ATE526975T1 - Pkr-aktivierung mittels hybridisierungskettenreaktion - Google Patents

Pkr-aktivierung mittels hybridisierungskettenreaktion

Info

Publication number
ATE526975T1
ATE526975T1 AT06836249T AT06836249T ATE526975T1 AT E526975 T1 ATE526975 T1 AT E526975T1 AT 06836249 T AT06836249 T AT 06836249T AT 06836249 T AT06836249 T AT 06836249T AT E526975 T1 ATE526975 T1 AT E526975T1
Authority
AT
Austria
Prior art keywords
chain reaction
rna
hybridization chain
pkr
hcr
Prior art date
Application number
AT06836249T
Other languages
English (en)
Inventor
Robert Dirks
Niles Pierce
Original Assignee
California Inst Of Techn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by California Inst Of Techn filed Critical California Inst Of Techn
Application granted granted Critical
Publication of ATE526975T1 publication Critical patent/ATE526975T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
AT06836249T 2005-10-07 2006-10-06 Pkr-aktivierung mittels hybridisierungskettenreaktion ATE526975T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72501105P 2005-10-07 2005-10-07
PCT/US2006/039571 WO2007044727A2 (en) 2005-10-07 2006-10-06 Pkr activation via hybridization chain reaction

Publications (1)

Publication Number Publication Date
ATE526975T1 true ATE526975T1 (de) 2011-10-15

Family

ID=37943474

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06836249T ATE526975T1 (de) 2005-10-07 2006-10-06 Pkr-aktivierung mittels hybridisierungskettenreaktion

Country Status (4)

Country Link
US (2) US7960357B2 (de)
EP (1) EP1931806B1 (de)
AT (1) ATE526975T1 (de)
WO (1) WO2007044727A2 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE602005023426D1 (de) * 2004-03-25 2010-10-21 California Inst Of Techn Hybridisierungskettenreaktion
US7727721B2 (en) 2005-03-08 2010-06-01 California Institute Of Technology Hybridization chain reaction amplification for in situ imaging
US7960357B2 (en) 2005-10-07 2011-06-14 California Institute Of Technology PKR activation via hybridization chain reaction
US8778846B2 (en) * 2006-12-04 2014-07-15 General Electric Company Composition, device and associated method
WO2008106658A2 (en) * 2007-03-01 2008-09-04 California Institute Of Technology TRIGGERED RNAi
US9217151B2 (en) 2007-05-16 2015-12-22 California Institute Of Technology Versatile nucleic acid hairpin motif for programming biomolecular self-assembly pathways
US8497364B2 (en) 2008-02-27 2013-07-30 California Institute Of Technology Triggered RNAi
US20100021904A1 (en) * 2008-05-21 2010-01-28 Pierce Niles A Shielded cross-linking probes
US20100021901A1 (en) * 2008-05-22 2010-01-28 Peng Yin Compositions and methods for detecting analytes
US8241854B2 (en) 2008-05-22 2012-08-14 California Institute Of Technology Triggered RNAi
RU2529804C2 (ru) * 2008-10-23 2014-09-27 Конинклейке Филипс Электроникс, Н.В. Молекулярная визуализация
CN101756151B (zh) * 2008-12-24 2012-12-12 安琪酵母股份有限公司 一种高谷氨酸酵母抽提物及其制备方法
JP2009159990A (ja) * 2009-04-21 2009-07-23 Sanei Gen Ffi Inc 高栄養食
US8658780B2 (en) * 2010-05-18 2014-02-25 California Institute Of Technology Triggered covalent probes for imaging and silencing genetic expression
US9834439B2 (en) 2010-07-20 2017-12-05 California Institute Of Technology Biomolecular self-assembly
US8877438B2 (en) 2010-07-20 2014-11-04 California Institute Of Technology Self-assembled polynucleotide structure
US8962241B2 (en) 2010-07-20 2015-02-24 California Institute Of Technology Triggered molecular geometry based bioimaging probes
DE102012203964B3 (de) * 2012-03-14 2013-02-28 GNA Biosolultions GmbH Verfahren und Kit zur Detektion von Nukleinsäuren
US9856472B2 (en) 2013-07-01 2018-01-02 California Institute Of Technology Small conditional RNAs
GB201401885D0 (en) 2014-02-04 2014-03-19 Olink Ab Proximity assay with detection based on hybridisation chain reaction (HCR)
WO2018009463A2 (en) 2016-07-05 2018-01-11 California Institute Of Technology Fractional initiator hybridization chain reaction
WO2018044939A1 (en) 2016-08-30 2018-03-08 California Institute Of Technology Immunohistochemistry via hybridization chain reaction
AU2018272848B2 (en) * 2017-05-23 2022-03-31 Rutgers, The State University Of New Jersey Target mediated
US12054711B2 (en) 2017-07-14 2024-08-06 City Of Hope Meta-stable oligonucleotides junctions for delivery of therapeutics
WO2019033079A1 (en) 2017-08-10 2019-02-14 City Of Hope CONDITIONAL RNAIDS AND THEIR USES IN THE TREATMENT OF CARDIAC HYPERTROPHY
CN110286216B (zh) * 2019-05-16 2021-10-15 中国科学院武汉物理与数学研究所 一种快速可视化的溶血性大肠杆菌o157：h7检测方法
US11873485B2 (en) 2021-01-26 2024-01-16 California Institute Of Technology Allosteric conditional guide RNAs for cell-selective regulation of CRISPR/Cas
EP4382110A4 (de) * 2021-08-04 2025-10-29 Univ Tokyo Haarnadel-nukleinsäurezusammensetzung
WO2024005045A1 (ja) * 2022-06-28 2024-01-04 国立大学法人東京大学 ヘアピン核酸組成物
JPWO2024166539A1 (de) * 2023-02-07 2024-08-15
US20240336956A1 (en) 2023-04-04 2024-10-10 California Institute Of Technology Ultrasensitive molecular detection via hybridization chain reaction

Family Cites Families (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4120706A (en) * 1977-09-16 1978-10-17 Harris Corporation Heteroepitaxial deposition of gap on silicon substrates
US4965204A (en) * 1984-02-06 1990-10-23 The Johns Hopkins University Human stem cells and monoclonal antibodies
US4714680B1 (en) * 1984-02-06 1995-06-27 Univ Johns Hopkins Human stem cells
US4897355A (en) * 1985-01-07 1990-01-30 Syntex (U.S.A.) Inc. N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
EP0273085A1 (de) 1986-12-29 1988-07-06 IntraCel Corporation Verfahren zur Einführung fremder Nukleinsäuren in eukaryotische Zellen
US5057410A (en) * 1988-08-05 1991-10-15 Cetus Corporation Chimeric messenger RNA detection methods
US5118801A (en) 1988-09-30 1992-06-02 The Public Health Research Institute Nucleic acid process containing improved molecular switch
US5061620A (en) * 1990-03-30 1991-10-29 Systemix, Inc. Human hematopoietic stem cell
US5264618A (en) * 1990-04-19 1993-11-23 Vical, Inc. Cationic lipids for intracellular delivery of biologically active molecules
US5270163A (en) 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
EP0547142A1 (de) 1990-08-28 1993-06-23 Epoch Pharmaceuticals, Inc. Festträger Synthese von 3'-Ende Oligonukleotiden über ein Brückenmolekül
US5563256A (en) 1991-05-29 1996-10-08 Merck & Co., Inc. Eimeria tenella 16S rDNA probes
WO1997027214A1 (en) 1996-01-24 1997-07-31 Third Wave Technologies, Inc. Invasive cleavage of nucleic acids
US5424413A (en) 1992-01-22 1995-06-13 Gen-Probe Incorporated Branched nucleic acid probes
FI946201A0 (fi) * 1992-07-02 1994-12-30 Hybridon Inc Itsestabiloidut oligonukleotidit terapeuttisina aineina
US5677136A (en) * 1994-11-14 1997-10-14 Systemix, Inc. Methods of obtaining compositions enriched for hematopoietic stem cells, compositions derived therefrom and methods of use thereof
US5787104A (en) * 1995-01-19 1998-07-28 Matsushita Electric Industrial Co., Ltd. Semiconductor light emitting element and method for fabricating the same
CA2215162A1 (en) * 1995-03-23 1996-09-26 Cantab Pharmaceuticals Research Limited Vectors for gene delivery
WO1997005266A1 (en) * 1995-07-25 1997-02-13 Introgene B.V. Methods and means for targeted gene delivery
US5579793A (en) * 1995-11-15 1996-12-03 Rubbermaid Health Care Products, Inc. Foldable walker
US6361944B1 (en) * 1996-07-29 2002-03-26 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US5691145A (en) 1996-08-27 1997-11-25 Becton, Dickinson And Company Detection of nucleic acids using G-quartets
US6344317B2 (en) 1996-10-04 2002-02-05 Chronix Biomedical, Inc. Diagnostic detection of nucleic acids
ES2375764T3 (es) 1996-11-29 2012-03-06 Third Wave Technologies, Inc. Endonucleasas fen-1, mezclas y procedimientos de escisión.
US6555367B1 (en) * 1997-10-10 2003-04-29 The United States Of America As Represented By The Department Of Health And Human Services Complex of biotinylated viral vector and ligand for targeted gene delivery
GB9721909D0 (en) * 1997-10-17 1997-12-17 Cantab Pharma Res Gene delivery vectors and their uses
US5989823A (en) * 1998-09-18 1999-11-23 Nexstar Pharmaceuticals, Inc. Homogeneous detection of a target through nucleic acid ligand-ligand beacon interaction
US6242246B1 (en) * 1997-12-15 2001-06-05 Somalogic, Inc. Nucleic acid ligand diagnostic Biochip
EP1049803A4 (de) * 1997-12-15 2002-08-21 Nexstar Pharmaceuticals Inc Gleichmässige erkennung von zielmolekül durch nukleinsäure ligand - beacon ligand interaktion
US6506559B1 (en) * 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
WO1999047180A1 (en) * 1998-03-20 1999-09-23 Genzyme Corporation Chimeric adenoviral vectors for targeted gene delivery
US6255469B1 (en) 1998-05-06 2001-07-03 New York University Periodic two and three dimensional nucleic acid structures
US6290839B1 (en) 1998-06-23 2001-09-18 Clinical Micro Sensors, Inc. Systems for electrophoretic transport and detection of analytes
JP4646404B2 (ja) * 1998-07-02 2011-03-09 ジェン−プローブ・インコーポレーテッド 分子トーチ（ｔｏｒｃｈ）
US6899871B2 (en) * 1998-10-01 2005-05-31 University Of Southern California Gene delivery system and methods of use
EP1059357A1 (de) * 1999-06-09 2000-12-13 Universite Pierre Et Marie Curie Paris Vi Replizierende oder 'semi-replizierende' retrovirale Konstrukte, ihre Herstellung und Verwendungen für den Gentransfer
CA2360342A1 (en) 1999-12-02 2001-06-07 Molecular Staging Inc. Generation of single-strand circular dna from linear self-annealing segments
US20050239061A1 (en) 2000-03-01 2005-10-27 Marshall William S Identification and use of effectors and allosteric molecules for the alteration of gene expression
US20040009510A1 (en) 2000-03-06 2004-01-15 Scott Seiwert Allosteric nucleic acid sensor molecules
JP2003535600A (ja) * 2000-06-02 2003-12-02 バイエル コーポレイション インサイチュ分枝ｄｎａハイブリダイゼーションを用いた高感度遺伝子検出および位置決定
CA2451614C (en) 2001-06-25 2011-01-04 Georgia Tech Research Corporation Dual resonance energy transfer nucleic acid probes
US6814832B2 (en) * 2001-07-24 2004-11-09 Seiko Epson Corporation Method for transferring element, method for producing element, integrated circuit, circuit board, electro-optical device, IC card, and electronic appliance
EP1474513A1 (de) 2002-01-22 2004-11-10 McMaster University Signalübermittelnde aptamerkomplexe
US20040126773A1 (en) 2002-05-23 2004-07-01 Beske Oren E. Assays with coded sensor particles to sense assay conditions
US20040043386A1 (en) 2002-08-30 2004-03-04 Todd Pray Methods and compositions for functional ubiquitin assays
US20040223953A1 (en) * 2003-03-17 2004-11-11 Hsiang-Fu Kung Combined adeno-associated virus and adenovirus cocktail gene delivery system for high efficiency gene expression without eliciting immune response in immuno-competent subjects
US20050112614A1 (en) 2003-05-15 2005-05-26 California Institute Of Technology Self-assembled circuits and circuit patterns
DE602005023426D1 (de) 2004-03-25 2010-10-21 California Inst Of Techn Hybridisierungskettenreaktion
US20060035375A1 (en) 2004-08-16 2006-02-16 Head Jonathan F Method for selectively culturing epithelial or carcinoma cells
EP1815010A2 (de) 2004-09-24 2007-08-08 Ingeneus Inc. Genom-assay
ATE514776T1 (de) 2004-10-05 2011-07-15 California Inst Of Techn Aptamer-regulierte nukleinsäuren und verwendungen davon
CA2587010C (en) 2004-11-08 2017-08-15 Vipergen Aps Structural nucleic acid guided chemical synthesis
US20060234261A1 (en) * 2005-03-08 2006-10-19 Pierce Niles A Colorimetric readout of hybridization chain reaction
US7727721B2 (en) * 2005-03-08 2010-06-01 California Institute Of Technology Hybridization chain reaction amplification for in situ imaging
JP4986406B2 (ja) * 2005-03-31 2012-07-25 住友電工デバイス・イノベーション株式会社 半導体装置の製造方法
US7968289B2 (en) 2005-05-03 2011-06-28 Ensemble Therapeutics Corporation Turn over probes and use thereof for nucleic acid detection
US7842793B2 (en) 2005-06-14 2010-11-30 The California Institute Of Technology Methods of making nucleic acid nanostructures
US7960357B2 (en) 2005-10-07 2011-06-14 California Institute Of Technology PKR activation via hybridization chain reaction
GB0607866D0 (en) 2006-04-20 2006-05-31 Isis Innovation Nanostructures
US8445655B2 (en) 2006-06-16 2013-05-21 Cornell Research Foundation, Inc. Functional nucleic acid ligands to fluorescent proteins
WO2008106658A2 (en) 2007-03-01 2008-09-04 California Institute Of Technology TRIGGERED RNAi
CA2686216C (en) 2007-05-14 2016-04-12 Universidad Nacional Autonoma De Mexico Vm23 and vm24, two scorpion peptides that block human t-lymphocyte potassium channels (sub-type kv1.3) with high selectivity and decrease the in vivo dth-responses in rats
US9217151B2 (en) * 2007-05-16 2015-12-22 California Institute Of Technology Versatile nucleic acid hairpin motif for programming biomolecular self-assembly pathways
US8497364B2 (en) 2008-02-27 2013-07-30 California Institute Of Technology Triggered RNAi
US20100021904A1 (en) 2008-05-21 2010-01-28 Pierce Niles A Shielded cross-linking probes
US20100021901A1 (en) 2008-05-22 2010-01-28 Peng Yin Compositions and methods for detecting analytes
US8241854B2 (en) 2008-05-22 2012-08-14 California Institute Of Technology Triggered RNAi
WO2009152492A1 (en) 2008-06-13 2009-12-17 University Of Connecticut Nucleic acid materials for nonradiative energy transfer and methods of production and use
US8642260B2 (en) 2008-10-21 2014-02-04 The Research Foundation Of The City University Of New York Single quantum-dot based aptameric nanosensors
US8478543B2 (en) 2010-04-05 2013-07-02 California Institute Of Technology System and method for nucleic acid sequence design
US8658780B2 (en) 2010-05-18 2014-02-25 California Institute Of Technology Triggered covalent probes for imaging and silencing genetic expression
US8962241B2 (en) 2010-07-20 2015-02-24 California Institute Of Technology Triggered molecular geometry based bioimaging probes
US8877438B2 (en) 2010-07-20 2014-11-04 California Institute Of Technology Self-assembled polynucleotide structure
US9834439B2 (en) 2010-07-20 2017-12-05 California Institute Of Technology Biomolecular self-assembly

Also Published As

Publication number Publication date
US7960357B2 (en) 2011-06-14
US20110313030A1 (en) 2011-12-22
US8962582B2 (en) 2015-02-24
WO2007044727A3 (en) 2009-05-28
WO2007044727A2 (en) 2007-04-19
EP1931806A2 (de) 2008-06-18
US20070087334A1 (en) 2007-04-19
EP1931806B1 (de) 2011-10-05
EP1931806A4 (de) 2010-05-26

Similar Documents

Publication Publication Date Title
EP1931806A4 (de) Pkr-aktivierung mittels hybridisierungskettenreaktion
JOP20210207A1 (ar) مركبات ترابطية مستهدفة
EA201591281A1 (ru) Рибонуклеиновые кислоты с 4'-тиомодифицированными нуклеотидами и связанные с ними способы
ES2422739T3 (es) Composición para el diagnóstico, prevención o tratamiento de enfermedades relacionadas con células que expresan IL-8 o GRO-, que comprende MSC de UCB
DE602007013559D1 (de) Nanoteilchen zur abgabe von nukleinsäure
NZ704295A (en) Compositions and methods for the treatment of infections and tumors
WO2005005599A3 (en) Modulation of c-reactive protein expression
UA102065C2 (xx) Заміщені 4-арил-1,4-дигідро-1,6-нафтиридинаміди і їх застосування$замещенные 4-арил-1,4-дигидро-1,6-нафтиридинамиды и их применение
UY31862A (es) Inmunoglobulina con dominio variable dual y usos de la misma
UY31484A1 (es) Piperidinas heteroaril-sustituidas
WO2006026485A3 (en) Modulation of hif1-beta expression
NO20081884L (no) Modulasjon av glukagonreseptorekspresjon
CL2009001476A1 (es) Compuestos derivados de 2,4-diamin-n2-fenil pirimidina sustituidos, mediadores de la inhibicion de igf-1r; composicion farmaceutica que comprende a dichos compuestos; y su uso en el tratamiento de enfermedades autoinmune, por trasplante, infecciosas o un trastorno proliferativo celular.
WO2007065010A3 (en) Anti-angiogenesis compounds
WO2004048534A3 (en) Modulation of cytokine-inducible kinase expression
EA200800835A1 (ru) Циклопропиламины в качестве модуляторов рецептора гистамина н
WO2005071080A3 (en) Modulation of glucocorticoid receptor expression
DK1526840T3 (da) Nanopartikler til DNA administration til et målorgan
EA201001266A1 (ru) Эффективные противоопухолевые парамиксовирусы
WO2005079532A3 (en) Methods and compositions for enhancing risc activity in vitro and in vivo
WO2004009024A3 (en) Modulation of protein kinase c-iota expression
WO2009051659A3 (en) Therapeutic sirna molecules for reducing vegfr1 expression in vitro and in vivo
WO2005042552A3 (en) Modulation of sglt2 expression
EA201070637A1 (ru) Соединения циклоалкилокси- и гетероциклоалкилоксипиридина как модуляторы гистаминового рецептора н
EA200701592A1 (ru) Композиты и способы их получения и использования

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties