ATE524449T1 - Verfahren zur herstellung von cis-8b- methyldecahydro-2a,4a,6a,8a- tetraazacyclopentaäfgüacenaphthylen, cis- decahydro-2a,4a,6a,8a- tetraazacyclopentaäfgüacenaphthylen, cyclen und funktionalisierten cyclenen - Google Patents

Verfahren zur herstellung von cis-8b- methyldecahydro-2a,4a,6a,8a- tetraazacyclopentaäfgüacenaphthylen, cis- decahydro-2a,4a,6a,8a- tetraazacyclopentaäfgüacenaphthylen, cyclen und funktionalisierten cyclenen

Info

Publication number: ATE524449T1
Authority: AT; Austria
Prior art keywords: viii; formula; preparation; tetraaza; iib
Prior art date: 2003-06-13

Application number

AT04785719T

Other languages

English (en)

Inventor

Frederic Boschetti

Fanny Chaux

Franck Denat

Roger Guilard

Henry Ledon

Original Assignee

Centre Nat Rech Scient

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-06-13

Filing date

2004-06-04

Publication date

2011-09-15

2004-06-04 Application filed by Centre Nat Rech Scient filed Critical Centre Nat Rech Scient

2011-09-15 Application granted granted Critical

2011-09-15 Publication of ATE524449T1 publication Critical patent/ATE524449T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 3
238000002360 preparation method Methods 0.000 abstract 8
QBPPRVHXOZRESW-UHFFFAOYSA-N 1,4,7,10-tetraazacyclododecane Chemical compound C1CNCCNCCNCCN1 QBPPRVHXOZRESW-UHFFFAOYSA-N 0.000 abstract 7
125000000217 alkyl group Chemical group 0.000 abstract 6
238000006243 chemical reaction Methods 0.000 abstract 6
125000003118 aryl group Chemical group 0.000 abstract 4
150000001875 compounds Chemical class 0.000 abstract 3
238000005580 one pot reaction Methods 0.000 abstract 3
VILCJCGEZXAXTO-UHFFFAOYSA-N 2,2,2-tetramine Chemical compound NCCNCCNCCN VILCJCGEZXAXTO-UHFFFAOYSA-N 0.000 abstract 2
101100294102 Caenorhabditis elegans nhr-2 gene Proteins 0.000 abstract 2
PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 abstract 2
125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 2
125000001072 heteroaryl group Chemical group 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
229960001124 trientine Drugs 0.000 abstract 2
238000005904 alkaline hydrolysis reaction Methods 0.000 abstract 1
-1 halo compound Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
238000007327 hydrogenolysis reaction Methods 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT04785719T 2003-06-13 2004-06-04 Verfahren zur herstellung von cis-8b- methyldecahydro-2a,4a,6a,8a- tetraazacyclopentaäfgüacenaphthylen, cis- decahydro-2a,4a,6a,8a- tetraazacyclopentaäfgüacenaphthylen, cyclen und funktionalisierten cyclenen ATE524449T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0350217A FR2856063B1 (fr)	2003-06-13	2003-06-13	Procede de preparation du cis-8b-methyldecahydro-2a,4a,6a, 8a-tetraazacyclopenta[fg]acenaphthylene,ou du cis-decahydro-2a,4a,6a,8a-tetraazacyclopenta[fg] acenaphthylene, du cyclene, et de cyclenes fonctionnalises
PCT/FR2004/050213 WO2005000823A1 (fr)	2003-06-13	2004-06-04	Procede de preparation du cis-8b-methyldecahydro-2a,4a,6a,8a-tetraazacyclopenta[fg]acenaphthylene, du cis-decahydro-2a,4a,6a,8a-tetraazacyclopenta[fg]acenaphthylene, du cyclene, et de cyclenes fonctionnalises

Publications (1)

Publication Number	Publication Date
ATE524449T1 true ATE524449T1 (de)	2011-09-15

Family

ID=33484719

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT04785719T ATE524449T1 (de)	2003-06-13	2004-06-04	Verfahren zur herstellung von cis-8b- methyldecahydro-2a,4a,6a,8a- tetraazacyclopentaäfgüacenaphthylen, cis- decahydro-2a,4a,6a,8a- tetraazacyclopentaäfgüacenaphthylen, cyclen und funktionalisierten cyclenen

Country Status (7)

Country	Link
US (1)	US7659393B2 (de)
EP (1)	EP1644344B1 (de)
JP (1)	JP2006527241A (de)
AT (1)	ATE524449T1 (de)
CA (1)	CA2529332A1 (de)
FR (1)	FR2856063B1 (de)
WO (1)	WO2005000823A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2982611B1 (fr) *	2011-11-16	2014-01-03	Univ Bretagne Occidentale	Procedes de preparation de composes tetraazacycloalcanes fonctionnels a l'aide d'un compose cyclique bisaminal particulier.
FR3072093A1 (fr)	2017-10-11	2019-04-12	Universite Paris-Sud	Cryptands a base de calix[4]arenes associes a un macrocycle azote et leur utilisation pour l'extraction selective de metaux strategiques
CN110698419A (zh) *	2019-09-26	2020-01-17	广州康瑞泰药业有限公司	一种轮环藤宁的制备方法
CN113072514B (zh) *	2020-01-06	2023-09-01	联化科技股份有限公司	轮环藤宁及其中间体的制备方法
RU2749722C1 (ru) *	2020-07-15	2021-06-16	Федеральное государственное бюджетное образовательное учреждение высшего образования "Уфимский государственный нефтяной технический университет"	Способ получения четвертичной аммониевой соли, обладающей противоопухолевым действием
CN113956262B (zh) *	2021-10-18	2023-03-07	苏州百灵威超精细材料有限公司	一种四氮杂环烷类化合物及其中间体的合成方法
CN113999255A (zh) *	2021-11-11	2022-02-01	中国科学院成都有机化学有限公司	多元稠杂环类化合物及其制备方法
CN115785013A (zh) *	2022-11-17	2023-03-14	安庆朗坤药业有限公司	一种轮环藤宁的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2156143T3 (es) *	1993-12-30	2001-06-16	Guerbet Sa	Ligandos poliaminados, complejos metalicos, procedimiento de preparacion, aplicaciones diagnosticas y terapeuticas.
GB9504922D0 (en) *	1995-03-10	1995-04-26	Nycomed As	Process
IT1284046B1 (it) *	1996-06-21	1998-05-08	Bracco Spa	Processo per la preparazione di tetraazamacrocicli
DE19652386A1 (de) *	1996-12-04	1998-06-10	Schering Ag	Verfahren zur Herstellung von Metallkomplexcarbonsäureamiden
JP2002531457A (ja) *	1998-11-30	2002-09-24	ザ、プロクター、エンド、ギャンブル、カンパニー	架橋テトラアザマクロサイクル類の製造方法
WO2002006287A2 (en) *	2000-07-17	2002-01-24	California Institute Of Technology	Macrocyclic mri contrast agents
CA2435653A1 (en) *	2001-01-24	2002-08-01	Auckland Uniservices Limited	Anti-cancer 2,3-dihydro-1h-pyrrolo[3,2-f]quinoline complexes of cobalt and chromium
FR2830253B1 (fr) *	2001-09-28	2005-02-04	Air Liquide	Nouveau procede de preparation de macrocycles azotes c-fonctionnalises et nouveaux intermediaires obtenus

2003
- 2003-06-13 FR FR0350217A patent/FR2856063B1/fr not_active Expired - Lifetime
2004
- 2004-06-04 WO PCT/FR2004/050213 patent/WO2005000823A1/fr not_active Ceased
- 2004-06-04 AT AT04785719T patent/ATE524449T1/de not_active IP Right Cessation
- 2004-06-04 JP JP2006516343A patent/JP2006527241A/ja active Pending
- 2004-06-04 CA CA002529332A patent/CA2529332A1/fr not_active Abandoned
- 2004-06-04 EP EP04785719A patent/EP1644344B1/de not_active Expired - Lifetime
- 2004-06-04 US US10/560,162 patent/US7659393B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1644344B1 (de)	2011-09-14
US7659393B2 (en)	2010-02-09
CA2529332A1 (fr)	2005-01-06
US20060217548A1 (en)	2006-09-28
FR2856063B1 (fr)	2005-10-07
JP2006527241A (ja)	2006-11-30
WO2005000823A1 (fr)	2005-01-06
EP1644344A1 (de)	2006-04-12
FR2856063A1 (fr)	2004-12-17

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Legal Events

Date	Code	Title	Description
2012-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties