ATE527552T1 - Mr-darstellungsverfahren zur diskriminierung zwischen gesundem und tumorgewebe - Google Patents

Mr-darstellungsverfahren zur diskriminierung zwischen gesundem und tumorgewebe

Info

Publication number
ATE527552T1
ATE527552T1 AT05771198T AT05771198T ATE527552T1 AT E527552 T1 ATE527552 T1 AT E527552T1 AT 05771198 T AT05771198 T AT 05771198T AT 05771198 T AT05771198 T AT 05771198T AT E527552 T1 ATE527552 T1 AT E527552T1
Authority
AT
Austria
Prior art keywords
discrimination
healthy
tumor tissue
imaging method
sup
Prior art date
Application number
AT05771198T
Other languages
English (en)
Inventor
Mikkel Thaning
Rene In T Zandt
Original Assignee
Ge Healthcare As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare As filed Critical Ge Healthcare As
Application granted granted Critical
Publication of ATE527552T1 publication Critical patent/ATE527552T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/483—NMR imaging systems with selection of signals or spectra from particular regions of the volume, e.g. in vivo spectroscopy
    • G01R33/485—NMR imaging systems with selection of signals or spectra from particular regions of the volume, e.g. in vivo spectroscopy based on chemical shift information [CSI] or spectroscopic imaging, e.g. to acquire the spatial distributions of metabolites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0404—Lipids, e.g. triglycerides; Polycationic carriers
    • A61K51/0406—Amines, polyamines, e.g. spermine, spermidine, amino acids, (bis)guanidines
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Optics & Photonics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Signal Processing (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Lasers (AREA)
AT05771198T 2004-07-30 2005-07-28 Mr-darstellungsverfahren zur diskriminierung zwischen gesundem und tumorgewebe ATE527552T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NO20043226 2004-07-30
PCT/NO2005/000282 WO2006011810A2 (en) 2004-07-30 2005-07-28 Mr imaging method for the discrimination between healthy and tumour tissue

Publications (1)

Publication Number Publication Date
ATE527552T1 true ATE527552T1 (de) 2011-10-15

Family

ID=35501891

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05771198T ATE527552T1 (de) 2004-07-30 2005-07-28 Mr-darstellungsverfahren zur diskriminierung zwischen gesundem und tumorgewebe

Country Status (15)

Country Link
EP (1) EP1784227B1 (de)
JP (1) JP5362987B2 (de)
KR (1) KR101126952B1 (de)
CN (2) CN102565735B (de)
AT (1) ATE527552T1 (de)
AU (1) AU2005267669B2 (de)
BR (1) BRPI0513896A (de)
CA (1) CA2576202A1 (de)
ES (1) ES2372058T3 (de)
IL (1) IL180896A (de)
MX (1) MX2007001033A (de)
PL (1) PL1784227T3 (de)
RU (1) RU2369406C2 (de)
WO (1) WO2006011810A2 (de)
ZA (1) ZA200701280B (de)

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US20100233096A1 (en) * 2006-03-29 2010-09-16 Lerche Mathilde H Method to produce hyperpolarised carboxylates and sulphonates
US7202665B1 (en) 2006-04-19 2007-04-10 Wisconsin Alumni Research Foundation Magnetic resonance spectroscopy of species with multiple peaks
JP2010501483A (ja) * 2006-08-18 2010-01-21 ジーイー・ヘルスケア・アクスイェ・セルスカプ 乳酸塩及び過分極１３ｃ−ピルビン酸塩を含むイメージング剤
WO2008020764A1 (en) * 2006-08-18 2008-02-21 Ge Healthcare As 13c-mr imaging or spectroscopy of cell death
JP5269791B2 (ja) 2006-08-30 2013-08-21 ジーイー・ヘルスケア・アクスイェ・セルスカプ 動的核分極（ｄｎｐ）方法並びに該方法で使用するための化合物及び組成物
JP5512272B2 (ja) * 2006-10-17 2014-06-04 ジーイー・ヘルスケア・アクスイェ・セルスカプ α−ケト酸及びそのエステルの製造方法
US8812076B2 (en) * 2006-11-21 2014-08-19 General Electric Company Proton decoupled hyperpolarized magnetic resonance imaging
AU2007322450A1 (en) * 2006-11-21 2008-05-29 Ge Healthcare As Method for managing patients with cancers
EP2117607A4 (de) 2007-01-11 2012-08-08 Huntington Medical Res Inst Abbildungswirkstoffe und verfahren zu ihrer verwendung
US7470813B2 (en) 2007-03-30 2008-12-30 Ge Healthcare Limited Method for the production of pyruvic acid
US20080242974A1 (en) * 2007-04-02 2008-10-02 Urbahn John A Method and apparatus to hyperpolarize materials for enhanced mr techniques
US7741844B2 (en) * 2007-05-07 2010-06-22 General Electric Company Method and system for magnetic resonance imaging using labeled contrast agents
CN101730504A (zh) * 2007-05-17 2010-06-09 通用电气公司 使用包含超极化13c-丙酮酸盐的成像介质使肿瘤分级的mr方法
US20100196283A1 (en) * 2007-07-26 2010-08-05 Lerche Matilde H Method and imaging medium for use in the method
MX2010002193A (es) * 2007-09-07 2010-03-18 Ge Healthcare Ltd Metodo de determinacion de actividad pdh y generacion de imagen para su uso en dicho metodo.
JP5448397B2 (ja) * 2007-09-07 2014-03-19 キヤノン株式会社 基質プローブ、多重核磁気共鳴法による酵素活性の検出方法および酵素活性のイメージング方法
EP2902041A1 (de) 2007-12-19 2015-08-05 GE Healthcare Limited Zusammensetzung und Verfahren zur Erzeugung eines metabolischen Profils bei Verwendung von 13C-MR
CN101951963B (zh) * 2007-12-21 2013-07-17 通用电气健康护理有限公司 Mr成像剂、成像介质和其中使用该成像介质的成像方法
WO2009098192A1 (en) * 2008-02-04 2009-08-13 Ge Healthcare Limited Mr imaging agent or medium compressing hzperpolarised 13c alanine and methods of imaging wherein such an imaging medium is used
WO2009129265A1 (en) 2008-04-14 2009-10-22 Huntington Medical Research Institutes Methods and apparatus for pasadena hyperpolarization
US8763410B2 (en) * 2008-04-21 2014-07-01 General Electric Company Method and apparatus for the dissolution and filtration of a hyperpolarized agent with a neutral dissolution media
WO2009133169A1 (en) 2008-05-02 2009-11-05 General Electric Company Method of determining alanine transaminase (alt) activity by 13c-mr detection using hyperpolarised 13c-pyruvate
BRPI1013677A2 (pt) 2009-04-02 2016-04-26 Ge Healthcare Ltd método para detectar inflamação ou infecção, e, usos de um 13c-piruvato hiperpolarizado, e de um meio de formação de imagem.
EP2476009A1 (de) 2009-09-10 2012-07-18 GE Healthcare UK Limited 13c-mr-detektion mit hyperpolarisierter 13-c-fructose
US9069098B2 (en) * 2011-09-09 2015-06-30 Schlumberger Technology Corporation Three or more multiple figure-eight coils for NMR well-logging measurements with azimuthal directional sensitivity
JP6328624B2 (ja) 2012-06-29 2018-05-23 セェーアール ディベロップメント アクチエボラグＣｒ Ｄｅｖｅｌｏｐｍｅｎｔ Ａｂ 組織微小毛細血管網中の水の相対量の定量化
EP2972441B1 (de) 2013-03-14 2016-11-30 Ecole Polytechnique Fédérale de Lausanne (EPFL) Verfahren zur erzeugung von radikalen für eine dynamische kernspinpolarisierung und anwendungen in der nmr, mrs und mrt
US9874622B2 (en) 2013-09-27 2018-01-23 General Electric Company Hyperpolarized media transport vessel
EP3058375B1 (de) * 2013-10-15 2018-12-26 Technische Universität München Ph-biosensoren auf der basis von verbindungen aus brenztraubensäure für magnetresonanzbildgebung und spektroskopie sowie deren verwendungen
EP2863229A1 (de) * 2013-10-15 2015-04-22 Technische Universität München pH-Biosensoren auf Basis von Verbindungen mit pH-sensiblen Enolgruppen zur Magnetresonanzbildgebung und Spektroskopie und deren Verwendungen
KR101516634B1 (ko) * 2014-07-09 2015-05-06 연세대학교 산학협력단 13c-자기공명분광영상을 이용한 암 환자의 치료 예후를 예측하는 방법
WO2017147418A1 (en) 2016-02-24 2017-08-31 Ohio State Innovation Foundation Methods and devices for contrast agent magnetic resonance imaging
WO2017156124A1 (en) * 2016-03-10 2017-09-14 Memorial Sloan Kettering Cancer Center Hyperpolarized micro-nmr system and methods
RU2634783C1 (ru) * 2016-07-05 2017-11-03 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии имени Н.Н. Петрова" Министерства здравоохранения Российской Федерации Способ дифференциальной диагностики образований молочной железы и мягких тканей
KR101939454B1 (ko) * 2017-03-21 2019-01-16 전남대학교산학협력단 생체 내 과분극화 c13 피루베이트 자기공명분광법을 이용하여 새로운 정량적 생체지표를 통한 비알코올성 지방간질환 진단 방법
KR102441674B1 (ko) * 2017-11-21 2022-09-08 솔벡스 리미티드 라이어빌리티 컴퍼니 중수소화된 2-아미노-2-메틸프로피온산 및/또는 2-(n-메틸아미노)-2-메틸프로피온산을 포함하는, 종양성 질환의 자기공명진단을 위한 제제, 및 상기 제제를 이용한 진단방법
RU2741212C1 (ru) * 2020-03-12 2021-01-22 Государственное автономное учреждение здравоохранения «Республиканский клинический онкологический диспансер Министерства здравоохранения Республики Татарстан» (ГАУЗ «РКОД МЗ РТ») Способ диагностики злокачественных очаговых образований периферической зоны предстательной железы
RU2749126C1 (ru) * 2020-05-06 2021-06-04 Государственное автономное учреждение здравоохранения «Республиканский клинический онкологический диспансер Министерства здравоохранения Республики Татарстан» (ГАУЗ «РКОД МЗ РТ») Способ дифференциальной диагностики очаговых образований предстательной железы
EP4140505A1 (de) * 2021-08-26 2023-03-01 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Gereinigte signalverstärkte kontrastmittel für die magnetresonanzbildgebung

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Also Published As

Publication number Publication date
RU2369406C2 (ru) 2009-10-10
CN102565735B (zh) 2016-02-10
EP1784227B1 (de) 2011-10-05
PL1784227T3 (pl) 2012-03-30
EP1784227A2 (de) 2007-05-16
JP2008508023A (ja) 2008-03-21
RU2007102845A (ru) 2008-09-10
ES2372058T3 (es) 2012-01-13
KR101126952B1 (ko) 2012-03-20
JP5362987B2 (ja) 2013-12-11
MX2007001033A (es) 2007-07-25
AU2005267669A1 (en) 2006-02-02
CN102565735A (zh) 2012-07-11
CA2576202A1 (en) 2006-02-02
BRPI0513896A (pt) 2008-05-20
CN101031811A (zh) 2007-09-05
IL180896A (en) 2013-07-31
ZA200701280B (en) 2008-09-25
WO2006011810A3 (en) 2006-04-13
AU2005267669B2 (en) 2011-02-24
WO2006011810A2 (en) 2006-02-02
IL180896A0 (en) 2007-07-04
KR20070061806A (ko) 2007-06-14
HK1107003A1 (en) 2008-03-28

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