DK1875239T3 - Fremgangsmåde til fremstilling af billeddannelsessonder under anvendelse af klik-kemi - Google Patents

Fremgangsmåde til fremstilling af billeddannelsessonder under anvendelse af klik-kemi

Info

Publication number
DK1875239T3
DK1875239T3 DK06751892.8T DK06751892T DK1875239T3 DK 1875239 T3 DK1875239 T3 DK 1875239T3 DK 06751892 T DK06751892 T DK 06751892T DK 1875239 T3 DK1875239 T3 DK 1875239T3
Authority
DK
Denmark
Prior art keywords
imaging probe
candidate
library
click chemistry
identifying
Prior art date
Application number
DK06751892.8T
Other languages
English (en)
Inventor
Hartmuth C Kolb
Vani P Mocharla
Joseph C Walsh
Original Assignee
Siemens Medical Solutions
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Siemens Medical Solutions filed Critical Siemens Medical Solutions
Application granted granted Critical
Publication of DK1875239T3 publication Critical patent/DK1875239T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/534—Production of labelled immunochemicals with radioactive label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
DK06751892.8T 2005-04-27 2006-04-27 Fremgangsmåde til fremstilling af billeddannelsessonder under anvendelse af klik-kemi DK1875239T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67529005P 2005-04-27 2005-04-27
PCT/US2006/016428 WO2006116736A2 (en) 2005-04-27 2006-04-27 A method for the preparation of imaging probes using click chemistry

Publications (1)

Publication Number Publication Date
DK1875239T3 true DK1875239T3 (da) 2012-01-23

Family

ID=36954603

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06751892.8T DK1875239T3 (da) 2005-04-27 2006-04-27 Fremgangsmåde til fremstilling af billeddannelsessonder under anvendelse af klik-kemi

Country Status (9)

Country Link
US (1) US20060269942A1 (da)
EP (1) EP1875239B1 (da)
JP (1) JP4790012B2 (da)
KR (1) KR100973156B1 (da)
AT (1) ATE527542T1 (da)
CA (1) CA2606477C (da)
DK (1) DK1875239T3 (da)
ES (1) ES2375495T3 (da)
WO (1) WO2006116736A2 (da)

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US8071718B2 (en) 2004-12-22 2011-12-06 General Electric Company Selective radiolabeling of biomolecules
CA2617907A1 (en) * 2005-08-05 2007-02-15 Syntarga B.V. Triazole-containing releasable linkers and conjugates comprising the same
ATE519114T1 (de) 2006-03-14 2011-08-15 Univ Basel Verfahren zur identifizierung neuer leitverbindungen für arzneistoffkandidaten
US20100022481A1 (en) * 2006-08-02 2010-01-28 Dong Wang Drug Carriers, Their Synthesis, and Methods of Use Thereof
WO2008124703A2 (en) * 2007-04-05 2008-10-16 Siemens Medical Solutions Usa, Inc. Development of molecular imaging probes for carbonic anhydrase-ix using click chemistry
CA2711678A1 (en) * 2008-01-09 2009-07-16 Molecular Insight Pharmaceuticals, Inc. Inhibitors of carbonic anhydrase ix
WO2009105746A2 (en) * 2008-02-22 2009-08-27 University Of South Florida Triazoles and processes for producing the same
WO2009155420A1 (en) * 2008-06-18 2009-12-23 California Institute Of Technology Multi-ligand capture agents and related compositions, methods and systems
US8618297B2 (en) 2008-07-25 2013-12-31 Basf Se Azide substituted naphthylene or rylene imide derivatives and their use as reagents in click-reactions
CN102271712B (zh) * 2008-10-31 2015-11-25 通用医疗公司 用于将物质递送至生物靶标的组合物和方法
WO2010065899A2 (en) 2008-12-05 2010-06-10 Molecular Insight Pharmaceuticals, Inc. Technetium-and rhenium-bis(heteroaryl)complexes and methods of use thereof
EP2400992B1 (en) 2009-02-27 2015-07-22 Genentech, Inc. Methods and compositions for protein labelling
CN103739605B (zh) 2009-03-23 2016-08-17 伊莱利利公司 用于检测神经障碍的显像剂
US8691187B2 (en) 2009-03-23 2014-04-08 Eli Lilly And Company Imaging agents for detecting neurological disorders
AU2010260195B2 (en) 2009-06-15 2014-11-20 Molecular Insight Pharmaceuticals, Inc. Process for production of heterodimers of glutamic acid
CN102791827B (zh) 2009-11-09 2016-11-16 华盛顿大学商业化中心 官能化发色聚合物点及其生物共轭体
WO2012074840A2 (en) 2010-11-22 2012-06-07 The General Hospital Corporation Compositions and methods for in vivo imaging
CN103502218B (zh) * 2011-03-04 2016-08-17 生命科技公司 用于缀合生物分子的化合物和方法
US9289516B2 (en) 2011-03-09 2016-03-22 The General Hospital Corporation Imaging beta cell mass
US10796494B2 (en) 2011-06-06 2020-10-06 Microsoft Technology Licensing, Llc Adding attributes to virtual representations of real-world objects
EP2800471A4 (en) 2012-01-06 2015-11-04 Molecular Insight Pharm Inc METAL COMPLEX OF POLY (CARBOXYL) AMINE CONTAINING LIGANDS HAVING AFFINITY FOR CARBON IX ANHYDRASE
EP2888253A4 (en) * 2012-08-24 2016-01-06 Univ Texas HETEROCYCLIC HIF ACTIVITY MODULATORS FOR THE TREATMENT OF DISEASES
ES2691643T3 (es) * 2012-08-24 2018-11-28 Board Of Regents, The University Of Texas System Moduladores heterocíclicos de la actividad de HIF para el tratamiento de enfermedades
US9902705B2 (en) 2012-10-24 2018-02-27 The General Hospital Corporation Functionalized 1,2,4,5-tetrazine compounds for use in bioorthogonal coupling reactions
EP3300746B1 (en) 2013-01-14 2019-05-15 Molecular Insight Pharmaceuticals, Inc. Triazine based radiopharmaceuticals and radioimaging agents
US10517965B2 (en) 2013-05-06 2019-12-31 The General Hospital Corporation Bioorthogonal turn-on probes
WO2015130790A2 (en) 2014-02-25 2015-09-03 Board Of Regents, University Of Texas System Salts of heterocyclic modulators of hif activity for treatment of disease
US10731202B2 (en) 2014-11-24 2020-08-04 Battelle Memorial Institute Chromatin activity precipitation method and system
WO2020084623A2 (en) * 2018-10-24 2020-04-30 Apa- Advanced Technologies Ltd. Fusogenic liposomes for selective imaging of tumor cells
CN112176418B (zh) * 2019-07-05 2024-11-29 中宏鑫投资控股(深圳)有限公司 高通量的化合物库构建和筛选方法以及反应装置

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DE3424525A1 (de) * 1984-07-04 1986-01-16 Kernforschungsanlage Jülich GmbH, 5170 Jülich Verfahren zur herstellung von (pfeil hoch)1(pfeil hoch)(pfeil hoch)8(pfeil hoch)f-alkyl- und arylverbindungen durch halogenaustausch
US5519931A (en) * 1994-03-16 1996-05-28 Syncor International Corporation Container and method for transporting a syringe containing radioactive material
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US6210655B1 (en) * 1997-06-18 2001-04-03 University Of Medicine & Dentistry Of Nj Site-specific 13C-enriched reagents for diagnostic medicine by magnetic resonance imaging
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US20030190602A1 (en) * 2001-03-12 2003-10-09 Monogen, Inc. Cell-based detection and differentiation of disease states
US6808308B2 (en) * 2001-05-25 2004-10-26 Scanwell Systems Removable shielding for use during neurological examinations on a whole body pet scanner
WO2003081210A2 (en) * 2002-03-21 2003-10-02 Sunesis Pharmaceuticals, Inc. Identification of kinase inhibitors
AU2003240482B2 (en) * 2002-05-30 2009-03-12 The Scripps Research Institute Copper-catalysed ligation of azides and acetylenes
WO2004057340A1 (en) * 2002-12-23 2004-07-08 Astex Technology Limited Synthesis and screening of ligands using x-ray crystallography
US20060067879A1 (en) * 2004-09-27 2006-03-30 Schuller Hildegard M Diagnosis of diseases associated with COX-2 expression

Also Published As

Publication number Publication date
EP1875239B1 (en) 2011-10-05
JP4790012B2 (ja) 2011-10-12
KR100973156B1 (ko) 2010-07-30
ES2375495T3 (es) 2012-03-01
US20060269942A1 (en) 2006-11-30
JP2008541014A (ja) 2008-11-20
KR20080003441A (ko) 2008-01-07
CA2606477A1 (en) 2006-11-02
WO2006116736A3 (en) 2007-02-01
EP1875239A2 (en) 2008-01-09
ATE527542T1 (de) 2011-10-15
CA2606477C (en) 2013-05-28
WO2006116736A2 (en) 2006-11-02

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