ATE527272T1 - Synthese von triphenylphosphoniumchinolen und - chinonen - Google Patents
Synthese von triphenylphosphoniumchinolen und - chinonenInfo
- Publication number
- ATE527272T1 ATE527272T1 AT02760924T AT02760924T ATE527272T1 AT E527272 T1 ATE527272 T1 AT E527272T1 AT 02760924 T AT02760924 T AT 02760924T AT 02760924 T AT02760924 T AT 02760924T AT E527272 T1 ATE527272 T1 AT E527272T1
- Authority
- AT
- Austria
- Prior art keywords
- quinones
- sub
- triphenylphosphoniumquinoles
- synthesis
- typified
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000005208 1,4-dihydroxybenzenes Chemical class 0.000 abstract 1
- SIRZPOBKMRMKDI-UHFFFAOYSA-O 10-(2,5-dihydroxy-3,4-dimethoxy-6-methylphenyl)decyl-triphenylphosphanium Chemical compound OC1=C(OC)C(OC)=C(O)C(C)=C1CCCCCCCCCC[P+](C=1C=CC=CC=1)(C=1C=CC=CC=1)C1=CC=CC=C1 SIRZPOBKMRMKDI-UHFFFAOYSA-O 0.000 abstract 1
- OIIMUKXVVLRCAF-UHFFFAOYSA-N 10-(4,5-dimethoxy-2-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl)decyl-triphenylphosphanium Chemical compound O=C1C(OC)=C(OC)C(=O)C(CCCCCCCCCC[P+](C=2C=CC=CC=2)(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1C OIIMUKXVVLRCAF-UHFFFAOYSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- JGPMMRGNQUBGND-UHFFFAOYSA-N idebenone Chemical compound COC1=C(OC)C(=O)C(CCCCCCCCCCO)=C(C)C1=O JGPMMRGNQUBGND-UHFFFAOYSA-N 0.000 abstract 1
- 229960004135 idebenone Drugs 0.000 abstract 1
- 150000004053 quinones Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/54—Quaternary phosphonium compounds
- C07F9/5456—Arylalkanephosphonium compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fireproofing Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ513547A NZ513547A (en) | 2001-08-13 | 2001-08-13 | Synthesis of triphenylphosphonium quinols (e.g. mitoquinol) and/or quinones (e.g. mitoquinone) |
| PCT/NZ2002/000154 WO2003016323A1 (en) | 2001-08-13 | 2002-08-12 | Synthesis of triphenylphosphonium quinols snd quinones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE527272T1 true ATE527272T1 (de) | 2011-10-15 |
Family
ID=19928579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02760924T ATE527272T1 (de) | 2001-08-13 | 2002-08-12 | Synthese von triphenylphosphoniumchinolen und - chinonen |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7179928B2 (de) |
| EP (1) | EP1423396B1 (de) |
| AT (1) | ATE527272T1 (de) |
| NZ (1) | NZ513547A (de) |
| WO (1) | WO2003016323A1 (de) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080275005A1 (en) * | 1998-11-25 | 2008-11-06 | Murphy Michael P | Mitochondrially targeted antioxidants |
| US20060229278A1 (en) * | 1998-11-25 | 2006-10-12 | Antipodean Pharmaceuticals, Inc. | Mitoquinone derivatives used as mitochondrially targeted antioxidants |
| US7888334B2 (en) | 2003-08-22 | 2011-02-15 | Antipodean Pharmaceuticals, Inc. | Mitoquinone derivatives used as mitochondrially targeted antioxidants |
| KR101003960B1 (ko) * | 2003-08-22 | 2010-12-30 | 안티포딘 파마슈티칼스, 인코포레이티드 | 미토콘드리아 표적화 산화방지제로서 사용되는 미토퀴논 유도체를 포함하는 약제학적 조성물 |
| AU2004266988B2 (en) * | 2003-08-22 | 2011-05-26 | Antipodean Pharmaceuticals, Inc. | Mitoquinone derivatives used as mitochondrially targeted antioxidants |
| AU2005261654A1 (en) * | 2004-07-13 | 2006-01-19 | Oridis Biomed Forschungs- Und Entwicklungs Gmbh | Mitochondrially targeted antioxidants in the treatment of liver diseases and epithelial cancers |
| EA035619B1 (ru) | 2005-06-01 | 2020-07-16 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Композиции для использования в способе лечения митохондриальных нарушений |
| JP2009508867A (ja) * | 2005-09-15 | 2009-03-05 | エジソン ファーマシューティカルズ， インコーポレイテッド | ミトコンドリア病および関連した様態の治療ならびにエネルギーバイオマーカーの調節のための酸化還元活性治療剤のテイル改変体 |
| EP1986636B1 (de) | 2006-02-22 | 2013-04-24 | Edison Pharmaceuticals, Inc. | Phenol- und 1,4-benzochinon-derivate zur verwendung in der behandlung von erkrankungen der mitochondrien |
| EP2332534B1 (de) | 2006-02-22 | 2018-11-14 | Bioelectron Technology Corporation | Phenol- und Benzoquinonederivate zur Verwendung in der Behandlung von Mitochondriopathien und zur Modulation von Energie-Biomarkern |
| WO2008086025A2 (en) * | 2007-01-10 | 2008-07-17 | Edison Pharmaceuticals, Inc. | Treatment of respiratory chain disorders using compounds having erythropoietin or thrombopoietin activity |
| PL2220030T3 (pl) | 2007-11-06 | 2016-07-29 | Bioelectron Tech Corp | Pochodne 4-(p-chinonylo)-2-hydroksybutanamidu do leczenia chorób mitochondrialnych |
| EP2237664A4 (de) | 2008-01-08 | 2013-05-22 | Edison Pharmaceuticals Inc | (HET) ARYL-p-CHINONDERIVATE ZUR BEHANDLUNG MITOCHONDRIALER ERKRANKUNGEN |
| WO2009111576A2 (en) | 2008-03-05 | 2009-09-11 | Edison Pharmaceuticals, Inc. | 2-SUBSTITUTED-p-QUINONE DERIVATIVES FOR TREATMENT OF OXIDATIVE STRESS DISEASES |
| WO2009143268A2 (en) * | 2008-05-22 | 2009-11-26 | Edison Pharmaceuticals, Inc. | Treatment of mitochondrial diseases with an erythropoietin mimetic |
| EP2303824B1 (de) * | 2008-06-25 | 2015-03-25 | Edison Pharmaceuticals, Inc. | 2-heterocyclylaminoalkyl-(p-chinon)-derivate zur behandlung von krankheiten mit oxidativem stress |
| EP2344142B1 (de) | 2008-09-10 | 2024-06-26 | PTC Therapeutics, Inc. | Behandlung von pervasiven entwicklungsstörungen mit redox-aktiven therapeutika |
| KR102020579B1 (ko) | 2011-04-26 | 2019-09-10 | 레트로토프 인코포레이티드 | 에너지 프로세싱 손상 장애 및 미토콘드리아 결함 |
| US10058522B2 (en) | 2011-04-26 | 2018-08-28 | Retrotope, Inc. | Oxidative retinal diseases |
| WO2012148929A2 (en) | 2011-04-26 | 2012-11-01 | Retrotope, Inc. | Disorders implicating pufa oxidation |
| US10154983B2 (en) | 2011-04-26 | 2018-12-18 | Retrotope, Inc. | Neurodegenerative disorders and muscle diseases implicating PUFAs |
| KR102137450B1 (ko) | 2012-07-12 | 2020-07-27 | 콘드리온 아이피 비.브이. | 미토콘드리아 질환을 치료하기 위한 크로마닐 유도체 |
| CA2883879A1 (en) | 2012-09-07 | 2014-03-13 | Edison Pharmaceuticals, Inc. | Quinone derivatives for use in the modulation of redox status of individuals |
| US9670170B2 (en) | 2013-03-15 | 2017-06-06 | Bioelectron Technology Corporation | Resorufin derivatives for treatment of oxidative stress disorders |
| US20140275045A1 (en) | 2013-03-15 | 2014-09-18 | Edison Pharmaceuticals, Inc. | Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders |
| JP2016515526A (ja) | 2013-03-15 | 2016-05-30 | エジソン ファーマシューティカルズ， インコーポレイテッド | 酸化ストレス障害の処置のためのアルキル−ヘテロアリール置換されたキノン誘導体 |
| US9868711B2 (en) | 2013-03-15 | 2018-01-16 | Bioelectron Technology Corporation | Phenazine-3-one and phenothiazine-3-one derivatives for treatment of oxidative stress disorders |
| US9296712B2 (en) | 2013-03-15 | 2016-03-29 | Edison Pharmaceuticals, Inc. | Resorufin derivatives for treatment of oxidative stress disorders |
| WO2014194292A1 (en) | 2013-05-31 | 2014-12-04 | Edison Pharmaceuticals, Inc. | Carboxylic acid derivatives for treatment of oxidative stress disorders |
| AU2015229240B9 (en) | 2014-03-13 | 2019-05-02 | Biojiva Llc | Optic neuropathy treatment and reduction of steroid-induced oxidative stress with stabilized polyunsaturated substances |
| US9314457B2 (en) | 2014-06-19 | 2016-04-19 | The University Of Utah Research Foundation | Methods of treating and preventing vascular instability diseases |
| HUE058877T2 (hu) | 2014-12-16 | 2022-09-28 | Ptc Therapeutics Inc | (R)-2-hidroxi-2-metil-4-(2,4,5-trimetil-3,6-dioxociklohexa-1,4-dienil)butánamid polimorf és amorf alakjai |
| ES3033538T3 (en) | 2015-10-08 | 2025-08-05 | Khondrion Ip B V | Novel compounds for treating mitochondrial disease |
| EP3389646A1 (de) | 2015-12-17 | 2018-10-24 | BioElectron Technology Corporation | Flouralkyl, flouralkoxy, phenoxy, heteroaryloxy, alkoxy und amin-1,4-benzochinon-derivate zur behandlung von oxidativen stresserkrankungen |
| WO2018094116A1 (en) | 2016-11-17 | 2018-05-24 | Retrotope, Inc. | Isotopically modified components and therapeutic uses thereof |
| WO2018129411A1 (en) | 2017-01-06 | 2018-07-12 | Bioelectron Technology Corporation | Aryl- and heteroaryl-resorufin derivatives for treatment of oxidative stress disorders and liver and kidney disorders |
| CN109793720B (zh) * | 2019-01-28 | 2022-01-14 | 温州医科大学 | 一种基于透明质酸的线粒体靶向抗氧化剂Mito Q纳米制剂的制备方法及应用 |
| WO2020252414A1 (en) | 2019-06-13 | 2020-12-17 | Ptc Therapeutics, Inc. | Naphthoquinone derivatives for treatment of oxidative stress disorders |
| CA3164800A1 (en) | 2019-12-16 | 2021-06-24 | Unist(Ulsan National Institute Of Science And Technology) | Compound for inhibiting neovascularization factors and use thereof |
| WO2022019362A1 (ko) * | 2020-07-24 | 2022-01-27 | 울산과학기술원 | Tpp 유도체 화합물 및 이를 포함하는 노화 또는 노화 관련 질환의 치료 또는 예방을 위한 약학적 조성물 |
| US11389431B2 (en) | 2020-09-09 | 2022-07-19 | Social Profit Network | Methods and compositions for delivery of biotin to mitochondria |
| US12109194B2 (en) | 2021-02-05 | 2024-10-08 | Biojiva Llc | Synergistic combination therapy for treating ALS |
| US11491130B2 (en) | 2021-02-05 | 2022-11-08 | Retrotope, Inc. | Methods of treating amyotrophic lateral sclerosis |
| WO2026008715A1 (en) | 2024-07-02 | 2026-01-08 | Université Catholique de Louvain | Mitochondrially-targeted antioxidant compound for use in radiation therapy |
| CN118994239B (zh) * | 2024-08-09 | 2025-09-26 | 苏州满元生物科技有限公司 | 氧化制备米托醌的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0237338B2 (ja) | 1982-08-27 | 1990-08-23 | Takeda Chemical Industries Ltd | 99*3*44jimetokishii22hidorokishii66mechirubenzoiru*nonanoeetonoseizoho |
| ES2051841T3 (es) | 1987-04-27 | 1994-07-01 | Takeda Chemical Industries Ltd | Reduccion de esteres carboxilicos. |
| JPH07223991A (ja) | 1993-12-17 | 1995-08-22 | Takeda Chem Ind Ltd | アシル置換芳香族化合物の製造法 |
| JP2637705B2 (ja) | 1995-03-02 | 1997-08-06 | 株式会社ナード研究所 | ベンゾキノン系誘導体の製造法 |
| US6331532B1 (en) * | 1998-11-25 | 2001-12-18 | University Of Otago | Mitochondrially targeted antioxidants |
-
2001
- 2001-08-13 NZ NZ513547A patent/NZ513547A/xx not_active IP Right Cessation
-
2002
- 2002-08-12 AT AT02760924T patent/ATE527272T1/de not_active IP Right Cessation
- 2002-08-12 EP EP02760924A patent/EP1423396B1/de not_active Expired - Lifetime
- 2002-08-12 WO PCT/NZ2002/000154 patent/WO2003016323A1/en not_active Ceased
- 2002-08-12 US US10/486,797 patent/US7179928B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003016323A1 (en) | 2003-02-27 |
| EP1423396A1 (de) | 2004-06-02 |
| EP1423396A4 (de) | 2006-02-22 |
| NZ513547A (en) | 2002-09-27 |
| EP1423396B1 (de) | 2011-10-05 |
| US20050043553A1 (en) | 2005-02-24 |
| US7179928B2 (en) | 2007-02-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |