
US20100041686A1 (en)	2010-02-18
MA32486B1 (fr)	2011-07-03
CA2728480A1 (en)	2010-01-28
KR20110020936A (ko)	2011-03-03
KR101307007B1 (ko)	2013-09-11
TW201008916A (en)	2010-03-01
JP2011528685A (ja)	2011-11-24
AR072876A1 (es)	2010-09-29
ES2556633T3 (es)	2016-01-19
EP2321287B1 (en)	2015-11-11
PE20110215A1 (es)	2011-03-31
CN102083805A (zh)	2011-06-01
US20120165294A1 (en)	2012-06-28
CR11843A (es)	2011-02-16
IL209423A0 (en)	2011-01-31
AU2009273324A1 (en)	2010-01-28
CO6331336A2 (es)	2011-10-20
CL2011000137A1 (es)	2011-07-15

Legal Events

Date	Code	Title	Description
2018-06-12	B07D	Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
2018-06-19	B06F	Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
2019-05-14	B08F	Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]	Free format text: REFERENTE A 10A ANUIDADE.
2019-09-03	B08K	Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]	Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2523 DE 14-05-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.

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ATE555107T1 (de)	2012-05-15	2-aza-bicyclo-ä2,2,1-üheptan-derivate
BRPI0811718A2 (pt)	2014-11-18	Derivados de 3,3-espiroindolinona
BRPI0907563A2 (pt)	2015-08-04	Derivados de 4,5-di-hidro-xazol-2-il amina
BRPI0916363A2 (pt)	2018-05-29	derivados de 4,5-di-hidro-oxazol-2-ila
DE602008005634D1 (de)	2011-04-28	1,1,1-trifluor-2-hydroxy-3-phenylpropan-derivate
BRPI0816970A2 (pt)	2015-03-24	1,3-dissubstituídas-4-fenil-1h-piridin-2-onas
ATE540040T1 (de)	2012-01-15	Dioxabicycloä3.2.1üoctan-2,3,4-triolderivate
BRPI0813707A2 (pt)	2014-12-30	Derivados de pirimidinil-piridazinona
BRPI0820112A2 (pt)	2015-05-05	Derivados de isoxazol-piridina
BRPI0809992A2 (pt)	2014-10-14	Derivados de pirrolopirimidina
BRPI0820113A2 (pt)	2015-05-05	Derivados de isoxazolo-piridazina
ATE481383T1 (de)	2010-10-15	3-aza-bicycloä3.1.0ühexanderivate
ATE469145T1 (de)	2010-06-15	4-ä5-methoxy-6-(2-methyl-6-ä1,2,4ütriazol-1-yl-
BRPI0923786A2 (pt)	2016-07-26	compostos 5,6-dihidro-6-fenilbenzo(f) isoquinolina-2- amina substituidos
BRPI0812155A2 (pt)	2019-09-24	derivados de espiroindolinona
BRPI0817935A2 (pt)	2015-04-07	Derivados de biarila
EP2244576A4 (en)	2011-06-08	3,5-substituted-1,3-oxazolidine-2-one derivatives
BRPI0814236A2 (pt)	2015-01-06	Derivados de quinazolinamida
EP2291078A4 (en)	2011-08-24	OXAZOLBENZIMIDAZOLDERIVATE
BRPI0812518A2 (pt)	2015-03-31	Derivados de indazolamida
BRPI0820649A2 (pt)	2015-06-16	Derivados de isoxazalo-pirazina
EP2344471A4 (en)	2012-05-30	7-PIPERIDINALKYL-3,4-dihydroquinolone DERIVATIVE
EP2279532A4 (en)	2011-07-27	OXAZOLBENZIMIDAZOLDERIVATE
DE602007001681D1 (de)	2009-09-03	1,3-dioxan-carboxylsäuren
BRPI0917446A2 (pt)	2015-12-22	derivados de acilaminobenzamida.