ATE524459T1 - Pyrazolederivate und ihr einsatz als hemmer von cyclinabhängigen kinasen - Google Patents
Pyrazolederivate und ihr einsatz als hemmer von cyclinabhängigen kinasenInfo
- Publication number
- ATE524459T1 ATE524459T1 AT08857078T AT08857078T ATE524459T1 AT E524459 T1 ATE524459 T1 AT E524459T1 AT 08857078 T AT08857078 T AT 08857078T AT 08857078 T AT08857078 T AT 08857078T AT E524459 T1 ATE524459 T1 AT E524459T1
- Authority
- AT
- Austria
- Prior art keywords
- cyclin
- inhibitors
- pyrazole derivatives
- dependent kinases
- useful
- Prior art date
Links
- 108091007914 CDKs Proteins 0.000 title 1
- 102000003903 Cyclin-dependent kinases Human genes 0.000 title 1
- 108090000266 Cyclin-dependent kinases Proteins 0.000 title 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical class C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 150000002894 organic compounds Chemical class 0.000 abstract 2
- 102000001253 Protein Kinase Human genes 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 108060006633 protein kinase Proteins 0.000 abstract 1
- 150000003217 pyrazoles Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1227607P | 2007-12-07 | 2007-12-07 | |
| PCT/EP2008/067037 WO2009071701A1 (en) | 2007-12-07 | 2008-12-08 | Pyrazole derivatives and use thereof as inhibitors of cyclin dependent kinases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE524459T1 true ATE524459T1 (de) | 2011-09-15 |
Family
ID=40343520
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08857078T ATE524459T1 (de) | 2007-12-07 | 2008-12-08 | Pyrazolederivate und ihr einsatz als hemmer von cyclinabhängigen kinasen |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8367687B2 (de) |
| EP (1) | EP2231636B1 (de) |
| JP (1) | JP2011506303A (de) |
| KR (1) | KR20100098521A (de) |
| CN (1) | CN101883764B (de) |
| AT (1) | ATE524459T1 (de) |
| AU (1) | AU2008333136B2 (de) |
| BR (1) | BRPI0821151A2 (de) |
| CA (1) | CA2707989A1 (de) |
| EA (1) | EA018459B1 (de) |
| ES (1) | ES2374480T3 (de) |
| MX (1) | MX2010006203A (de) |
| PL (1) | PL2231636T3 (de) |
| PT (1) | PT2231636E (de) |
| WO (1) | WO2009071701A1 (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101910150B (zh) | 2007-11-05 | 2013-09-18 | 诺瓦提斯公司 | 作为cetp抑制剂、可用于治疗疾病如高脂血症或动脉硬化的4-苄基氨基-1-羧基酰基哌啶衍生物 |
| MX2010006063A (es) | 2007-12-03 | 2010-07-01 | Novartis Ag | Derivados de 4-bencil-amino-pirrolidina 1,2-disustituida como inhibidores de la proteina de transferencia de colesteril-ester (cetp) utiles para el tratamiento de las enfermedades tales como hiperlipidemia o arterioesclerosis. |
| MX2011012343A (es) * | 2009-05-19 | 2011-12-14 | Dow Agrosciences Llc | Compuestos y metodos para controlar hongos. |
| EP2558092B1 (de) * | 2010-04-13 | 2018-06-27 | Novartis AG | Kombination mit einem hemmer der cyclin-abhängigen kinase-4 oder cyclinabhängigen kinase-6 (cdk4/6) und everolimus zur behandlung von krebs |
| ES2577829T3 (es) | 2010-06-04 | 2016-07-19 | F. Hoffmann-La Roche Ag | Derivados de aminopirimidina como moduladores de la LRRK2 |
| GB201017345D0 (en) | 2010-10-14 | 2010-11-24 | Proximagen Ltd | Receptor antagonists |
| NO2638031T3 (de) | 2010-11-10 | 2018-03-10 | ||
| CN103547580B (zh) | 2011-03-22 | 2016-12-07 | 阿迪维纳斯疗法有限公司 | 取代的稠合三环化合物、其组合物及医药用途 |
| CA2851788C (en) | 2011-10-11 | 2022-11-29 | Dana-Farber Cancer Institute, Inc. | Pyrazol-3-ones that activate pro-apoptotic bax |
| US9593115B2 (en) | 2012-09-21 | 2017-03-14 | Advinus Therapeutics Ltd. | Substituted fused tricyclic compounds, compositions, and medicinal applications thereof |
| NZ746607A (en) | 2012-11-21 | 2019-11-29 | Ptc Therapeutics Inc | Substituted reverse pyrimidine bmi-1 inhibitors |
| EA034866B1 (ru) | 2013-08-30 | 2020-03-31 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Замещенные пиримидиновые ингибиторы bmi-1 |
| WO2015076800A1 (en) | 2013-11-21 | 2015-05-28 | Ptc Therapeutics, Inc. | Substituted pyridine and pyrazine bmi-1 inhibitors |
| AU2016242118B2 (en) | 2015-04-02 | 2021-07-08 | Proximagen, Llc | Novel therapies for cancer |
| US10376511B2 (en) | 2015-08-04 | 2019-08-13 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Pyrazole pyrimidine derivative and uses thereof |
| BR112020018094A2 (pt) | 2018-03-08 | 2020-12-22 | Incyte Corporation | Compostos de aminopirazina diol como inibidores de pi3k-¿ |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
| EP3836932A2 (de) | 2018-08-17 | 2021-06-23 | PTC Therapeutics, Inc. | Verfahren zur behandlung von bauchspeicheldrüsenkrebs |
| US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
| US11384083B2 (en) | 2019-02-15 | 2022-07-12 | Incyte Corporation | Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors |
| TW202100520A (zh) | 2019-03-05 | 2021-01-01 | 美商英塞特公司 | 作為cdk2 抑制劑之吡唑基嘧啶基胺化合物 |
| WO2020205560A1 (en) | 2019-03-29 | 2020-10-08 | Incyte Corporation | Sulfonylamide compounds as cdk2 inhibitors |
| WO2020223469A1 (en) | 2019-05-01 | 2020-11-05 | Incyte Corporation | N-(1-(methylsulfonyl)piperidin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine derivatives and related compounds as cyclin-dependent kinase 2 (cdk2) inhibitors for treating cancer |
| US11447494B2 (en) | 2019-05-01 | 2022-09-20 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| CA3150681A1 (en) | 2019-08-14 | 2021-02-18 | Incyte Corporation | Imidazolyl pyrimidinylamine compounds as cdk2 inhibitors |
| US11851426B2 (en) | 2019-10-11 | 2023-12-26 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
| US11981671B2 (en) | 2021-06-21 | 2024-05-14 | Incyte Corporation | Bicyclic pyrazolyl amines as CDK2 inhibitors |
| US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
| US12084453B2 (en) | 2021-12-10 | 2024-09-10 | Incyte Corporation | Bicyclic amines as CDK12 inhibitors |
| EP4725942A1 (de) | 2024-10-09 | 2026-04-15 | Sibylla Biotech S.p.A. | Verbindungen mit wirkung auf den cyclin-d1-pfad und ihre verwendung |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6979686B1 (en) * | 2001-12-07 | 2005-12-27 | Pharmacia Corporation | Substituted pyrazoles as p38 kinase inhibitors |
| GB9919778D0 (en) * | 1999-08-21 | 1999-10-27 | Zeneca Ltd | Chemical compounds |
| ATE407132T1 (de) | 2000-12-05 | 2008-09-15 | Vertex Pharma | Inhibitoren von c-jun n-terminalen kinasen (jnk) und anderen proteinkinasen |
| GB0107901D0 (en) * | 2001-03-29 | 2001-05-23 | Cyclacel Ltd | Anti-cancer compounds |
| WO2002092573A2 (en) * | 2001-05-16 | 2002-11-21 | Vertex Pharmaceuticals Incorporated | Heterocyclic substituted pyrazoles as inhibitors of src and other protein kinases |
| WO2003051886A1 (en) * | 2001-12-17 | 2003-06-26 | Smithkline Beecham Corporation | Pyrazolopyridazine derivatives |
| GB0215844D0 (en) | 2002-07-09 | 2002-08-14 | Novartis Ag | Organic compounds |
| EP1551842A1 (de) | 2002-10-15 | 2005-07-13 | Smithkline Beecham Corporation | Pyridazinverbindungen als gsk-3-inhibitoren |
| GB0409080D0 (en) * | 2004-04-23 | 2004-05-26 | Biofocus Discovery Ltd | Compounds which interact with protein kinases |
| US20080242667A1 (en) | 2005-08-26 | 2008-10-02 | Smithkline Beecham Corporation | Pyrimidinyl-Pyrazole Inhibitors of Aurora Kinases |
| EA200802050A1 (ru) * | 2006-04-19 | 2009-04-28 | Лаборатуар Сероно Са | Новые гетероарилзамещенные ариламинопиридиновые производные в качестве мек ингибиторов |
| WO2007132220A1 (en) | 2006-05-12 | 2007-11-22 | Cyclacel Limited | Combination of a 2-substituted-4-heter0aryl-pyrimidine amine with a cytotoxic drug and use thereof in the treatment of a proliferative disorder |
| JP2010533147A (ja) * | 2007-07-13 | 2010-10-21 | アデックス ファルマ エス．エイ． | 代謝調節型グルタミン酸レセプターのモジュレーターとしてのピラゾール誘導体 |
-
2008
- 2008-12-08 CA CA2707989A patent/CA2707989A1/en not_active Abandoned
- 2008-12-08 ES ES08857078T patent/ES2374480T3/es active Active
- 2008-12-08 US US12/746,265 patent/US8367687B2/en not_active Expired - Fee Related
- 2008-12-08 AT AT08857078T patent/ATE524459T1/de active
- 2008-12-08 EP EP08857078A patent/EP2231636B1/de not_active Not-in-force
- 2008-12-08 BR BRPI0821151-5A patent/BRPI0821151A2/pt not_active IP Right Cessation
- 2008-12-08 WO PCT/EP2008/067037 patent/WO2009071701A1/en not_active Ceased
- 2008-12-08 AU AU2008333136A patent/AU2008333136B2/en not_active Ceased
- 2008-12-08 CN CN2008801187516A patent/CN101883764B/zh not_active Expired - Fee Related
- 2008-12-08 PT PT08857078T patent/PT2231636E/pt unknown
- 2008-12-08 PL PL08857078T patent/PL2231636T3/pl unknown
- 2008-12-08 KR KR1020107012317A patent/KR20100098521A/ko not_active Ceased
- 2008-12-08 JP JP2010536492A patent/JP2011506303A/ja active Pending
- 2008-12-08 EA EA201000879A patent/EA018459B1/ru not_active IP Right Cessation
- 2008-12-08 MX MX2010006203A patent/MX2010006203A/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| EA201000879A1 (ru) | 2010-12-30 |
| US20100280033A1 (en) | 2010-11-04 |
| JP2011506303A (ja) | 2011-03-03 |
| ES2374480T3 (es) | 2012-02-17 |
| WO2009071701A1 (en) | 2009-06-11 |
| EP2231636B1 (de) | 2011-09-14 |
| BRPI0821151A2 (pt) | 2015-06-16 |
| MX2010006203A (es) | 2010-06-25 |
| KR20100098521A (ko) | 2010-09-07 |
| EA018459B1 (ru) | 2013-08-30 |
| AU2008333136A1 (en) | 2009-06-11 |
| CA2707989A1 (en) | 2009-06-11 |
| CN101883764A (zh) | 2010-11-10 |
| PL2231636T3 (pl) | 2012-04-30 |
| AU2008333136B2 (en) | 2012-05-10 |
| CN101883764B (zh) | 2013-11-13 |
| EP2231636A1 (de) | 2010-09-29 |
| PT2231636E (pt) | 2012-01-02 |
| US8367687B2 (en) | 2013-02-05 |
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| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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