ATE527272T1 - Synthese von triphenylphosphoniumchinolen und - chinonen - Google Patents
Synthese von triphenylphosphoniumchinolen und - chinonenInfo
- Publication number
- ATE527272T1 ATE527272T1 AT02760924T AT02760924T ATE527272T1 AT E527272 T1 ATE527272 T1 AT E527272T1 AT 02760924 T AT02760924 T AT 02760924T AT 02760924 T AT02760924 T AT 02760924T AT E527272 T1 ATE527272 T1 AT E527272T1
- Authority
- AT
- Austria
- Prior art keywords
- quinones
- sub
- triphenylphosphoniumquinoles
- synthesis
- typified
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000005208 1,4-dihydroxybenzenes Chemical class 0.000 abstract 1
- SIRZPOBKMRMKDI-UHFFFAOYSA-O 10-(2,5-dihydroxy-3,4-dimethoxy-6-methylphenyl)decyl-triphenylphosphanium Chemical compound OC1=C(OC)C(OC)=C(O)C(C)=C1CCCCCCCCCC[P+](C=1C=CC=CC=1)(C=1C=CC=CC=1)C1=CC=CC=C1 SIRZPOBKMRMKDI-UHFFFAOYSA-O 0.000 abstract 1
- OIIMUKXVVLRCAF-UHFFFAOYSA-N 10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)decyl-triphenylphosphanium Chemical compound O=C1C(OC)=C(OC)C(=O)C(CCCCCCCCCC[P+](C=2C=CC=CC=2)(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1C OIIMUKXVVLRCAF-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- JGPMMRGNQUBGND-UHFFFAOYSA-N idebenone Chemical compound COC1=C(OC)C(=O)C(CCCCCCCCCCO)=C(C)C1=O JGPMMRGNQUBGND-UHFFFAOYSA-N 0.000 abstract 1
- 229960004135 idebenone Drugs 0.000 abstract 1
- 150000004053 quinones Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5456—Arylalkanephosphonium compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fireproofing Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ513547A NZ513547A (en) | 2001-08-13 | 2001-08-13 | Synthesis of triphenylphosphonium quinols (e.g. mitoquinol) and/or quinones (e.g. mitoquinone) |
| PCT/NZ2002/000154 WO2003016323A1 (en) | 2001-08-13 | 2002-08-12 | Synthesis of triphenylphosphonium quinols snd quinones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE527272T1 true ATE527272T1 (de) | 2011-10-15 |
Family
ID=19928579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02760924T ATE527272T1 (de) | 2001-08-13 | 2002-08-12 | Synthese von triphenylphosphoniumchinolen und - chinonen |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7179928B2 (de) |
| EP (1) | EP1423396B1 (de) |
| AT (1) | ATE527272T1 (de) |
| NZ (1) | NZ513547A (de) |
| WO (1) | WO2003016323A1 (de) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005019233A1 (en) * | 2003-08-22 | 2005-03-03 | Antipodean Pharmaceuticals, Inc. | Mitoquinone derivatives used as mitochondrially targeted antioxidants |
| US20080275005A1 (en) * | 1998-11-25 | 2008-11-06 | Murphy Michael P | Mitochondrially targeted antioxidants |
| US20060229278A1 (en) * | 1998-11-25 | 2006-10-12 | Antipodean Pharmaceuticals, Inc. | Mitoquinone derivatives used as mitochondrially targeted antioxidants |
| CN1839142B (zh) * | 2003-08-22 | 2010-06-16 | 澳新制药公司 | 用作靶向线粒体的抗氧化剂的线粒体醌衍生物 |
| US7888334B2 (en) | 2003-08-22 | 2011-02-15 | Antipodean Pharmaceuticals, Inc. | Mitoquinone derivatives used as mitochondrially targeted antioxidants |
| CN1997403A (zh) * | 2004-07-13 | 2007-07-11 | 奥里迪斯生物医学研究及开发有限责任公司 | 靶向线粒体的抗氧化剂在治疗肝病和上皮癌中的用途 |
| EP1888059B1 (de) * | 2005-06-01 | 2014-12-17 | Edison Pharmaceuticals, Inc. | Redoxaktive therapeutik zur behandlung von mitochondrialen erkrankungen und anderen zuständen sowie modulation von energie-biomarkern |
| PL1933821T3 (pl) * | 2005-09-15 | 2021-01-11 | Ptc Therapeutics, Inc. | Warianty łańcucha końcowego środków terapeutycznych o aktywności redoks do leczenia chorób mitochondrialnych i innych stanów oraz do modulacji biomarkerów energetycznych |
| JP5374162B2 (ja) | 2006-02-22 | 2013-12-25 | エジソン ファーマシューティカルズ， インコーポレイテッド | ミトコンドリア病および他の症状の処置のためのレドックス活性化治療の側鎖変異体およびエネルギーバイオマーカーの調節 |
| EP2617417A1 (de) | 2006-02-22 | 2013-07-24 | Edison Pharmaceuticals, Inc. | Seitenkettenvarianten von redoxaktiven Therapeutika zur Behandlung von mitochondrialen Erkrankungen und anderen Zuständen sowie Modulation von Energie-Biomarkern |
| JP2010515736A (ja) * | 2007-01-10 | 2010-05-13 | エジソン ファーマシューティカルズ， インコーポレイテッド | エリスロポイエチン活性またはトロンボポイエチン活性を有する化合物を用いる呼吸鎖障害の治療 |
| EP3456707B1 (de) | 2007-11-06 | 2020-04-15 | PTC Therapeutics, Inc. | 4-(p-quinonyl)-2-hydroxybutanamid-derivate zur behandlung von mitochondrialen erkrankungen |
| EA023618B1 (ru) | 2008-01-08 | 2016-06-30 | Эдисон Фармасьютикалз, Инк. | Производные (гет)арил-п-хинона для лечения митохондриальных болезней |
| EP2262508B1 (de) | 2008-03-05 | 2018-10-03 | BioElectron Technology Corporation | SUBSTITUIERTE p-CHINONDERIVATE ZUR BEHANDLUNG VON ERKRANKUNGEN IN VERBINDUNG MIT OXIDATIVEM STRESS |
| EA201001814A1 (ru) * | 2008-05-22 | 2011-04-29 | Эдисон Фармасьютикалз, Инк. | Лечение митохондриальных заболеваний миметиками эритропоэтина |
| EP2303824B1 (de) * | 2008-06-25 | 2015-03-25 | Edison Pharmaceuticals, Inc. | 2-heterocyclylaminoalkyl-(p-chinon)-derivate zur behandlung von krankheiten mit oxidativem stress |
| LT3827815T (lt) | 2008-09-10 | 2023-10-10 | Ptc Therapeutics, Inc. | Psichologinių raidos sutrikimų gydymas oksidacijos redukcijos atžvilgiu aktyviais vaistais |
| JP6093756B2 (ja) | 2011-04-26 | 2017-03-08 | レトロトップ、 インコーポレイテッドＲｅｔｒｏｔｏｐｅ， Ｉｎｃ． | 損なわれたエネルギー処理障害およびミトコンドリア欠損症 |
| ES2859753T3 (es) | 2011-04-26 | 2021-10-04 | Retrotope Inc | Trastornos que implican la oxidación de PUFA |
| EP3689342A1 (de) | 2011-04-26 | 2020-08-05 | Retrotope, Inc. | Oxidative netzhauterkrankungen |
| KR102020611B1 (ko) | 2011-04-26 | 2019-09-10 | 레트로토프 인코포레이티드 | Ｐｕｆａ와 관련된 신경퇴행성 질환 및 근육 질환 |
| SI2872497T2 (sl) | 2012-07-12 | 2019-12-31 | Khondrion Ip B.V. | Derivati kromanila za zdravljenje mitohondrijske bolezni |
| CA2883879A1 (en) | 2012-09-07 | 2014-03-13 | Edison Pharmaceuticals, Inc. | Quinone derivatives for use in the modulation of redox status of individuals |
| EP2970158B1 (de) | 2013-03-15 | 2019-02-20 | BioElectron Technology Corporation | Alkyl-heteroarylsubstituierte chinonderivate zur behandlung von oxidativen stresserkrankungen |
| US9868711B2 (en) | 2013-03-15 | 2018-01-16 | Bioelectron Technology Corporation | Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders |
| US9296712B2 (en) | 2013-03-15 | 2016-03-29 | Edison Pharmaceuticals, Inc. | Resorufin derivatives for treatment of oxidative stress disorders |
| US20140275045A1 (en) | 2013-03-15 | 2014-09-18 | Edison Pharmaceuticals, Inc. | Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders |
| US9670170B2 (en) | 2013-03-15 | 2017-06-06 | Bioelectron Technology Corporation | Resorufin derivatives for treatment of oxidative stress disorders |
| JP2016520621A (ja) | 2013-05-31 | 2016-07-14 | エジソン ファーマシューティカルズ， インコーポレイテッド | 酸化ストレス障害の処置のためのカルボン酸誘導体 |
| CN106170206A (zh) | 2014-03-13 | 2016-11-30 | 乐巢拓普有限公司 | 视神经病变治疗和用稳定的多不饱和物质减少类固醇诱导的氧化应激 |
| US9314457B2 (en) | 2014-06-19 | 2016-04-19 | The University Of Utah Research Foundation | Methods of treating and preventing vascular instability diseases |
| SG10202003299PA (en) | 2014-12-16 | 2020-05-28 | Ptc Therapeutics Inc | Polymorphic and amorphous forms of (r)-2-hydroxy-2-methyl-4-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dienyl)butanamide |
| US10815211B2 (en) | 2015-10-08 | 2020-10-27 | Khondrion Ip B.V. | Compounds for treating mitochondrial disease |
| JP6905527B2 (ja) | 2015-12-17 | 2021-07-21 | ピーティーシー セラピューティクス， インコーポレイテッド | 酸化ストレス障害を処置するためのフルオロアルキル、フルオロアルコキシ、フェノキシ、ヘテロアリールオキシ、アルコキシ、およびアミノ１，４−ベンゾキノン誘導体 |
| CN110167546A (zh) | 2016-11-17 | 2019-08-23 | 乐巢拓普有限公司 | 同位素修饰的组分及其治疗用途 |
| WO2018129411A1 (en) | 2017-01-06 | 2018-07-12 | Bioelectron Technology Corporation | Aryl- and heteroaryl-resorufin derivatives for treatment of oxidative stress disorders and liver and kidney disorders |
| CN109793720B (zh) * | 2019-01-28 | 2022-01-14 | 温州医科大学 | 一种基于透明质酸的线粒体靶向抗氧化剂Mito Q纳米制剂的制备方法及应用 |
| EP3983385B1 (de) | 2019-06-13 | 2023-08-30 | PTC Therapeutics, Inc. | Naphthochinonderivate zur behandlung von erkrankungen in verbindung mit oxidativem stress |
| KR20210076875A (ko) * | 2019-12-16 | 2021-06-24 | 주식회사 스마틴바이오 | 신생혈관형성인자의 억제를 위한 화합물 및 그 용도 |
| WO2022019362A1 (ko) * | 2020-07-24 | 2022-01-27 | 울산과학기술원 | Tpp 유도체 화합물 및 이를 포함하는 노화 또는 노화 관련 질환의 치료 또는 예방을 위한 약학적 조성물 |
| US11389431B2 (en) | 2020-09-09 | 2022-07-19 | Social Profit Network | Methods and compositions for delivery of biotin to mitochondria |
| US12109194B2 (en) | 2021-02-05 | 2024-10-08 | Biojiva Llc | Synergistic combination therapy for treating ALS |
| WO2026008715A1 (en) | 2024-07-02 | 2026-01-08 | Université Catholique de Louvain | Mitochondrially-targeted antioxidant compound for use in radiation therapy |
| CN118994239B (zh) * | 2024-08-09 | 2025-09-26 | 苏州满元生物科技有限公司 | 氧化制备米托醌的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0237338B2 (ja) | 1982-08-27 | 1990-08-23 | Takeda Chemical Industries Ltd | 99*3*44jimetokishii22hidorokishii66mechirubenzoiru*nonanoeetonoseizoho |
| EP0289223B1 (de) | 1987-04-27 | 1992-09-02 | Takeda Chemical Industries, Ltd. | Reduktion von Carbonsäureestern |
| JPH07223991A (ja) | 1993-12-17 | 1995-08-22 | Takeda Chem Ind Ltd | アシル置換芳香族化合物の製造法 |
| JP2637705B2 (ja) | 1995-03-02 | 1997-08-06 | 株式会社ナード研究所 | ベンゾキノン系誘導体の製造法 |
| US6331532B1 (en) | 1998-11-25 | 2001-12-18 | University Of Otago | Mitochondrially targeted antioxidants |
-
2001
- 2001-08-13 NZ NZ513547A patent/NZ513547A/xx not_active IP Right Cessation
-
2002
- 2002-08-12 AT AT02760924T patent/ATE527272T1/de not_active IP Right Cessation
- 2002-08-12 EP EP02760924A patent/EP1423396B1/de not_active Expired - Lifetime
- 2002-08-12 US US10/486,797 patent/US7179928B2/en not_active Expired - Lifetime
- 2002-08-12 WO PCT/NZ2002/000154 patent/WO2003016323A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| NZ513547A (en) | 2002-09-27 |
| US20050043553A1 (en) | 2005-02-24 |
| EP1423396B1 (de) | 2011-10-05 |
| WO2003016323A1 (en) | 2003-02-27 |
| EP1423396A1 (de) | 2004-06-02 |
| US7179928B2 (en) | 2007-02-20 |
| EP1423396A4 (de) | 2006-02-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |