ATE533774T1 - Neuartige nukleosidanaloge zur behandlung von virusinfektionen - Google Patents

Neuartige nukleosidanaloge zur behandlung von virusinfektionen

Info

Publication number
ATE533774T1
ATE533774T1 AT08708805T AT08708805T ATE533774T1 AT E533774 T1 ATE533774 T1 AT E533774T1 AT 08708805 T AT08708805 T AT 08708805T AT 08708805 T AT08708805 T AT 08708805T AT E533774 T1 ATE533774 T1 AT E533774T1
Authority
AT
Austria
Prior art keywords
treatment
virus infections
nucleoside analogues
novel nucleoside
novel
Prior art date
Application number
AT08708805T
Other languages
English (en)
Inventor
Zheng Yin
Jeyaraj Duraiswamy
Yen Chen
Original Assignee
Novartis Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39462074&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE533774(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Pharma Ag filed Critical Novartis Pharma Ag
Application granted granted Critical
Publication of ATE533774T1 publication Critical patent/ATE533774T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT08708805T 2007-02-09 2008-02-07 Neuartige nukleosidanaloge zur behandlung von virusinfektionen ATE533774T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07102027 2007-02-09
EP08150003 2008-01-02
PCT/EP2008/051527 WO2008095993A1 (en) 2007-02-09 2008-02-07 Novel nucleoside analogs for treatment of viral infections

Publications (1)

Publication Number Publication Date
ATE533774T1 true ATE533774T1 (de) 2011-12-15

Family

ID=39462074

Family Applications (1)

Application Number Title Priority Date Filing Date
AT08708805T ATE533774T1 (de) 2007-02-09 2008-02-07 Neuartige nukleosidanaloge zur behandlung von virusinfektionen

Country Status (18)

Country Link
US (1) US8278282B2 (de)
EP (1) EP2132216B1 (de)
JP (1) JP2010518047A (de)
KR (1) KR20090109102A (de)
CN (1) CN101600726B (de)
AR (1) AR065249A1 (de)
AT (1) ATE533774T1 (de)
AU (1) AU2008212752A1 (de)
BR (1) BRPI0807222A2 (de)
CA (1) CA2675462A1 (de)
CL (1) CL2008000409A1 (de)
EA (1) EA200901080A1 (de)
ES (1) ES2381093T3 (de)
MX (1) MX2009008495A (de)
PE (1) PE20090070A1 (de)
PT (1) PT2132216E (de)
TW (1) TW200838550A (de)
WO (1) WO2008095993A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR072906A1 (es) * 2008-08-06 2010-09-29 Novartis Ag Nucleosidos modificados utiles como antivirales
CN102526087B (zh) * 2010-12-30 2014-09-03 南开大学 核苷类化合物在制备治疗肠病毒71(ev71)感染疾病药物的应用
CN105669783B (zh) * 2014-12-03 2019-11-12 广东东阳光药业有限公司 一种制备呋喃糖的方法
WO2017024310A1 (en) 2015-08-06 2017-02-09 Chimerix, Inc. Pyrrolopyrimidine nucleosides and analogs thereof useful as antiviral agents
MX391226B (es) 2015-09-23 2025-03-21 Merck Sharp & Dohme Llc Inhibidores de transcriptasa inversa de nucleosido 4'-substituido y preparaciones de los mismos.
JP7129703B2 (ja) * 2016-04-28 2022-09-02 エモリー ユニバーシティー アルキン含有ヌクレオチド及びヌクレオシド治療組成物並びにそれらに関連した使用
TW201815821A (zh) * 2016-07-18 2018-05-01 美商再生元醫藥公司 抗茲卡病毒抗體及使用方法
US20190169221A1 (en) * 2016-08-12 2019-06-06 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
WO2019060692A1 (en) 2017-09-21 2019-03-28 Chimerix, Inc. MORPHIC FORMS OF 4-AMINO-7- (3,4-DIHYDROXY-5- (HYDROXYMETHYL) -ETRAHYDROFURAN-2-YL) -2-METHYL-7H-PYRROLO [2,3-D] PYRIMIDINE-5-CARBOXAMIDE AND THEIR USES
WO2020219447A1 (en) 2019-04-23 2020-10-29 Elementis Specialties, Inc. Slurry compositions containing mixed branched alkyl organoclay compositions
EP4454650A4 (de) * 2021-12-22 2025-10-22 Cj Cheiljedang Corp Antivirale zusammensetzung mit von nukleinsäure abgeleiteten nukleosidanalogen und pharmazeutisch unbedenkliches salz davon
CN117430571B (zh) * 2022-07-15 2025-08-29 宜昌东阳光长江药业股份有限公司 一种制备吡喃葡萄糖基衍生物的关键中间体及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1355916T1 (sl) * 2001-01-22 2007-04-30 Merck & Co Inc Nukleozidni derivati kot inhibitorji RNA-odvisne RNA virusne polimeraze
US7005448B2 (en) 2001-12-14 2006-02-28 Alcon, Inc. Aminoalkyl-benzofuran-5-ol compounds for the treatment of glaucoma
WO2003068244A1 (en) * 2002-02-13 2003-08-21 Merck & Co., Inc. Methods of inhibiting orthopoxvirus replication with nucleoside compounds
KR20050006221A (ko) * 2002-05-06 2005-01-15 제네랩스 테크놀로지스, 인코포레이티드 Ｃ형 간염 바이러스 감염 치료용의 뉴클레오시드 유도체
US7425547B2 (en) * 2002-09-30 2008-09-16 Genelabs Technologies, Inc. Nucleoside derivatives for treating hepatitis C virus infection
US20040259934A1 (en) * 2003-05-01 2004-12-23 Olsen David B. Inhibiting Coronaviridae viral replication and treating Coronaviridae viral infection with nucleoside compounds
EP1680436A1 (de) * 2003-10-27 2006-07-19 Genelabs Technologies, Inc. Nukleosidverbindungen zur behandlung viraler infektionen

Also Published As

Publication number Publication date
BRPI0807222A2 (pt) 2014-04-29
WO2008095993A1 (en) 2008-08-14
AR065249A1 (es) 2009-05-27
PE20090070A1 (es) 2009-03-19
EP2132216A1 (de) 2009-12-16
CN101600726A (zh) 2009-12-09
MX2009008495A (es) 2009-08-20
AU2008212752A1 (en) 2008-08-14
CN101600726B (zh) 2013-03-27
CA2675462A1 (en) 2008-08-14
EA200901080A1 (ru) 2010-02-26
TW200838550A (en) 2008-10-01
CL2008000409A1 (es) 2008-08-29
PT2132216E (pt) 2012-02-20
ES2381093T3 (es) 2012-05-23
JP2010518047A (ja) 2010-05-27
US20100227833A1 (en) 2010-09-09
KR20090109102A (ko) 2009-10-19
US8278282B2 (en) 2012-10-02
EP2132216B1 (de) 2011-11-16

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