ATE524509T1 - Verzweigte funktionalisierte polymere unter verwendung von verzweigten polyolen als kernen - Google Patents

Verzweigte funktionalisierte polymere unter verwendung von verzweigten polyolen als kernen

Info

Publication number
ATE524509T1
ATE524509T1 AT06800077T AT06800077T ATE524509T1 AT E524509 T1 ATE524509 T1 AT E524509T1 AT 06800077 T AT06800077 T AT 06800077T AT 06800077 T AT06800077 T AT 06800077T AT E524509 T1 ATE524509 T1 AT E524509T1
Authority
AT
Austria
Prior art keywords
polyol
branched
monosubstituted
groups
polyols
Prior art date
Application number
AT06800077T
Other languages
English (en)
Inventor
Samuel Mcmanus
Antoni Kozlowski
Original Assignee
Nektar Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics
Application granted granted Critical
Publication of ATE524509T1 publication Critical patent/ATE524509T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/34—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from hydroxy compounds or their metallic derivatives
    • C08G65/48—Polymers modified by chemical after-treatment
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G71/00—Macromolecular compounds obtained by reactions forming a ureide or urethane link, otherwise, than from isocyanate radicals in the main chain of the macromolecule
    • C08G71/04—Polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polyethers (AREA)
  • Medicinal Preparation (AREA)
AT06800077T 2005-07-18 2006-07-18 Verzweigte funktionalisierte polymere unter verwendung von verzweigten polyolen als kernen ATE524509T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70011405P 2005-07-18 2005-07-18
PCT/US2006/027529 WO2007011802A1 (en) 2005-07-18 2006-07-18 Method for preparing branched functionalized polymers using branched polyol cores

Publications (1)

Publication Number Publication Date
ATE524509T1 true ATE524509T1 (de) 2011-09-15

Family

ID=37398801

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06800077T ATE524509T1 (de) 2005-07-18 2006-07-18 Verzweigte funktionalisierte polymere unter verwendung von verzweigten polyolen als kernen

Country Status (4)

Country Link
US (2) US8568705B2 (de)
EP (2) EP2412744B1 (de)
AT (1) ATE524509T1 (de)
WO (1) WO2007011802A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2412744B1 (de) 2005-07-18 2014-01-22 Nektar Therapeutics Verfahren zur Herstellung von verzweigten funktionalisierten Polymeren mithilfe von verzweigten Polyol-Kernen
EP1986695B1 (de) 2006-02-21 2015-06-03 Nektar Therapeutics Segmentierte abbaubare polymere und daraus hergestellte konjugate
US20080220047A1 (en) * 2007-03-05 2008-09-11 Sawhney Amarpreet S Low-swelling biocompatible hydrogels
US8309773B2 (en) 2010-02-02 2012-11-13 Calanese International Corporation Process for recovering ethanol
EP2323695B1 (de) 2008-08-19 2018-12-05 Nektar Therapeutics Komplexe von small-interfering nukleinsäuren
US8450529B2 (en) * 2008-10-02 2013-05-28 Covidien Lp Branched polyamines and formulations thereof for use in medical devices
CN101724144A (zh) * 2008-11-03 2010-06-09 北京键凯科技有限公司 新型的多臂聚乙二醇及其制备方法和应用
CN102361911A (zh) 2009-03-27 2012-02-22 阿克塔马克斯手术器材有限责任公司 聚甘油醛
CN102365101A (zh) * 2009-03-27 2012-02-29 阿克塔马克斯手术器材有限责任公司 包含聚甘油醛的组织粘合剂和密封剂
WO2011063156A2 (en) * 2009-11-18 2011-05-26 Nektar Therapeutics Acid salt forms of polymer-drug conjugates and alkoxylation methods
CN102108119A (zh) * 2009-12-25 2011-06-29 天津键凯科技有限公司 多臂聚乙二醇衍生物及其与药物的结合物和凝胶
CA2798518A1 (en) 2010-05-17 2011-11-24 Cebix, Inc. Pegylated c-peptide
EP2750681B1 (de) * 2011-08-30 2020-05-27 Quanta Biodesign, Ltd. Verzweigte einzelne peg-konstrukte
WO2013188539A2 (en) * 2012-06-12 2013-12-19 Fina Biosolutions, Llc Differential functionalization of polymers with amino-oxy reagents for diagnostic assays
US10881839B2 (en) 2012-10-26 2021-01-05 Urotronic, Inc. Drug-coated balloon catheters for body lumens
US10850076B2 (en) 2012-10-26 2020-12-01 Urotronic, Inc. Balloon catheters for body lumens
US10806830B2 (en) 2012-10-26 2020-10-20 Urotronic, Inc. Drug-coated balloon catheters for body lumens
WO2020172560A1 (en) 2019-02-22 2020-08-27 Urotronic, Inc. Drug-coated balloon catheters for body lumens
US11504450B2 (en) 2012-10-26 2022-11-22 Urotronic, Inc. Drug-coated balloon catheters for body lumens
US10898700B2 (en) 2012-10-26 2021-01-26 Urotronic, Inc. Balloon catheters for body lumens
US11938287B2 (en) 2012-10-26 2024-03-26 Urotronic, Inc. Drug-coated balloon catheters for body lumens
US10672238B2 (en) 2015-06-23 2020-06-02 SkyBell Technologies, Inc. Doorbell communities
GB201409128D0 (en) * 2014-05-22 2014-07-09 Ketonex Ltd Method
GB201415972D0 (en) 2014-09-10 2014-10-22 Ketonex Ltd Process
US11904072B2 (en) 2015-04-24 2024-02-20 Urotronic, Inc. Drug coated balloon catheters for nonvascular strictures
US10888640B2 (en) 2015-04-24 2021-01-12 Urotronic, Inc. Drug coated balloon catheters for nonvascular strictures
EP3347311B1 (de) 2015-09-10 2019-10-23 Dow Global Technologies LLC Kesselsteinhemmungsverfahren
EP3196221B1 (de) 2016-01-25 2018-08-15 Technogel Italia S.R.L. Temperaturgeregelte polyurethangele
EP3489684B1 (de) * 2017-11-27 2024-06-26 Miltenyi Biotec B.V. & Co. KG Verfahren zum fotobleichen von angefärbten zellen
WO2019131515A1 (ja) * 2017-12-27 2019-07-04 三洋化成工業株式会社 医薬品原薬用原料又は医薬品用添加物及びこれらを用いた医薬品原薬又は医薬品
EP4106828B1 (de) 2020-02-21 2026-03-11 Tonic Medical, Inc. Polymerverkapselte wirkstoffpartikel
CN116023668B (zh) * 2021-10-26 2024-10-01 佳化化学(上海)有限公司 一种含有氨基酸及其衍生物的酰基改性超支化聚缩水甘油醚、制备方法及其应用

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3101374A (en) * 1958-08-19 1963-08-20 Wyandotte Chemicals Corp Polyoxyalkylene surface active agents having heteric polyoxyethylene solubilizing chains
US4278555A (en) * 1978-11-15 1981-07-14 Ethyl Corporation Lubricant composition
JPH0323529B2 (de) * 1979-03-21 1991-03-29 Nat Res Dev
EP0206448B1 (de) 1985-06-19 1990-11-14 Ajinomoto Co., Inc. Hämoglobin, das an ein Poly(alkenylenoxid) gebunden ist
US5080891A (en) * 1987-08-03 1992-01-14 Ddi Pharmaceuticals, Inc. Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
US6436425B1 (en) 1988-11-16 2002-08-20 Mdv Technologies, Inc. Method and non-gelling composition for inhibiting post-surgical adhesions
US5135751A (en) * 1988-11-16 1992-08-04 Mediventures Incorporated Composition for reducing postsurgical adhesions
US5681576A (en) * 1988-11-16 1997-10-28 Mdv Technologies, Inc. Method and composition for post surgical adhesion reduction
FR2665449B1 (fr) * 1990-08-02 1995-04-14 Aquitaine Developp Transf Sang Procede de fabrication de facteur von willebrand ayant une tres haute purete, depourvu en majeure partie de facteur antihemophilique (fviiic), et facteur von willebrand ainsi obtenu, ainsi qu'une composition pharmaceutique le contenant.
US5122614A (en) * 1989-04-19 1992-06-16 Enzon, Inc. Active carbonates of polyalkylene oxides for modification of polypeptides
JPH0367541A (ja) 1989-08-04 1991-03-22 Meiji Milk Prod Co Ltd 洋菓子及びコーヒー兼用のホイップ性合成クリーム
US5306501A (en) * 1990-05-01 1994-04-26 Mediventures, Inc. Drug delivery by injection with thermoreversible gels containing polyoxyalkylene copolymers
DE4017688A1 (de) 1990-06-01 1991-12-05 Bayer Ag Verbesserte funktionelle fluessigkeiten und neue polyoxyalkylenpolymere
WO1992000748A1 (en) 1990-07-06 1992-01-23 Enzon, Inc. Poly(alkylene oxide) amino acid copolymers and drug carriers and charged copolymers based thereon
IE912365A1 (en) 1990-07-23 1992-01-29 Zeneca Ltd Continuous release pharmaceutical compositions
US5252714A (en) * 1990-11-28 1993-10-12 The University Of Alabama In Huntsville Preparation and use of polyethylene glycol propionaldehyde
US5281698A (en) * 1991-07-23 1994-01-25 Cetus Oncology Corporation Preparation of an activated polymer ester for protein conjugation
CA2087125A1 (en) * 1992-01-23 1993-07-24 Mridula Nair Chemically fixed micelles
US6096331A (en) * 1993-02-22 2000-08-01 Vivorx Pharmaceuticals, Inc. Methods and compositions useful for administration of chemotherapeutic agents
US5298410A (en) 1993-02-25 1994-03-29 Sterling Winthrop Inc. Lyophilized formulation of polyethylene oxide modified proteins with increased shelf-life
US5359030A (en) 1993-05-10 1994-10-25 Protein Delivery, Inc. Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
US5681811A (en) * 1993-05-10 1997-10-28 Protein Delivery, Inc. Conjugation-stabilized therapeutic agent compositions, delivery and diagnostic formulations comprising same, and method of making and using the same
US5543158A (en) * 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
DE69414060T2 (de) * 1993-08-16 1999-03-18 Nalco/Exxon Energy Chemicals L.P., Sugar Land, Tex. Methode zum Demulgieren von Wasser-in-Öl-Emulsionen
US5965566A (en) * 1993-10-20 1999-10-12 Enzon, Inc. High molecular weight polymer-based prodrugs
US5919455A (en) * 1993-10-27 1999-07-06 Enzon, Inc. Non-antigenic branched polymer conjugates
US5605976A (en) * 1995-05-15 1997-02-25 Enzon, Inc. Method of preparing polyalkylene oxide carboxylic acids
US5643575A (en) * 1993-10-27 1997-07-01 Enzon, Inc. Non-antigenic branched polymer conjugates
US5446090A (en) 1993-11-12 1995-08-29 Shearwater Polymers, Inc. Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules
US5618528A (en) * 1994-02-28 1997-04-08 Sterling Winthrop Inc. Biologically compatible linear block copolymers of polyalkylene oxide and peptide units
US5629384A (en) 1994-05-17 1997-05-13 Consiglio Nazionale Delle Ricerche Polymers of N-acryloylmorpholine activated at one end and conjugates with bioactive materials and surfaces
US5626862A (en) 1994-08-02 1997-05-06 Massachusetts Institute Of Technology Controlled local delivery of chemotherapeutic agents for treating solid tumors
JP3067541B2 (ja) 1994-08-23 2000-07-17 日本油脂株式会社 グリセリンポリアルキレングリコールエーテル誘導体及びその製造方法
US5650234A (en) 1994-09-09 1997-07-22 Surface Engineering Technologies, Division Of Innerdyne, Inc. Electrophilic polyethylene oxides for the modification of polysaccharides, polypeptides (proteins) and surfaces
US5824784A (en) * 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
JP3562000B2 (ja) 1994-12-14 2004-09-08 日本油脂株式会社 ポリオキシアルキレンモノアミンの製造方法
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US5756593A (en) * 1995-05-15 1998-05-26 Enzon, Inc. Method of preparing polyalkyene oxide carboxylic acids
US5672662A (en) * 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
DK2111876T3 (da) * 1995-12-18 2011-12-12 Angiodevice Internat Gmbh Tværbundne polymerpræparater og fremgangsmåder til anvendelse deraf
US5610241A (en) * 1996-05-07 1997-03-11 Cornell Research Foundation, Inc. Reactive graft polymer with biodegradable polymer backbone and method for preparing reactive biodegradable polymers
US6214966B1 (en) * 1996-09-26 2001-04-10 Shearwater Corporation Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
US6258351B1 (en) 1996-11-06 2001-07-10 Shearwater Corporation Delivery of poly(ethylene glycol)-modified molecules from degradable hydrogels
US6056811A (en) 1997-08-25 2000-05-02 Canon Kabushiki Kaisha Water-based ink for ink-jet recording, ink-jet recording process, recording unit, ink cartridge and ink-jet recording apparatus
US6011042A (en) * 1997-10-10 2000-01-04 Enzon, Inc. Acyl polymeric derivatives of aromatic hydroxyl-containing compounds
US6448369B1 (en) 1997-11-06 2002-09-10 Shearwater Corporation Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
DE69840175D1 (de) * 1997-12-12 2008-12-11 Samyang Corp Biologisch abbaubare gemischte polymerische mizellen zur genverabreichung
JP3786832B2 (ja) 1998-01-07 2006-06-14 デビオ ルシェルシュ ファルマシュティーク ソシエテ アノニム 分解性のヘテロ二官能性ポリ（エチレングリコール）アクリレート及びそれから誘導されるゲル及び複合体
ATE268609T1 (de) 1998-03-12 2004-06-15 Nektar Therapeutics Al Corp Polyethylenglycolderivate mit benachbarten reaktiven gruppen
US6455639B1 (en) 1998-03-24 2002-09-24 Nof Corporation Oxirane derivative and process for the preparation thereof
US6328988B1 (en) 1999-04-23 2001-12-11 Rutgers, The State University Of New Jersey Hyperbranched polymeric micelles for encapsulation and delivery of hydrophobic molecules
US6348558B1 (en) 1999-12-10 2002-02-19 Shearwater Corporation Hydrolytically degradable polymers and hydrogels made therefrom
US6376604B2 (en) * 1999-12-22 2002-04-23 Shearwater Corporation Method for the preparation of 1-benzotriazolylcarbonate esters of poly(ethylene glycol)
AU2458501A (en) 2000-01-05 2001-07-16 Imarx Therapeutics, Inc. Pharmaceutical formulations for the delivery of drugs having low aqueous solubility
WO2001062827A2 (en) * 2000-02-22 2001-08-30 Shearwater Corporation N-maleimidyl polymer derivatives
DE10040464A1 (de) 2000-08-18 2002-02-28 Infineon Technologies Ag Grabenkondensator und Verfahren zu seiner Herstellung
TWI246524B (en) 2001-01-19 2006-01-01 Shearwater Corp Multi-arm block copolymers as drug delivery vehicles
DE60236796D1 (de) 2001-01-30 2010-08-05 Kyowa Hakko Kirin Co Ltd Verzweigte polyalkylenglykole
US6835802B2 (en) * 2001-06-04 2004-12-28 Nobex Corporation Methods of synthesizing substantially monodispersed mixtures of polymers having polyethylene glycol moieties
JP4123856B2 (ja) * 2001-07-31 2008-07-23 日油株式会社 生体関連物質の修飾剤およびポリオキシアルキレン誘導体の製造方法
EP1446438A2 (de) * 2001-11-07 2004-08-18 Nektar Therapeutics Al, Corporation Verzweigte polymere und ihre konjugate
GB0129121D0 (en) 2001-12-05 2002-01-23 Ic Vec Ltd Compound
DE60331330D1 (de) 2002-05-09 2010-04-01 Oncothyreon Inc Lipid-a- und andere kohlenhydrat-liganden-analoga
US7569214B2 (en) * 2002-09-09 2009-08-04 Nektar Therapeutics Al, Corporation Method for preparing water-soluble polymer derivatives bearing a terminal carboxylic acid
DE60329627D1 (de) * 2002-12-31 2009-11-19 Nektar Therapeutics Al Corp Hydrolysestabile maleimidendgruppen-enthaltende polymere
WO2004060966A2 (en) 2002-12-31 2004-07-22 Nektar Therapeutics Al, Corporation Maleamic acid polymer derivatives and their bioconjugates
SE525080C2 (sv) * 2003-03-21 2004-11-23 Perstorp Specialty Chem Ab Förfarande för framställning av en allyleter
US7887789B2 (en) * 2003-05-23 2011-02-15 Nektar Therapeutics Polymer derivatives having particular atom arrangements
PT1656410E (pt) * 2003-07-22 2010-06-11 Nektar Therapeutics Processo para preparação de polímeros funcionalizados a partir de álcoois poliméricos
EP2412744B1 (de) 2005-07-18 2014-01-22 Nektar Therapeutics Verfahren zur Herstellung von verzweigten funktionalisierten Polymeren mithilfe von verzweigten Polyol-Kernen
US8808748B2 (en) * 2010-04-20 2014-08-19 Vindico NanoBio Technology Inc. Biodegradable nanoparticles as novel hemoglobin-based oxygen carriers and methods of using the same

Also Published As

Publication number Publication date
EP2412744B1 (de) 2014-01-22
US20070031371A1 (en) 2007-02-08
US8901246B2 (en) 2014-12-02
WO2007011802A1 (en) 2007-01-25
US8568705B2 (en) 2013-10-29
EP1926768A1 (de) 2008-06-04
US20140039205A1 (en) 2014-02-06
EP2412744A3 (de) 2012-05-16
EP2412744A2 (de) 2012-02-01
EP1926768B1 (de) 2011-09-14

Similar Documents

Publication Publication Date Title
ATE524509T1 (de) Verzweigte funktionalisierte polymere unter verwendung von verzweigten polyolen als kernen
ATE548466T1 (de) Verfahren und zusammensetzungen zur verbesserung der genauigkeit bei einer nukleinsäuresynthesereaktion
ATE508363T1 (de) Verfahren zur herstellung eines bioanalytischen reagenzes, nachweisverfahren beruhend auf der verwendung des bioanalytischen reagenz, sowie dessen verwendung
ATE419291T1 (de) Niedrigviskose alkoxysilangruppenaufweisende prepolymere, ein verfahren zu ihrer herstellung sowie ihre verwendung
ATE536383T1 (de) Verfahren zur herstellung von polyurethanprodukten unter verwendung von autokatalytischen tert.-amin-verkappten polyetherpolyolen
ATE493136T1 (de) Neues einstufiges verfahren zur herstellung von vernetzten poly(allylamin)-polymeren
ATE462012T1 (de) Ezymatisches verfahren zur herstellung von 2-o- glyceryl-alpha-d-glucopyranosid
TW200627068A (en) Resist composition, process for producing resist pattern, and compound
MY156301A (en) Polymerizable liquid composition and process for the production of organic glass starting from polymerizable liquid compositions of the polyurethane type
ATE475635T1 (de) Verfahren zur herstellung von polyoxymethylendialkylethern aus trioxan und dialkylether
ATE460419T1 (de) Organosiliciumverbindungen, ihre herstellung und ihre verwendung
GEP20084361B (en) Piperidinylcarbonyl-pyrro-lidines and their use as melanocortin agonists
ATE431366T1 (de) Verfahren zur herstellung von polymerverbindungen durch eliminierungsreaktion
GB0501964D0 (en) Chemical compounds
ATE552284T1 (de) Verfahren zur herstellung von isocyanatgruppen enthaltenden prepolymeren
TW200611895A (en) Process for preparing diphenylazetidinone derivatives
ATE458484T1 (de) ßVERFAHREN UND ZWISCHENPRODUKTE ZUR HERSTELLUNG VON STATINEN; INSBESONDERE VON ROSUVASTATINß
EP1528063A4 (de) Verbindung mit phoshorylcholingruppe, dessen polymer und verfahren zu dessen herstellung
ATE397579T1 (de) Verfahren zur herstellung von 2,3,5- trimethylhydrochinondiacylaten
ATE402211T1 (de) Verfahren zur herstellung von farblosen, lagerstabilen biuretgruppenhaltigen polyisocyanaten
EP0347682A3 (de) Polycarbonate mit mesogenen Verbindungen als Endgruppen, ihre Herstellung und Verwendung
ATE473963T1 (de) Verfahren zur herstellung eines organischen hydroperoxids, industrielle einrichtung dafür und verfahren mittels verwendung eines derartigen hydroperoxids zur herstellung eines alkylenoxids
ATE386765T1 (de) Verfahren zur herstellung von polycarbonat
DE502006008569D1 (de) Verfahren zur herstellung wasserabsorbierender polymere
DE112007000952A5 (de) Verfahren zur Herstellung von Wasserstoffreichen Silanen, sowie neue chemische Verbindungen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties