ATE414793T1 - Invasive spaltung von nukleinsäuren - Google Patents

Invasive spaltung von nukleinsäuren

Info

Publication number
ATE414793T1
ATE414793T1 AT05016686T AT05016686T ATE414793T1 AT E414793 T1 ATE414793 T1 AT E414793T1 AT 05016686 T AT05016686 T AT 05016686T AT 05016686 T AT05016686 T AT 05016686T AT E414793 T1 ATE414793 T1 AT E414793T1
Authority
AT
Austria
Prior art keywords
nucleic acid
specific
present
acid sequences
nucleic acids
Prior art date
Application number
AT05016686T
Other languages
English (en)
Inventor
Jeff G Hall
Natascha Lyamicheva
Michael W Kaiser
James E Dahlberg
David Michael Olive
Victor I Lyamichev
Mary Ann D Brow
James R Prudent
Original Assignee
Third Wave Tech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/599,491 external-priority patent/US5846717A/en
Priority claimed from US08/756,386 external-priority patent/US5985557A/en
Priority claimed from US08/758,314 external-priority patent/US6090606A/en
Application filed by Third Wave Tech Inc filed Critical Third Wave Tech Inc
Application granted granted Critical
Publication of ATE414793T1 publication Critical patent/ATE414793T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6816Hybridisation assays characterised by the detection means
    • C12Q1/6823Release of bound markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
    • C12Q1/683Hybridisation assays for detection of mutation or polymorphism involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT05016686T 1996-01-24 1997-01-22 Invasive spaltung von nukleinsäuren ATE414793T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/599,491 US5846717A (en) 1996-01-24 1996-01-24 Detection of nucleic acid sequences by invader-directed cleavage
US08/682,853 US6001567A (en) 1996-01-24 1996-07-12 Detection of nucleic acid sequences by invader-directed cleavage
US08/756,386 US5985557A (en) 1996-01-24 1996-11-29 Invasive cleavage of nucleic acids
US08/758,314 US6090606A (en) 1996-01-24 1996-12-02 Cleavage agents
US08/759,038 US6090543A (en) 1996-01-24 1996-12-02 Cleavage of nucleic acids

Publications (1)

Publication Number Publication Date
ATE414793T1 true ATE414793T1 (de) 2008-12-15

Family

ID=27541970

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05016686T ATE414793T1 (de) 1996-01-24 1997-01-22 Invasive spaltung von nukleinsäuren

Country Status (8)

Country Link
EP (2) EP0904286A4 (de)
JP (2) JP3665648B2 (de)
AT (1) ATE414793T1 (de)
AU (1) AU731062B2 (de)
CA (1) CA2243353C (de)
DK (1) DK1634890T3 (de)
ES (1) ES2317113T3 (de)
WO (1) WO1997027214A1 (de)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7150982B2 (en) 1991-09-09 2006-12-19 Third Wave Technologies, Inc. RNA detection assays
US6759226B1 (en) 2000-05-24 2004-07-06 Third Wave Technologies, Inc. Enzymes for the detection of specific nucleic acid sequences
US7045289B2 (en) 1991-09-09 2006-05-16 Third Wave Technologies, Inc. Detection of RNA Sequences
US5994069A (en) * 1996-01-24 1999-11-30 Third Wave Technologies, Inc. Detection of nucleic acids by multiple sequential invasive cleavages
US6913881B1 (en) 1996-01-24 2005-07-05 Third Wave Technologies, Inc. Methods and compositions for detecting target sequences
AU781188B2 (en) * 1996-01-24 2005-05-12 Third Wave Technologies, Inc. Detection of nucleic acids by multiple sequential invasive cleavages
US7432048B2 (en) 1996-11-29 2008-10-07 Third Wave Technologies, Inc. Reactions on a solid surface
US7527928B2 (en) 1996-11-29 2009-05-05 Third Wave Technologies, Inc. Reactions on a solid surface
US6780982B2 (en) 1996-07-12 2004-08-24 Third Wave Technologies, Inc. Charge tags and the separation of nucleic acid molecules
EP2374890B1 (de) * 1996-11-29 2012-11-14 Third Wave Technologies, Inc. FEN-1-Endonucleasen, Mischungen und Spaltungsverfahren
US7101672B2 (en) 1998-05-05 2006-09-05 Third Wave Technologies, Inc. Target-dependent reactions using structure-bridging oligonucleotides
US6210880B1 (en) 1997-09-19 2001-04-03 Third Wave Technologies, Inc. Polymorphism analysis by nucleic acid structure probing with structure-bridging oligonucleotides
WO1998050403A1 (en) 1997-05-05 1998-11-12 Third Wave Technologies,Inc. Target-dependent reactions using structure-bridging oligonucleotides
US6194149B1 (en) 1998-03-03 2001-02-27 Third Wave Technologies, Inc. Target-dependent reactions using structure-bridging oligonucleotides
WO1998054364A1 (en) 1997-05-30 1998-12-03 Lxr Biotechnology Inc. Methods for detection of nucleic acid sequences in urine
US8182991B1 (en) 1997-11-26 2012-05-22 Third Wave Technologies, Inc. FEN-1 endonucleases, mixtures and cleavage methods
US7824859B2 (en) 1999-10-29 2010-11-02 Cytyc Corporation Methods for detection of a target nucleic acid by forming a cleavage structure using an RNA polymerase
US7118860B2 (en) 1999-10-29 2006-10-10 Stratagene California Methods for detection of a target nucleic acid by capture
US7838225B2 (en) 1999-10-29 2010-11-23 Hologic, Inc. Methods for detection of a target nucleic acid by forming a cleavage structure using a reverse transcriptase
US6528254B1 (en) * 1999-10-29 2003-03-04 Stratagene Methods for detection of a target nucleic acid sequence
WO2001073127A2 (en) 2000-03-27 2001-10-04 Applera Corporation Improved invasion assay
JP2004521606A (ja) * 2000-05-24 2004-07-22 サード・ウェーブ・テクノロジーズ・インク Rnaの検出法
US7060436B2 (en) 2000-06-17 2006-06-13 Third Wave Technologies, Inc. Nucleic acid accessible hybridization sites
JP2004507230A (ja) 2000-07-03 2004-03-11 アプレラ コーポレイション ポリヌクレオチド配列アッセイ
JP2005500821A (ja) * 2000-11-15 2005-01-13 サード・ウェーブ・テクノロジーズ・インク Fenエンドヌクレアーゼ
CN100351393C (zh) * 2001-02-15 2007-11-28 宝生物工程株式会社 核苷酸多态性的检测方法
US7303869B2 (en) 2001-07-17 2007-12-04 Northwestern University Solid-phase reactions
US7485443B2 (en) 2001-07-17 2009-02-03 Northwestern University Solid-phase reactions
US20040014067A1 (en) 2001-10-12 2004-01-22 Third Wave Technologies, Inc. Amplification methods and compositions
GB0205455D0 (en) 2002-03-07 2002-04-24 Molecular Sensing Plc Nucleic acid probes, their synthesis and use
US7312033B2 (en) 2002-11-14 2007-12-25 Third Wave Technologies, Inc. CFTR allele detection assays
US8206904B2 (en) 2002-12-18 2012-06-26 Third Wave Technologies, Inc. Detection of nucleic acids
WO2004057017A2 (en) 2002-12-18 2004-07-08 Third Wave Technologies, Inc. Detection of small nucleic acids
US7297780B2 (en) 2003-01-06 2007-11-20 Third Wave Technologies, Inc. Reactive functional groups for preparation of modified nucleic acid
US7700750B2 (en) 2003-01-09 2010-04-20 Third Wave Technologies, Inc. Connexin allele detection assays
US20040161749A1 (en) 2003-01-24 2004-08-19 Hall Jeff G. 3' end tagged oligonucleotides
CN1977050B (zh) 2004-01-07 2012-09-05 第三次浪潮技术公司 丙型肝炎病毒基因型的确定
US7462451B2 (en) 2004-04-26 2008-12-09 Third Wave Technologies, Inc. Compositions for modifying nucleic acids
US7727721B2 (en) 2005-03-08 2010-06-01 California Institute Of Technology Hybridization chain reaction amplification for in situ imaging
US7939257B2 (en) 2005-05-12 2011-05-10 Third Wave Technologies, Inc. Polymorphic GHSR nucleic acids and uses thereof
US7960357B2 (en) 2005-10-07 2011-06-14 California Institute Of Technology PKR activation via hybridization chain reaction
US7482127B2 (en) 2005-11-03 2009-01-27 Third Wave Technologies, Inc. Nucleic acid detection assays employing blocker oligonucleotides
US7674924B2 (en) 2006-05-22 2010-03-09 Third Wave Technologies, Inc. Compositions, probes, and conjugates and uses thereof
JP5260503B2 (ja) 2006-06-01 2013-08-14 サード ウェーブ テクノロジーズ,インコーポレーテッド 核酸の検出
US7759062B2 (en) 2006-06-09 2010-07-20 Third Wave Technologies, Inc. T-structure invasive cleavage assays, consistent nucleic acid dispensing, and low level target nucleic acid detection
WO2008045251A2 (en) 2006-10-04 2008-04-17 Third Wave Technologies, Inc. Snap-back primers and detectable hairpin structures
WO2008144562A1 (en) 2007-05-16 2008-11-27 California Institute Of Technology A versatile nucleic acid hairpin motif for programming biomolecular self-assembly pathways
BRPI0816274A2 (pt) 2007-09-07 2019-09-10 Third Wave Tech Inc método e aplicações para quantificação de alvo
US8497364B2 (en) 2008-02-27 2013-07-30 California Institute Of Technology Triggered RNAi
CN102301000B (zh) 2008-03-15 2015-04-29 豪洛捷公司 核酸分子扩增反应的分析组分及方法
ES2595489T3 (es) 2008-07-18 2016-12-30 Trovagene, Inc. Métodos para la detección de secuencias de ácidos nucleicos "ultracortos" basados en PCR
US8658780B2 (en) 2010-05-18 2014-02-25 California Institute Of Technology Triggered covalent probes for imaging and silencing genetic expression
US9834439B2 (en) 2010-07-20 2017-12-05 California Institute Of Technology Biomolecular self-assembly
US8962241B2 (en) 2010-07-20 2015-02-24 California Institute Of Technology Triggered molecular geometry based bioimaging probes
US8877438B2 (en) 2010-07-20 2014-11-04 California Institute Of Technology Self-assembled polynucleotide structure
ES2645418T3 (es) 2011-12-22 2017-12-05 Ibis Biosciences, Inc. Amplificación de una secuencia de un ácido ribonucleico
EP2865764B1 (de) * 2012-06-20 2018-09-05 Toray Industries, Inc. Verfahren zum nachweis von nukleinsäure und verwendung eines kits zum nachweis von nukleinsäure
WO2014158628A1 (en) 2013-03-14 2014-10-02 Hologic, Inc. Compositions and methods for analysis of nucleic acid molecules
BR112015023527A2 (pt) 2013-03-15 2017-07-18 Trovagene Inc detecção de ácidos nucléicos na urina
US9856472B2 (en) 2013-07-01 2018-01-02 California Institute Of Technology Small conditional RNAs
CA2983740C (en) 2015-05-01 2021-04-20 Gen-Probe Incorporated Multiplex invasive cleavage assays
EP3481843B1 (de) 2016-07-05 2022-01-26 California Institute of Technology Hybridisierungskettenreaktion mit fraktioniertem initiator
IL264831B (en) 2016-08-30 2022-09-01 California Inst Of Techn Immunohistochemistry via hybridization chain reaction
CN111032209A (zh) 2017-07-10 2020-04-17 简·探针公司 分析系统和方法
WO2019032809A1 (en) 2017-08-11 2019-02-14 Gen-Probe Incorporated COMPOSITIONS AND METHODS FOR DETECTING STAPHYLOCOCCUS AUREUS
US11662281B2 (en) 2017-12-13 2023-05-30 Gen-Probe Incorporated Compositions and methods for biological sample processing
JP2021506274A (ja) 2017-12-15 2021-02-22 ジェン−プローブ・インコーポレーテッド 毒素産生Clostridium difficileを検出するための組成物および方法
AU2019212931A1 (en) 2018-01-29 2020-08-27 Gen-Probe Incorporated Analytical systems and methods
JP7470095B2 (ja) 2018-07-10 2024-04-17 ジェン-プローブ・インコーポレーテッド 核酸を検出および定量するための方法およびシステム
WO2020142347A2 (en) 2018-12-31 2020-07-09 Gen-Probe Incorporated Systems and methods for filling multi-well cartridges with solid reagents
WO2020154513A1 (en) 2019-01-25 2020-07-30 Gen-Probe Incorporated Detection of drug-resistant mycoplasma genitalium
CA3176703C (en) 2019-05-03 2025-10-14 Gen-Probe Incorporated RECEPTACLE TRANSPORT SYSTEM FOR ANALYTICAL SYSTEM
CN111172164B (zh) * 2020-03-09 2022-11-15 中国药科大学 一种用于任意核酸编辑的组合物及方法
AU2021365165B2 (en) 2020-10-21 2026-03-05 Gen-Probe Incorporated Fluid container management system
EP4284925A4 (de) 2021-01-26 2025-08-13 California Inst Of Techn Allosterische bedingte guide-rnas zur zellselektiven regulierung von crispr/cas
CN113774141B (zh) * 2021-09-30 2024-02-27 重庆大学 一种用于双位点顺反式突变检测的引物、探针组合物及其应用
EP4508245A2 (de) * 2022-04-14 2025-02-19 National University of Singapore Verfahren zum nachweis eines polynukleotidanalyten
WO2024054924A1 (en) 2022-09-08 2024-03-14 Gen-Probe Incorporated Method of detecting nucleic acid analytes using dual-specificity primers

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5118605A (en) * 1984-10-16 1992-06-02 Chiron Corporation Polynucleotide determination with selectable cleavage sites
CA1337639C (en) * 1989-08-01 1995-11-28 Joseph Eugene Celebuski Dna probe assay using neutrally charged probe strands
US5210015A (en) * 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
ATE217347T1 (de) * 1992-12-04 2002-05-15 Univ Yale Diagnose mittels signalverstärkung durch ein ribozym
US5422253A (en) * 1992-12-07 1995-06-06 Wisconsin Alumni Research Foundation Method of site specific nucleic acid cleavage
US5541311A (en) * 1992-12-07 1996-07-30 Third Wave Technologies, Inc. Nucleic acid encoding synthesis-deficient thermostable DNA polymerase
AU4234796A (en) * 1994-11-09 1996-06-06 Third Wave Technologies, Inc. Rapid detection and identification of nucleic acid variants and pathogens

Also Published As

Publication number Publication date
EP0904286A1 (de) 1999-03-31
EP1634890A1 (de) 2006-03-15
JP2005160481A (ja) 2005-06-23
AU731062B2 (en) 2001-03-22
CA2243353A1 (en) 1997-07-31
WO1997027214A1 (en) 1997-07-31
EP1634890B1 (de) 2008-11-19
AU1836497A (en) 1997-08-20
JP4295715B2 (ja) 2009-07-15
JP2002515737A (ja) 2002-05-28
CA2243353C (en) 2010-03-30
JP3665648B2 (ja) 2005-06-29
DK1634890T3 (da) 2009-03-09
EP0904286A4 (de) 2004-01-14
ES2317113T3 (es) 2009-04-16

Similar Documents

Publication Publication Date Title
ATE414793T1 (de) Invasive spaltung von nukleinsäuren
CA2284552A1 (en) Detection of nucleic acids by multiple sequential invasive cleavages
EP2058407A3 (de) Invasive Spaltung von Nukleinsäuren
DK0966542T3 (da) FEN-1 endonukleaser, blandinger og spaltningsmethoder
DE60139200D1 (de) Nachweis von rna
ATE274587T1 (de) 5'-nukleasen aus thermostabilen dna-polymerasen
DE60334985D1 (de) Rna-nachweisenzyme
WO2001090337A3 (en) Detection of rna
WO2002070755A3 (en) Fen endonucleases
AU8234998A (en) Categorising nucleic acid
DE69534855D1 (de) Enzymaktive dna moleküle
DE60131903D1 (de) Direkte multiplex charakterisierung von genomischer dna
WO1999001569A3 (en) Additives for use in cycling probe reactions
SE9403805D0 (sv) Method of preparing oligonucleotide probes or primers, vector therefor and use thereof
CA2203627A1 (en) Rapid detection and identification of nucleic acid variants and pathogens
DE10082230D2 (de) Verfahren zur Charakterisierung von Nukleinsäurefragmenten
WO2002042497A3 (en) Methods using fluorescens energy transfer probes for detecting cleavage of nucleic acids

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1634890

Country of ref document: EP