ATE371661T1 - Tumorhemmende derivate von et-743 - Google Patents

Tumorhemmende derivate von et-743

Info

Publication number
ATE371661T1
ATE371661T1 AT02747577T AT02747577T ATE371661T1 AT E371661 T1 ATE371661 T1 AT E371661T1 AT 02747577 T AT02747577 T AT 02747577T AT 02747577 T AT02747577 T AT 02747577T AT E371661 T1 ATE371661 T1 AT E371661T1
Authority
AT
Austria
Prior art keywords
substituted
unsubstituted
alkenyl
alkyl
alkynyl
Prior art date
Application number
AT02747577T
Other languages
English (en)
Inventor
Valentin Martinez
Maria Flores
Pilar Gallego
Carmen Cuevas
Simon Munt
Ignacio Manzanares
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Application granted granted Critical
Publication of ATE371661T1 publication Critical patent/ATE371661T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT02747577T 2001-07-17 2002-07-17 Tumorhemmende derivate von et-743 ATE371661T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0117402.8A GB0117402D0 (en) 2001-07-17 2001-07-17 New antitumoral derivatives of et-743

Publications (1)

Publication Number Publication Date
ATE371661T1 true ATE371661T1 (de) 2007-09-15

Family

ID=9918658

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02747577T ATE371661T1 (de) 2001-07-17 2002-07-17 Tumorhemmende derivate von et-743

Country Status (16)

Country Link
US (2) US7759345B2 (de)
EP (3) EP1854800B1 (de)
JP (1) JP4653950B2 (de)
AT (1) ATE371661T1 (de)
AU (2) AU2002317967C1 (de)
CA (1) CA2453991C (de)
CY (2) CY1107809T1 (de)
DE (1) DE60222135T2 (de)
DK (3) DK1406907T3 (de)
ES (3) ES2389671T3 (de)
GB (1) GB0117402D0 (de)
MX (1) MXPA04000506A (de)
NO (2) NO335262B1 (de)
PT (3) PT1854800E (de)
SI (2) SI2298780T1 (de)
WO (1) WO2003008423A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02011319A (es) * 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
JP2008514688A (ja) * 2004-09-29 2008-05-08 ファルマ・マル・エス・アー， ソシエダッド・ユニペルソナル 抗炎症剤としてのエクテイナシジン化合物
GB0521536D0 (en) * 2005-10-22 2005-11-30 Invibio Ltd Fiducial marker
CA2800097C (en) 2010-05-25 2019-01-08 Pharma Mar, S.A. Synthetic process for the manufacture of ecteinascidin compounds and intermediates
SI4101855T1 (sl) 2017-04-27 2024-03-29 Pharma Mar S.A. Protitumorske spojine
WO2024186263A1 (en) * 2023-03-07 2024-09-12 Axcynsis Therapeutics Pte. Ltd. Antibody-drug conjugates comprising trabectedin and lurbinectedin derivatives
CN119591621A (zh) * 2023-09-11 2025-03-11 泰诚思(上海)生物医药有限公司 新型海鞘素衍生物、其制备方法及用途、抗体药物偶联物及其应用
WO2025077996A1 (en) 2023-10-09 2025-04-17 Pharma Mar, S.A. Synthetic process for the manufacture of ecteinascidin compounds
TW202535413A (zh) * 2024-02-08 2025-09-16 大陸商映恩生物科技（上海）有限公司 海鞘素類化合物及其應用
WO2026022359A2 (en) 2024-07-26 2026-01-29 Pharma Mar, S.A. Synthetic process for the manufacture of ecteinascidin compounds

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59225189A (ja) 1983-06-03 1984-12-18 Shionogi & Co Ltd キノナミン誘導体およびその製造法
JPS6084288A (ja) 1983-10-13 1985-05-13 Shionogi & Co Ltd シアノキノナミンアセテ−ト類およびその製造法
US5149804A (en) * 1990-11-30 1992-09-22 The Board Of Trustees Of The University Of Illinois Ecteinascidins 736 and 722
JP2562162B2 (ja) * 1986-06-09 1996-12-11 ユニバーシティ・オブ・イリノイ エクテインアシジン７２９、７４３、７４５、７５９ａ、７５９ｂおよび７７０
US5256663A (en) * 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
US5089273A (en) * 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
US5478932A (en) * 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
US20040059112A1 (en) * 1994-02-18 2004-03-25 Rinehart Kenneth L. Ecteinascidins
US5721362A (en) 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds
US5985876A (en) * 1997-04-15 1999-11-16 Univ Illinois Nucleophile substituted ecteinascidins and N-oxide ecteinascidins
DE69936845T2 (de) * 1998-04-06 2008-05-08 The Board Of Trustees Of The University Of Illinois, Urbana Halbsynthetische ectein-ascidine
EP1076486B1 (de) * 1998-05-05 2005-08-31 Pharma Mar, S.A. Kultivierung von sessilen meerestieren
BR9910419A (pt) * 1998-05-11 2001-01-09 Pharma Mar Sa Etm-305, etm-204, etm-775, substancialmente puros, processos para tratar leucemia de mamìferos, para tratar carcinoma de pulmão de mamìferos, para tratar adenocarcinoma de cólon de mamìferos, e para tratar melanoma maligno de mamìferos, composição farmacêutica, e, processo para testar o metabolismo citocromo humano cyp3a4 de ecteinascidina 743
US6124292A (en) 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
MY164077A (en) * 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
AR035842A1 (es) 1999-05-14 2004-07-21 Pharma Mar Sa Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo
US6686470B2 (en) * 2000-01-19 2004-02-03 The Trustees Of Columbia University In The City Of New York Compounds of the saframycin-ecteinascidin series, uses, and synthesis thereof
US6815544B2 (en) * 2000-02-11 2004-11-09 President And Fellows Of Harvard College Synthetic process for an intermediate for ecteinascidin and phthalascidin compounds
US6569859B1 (en) * 2000-02-22 2003-05-27 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
US7919493B2 (en) * 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
CZ304749B6 (cs) 2000-04-12 2014-09-24 Pharma Mar, S. A. Ecteinascidin mající pět spojených kruhů s 1,4-můstkem, farmaceutický prostředek, použití a způsob
US7420051B2 (en) * 2000-05-15 2008-09-02 Pharma Mar, S.A. Synthetic process for the manufacture of an ecteinaschidin compound
MXPA02011319A (es) * 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
CN100374162C (zh) * 2000-11-06 2008-03-12 法马马有限公司 海鞘素－743在制备用于治疗肿瘤的药剂中的应用
KR20050038578A (ko) * 2001-10-19 2005-04-27 파르마 마르, 에스.에이. 항종양성 화합물의 암치료에 있어서의 향상된 용도
GB0202544D0 (en) * 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0218813D0 (en) * 2002-08-13 2002-09-18 Pharma Mar Sa DNA sequences from an endosymbiont and their uses
GB0229793D0 (en) * 2002-12-20 2003-01-29 Pharma Mar Sa The gene cluster involved in safracin biosynthesis and its uses for genetic engineering
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
JP2007511499A (ja) * 2003-11-13 2007-05-10 ファーマ・マール・エス・アー・ウー コンビネーション
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
AU2004291037A1 (en) * 2003-11-14 2005-06-02 Pharma Mar, S.A. Combination therapy comprising the use of ET-743 and paclitaxel for treating cancer
NZ552607A (en) * 2004-07-09 2009-07-31 Pharma Mar Sa Prognostic molecular markers
JP2008514688A (ja) * 2004-09-29 2008-05-08 ファルマ・マル・エス・アー， ソシエダッド・ユニペルソナル 抗炎症剤としてのエクテイナシジン化合物
PL1827500T3 (pl) * 2004-10-26 2009-09-30 Pharma Mar Sa Pegylowana liposomalna doksorubicyna w kombinacji z ekteinascydyną 743
ATE368461T1 (de) * 2004-10-29 2007-08-15 Pharma Mar Sa Zusammensetzungen enthaltend ecteinascidin und einen disaccharide
GB0522082D0 (en) * 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
DE602006020335D1 (de) * 2005-11-25 2011-04-07 Pharma Mar Sa Verwendung von parp-1-hemmern
WO2007134203A2 (en) * 2006-05-12 2007-11-22 Pharma Mar, S.A. Anticancer treatments with a combination of docetaxel and ecteinascidin
US20100267732A1 (en) 2007-10-19 2010-10-21 Pharma Mar, S.A. Prognostic Molecular Markers for ET-743 Treatment
MX2010012358A (es) 2008-05-16 2011-01-25 Pharma Mar Sa Tratamientos para el mieloma multiple.
NZ589269A (en) 2008-05-16 2013-03-28 Pharma Mar Sa Combination therapy with an antitumor alkaloid

Also Published As

Publication number Publication date
NO340213B1 (no) 2017-03-20
ES2291479T3 (es) 2008-03-01
US20100197695A1 (en) 2010-08-05
SI1854800T1 (sl) 2012-11-30
SI2298780T1 (sl) 2013-01-31
CY1113359T1 (el) 2016-06-22
EP1854800A1 (de) 2007-11-14
US8076337B2 (en) 2011-12-13
US7759345B2 (en) 2010-07-20
DE60222135D1 (de) 2007-10-11
ES2389671T3 (es) 2012-10-30
NO20040189L (no) 2004-03-16
NO20140711L (no) 2004-03-16
EP1406907A1 (de) 2004-04-14
GB0117402D0 (en) 2001-09-05
JP4653950B2 (ja) 2011-03-16
DE60222135T2 (de) 2008-05-21
PT1854800E (pt) 2012-09-25
EP2298780B1 (de) 2012-09-12
JP2004536132A (ja) 2004-12-02
ES2394772T3 (es) 2013-02-05
CA2453991C (en) 2011-12-20
DK2298780T3 (da) 2013-01-07
AU2008207381B2 (en) 2011-07-14
CY1107809T1 (el) 2013-06-19
EP1854800B1 (de) 2012-06-27
PT1406907E (pt) 2007-12-10
EP2298780A1 (de) 2011-03-23
EP1406907B1 (de) 2007-08-29
AU2002317967C1 (en) 2009-01-22
PT2298780E (pt) 2012-12-17
MXPA04000506A (es) 2004-07-23
WO2003008423A1 (en) 2003-01-30
CA2453991A1 (en) 2003-01-30
DK1854800T3 (da) 2012-10-01
US20060106021A1 (en) 2006-05-18
DK1406907T3 (da) 2008-02-04
NO335262B1 (no) 2014-10-27
AU2008207381A1 (en) 2008-09-11
AU2002317967B2 (en) 2008-06-05

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