ATE371661T1 - Tumorhemmende derivate von et-743 - Google Patents

Tumorhemmende derivate von et-743

Info

Publication number: ATE371661T1
Authority: AT; Austria
Prior art keywords: substituted; unsubstituted; alkenyl; alkyl; alkynyl
Prior art date: 2001-07-17

Application number

AT02747577T

Other languages

English (en)

Inventor

Valentin Martinez

Maria Flores

Pilar Gallego

Carmen Cuevas

Simon Munt

Ignacio Manzanares

Original Assignee

Pharma Mar Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-17

Filing date

2002-07-17

Publication date

2007-09-15

2002-07-17 Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa

2007-09-15 Application granted granted Critical

2007-09-15 Publication of ATE371661T1 publication Critical patent/ATE371661T1/de

Links

206010028980 Neoplasm Diseases 0.000 title 1
125000003118 aryl group Chemical group 0.000 abstract 6
125000003342 alkenyl group Chemical group 0.000 abstract 5
125000000217 alkyl group Chemical group 0.000 abstract 5
125000000304 alkynyl group Chemical group 0.000 abstract 5
229910052799 carbon Inorganic materials 0.000 abstract 3
229910052736 halogen Inorganic materials 0.000 abstract 3
150000002367 halogens Chemical class 0.000 abstract 3
125000000623 heterocyclic group Chemical group 0.000 abstract 2
125000001424 substituent group Chemical group 0.000 abstract 2
150000001413 amino acids Chemical class 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001072 heteroaryl group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000004151 quinonyl group Chemical group 0.000 abstract 1
125000005017 substituted alkenyl group Chemical group 0.000 abstract 1
125000000547 substituted alkyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT02747577T 2001-07-17 2002-07-17 Tumorhemmende derivate von et-743 ATE371661T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0117402.8A GB0117402D0 (en)	2001-07-17	2001-07-17	New antitumoral derivatives of et-743

Publications (1)

Publication Number	Publication Date
ATE371661T1 true ATE371661T1 (de)	2007-09-15

Family

ID=9918658

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02747577T ATE371661T1 (de)	2001-07-17	2002-07-17	Tumorhemmende derivate von et-743

Country Status (16)

Country	Link
US (2)	US7759345B2 (de)
EP (3)	EP2298780B1 (de)
JP (1)	JP4653950B2 (de)
AT (1)	ATE371661T1 (de)
AU (2)	AU2002317967C1 (de)
CA (1)	CA2453991C (de)
CY (2)	CY1107809T1 (de)
DE (1)	DE60222135T2 (de)
DK (3)	DK1854800T3 (de)
ES (3)	ES2394772T3 (de)
GB (1)	GB0117402D0 (de)
MX (1)	MXPA04000506A (de)
NO (2)	NO335262B1 (de)
PT (3)	PT1854800E (de)
SI (2)	SI1854800T1 (de)
WO (1)	WO2003008423A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MXPA02011319A (es)	2000-05-15	2003-06-06	Pharma Mar Sa	Analogos antitumorales de ecteinascidina 743.
GB0202544D0 (en) *	2002-02-04	2002-03-20	Pharma Mar Sa	The synthesis of naturally occuring ecteinascidins and related compounds
AU2005288696A1 (en) *	2004-09-28	2006-04-06	Pharma Mar S.A., Sociedad Unipersonal	Ecteinascidin compounds as anti -inflammatory agents
GB0521536D0 (en) *	2005-10-22	2005-11-30	Invibio Ltd	Fiducial marker
CN103038240A (zh)	2010-05-25	2013-04-10	法马马有限公司	制备海鞘素化合物的合成方法
KR102491180B1 (ko)	2017-04-27	2023-01-20	파르마 마르 에스.에이.	항종양 화합물
WO2024186263A1 (en) *	2023-03-07	2024-09-12	Axcynsis Therapeutics Pte. Ltd.	Antibody-drug conjugates comprising trabectedin and lurbinectedin derivatives
WO2025055920A1 (zh) *	2023-09-11	2025-03-20	泰诚思(上海)生物医药有限公司	新型海鞘素衍生物、其制备方法及用途、抗体药物偶联物及其应用
WO2025077996A1 (en)	2023-10-09	2025-04-17	Pharma Mar, S.A.	Synthetic process for the manufacture of ecteinascidin compounds
CN121039136A (zh) *	2024-02-08	2025-11-28	映恩生物科技(上海)有限公司	海鞘素类化合物及其应用
WO2026022359A2 (en)	2024-07-26	2026-01-29	Pharma Mar, S.A.	Synthetic process for the manufacture of ecteinascidin compounds

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS59225189A (ja)	1983-06-03	1984-12-18	Shionogi & Co Ltd	キノナミン誘導体およびその製造法
JPS6084288A (ja)	1983-10-13	1985-05-13	Shionogi & Co Ltd	シアノキノナミンアセテ−ト類およびその製造法
US5149804A (en) *	1990-11-30	1992-09-22	The Board Of Trustees Of The University Of Illinois	Ecteinascidins 736 and 722
EP0309477B1 (de)	1986-06-09	1991-11-06	The Board Of Trustees Of The University Of Illinois	Ekteinascidine 729, 743, 745, 759a, 759b und 770
US5089273A (en)	1986-06-09	1992-02-18	Board Of Trustees Of The University Of Illinois	Ecteinascidins 729, 743, 745, 759A, 759B and 770
US5256663A (en)	1986-06-09	1993-10-26	The Board Of Trustees Of The University Of Illinois	Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
US5478932A (en) *	1993-12-02	1995-12-26	The Board Of Trustees Of The University Of Illinois	Ecteinascidins
US20040059112A1 (en)	1994-02-18	2004-03-25	Rinehart Kenneth L.	Ecteinascidins
US5721362A (en)	1996-09-18	1998-02-24	President And Fellows Of Harvard College	Process for producing ecteinascidin compounds
US5985876A (en)	1997-04-15	1999-11-16	Univ Illinois	Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
BR9909488B1 (pt) *	1998-04-06	2011-02-08		ecteinascidinas semi-sintéticas e composição farmacêutica.
AU759494B2 (en) *	1998-05-05	2003-04-17	Pharma Mar S.A.	Culture of sessile marine animals
CA2331593C (en) *	1998-05-11	2008-08-05	Pharma Mar, S.A.	Metabolites of ecteinascidin 743
US6124292A (en) *	1998-09-30	2000-09-26	President And Fellows Of Harvard College	Synthetic analogs of ecteinascidin-743
MY164077A (en)	1999-05-13	2017-11-30	Pharma Mar Sa	Compositions and uses of et743 for treating cancer
AR035842A1 (es) *	1999-05-14	2004-07-21	Pharma Mar Sa	Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo
CA2397597A1 (en) *	2000-01-19	2001-07-26	The Trustees Of Columbia University In The City Of New York	Compounds of the saframycin-ecteinascidin series, uses, and synthesis thereof
US6815544B2 (en) *	2000-02-11	2004-11-09	President And Fellows Of Harvard College	Synthetic process for an intermediate for ecteinascidin and phthalascidin compounds
US6569859B1 (en) *	2000-02-22	2003-05-27	President And Fellows Of Harvard College	Synthetic analogs of ecteinascidin-743
WO2001077115A1 (en) *	2000-04-12	2001-10-18	Pharma Mar, S.A.	Antitumoral ecteinascidin derivatives
US7919493B2 (en)	2000-04-12	2011-04-05	Pharma Mar, S.A.	Anititumoral ecteinascidin derivatives
US7420051B2 (en)	2000-05-15	2008-09-02	Pharma Mar, S.A.	Synthetic process for the manufacture of an ecteinaschidin compound
MXPA02011319A (es) *	2000-05-15	2003-06-06	Pharma Mar Sa	Analogos antitumorales de ecteinascidina 743.
BR0115162A (pt)	2000-11-06	2003-10-21	Pharma Mar Sa	Tratamentos antitumorais eficazes
PL368458A1 (en)	2001-10-19	2005-03-21	Pharmamar S.A.	Improved use of antitumoral compound in cancer therapy
GB0202544D0 (en)	2002-02-04	2002-03-20	Pharma Mar Sa	The synthesis of naturally occuring ecteinascidins and related compounds
GB0218813D0 (en) *	2002-08-13	2002-09-18	Pharma Mar Sa	DNA sequences from an endosymbiont and their uses
GB0229793D0 (en)	2002-12-20	2003-01-29	Pharma Mar Sa	The gene cluster involved in safracin biosynthesis and its uses for genetic engineering
GB0312407D0 (en)	2003-05-29	2003-07-02	Pharma Mar Sau	Treatment
GB0324201D0 (en)	2003-10-15	2003-11-19	Pharma Mar Sau	Improved antitumoral combinations
HRP20080598T3 (en) *	2003-11-13	2009-01-31	Pharma Mar	Combination of et-743 with 5-fluorouracil pro-drugs for the treatment of cancer
GB0326486D0 (en)	2003-11-14	2003-12-17	Pharma Mar Sau	Combination treatment
AU2004291037A1 (en)	2003-11-14	2005-06-02	Pharma Mar, S.A.	Combination therapy comprising the use of ET-743 and paclitaxel for treating cancer
WO2006005602A2 (en)	2004-07-09	2006-01-19	Pharma Mar, S.A.	Use of ecteinascidin in the treatment of cancer in patients with low level of brca1
AU2005288696A1 (en)	2004-09-28	2006-04-06	Pharma Mar S.A., Sociedad Unipersonal	Ecteinascidin compounds as anti -inflammatory agents
EP1827500B1 (de)	2004-10-26	2009-05-06	Pharma Mar S.A., Sociedad Unipersonal	Pegyliertes liposomales doxorubicin in kombination mit ecteinescidin 743
ATE368461T1 (de)	2004-10-29	2007-08-15	Pharma Mar Sa	Zusammensetzungen enthaltend ecteinascidin und einen disaccharide
GB0522082D0 (en)	2005-10-31	2005-12-07	Pharma Mar Sa	Formulations
ES2361566T3 (es)	2005-11-25	2011-06-20	Pharma Mar S.A., Sociedad Unipersonal	Uso de inhibidores de parp-1.
CA2652035A1 (en)	2006-05-12	2007-11-22	Pharma Mar, S.A.	Anticancer treatments
US20100267732A1 (en)	2007-10-19	2010-10-21	Pharma Mar, S.A.	Prognostic Molecular Markers for ET-743 Treatment
JP2011520921A (ja)	2008-05-16	2011-07-21	ファルマ・マール・ソシエダード・アノニマ	抗腫瘍アルカロイドとの併用療法
NZ589270A (en)	2008-05-16	2011-12-22	Pharma Mar Sa	Multiple myeloma treatments

2001
- 2001-07-17 GB GBGB0117402.8A patent/GB0117402D0/en not_active Ceased
2002
- 2002-07-17 SI SI200231003T patent/SI1854800T1/sl unknown
- 2002-07-17 EP EP10180049A patent/EP2298780B1/de not_active Expired - Lifetime
- 2002-07-17 DE DE60222135T patent/DE60222135T2/de not_active Expired - Lifetime
- 2002-07-17 ES ES10180049T patent/ES2394772T3/es not_active Expired - Lifetime
- 2002-07-17 DK DK07011446.7T patent/DK1854800T3/da active
- 2002-07-17 ES ES02747577T patent/ES2291479T3/es not_active Expired - Lifetime
- 2002-07-17 CA CA2453991A patent/CA2453991C/en not_active Expired - Lifetime
- 2002-07-17 DK DK02747577T patent/DK1406907T3/da active
- 2002-07-17 AT AT02747577T patent/ATE371661T1/de active
- 2002-07-17 SI SI200231015T patent/SI2298780T1/sl unknown
- 2002-07-17 PT PT07011446T patent/PT1854800E/pt unknown
- 2002-07-17 JP JP2003513982A patent/JP4653950B2/ja not_active Expired - Lifetime
- 2002-07-17 WO PCT/GB2002/003288 patent/WO2003008423A1/en not_active Ceased
- 2002-07-17 PT PT101800498T patent/PT2298780E/pt unknown
- 2002-07-17 EP EP02747577A patent/EP1406907B1/de not_active Expired - Lifetime
- 2002-07-17 US US10/484,060 patent/US7759345B2/en not_active Expired - Lifetime
- 2002-07-17 AU AU2002317967A patent/AU2002317967C1/en not_active Expired
- 2002-07-17 EP EP07011446A patent/EP1854800B1/de not_active Expired - Lifetime
- 2002-07-17 PT PT02747577T patent/PT1406907E/pt unknown
- 2002-07-17 DK DK10180049.8T patent/DK2298780T3/da active
- 2002-07-17 ES ES07011446T patent/ES2389671T3/es not_active Expired - Lifetime
- 2002-07-17 MX MXPA04000506A patent/MXPA04000506A/es active IP Right Grant
2004
- 2004-01-16 NO NO20040189A patent/NO335262B1/no not_active IP Right Cessation
2007
- 2007-11-21 CY CY20071101494T patent/CY1107809T1/el unknown
2008
- 2008-08-20 AU AU2008207381A patent/AU2008207381B2/en not_active Expired
2010
- 2010-04-06 US US12/755,218 patent/US8076337B2/en not_active Expired - Fee Related
2012
- 2012-09-20 CY CY20121100864T patent/CY1113359T1/el unknown
2014
- 2014-06-06 NO NO20140711A patent/NO340213B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU2002317967C1 (en)	2009-01-22
DK1854800T3 (da)	2012-10-01
EP2298780B1 (de)	2012-09-12
CA2453991A1 (en)	2003-01-30
EP1406907B1 (de)	2007-08-29
DE60222135T2 (de)	2008-05-21
WO2003008423A1 (en)	2003-01-30
MXPA04000506A (es)	2004-07-23
US8076337B2 (en)	2011-12-13
US20100197695A1 (en)	2010-08-05
AU2002317967B2 (en)	2008-06-05
EP2298780A1 (de)	2011-03-23
EP1854800B1 (de)	2012-06-27
DK1406907T3 (da)	2008-02-04
AU2008207381A1 (en)	2008-09-11
GB0117402D0 (en)	2001-09-05
US7759345B2 (en)	2010-07-20
CY1113359T1 (el)	2016-06-22
ES2291479T3 (es)	2008-03-01
NO340213B1 (no)	2017-03-20
JP4653950B2 (ja)	2011-03-16
PT2298780E (pt)	2012-12-17
NO335262B1 (no)	2014-10-27
PT1854800E (pt)	2012-09-25
EP1854800A1 (de)	2007-11-14
EP1406907A1 (de)	2004-04-14
JP2004536132A (ja)	2004-12-02
US20060106021A1 (en)	2006-05-18
NO20040189L (no)	2004-03-16
SI1854800T1 (sl)	2012-11-30
DK2298780T3 (da)	2013-01-07
ES2389671T3 (es)	2012-10-30
DE60222135D1 (de)	2007-10-11
ES2394772T3 (es)	2013-02-05
CY1107809T1 (el)	2013-06-19
AU2008207381B2 (en)	2011-07-14
SI2298780T1 (sl)	2013-01-31
PT1406907E (pt)	2007-12-10
CA2453991C (en)	2011-12-20
NO20140711L (no)	2004-03-16

Legal Events

Date

Code

Title

Description

2008-02-15

UEP

Publication of translation of european patent specification

Ref document number: 1406907

Country of ref document: EP

Publication	Publication Date	Title
CY1113359T1 (el)	2016-06-22	Αντι-νεοπλασιακα παραγωγα του et-743
MXPA04001240A (es)	2004-06-03	Analogos antitumorales.
DE60033857D1 (de)	2007-04-19	Derivate des N-((Chinolinyl)oxy)-phenyl)-Harnstoffs und des N-((Chinazolinyl)oxy)-phenyl)-Harnstoffs mit Antitumor Aktivität
DK1117297T3 (da)	2006-01-09	Syntetiske analoger af ecteinascidin-743
PT1280809E (pt)	2005-11-30	Derivados antitumorais de ecteinascidina
DK1424330T3 (da)	2012-01-16	Aktivator for peroxisom proliferator-responsiv receptor delta
CY1108313T1 (el)	2014-02-12	Παραγωγα της κινολινης και η χρηση τους ως προσδεματων 5-ht6
FI965020A0 (fi)	1996-12-13	Uusia yhdisteitä, menetelmiä niiden valmistamiseksi ja kasvaintenvastaisia aineita
ES8601146A1 (es)	1985-11-01	Procedimiento para preparar derivados azolicos
ATE322483T1 (de)	2006-04-15	Inhibitoren für asparagin-proteasen
ATE232528T1 (de)	2003-02-15	Pyrimidinylpyrazolderivate
DE3474022D1 (de)	1988-10-20	Quinazoline and isoquinoline derivatives
TR200201600T2 (tr)	2002-10-21	Yer-alıma tabi tutulan, yeni, dallı 3-amino-1-fenil-1H-[1,2,4]triazol amino türevleri, bunların hazırlanması için prosesler ve bunları içeren farmasötik kompozisyonlar.
FI894783A0 (fi)	1989-10-09	Substituerade aromatiska foereningar med verkan pao det centrala nervsystemet.
GB9012223D0 (en)	1990-07-18	Amines
GB0116966D0 (en)	2001-09-05	Anittumoral compounds