ATE526975T1 - Pkr-aktivierung mittels hybridisierungskettenreaktion - Google Patents
Pkr-aktivierung mittels hybridisierungskettenreaktionInfo
- Publication number
- ATE526975T1 ATE526975T1 AT06836249T AT06836249T ATE526975T1 AT E526975 T1 ATE526975 T1 AT E526975T1 AT 06836249 T AT06836249 T AT 06836249T AT 06836249 T AT06836249 T AT 06836249T AT E526975 T1 ATE526975 T1 AT E526975T1
- Authority
- AT
- Austria
- Prior art keywords
- chain reaction
- rna
- hybridization chain
- pkr
- hcr
- Prior art date
Links
- 230000004913 activation Effects 0.000 title abstract 2
- 238000009396 hybridization Methods 0.000 title abstract 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 229920002477 rna polymer Polymers 0.000 abstract 2
- 102000040650 (ribonucleotides)n+m Human genes 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 230000008685 targeting Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72501105P | 2005-10-07 | 2005-10-07 | |
| PCT/US2006/039571 WO2007044727A2 (en) | 2005-10-07 | 2006-10-06 | Pkr activation via hybridization chain reaction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE526975T1 true ATE526975T1 (de) | 2011-10-15 |
Family
ID=37943474
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06836249T ATE526975T1 (de) | 2005-10-07 | 2006-10-06 | Pkr-aktivierung mittels hybridisierungskettenreaktion |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US7960357B2 (de) |
| EP (1) | EP1931806B1 (de) |
| AT (1) | ATE526975T1 (de) |
| WO (1) | WO2007044727A2 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1730161B1 (de) * | 2004-03-25 | 2010-09-08 | California Institute Of Technology | Hybridisierungskettenreaktion |
| US7727721B2 (en) | 2005-03-08 | 2010-06-01 | California Institute Of Technology | Hybridization chain reaction amplification for in situ imaging |
| WO2007044727A2 (en) | 2005-10-07 | 2007-04-19 | California Institute Of Technology | Pkr activation via hybridization chain reaction |
| US8778846B2 (en) | 2006-12-04 | 2014-07-15 | General Electric Company | Composition, device and associated method |
| US8318921B2 (en) | 2007-03-01 | 2012-11-27 | California Institute Of Technology | Triggered RNAi |
| US9217151B2 (en) | 2007-05-16 | 2015-12-22 | California Institute Of Technology | Versatile nucleic acid hairpin motif for programming biomolecular self-assembly pathways |
| US8497364B2 (en) * | 2008-02-27 | 2013-07-30 | California Institute Of Technology | Triggered RNAi |
| US20100021904A1 (en) * | 2008-05-21 | 2010-01-28 | Pierce Niles A | Shielded cross-linking probes |
| US20100021901A1 (en) * | 2008-05-22 | 2010-01-28 | Peng Yin | Compositions and methods for detecting analytes |
| US8241854B2 (en) | 2008-05-22 | 2012-08-14 | California Institute Of Technology | Triggered RNAi |
| EP2344040B1 (de) * | 2008-10-23 | 2020-05-20 | Koninklijke Philips N.V. | Molekulare bildgebung |
| CN101756151B (zh) * | 2008-12-24 | 2012-12-12 | 安琪酵母股份有限公司 | 一种高谷氨酸酵母抽提物及其制备方法 |
| JP2009159990A (ja) * | 2009-04-21 | 2009-07-23 | Sanei Gen Ffi Inc | 高栄養食 |
| US8658780B2 (en) | 2010-05-18 | 2014-02-25 | California Institute Of Technology | Triggered covalent probes for imaging and silencing genetic expression |
| US8877438B2 (en) | 2010-07-20 | 2014-11-04 | California Institute Of Technology | Self-assembled polynucleotide structure |
| US8962241B2 (en) | 2010-07-20 | 2015-02-24 | California Institute Of Technology | Triggered molecular geometry based bioimaging probes |
| US9834439B2 (en) | 2010-07-20 | 2017-12-05 | California Institute Of Technology | Biomolecular self-assembly |
| DE102012203964B3 (de) * | 2012-03-14 | 2013-02-28 | GNA Biosolultions GmbH | Verfahren und Kit zur Detektion von Nukleinsäuren |
| US9856472B2 (en) | 2013-07-01 | 2018-01-02 | California Institute Of Technology | Small conditional RNAs |
| GB201401885D0 (en) | 2014-02-04 | 2014-03-19 | Olink Ab | Proximity assay with detection based on hybridisation chain reaction (HCR) |
| IL324487A (en) | 2016-07-05 | 2026-01-01 | California Inst Of Techn | Hybridization chain reaction based on a minimal initiator |
| AU2017321492A1 (en) | 2016-08-30 | 2019-03-14 | California Institute Of Technology | Immunohistochemistry via hybridization chain reaction |
| AU2018272848B2 (en) * | 2017-05-23 | 2022-03-31 | Rutgers, The State University Of New Jersey | Target mediated |
| US12054711B2 (en) | 2017-07-14 | 2024-08-06 | City Of Hope | Meta-stable oligonucleotides junctions for delivery of therapeutics |
| US12385041B2 (en) | 2017-08-10 | 2025-08-12 | City Of Hope | Conditional-siRNAS and uses thereof in treating cardiac hypertrophy |
| CN110286216B (zh) * | 2019-05-16 | 2021-10-15 | 中国科学院武汉物理与数学研究所 | 一种快速可视化的溶血性大肠杆菌o157:h7检测方法 |
| US11873485B2 (en) | 2021-01-26 | 2024-01-16 | California Institute Of Technology | Allosteric conditional guide RNAs for cell-selective regulation of CRISPR/Cas |
| EP4382110A4 (de) * | 2021-08-04 | 2025-10-29 | Univ Tokyo | Haarnadel-nukleinsäurezusammensetzung |
| WO2024005045A1 (ja) * | 2022-06-28 | 2024-01-04 | 国立大学法人東京大学 | ヘアピン核酸組成物 |
| WO2024166539A1 (ja) * | 2023-02-07 | 2024-08-15 | 国立大学法人東京大学 | 核酸集合体医薬 |
| WO2024211429A1 (en) | 2023-04-04 | 2024-10-10 | California Institute Of Technology | Ultrasensitive molecular detection via hybridization chain reaction |
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| US4120706A (en) * | 1977-09-16 | 1978-10-17 | Harris Corporation | Heteroepitaxial deposition of gap on silicon substrates |
| US4714680B1 (en) * | 1984-02-06 | 1995-06-27 | Univ Johns Hopkins | Human stem cells |
| US4965204A (en) * | 1984-02-06 | 1990-10-23 | The Johns Hopkins University | Human stem cells and monoclonal antibodies |
| US4897355A (en) * | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| EP0273085A1 (de) | 1986-12-29 | 1988-07-06 | IntraCel Corporation | Verfahren zur Einführung fremder Nukleinsäuren in eukaryotische Zellen |
| US5057410A (en) * | 1988-08-05 | 1991-10-15 | Cetus Corporation | Chimeric messenger RNA detection methods |
| US5118801A (en) | 1988-09-30 | 1992-06-02 | The Public Health Research Institute | Nucleic acid process containing improved molecular switch |
| US5061620A (en) * | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
| US5264618A (en) * | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| US5270163A (en) | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
| EP0547142A1 (de) | 1990-08-28 | 1993-06-23 | Epoch Pharmaceuticals, Inc. | Festträger Synthese von 3'-Ende Oligonukleotiden über ein Brückenmolekül |
| US5563256A (en) | 1991-05-29 | 1996-10-08 | Merck & Co., Inc. | Eimeria tenella 16S rDNA probes |
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| RU94046425A (ru) * | 1992-07-02 | 1997-03-20 | Хайбрайдон | Самостабилизированный олигонуклеотид и способ ингибирования генной экспрессии |
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| CA2215162A1 (en) * | 1995-03-23 | 1996-09-26 | Cantab Pharmaceuticals Research Limited | Vectors for gene delivery |
| US6261554B1 (en) * | 1995-07-25 | 2001-07-17 | Introgene B.V. | Compositions for targeted gene delivery |
| US5579793A (en) * | 1995-11-15 | 1996-12-03 | Rubbermaid Health Care Products, Inc. | Foldable walker |
| DK1634890T3 (da) | 1996-01-24 | 2009-03-09 | Third Wave Tech Inc | Invasiv klövning af nukleinsyrer |
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| US6361944B1 (en) * | 1996-07-29 | 2002-03-26 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| US5691145A (en) | 1996-08-27 | 1997-11-25 | Becton, Dickinson And Company | Detection of nucleic acids using G-quartets |
| EP0960210A4 (de) | 1996-10-04 | 2004-06-09 | Chronix Biomedical | Diagnostische nukleinsäure-detektion |
| WO1999019500A1 (en) * | 1997-10-10 | 1999-04-22 | The Government Of The United States Of America, Represented By The Secretary, Department Of Healt H And Human Services | Complex of biotinylated viral vector and ligand for targeted gene delivery |
| GB9721909D0 (en) * | 1997-10-17 | 1997-12-17 | Cantab Pharma Res | Gene delivery vectors and their uses |
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| AU3909199A (en) * | 1997-12-15 | 1999-07-05 | Nexstar Pharmaceuticals, Inc. | Homogeneous detection of a target through nucleic acid ligand-ligand beacon interaction |
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| US6506559B1 (en) * | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| WO1999047180A1 (en) * | 1998-03-20 | 1999-09-23 | Genzyme Corporation | Chimeric adenoviral vectors for targeted gene delivery |
| US6255469B1 (en) | 1998-05-06 | 2001-07-03 | New York University | Periodic two and three dimensional nucleic acid structures |
| US6290839B1 (en) | 1998-06-23 | 2001-09-18 | Clinical Micro Sensors, Inc. | Systems for electrophoretic transport and detection of analytes |
| CA2333253C (en) * | 1998-07-02 | 2010-09-07 | Gen-Probe Incorporated | Molecular torches |
| US6899871B2 (en) * | 1998-10-01 | 2005-05-31 | University Of Southern California | Gene delivery system and methods of use |
| EP1059357A1 (de) * | 1999-06-09 | 2000-12-13 | Universite Pierre Et Marie Curie Paris Vi | Replizierende oder 'semi-replizierende' retrovirale Konstrukte, ihre Herstellung und Verwendungen für den Gentransfer |
| WO2001040516A2 (en) | 1999-12-02 | 2001-06-07 | Molecular Staging Inc. | Generation of single-strand circular dna from linear self-annealing segments |
| US20050239061A1 (en) | 2000-03-01 | 2005-10-27 | Marshall William S | Identification and use of effectors and allosteric molecules for the alteration of gene expression |
| US20040009510A1 (en) | 2000-03-06 | 2004-01-15 | Scott Seiwert | Allosteric nucleic acid sensor molecules |
| DE60128908T2 (de) * | 2000-06-02 | 2008-02-28 | Bayer Corp. | Verfahren zum Nachweis und zur Lokalisierung von Genen in situ durch Hybridisierung einer verzweigten DNA |
| EP1409735A4 (de) | 2001-06-25 | 2005-10-05 | Georgia Tech Res Inst | Doppel-resonanzenergietransfer-nukleinsäuresonden |
| US6814832B2 (en) * | 2001-07-24 | 2004-11-09 | Seiko Epson Corporation | Method for transferring element, method for producing element, integrated circuit, circuit board, electro-optical device, IC card, and electronic appliance |
| WO2003062422A1 (en) | 2002-01-22 | 2003-07-31 | Mcmaster University | Signalling aptamer complexes |
| US20040126773A1 (en) | 2002-05-23 | 2004-07-01 | Beske Oren E. | Assays with coded sensor particles to sense assay conditions |
| US20040043386A1 (en) | 2002-08-30 | 2004-03-04 | Todd Pray | Methods and compositions for functional ubiquitin assays |
| US20040223953A1 (en) * | 2003-03-17 | 2004-11-11 | Hsiang-Fu Kung | Combined adeno-associated virus and adenovirus cocktail gene delivery system for high efficiency gene expression without eliciting immune response in immuno-competent subjects |
| WO2005030978A2 (en) | 2003-05-15 | 2005-04-07 | California Institute Of Technology | Self-assembled circuits and circuit patterns |
| EP1730161B1 (de) | 2004-03-25 | 2010-09-08 | California Institute Of Technology | Hybridisierungskettenreaktion |
| US20060035375A1 (en) | 2004-08-16 | 2006-02-16 | Head Jonathan F | Method for selectively culturing epithelial or carcinoma cells |
| KR20070062575A (ko) | 2004-09-24 | 2007-06-15 | 인제네우스 인크. | 게놈 분석 |
| ATE514776T1 (de) | 2004-10-05 | 2011-07-15 | California Inst Of Techn | Aptamer-regulierte nukleinsäuren und verwendungen davon |
| CA2587010C (en) | 2004-11-08 | 2017-08-15 | Vipergen Aps | Structural nucleic acid guided chemical synthesis |
| US7727721B2 (en) | 2005-03-08 | 2010-06-01 | California Institute Of Technology | Hybridization chain reaction amplification for in situ imaging |
| US20060234261A1 (en) * | 2005-03-08 | 2006-10-19 | Pierce Niles A | Colorimetric readout of hybridization chain reaction |
| JP4986406B2 (ja) * | 2005-03-31 | 2012-07-25 | 住友電工デバイス・イノベーション株式会社 | 半導体装置の製造方法 |
| CN101189347A (zh) | 2005-05-03 | 2008-05-28 | 通信探索公司 | 反转探针及其用于核酸检测的用途 |
| US7842793B2 (en) | 2005-06-14 | 2010-11-30 | The California Institute Of Technology | Methods of making nucleic acid nanostructures |
| WO2007044727A2 (en) | 2005-10-07 | 2007-04-19 | California Institute Of Technology | Pkr activation via hybridization chain reaction |
| GB0607866D0 (en) | 2006-04-20 | 2006-05-31 | Isis Innovation | Nanostructures |
| WO2007147159A2 (en) | 2006-06-16 | 2007-12-21 | Cornell Research Foundation, Inc. | Functional nucleic acid ligands to fluorescent proteins |
| US8318921B2 (en) | 2007-03-01 | 2012-11-27 | California Institute Of Technology | Triggered RNAi |
| BRPI0721664A8 (pt) | 2007-05-14 | 2019-01-22 | Univ Mexico Nac Autonoma | vm23 e vm24, dois peptídeos de escorpião que bloqueiam canais de potássio de linfócitos-t humanos(sub-tipo kv1.3) com alta seletividade e diminuem as respostas de dth invivo em ratos |
| US9217151B2 (en) * | 2007-05-16 | 2015-12-22 | California Institute Of Technology | Versatile nucleic acid hairpin motif for programming biomolecular self-assembly pathways |
| US8497364B2 (en) | 2008-02-27 | 2013-07-30 | California Institute Of Technology | Triggered RNAi |
| US20100021904A1 (en) | 2008-05-21 | 2010-01-28 | Pierce Niles A | Shielded cross-linking probes |
| US20100021901A1 (en) | 2008-05-22 | 2010-01-28 | Peng Yin | Compositions and methods for detecting analytes |
| US8241854B2 (en) | 2008-05-22 | 2012-08-14 | California Institute Of Technology | Triggered RNAi |
| US20090311799A1 (en) | 2008-06-13 | 2009-12-17 | Sotzing Gregory A | Nucleic Acid Materials for Nonradiative Energy Transfer and Methods of Production and Use |
| US8642260B2 (en) | 2008-10-21 | 2014-02-04 | The Research Foundation Of The City University Of New York | Single quantum-dot based aptameric nanosensors |
| WO2011126996A2 (en) | 2010-04-05 | 2011-10-13 | California Institute Of Technology | System and method for nucleic acid sequence design |
| US8658780B2 (en) | 2010-05-18 | 2014-02-25 | California Institute Of Technology | Triggered covalent probes for imaging and silencing genetic expression |
| US9834439B2 (en) | 2010-07-20 | 2017-12-05 | California Institute Of Technology | Biomolecular self-assembly |
| US8877438B2 (en) | 2010-07-20 | 2014-11-04 | California Institute Of Technology | Self-assembled polynucleotide structure |
| US8962241B2 (en) | 2010-07-20 | 2015-02-24 | California Institute Of Technology | Triggered molecular geometry based bioimaging probes |
-
2006
- 2006-10-06 WO PCT/US2006/039571 patent/WO2007044727A2/en not_active Ceased
- 2006-10-06 EP EP06836249A patent/EP1931806B1/de not_active Not-in-force
- 2006-10-06 AT AT06836249T patent/ATE526975T1/de not_active IP Right Cessation
- 2006-10-06 US US11/544,306 patent/US7960357B2/en not_active Expired - Fee Related
-
2011
- 2011-06-07 US US13/154,989 patent/US8962582B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007044727A2 (en) | 2007-04-19 |
| US20070087334A1 (en) | 2007-04-19 |
| WO2007044727A3 (en) | 2009-05-28 |
| US20110313030A1 (en) | 2011-12-22 |
| US8962582B2 (en) | 2015-02-24 |
| EP1931806B1 (de) | 2011-10-05 |
| US7960357B2 (en) | 2011-06-14 |
| EP1931806A4 (de) | 2010-05-26 |
| EP1931806A2 (de) | 2008-06-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |