ATE522529T1 - Verfahren zur herstellung von pyridoä2,1- aüisochinolinderivaten, das die racematspaltung eines enamins umfasst - Google Patents

Verfahren zur herstellung von pyridoä2,1- aüisochinolinderivaten, das die racematspaltung eines enamins umfasst

Info

Publication number
ATE522529T1
ATE522529T1 AT07803228T AT07803228T ATE522529T1 AT E522529 T1 ATE522529 T1 AT E522529T1 AT 07803228 T AT07803228 T AT 07803228T AT 07803228 T AT07803228 T AT 07803228T AT E522529 T1 ATE522529 T1 AT E522529T1
Authority
AT
Austria
Prior art keywords
enamine
pyridoä2
racemat
cleavage
producing
Prior art date
Application number
AT07803228T
Other languages
English (en)
Inventor
Stefan Abrecht
Jean-Michel Adam
Alec Fettes
Stefan Hildbrand
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE522529T1 publication Critical patent/ATE522529T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/235—Saturated compounds containing more than one carboxyl group
    • C07C59/305—Saturated compounds containing more than one carboxyl group containing ether groups, groups, groups, or groups
    • C07C59/31—Saturated compounds containing more than one carboxyl group containing ether groups, groups, groups, or groups containing rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT07803228T 2006-09-15 2007-09-05 Verfahren zur herstellung von pyridoä2,1- aüisochinolinderivaten, das die racematspaltung eines enamins umfasst ATE522529T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06120722 2006-09-15
PCT/EP2007/059264 WO2008031749A1 (en) 2006-09-15 2007-09-05 Process for the preparation of pyrido[2,1-a]isoquinoline derivatives comprising optical resolution of an enamine

Publications (1)

Publication Number Publication Date
ATE522529T1 true ATE522529T1 (de) 2011-09-15

Family

ID=38779613

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07803228T ATE522529T1 (de) 2006-09-15 2007-09-05 Verfahren zur herstellung von pyridoä2,1- aüisochinolinderivaten, das die racematspaltung eines enamins umfasst

Country Status (8)

Country Link
US (4) US20080071087A1 (de)
EP (1) EP2066667B1 (de)
JP (1) JP5235018B2 (de)
CN (1) CN101516880B (de)
AT (1) ATE522529T1 (de)
CA (1) CA2662413C (de)
ES (1) ES2371369T3 (de)
WO (1) WO2008031749A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2008002427A1 (es) 2007-08-16 2009-09-11 Boehringer Ingelheim Int Composicion farmaceutica que comprende 1-cloro-4-(b-d-glucopiranos-1-il)-2-[4-((s)-tetrahidrofurano-3-iloxi)bencil]-benceno combinado con 1-[(4-metilquinazolin-2-il)metil]-3-metil-7-(2-butin-1-il)-8-(3-(r)-aminopiperidin-1-il)xantina; y su uso para tratar diabetes mellitus tipo 2.
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
NZ604091A (en) 2008-08-15 2014-08-29 Boehringer Ingelheim Int Purin derivatives for use in the treatment of fab-related diseases
AR074990A1 (es) 2009-01-07 2011-03-02 Boehringer Ingelheim Int Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
AR075204A1 (es) 2009-01-29 2011-03-16 Boehringer Ingelheim Int Inhibidores de dpp-4 y composiciones farmaceuticas que los comprenden, utiles para tratar enfermedades metabolicas en pacientes pediatricos, particularmente diabetes mellitus tipo 2
AU2010212823B2 (en) 2009-02-13 2016-01-28 Boehringer Ingelheim International Gmbh Antidiabetic medications comprising a DPP-4 inhibitor (linagliptin) optionally in combination with other antidiabetics
JP5685550B2 (ja) 2009-02-13 2015-03-18 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｓｇｌｔ２阻害剤、ｄｐｐ−ｉｖ阻害剤、更に必要により抗糖尿病薬を含む医薬組成物及びその使用
KR20240090632A (ko) 2009-11-27 2024-06-21 베링거 인겔하임 인터내셔날 게엠베하 리나글립틴과 같은 ｄｐｐ－ｉｖ 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료
EP2547339A1 (de) 2010-03-18 2013-01-23 Boehringer Ingelheim International GmbH Kombination eines gpr119-agonisten und des dpp-iv-hemmers linagliptin zur verwendung bei der behandlung von diabetes und zugehöriger erkrankungen
CN102946875A (zh) 2010-05-05 2013-02-27 贝林格尔.英格海姆国际有限公司 组合疗法
WO2011161161A1 (en) 2010-06-24 2011-12-29 Boehringer Ingelheim International Gmbh Diabetes therapy
EP2599769A4 (de) * 2010-07-28 2015-05-20 Sumitomo Chemical Co Verfahren zur herstellung eines carboxylsäureamids
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
US9227901B2 (en) 2012-07-05 2016-01-05 Abbvie Inc. Process for preparing bicyclic amine derivatives
WO2014152768A1 (en) * 2013-03-15 2014-09-25 Portola Pharmaceuticals, Inc. Cyclohexanediamine compounds and methods for their preparation
JP6253564B2 (ja) * 2014-11-13 2017-12-27 日本電信電話株式会社 画像符号化装置，画像復号装置，画像符号化方法，画像復号方法，画像符号化プログラムおよび画像復号プログラム
CN111632400B (zh) * 2020-06-21 2022-04-05 赤峰制药股份有限公司 一种烯胺盐重结晶纯化方法
CN115197137B (zh) * 2022-07-07 2024-04-02 中国科学院成都生物研究所 异喹啉酮类化合物及其合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6727261B2 (en) * 2001-12-27 2004-04-27 Hoffman-La Roche Inc. Pyrido[2,1-A]Isoquinoline derivatives
WO2005000848A1 (en) * 2003-06-20 2005-01-06 F. Hoffmann-La Roche Ag Pyrido` 2, 1-a - isoquinoline derivatives as dpp-iv inhibitors
ATE437876T1 (de) * 2003-06-20 2009-08-15 Hoffmann La Roche Hexahydropyridoisochinoline als dpp-iv- inhibitoren

Also Published As

Publication number Publication date
ES2371369T3 (es) 2011-12-30
CN101516880A (zh) 2009-08-26
WO2008031749A1 (en) 2008-03-20
EP2066667B1 (de) 2011-08-31
US20080071087A1 (en) 2008-03-20
CA2662413C (en) 2015-08-25
EP2066667A1 (de) 2009-06-10
JP5235018B2 (ja) 2013-07-10
US20120022260A1 (en) 2012-01-26
US20130018191A1 (en) 2013-01-17
CA2662413A1 (en) 2008-03-20
JP2010503634A (ja) 2010-02-04
US20130338366A1 (en) 2013-12-19
CN101516880B (zh) 2012-06-20

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