ATE531733T1 - Kir-bindende wirkstoffe und verfahren zu ihrer verwendung - Google Patents
Kir-bindende wirkstoffe und verfahren zu ihrer verwendungInfo
- Publication number
- ATE531733T1 ATE531733T1 AT06701729T AT06701729T ATE531733T1 AT E531733 T1 ATE531733 T1 AT E531733T1 AT 06701729 T AT06701729 T AT 06701729T AT 06701729 T AT06701729 T AT 06701729T AT E531733 T1 ATE531733 T1 AT E531733T1
- Authority
- AT
- Austria
- Prior art keywords
- kir
- reducing
- binding
- methods
- hla
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Fats And Perfumes (AREA)
- Pyridine Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200500021 | 2005-01-06 | ||
| PCT/EP2006/050073 WO2006072626A1 (en) | 2005-01-06 | 2006-01-06 | Kir-binding agents and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE531733T1 true ATE531733T1 (de) | 2011-11-15 |
Family
ID=36001100
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06701729T ATE531733T1 (de) | 2005-01-06 | 2006-01-06 | Kir-bindende wirkstoffe und verfahren zu ihrer verwendung |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US8222376B2 (de) |
| EP (1) | EP1836225B1 (de) |
| JP (2) | JP5295568B2 (de) |
| CN (2) | CN101103043A (de) |
| AT (1) | ATE531733T1 (de) |
| CY (1) | CY1112897T1 (de) |
| DK (1) | DK1836225T3 (de) |
| ES (1) | ES2374603T3 (de) |
| PL (1) | PL1836225T3 (de) |
| PT (1) | PT1836225E (de) |
| SI (1) | SI1836225T1 (de) |
| WO (1) | WO2006072626A1 (de) |
Families Citing this family (85)
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|---|---|---|---|---|
| US20090191213A9 (en) * | 2003-07-02 | 2009-07-30 | Novo Nordisk A/S | Compositions and methods for regulating NK cell activity |
| BRPI0412138B8 (pt) | 2003-07-02 | 2021-05-25 | Innate Pharma | método de selecionar um anticorpo monoclonal, método de selecionar um anticorpo monoclonal ou seu fragmento de ligação em antígeno, método de detectar a presença de células nk, e, método de purificar de uma amostra células nk |
| CA2601417C (en) * | 2004-07-01 | 2018-10-30 | Novo Nordisk A/S | Human anti-kir antibodies |
| ES2925912T3 (es) | 2004-07-10 | 2022-10-20 | The Institute For Cancer Res | Líneas de células asesinas naturales humanas genéticamente modificadas |
| EP1835929B8 (de) * | 2005-01-06 | 2016-07-27 | Novo Nordisk A/S | Behandlungen und verfahren mit anti-kir-kombination |
| EP1715344A1 (de) * | 2005-04-22 | 2006-10-25 | Universiteit Utrecht Holding B.V. | Immobilisierung der Antigenkohlenhydrate, zum der pathogenen Mikroorganismen zu ermitteln |
| CN101578113B (zh) | 2007-01-11 | 2015-04-22 | 诺和诺德公司 | 抗-kir抗体、制剂及其应用 |
| CN106963947A (zh) * | 2010-11-22 | 2017-07-21 | 伊纳特医药股份有限公司 | Nk细胞调节治疗和用于治疗血液恶性疾病的方法 |
| CA3027071A1 (en) | 2011-01-14 | 2013-07-19 | The Regents Of The University Of California | Therapeutic antibodies against ror-1 protein and methods for use of same |
| WO2012160448A2 (en) * | 2011-05-25 | 2012-11-29 | Innate Pharma, S.A. | Anti-kir antibodies for the treatment of inflammatory disorders |
| BR112015007184A2 (pt) | 2012-10-02 | 2017-08-08 | Bristol Myers Squibb Co | combinação de anticorpos anti-kir e anticorpos anti-pd-1 para tratar câncer |
| US9135515B2 (en) | 2012-10-22 | 2015-09-15 | Qiagen Gaithersburg, Inc. | Automated pelletized sample vision inspection apparatus and methods |
| ES2878749T3 (es) | 2013-02-20 | 2021-11-19 | Innate Pharma | Un compuesto que se une específicamente a KIR3DL2 para el uso en el tratamiento de linfoma de células T periférico |
| US9212976B2 (en) | 2013-03-15 | 2015-12-15 | Qiagen Gaithersburg, Inc. | Vision-guided aspiration apparatus and methods |
| WO2015069785A1 (en) | 2013-11-06 | 2015-05-14 | Bristol-Myers Squibb Company | Combination of anti-kir and anti-cs1 antibodies to treat multiple myeloma |
| CA2961636A1 (en) * | 2014-09-17 | 2016-03-24 | Boris ENGELS | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
| EA201792273A1 (ru) | 2015-04-17 | 2018-04-30 | Бристол-Маерс Сквибб Компани | Композиции, содержащие комбинацию анти-pd-1 антитела и другого антитела |
| KR102138209B1 (ko) | 2015-05-06 | 2020-07-28 | 스니프르 테크놀로지스 리미티드 | 미생물 개체군 변경 및 미생물군 변형 |
| KR20190080992A (ko) | 2015-05-21 | 2019-07-08 | 하푼 테라퓨틱스, 인크. | 삼중특이성 결합 단백질 및 사용 방법 |
| EP3322431A2 (de) | 2015-07-16 | 2018-05-23 | Biokine Therapeutics Ltd. | Zusammensetzungen und verfahren zur behandlung von krebs |
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| AU2016349632A1 (en) | 2015-11-07 | 2018-05-24 | Multivir Inc. | Compositions comprising tumor suppressor gene therapy and immune checkpoint blockade for the treatment of cancer |
| CA3007996A1 (en) * | 2015-12-09 | 2017-06-15 | Nant Holdings Ip, Llc | Compositions and methods for treatment of her2 positive metastatic breast cancer |
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| KR102369735B1 (ko) | 2016-05-20 | 2022-03-02 | 바이오하벤 파마슈티컬 홀딩 컴퍼니 엘티디. | 암을 치료하기 위한 면역요법과의 글루타메이트 조정제의 용도 |
| GB201609811D0 (en) | 2016-06-05 | 2016-07-20 | Snipr Technologies Ltd | Methods, cells, systems, arrays, RNA and kits |
| US10858431B2 (en) | 2016-06-30 | 2020-12-08 | Trellis Bioscience, Llc | Monoclonal antibodies targeting killer immunoglobulin-like receptor (KIR) family signaling |
| KR102708641B1 (ko) | 2016-09-27 | 2024-09-24 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 미생물유전체를 조정함으로써 면역 체크포인트 차단 요법을 증강시키는 방법 |
| CA3040458A1 (en) | 2016-10-12 | 2018-04-19 | Board Of Regents, The University Of Texas System | Methods and compositions for tusc2 immunotherapy |
| AU2017345203B2 (en) | 2016-10-21 | 2024-08-01 | Innate Pharma | Treatment with anti-KIR3DL2 agents |
| CA3046961A1 (en) | 2016-12-12 | 2018-06-21 | Multivir Inc. | Methods and compositions comprising viral gene therapy and an immune checkpoint inhibitor for treatment and prevention of cancer and infectious diseases |
| WO2018183928A1 (en) | 2017-03-31 | 2018-10-04 | Bristol-Myers Squibb Company | Methods of treating tumor |
| CN121159691A (zh) | 2017-05-12 | 2025-12-19 | 哈普恩治疗公司 | 间皮素结合蛋白质 |
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| IL315737A (en) | 2017-10-13 | 2024-11-01 | Harpoon Therapeutics Inc | B-cell maturation antigen-binding proteins |
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| MX2021003554A (es) | 2018-09-25 | 2021-05-27 | Harpoon Therapeutics Inc | Proteinas de union a dll3 y metodos de uso. |
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| IL282838B2 (en) | 2018-12-21 | 2025-05-01 | Valerio Therapeutics | Conjugated nucleic acid molecules and their uses |
| CN109833480B (zh) * | 2019-03-22 | 2021-09-07 | 中国科学院上海巴斯德研究所 | 靶向nk细胞免疫检查点治疗感染性疾病的方法 |
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| CN114127315A (zh) | 2019-05-30 | 2022-03-01 | 百时美施贵宝公司 | 鉴定适合于免疫肿瘤学(i-o)疗法的受试者的方法 |
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| JP2023509359A (ja) | 2019-12-17 | 2023-03-08 | フラグシップ パイオニアリング イノベーションズ ブイ，インコーポレーテッド | 鉄依存性細胞分解の誘導物質との併用抗癌療法 |
| TW202214857A (zh) | 2020-06-19 | 2022-04-16 | 法商昂席歐公司 | 新型結合核酸分子及其用途 |
| CN116096906A (zh) | 2020-06-29 | 2023-05-09 | 旗舰创业创新五公司 | 工程化以促进萨诺传递的病毒及其在治疗癌症中的用途 |
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| TW202245808A (zh) | 2020-12-21 | 2022-12-01 | 德商拜恩迪克公司 | 用於治療癌症之治療性ｒｎａ |
| WO2022135667A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Therapeutic rna for treating cancer |
| WO2022135666A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Treatment schedule for cytokine proteins |
| CA3196999A1 (en) | 2020-12-28 | 2022-07-07 | Masano HUANG | Methods of treating tumors |
| EP4267105B1 (de) | 2020-12-28 | 2025-03-26 | Bristol-Myers Squibb Company | Antikörperzusammensetzungen und verfahren zur verwendung davon |
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| US20240376224A1 (en) | 2021-04-02 | 2024-11-14 | The Regents Of The University Of California | Antibodies against cleaved cdcp1 and uses thereof |
| KR20240026507A (ko) | 2021-06-29 | 2024-02-28 | 플래그쉽 파이어니어링 이노베이션스 브이, 인크. | 타노트랜스미션을 촉진시키도록 엔지니어링된 면역 세포 및 이의 용도 |
| IL309831A (en) | 2021-07-13 | 2024-02-01 | BioNTech SE | Multispecific binding agents against CD40 and CD137 in combined cancer therapy |
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| WO2026033885A1 (en) | 2024-08-08 | 2026-02-12 | Astellas Pharma Inc. | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and agents stabilizing or increasing expression of cldn18.2 |
| WO2025120867A1 (en) | 2023-12-08 | 2025-06-12 | Astellas Pharma Inc. | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and anti-vegfr2 antibodies |
| AR134560A1 (es) | 2023-12-08 | 2026-01-28 | Astellas Pharma Inc | Terapia de combinación que implica agentes de unión biespecíficos que se unen a cldn18.2 y cd3 y agentes que estabilizan o aumentan la expresión de cldn18.2 |
| US20250215087A1 (en) | 2023-12-29 | 2025-07-03 | Bristol-Myers Squibb Company | Combination therapy of kras inhibitor and treg depleting agent |
| WO2025230843A2 (en) * | 2024-05-01 | 2025-11-06 | BioLegend, Inc. | Kir binding antibodies and antigen binding fragments thereof |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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2006
- 2006-01-06 CN CNA2006800019196A patent/CN101103043A/zh active Pending
- 2006-01-06 JP JP2007549896A patent/JP5295568B2/ja not_active Expired - Fee Related
- 2006-01-06 PL PL06701729T patent/PL1836225T3/pl unknown
- 2006-01-06 US US11/813,402 patent/US8222376B2/en active Active
- 2006-01-06 PT PT06701729T patent/PT1836225E/pt unknown
- 2006-01-06 WO PCT/EP2006/050073 patent/WO2006072626A1/en not_active Ceased
- 2006-01-06 SI SI200631250T patent/SI1836225T1/sl unknown
- 2006-01-06 ES ES06701729T patent/ES2374603T3/es not_active Expired - Lifetime
- 2006-01-06 DK DK06701729.3T patent/DK1836225T3/da active
- 2006-01-06 EP EP06701729A patent/EP1836225B1/de not_active Expired - Lifetime
- 2006-01-06 AT AT06701729T patent/ATE531733T1/de active
- 2006-01-06 CN CN201510214401.1A patent/CN104829720B/zh not_active Expired - Fee Related
-
2008
- 2008-10-02 US US12/244,101 patent/US8388970B2/en active Active
-
2012
- 2012-01-30 CY CY20121100104T patent/CY1112897T1/el unknown
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2013
- 2013-01-11 JP JP2013003780A patent/JP2013100320A/ja active Pending
- 2013-01-18 US US13/745,081 patent/US9018366B2/en active Active
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- 2015-03-23 US US14/665,731 patent/US9708403B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1836225B1 (de) | 2011-11-02 |
| US9018366B2 (en) | 2015-04-28 |
| CN104829720B (zh) | 2019-01-01 |
| US8222376B2 (en) | 2012-07-17 |
| CN101103043A (zh) | 2008-01-09 |
| PT1836225E (pt) | 2012-01-10 |
| EP1836225A1 (de) | 2007-09-26 |
| US8388970B2 (en) | 2013-03-05 |
| JP2008526221A (ja) | 2008-07-24 |
| CY1112897T1 (el) | 2016-04-13 |
| JP2013100320A (ja) | 2013-05-23 |
| DK1836225T3 (da) | 2012-02-27 |
| US20080305117A1 (en) | 2008-12-11 |
| WO2006072626A1 (en) | 2006-07-13 |
| US9708403B2 (en) | 2017-07-18 |
| PL1836225T3 (pl) | 2012-05-31 |
| SI1836225T1 (sl) | 2012-06-29 |
| CN104829720A (zh) | 2015-08-12 |
| US20160046712A1 (en) | 2016-02-18 |
| JP5295568B2 (ja) | 2013-09-18 |
| US20090075340A1 (en) | 2009-03-19 |
| ES2374603T3 (es) | 2012-02-20 |
| US20130143269A1 (en) | 2013-06-06 |
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