ATE528299T1 - Cyclische ketale als beta-sekretase-inhibitoren zur behandlung von alzheimer-krankheit - Google Patents
Cyclische ketale als beta-sekretase-inhibitoren zur behandlung von alzheimer-krankheitInfo
- Publication number
- ATE528299T1 ATE528299T1 AT06789003T AT06789003T ATE528299T1 AT E528299 T1 ATE528299 T1 AT E528299T1 AT 06789003 T AT06789003 T AT 06789003T AT 06789003 T AT06789003 T AT 06789003T AT E528299 T1 ATE528299 T1 AT E528299T1
- Authority
- AT
- Austria
- Prior art keywords
- beta
- treatment
- alzheimer
- disease
- cyclic
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 title abstract 2
- 239000002439 beta secretase inhibitor Substances 0.000 title 1
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 abstract 3
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/22—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70507505P | 2005-08-03 | 2005-08-03 | |
| PCT/US2006/029766 WO2007019111A2 (en) | 2005-08-03 | 2006-07-28 | Cyclic ketal beta-secretase inhibitors for the treatment of alzheimer's disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE528299T1 true ATE528299T1 (de) | 2011-10-15 |
Family
ID=37727855
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06789003T ATE528299T1 (de) | 2005-08-03 | 2006-07-28 | Cyclische ketale als beta-sekretase-inhibitoren zur behandlung von alzheimer-krankheit |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7816378B2 (de) |
| EP (1) | EP1912963B1 (de) |
| JP (1) | JP2009503085A (de) |
| CN (1) | CN101238111A (de) |
| AT (1) | ATE528299T1 (de) |
| AU (1) | AU2006278713A1 (de) |
| CA (1) | CA2616854A1 (de) |
| WO (1) | WO2007019111A2 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2629317A1 (en) | 2005-11-16 | 2007-05-24 | Merck & Co., Inc. | Imidazolidinone compounds useful as beta-secretase inhibitors for the treatment of alzheimer's disease |
| UA108363C2 (uk) | 2009-10-08 | 2015-04-27 | Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6486194B2 (en) * | 1993-06-24 | 2002-11-26 | Merck Frosst Canada, Inc. | Use of inhibitors of cyclooxygenase in the treatment of neurodegenerative diseases |
| WO2003106405A1 (en) * | 2002-06-01 | 2003-12-24 | Sunesis Pharmaceuticals, Inc. | Aspartyl protease inhibitors |
| US7115652B2 (en) * | 2002-06-17 | 2006-10-03 | Sunesis Pharmaceuticals, Inc. | Aspartyl protease inhibitors |
| ATE443043T1 (de) * | 2002-11-12 | 2009-10-15 | Merck & Co Inc | Phenylcarboxamide als beta-sekretase-hemmer zur behandlung von alzheimer |
| CA2507484A1 (en) * | 2002-11-27 | 2004-06-17 | Elan Pharmaceuticals, Inc. | Substituted ureas and carbamates |
| JP2007516207A (ja) * | 2003-06-30 | 2007-06-21 | メルク エンド カムパニー インコーポレーテッド | アルツハイマー病の治療のためのＮ−アルキルフェニルカルボキサミドβ−セクレターゼ阻害剤 |
| AU2004255191A1 (en) * | 2003-07-01 | 2005-01-20 | Merck & Co., Inc. | Phenylcarboxylate beta-secretase inhibitors for the treatment of Alzheimer's disease |
| EP1673078B1 (de) * | 2003-10-03 | 2008-05-28 | Merck & Co., Inc. | Benzylether- und benzylamino-beta-sekretase-hemmer zur behandlung von alzheimer-krankheit |
| ATE517861T1 (de) * | 2003-11-24 | 2011-08-15 | Merck Sharp & Dohme | Benzylether und benzylaminoverbindungen als inhibitoren von beta-secretase zur behandlung von alzheimer-krankheit |
| US7550481B2 (en) * | 2003-12-19 | 2009-06-23 | Merck & Co., Inc. | Phenylamide and pyridylamide beta-secretase inhibitors for the treatment of Alzheimer's disease |
-
2006
- 2006-07-28 AU AU2006278713A patent/AU2006278713A1/en not_active Abandoned
- 2006-07-28 CN CNA2006800285334A patent/CN101238111A/zh active Pending
- 2006-07-28 US US11/989,990 patent/US7816378B2/en active Active
- 2006-07-28 AT AT06789003T patent/ATE528299T1/de not_active IP Right Cessation
- 2006-07-28 CA CA002616854A patent/CA2616854A1/en not_active Abandoned
- 2006-07-28 WO PCT/US2006/029766 patent/WO2007019111A2/en not_active Ceased
- 2006-07-28 JP JP2008525082A patent/JP2009503085A/ja not_active Withdrawn
- 2006-07-28 EP EP06789003A patent/EP1912963B1/de not_active Not-in-force
Also Published As
| Publication number | Publication date |
|---|---|
| EP1912963A2 (de) | 2008-04-23 |
| CA2616854A1 (en) | 2007-02-15 |
| CN101238111A (zh) | 2008-08-06 |
| WO2007019111A2 (en) | 2007-02-15 |
| EP1912963A4 (de) | 2010-08-25 |
| WO2007019111A3 (en) | 2008-01-03 |
| EP1912963B1 (de) | 2011-10-12 |
| AU2006278713A1 (en) | 2007-02-15 |
| JP2009503085A (ja) | 2009-01-29 |
| US7816378B2 (en) | 2010-10-19 |
| US20090176836A1 (en) | 2009-07-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |