ATE534407T1 - Verfahren zur dynamischen kernpolarisation (dnp) unter verwendung eines tritylrests und eines paramagnetischen metallions - Google Patents

Verfahren zur dynamischen kernpolarisation (dnp) unter verwendung eines tritylrests und eines paramagnetischen metallions

Info

Publication number
ATE534407T1
ATE534407T1 AT06824360T AT06824360T ATE534407T1 AT E534407 T1 ATE534407 T1 AT E534407T1 AT 06824360 T AT06824360 T AT 06824360T AT 06824360 T AT06824360 T AT 06824360T AT E534407 T1 ATE534407 T1 AT E534407T1
Authority
AT
Austria
Prior art keywords
dnp
metal ion
paramagnetic metal
dynamic nuclear
nuclear polarization
Prior art date
Application number
AT06824360T
Other languages
English (en)
Inventor
Mikkel Thaning
Rolf Servin
Original Assignee
Ge Healthcare As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from NO20055681A external-priority patent/NO20055681D0/no
Priority claimed from NO20055705A external-priority patent/NO20055705D0/no
Application filed by Ge Healthcare As filed Critical Ge Healthcare As
Application granted granted Critical
Publication of ATE534407T1 publication Critical patent/ATE534407T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/20—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
AT06824360T 2005-12-01 2006-12-01 Verfahren zur dynamischen kernpolarisation (dnp) unter verwendung eines tritylrests und eines paramagnetischen metallions ATE534407T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
NO20055681A NO20055681D0 (no) 2005-12-01 2005-12-01 Method of dynamic nuclear polarisation
NO20055705A NO20055705D0 (no) 2005-12-02 2005-12-02 Method of dynamic nuclear polarisation
NO20063119 2006-07-05
PCT/NO2006/000449 WO2007064226A2 (en) 2005-12-01 2006-12-01 Method of dynamic nuclear polarisation (dnp) using a trityl radical and a paramagnetic metal ion

Publications (1)

Publication Number Publication Date
ATE534407T1 true ATE534407T1 (de) 2011-12-15

Family

ID=38092667

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06824360T ATE534407T1 (de) 2005-12-01 2006-12-01 Verfahren zur dynamischen kernpolarisation (dnp) unter verwendung eines tritylrests und eines paramagnetischen metallions

Country Status (10)

Country Link
US (1) US8951502B2 (de)
EP (1) EP1954321B1 (de)
JP (1) JP5475995B2 (de)
KR (2) KR20130116383A (de)
AT (1) ATE534407T1 (de)
AU (1) AU2006321057B2 (de)
CA (1) CA2628539C (de)
ES (1) ES2375089T3 (de)
PL (1) PL1954321T3 (de)
WO (1) WO2007064226A2 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1962912B1 (de) * 2005-12-16 2012-09-26 Ge Healthcare As Verfahren zur herstellung hyperpolarisierter carboxylate organischer amine
CN101506179B (zh) * 2006-08-30 2012-08-22 通用电气医疗集团股份有限公司 动态核极化(dnp)的方法及用于所述方法的化合物和组合物
WO2008086534A1 (en) 2007-01-11 2008-07-17 Huntington Medical Research Institutes Imaging agents and methods of use thereof
GB0713074D0 (en) * 2007-07-05 2007-08-15 Univ London A method of hyperpolarising a magnetic resonance agent
CN101970014A (zh) * 2007-07-26 2011-02-09 通用电气医疗集团英国有限公司 包含超极化的13c-乳酸盐的成像介质及其用途
ATE534408T1 (de) * 2007-08-27 2011-12-15 Ge Healthcare Ltd Bildgebungsmedium mit hyperpolarisiertem uüc- acetat und seine verwendung
EP2902041A1 (de) * 2007-12-19 2015-08-05 GE Healthcare Limited Zusammensetzung und Verfahren zur Erzeugung eines metabolischen Profils bei Verwendung von 13C-MR
WO2009080739A1 (en) * 2007-12-21 2009-07-02 Ge Healthcare Limited Mr imaging agent, imaging medium and methods of imaging wherein such an imaging medium is used
WO2009098192A1 (en) * 2008-02-04 2009-08-13 Ge Healthcare Limited Mr imaging agent or medium compressing hzperpolarised 13c alanine and methods of imaging wherein such an imaging medium is used
WO2009098191A2 (en) * 2008-02-04 2009-08-13 Ge Healthcare Limited Method to produce hyperpolarised amino acids and aminosulphonic acids
WO2009150211A1 (en) * 2008-06-13 2009-12-17 Ge Healthcare Limited Dnp polariser and method of producing a hyperpolarised selected material
WO2010014893A2 (en) * 2008-07-31 2010-02-04 Duke University Magnetic resonance imaging and/or spectroscopy contrast agents and methods of use thereof
US8697034B2 (en) * 2008-10-10 2014-04-15 The Board Of Regents Of The University Of Texas System Hyperpolarized 89-yttrium and methods relating thereto
JP5868311B2 (ja) 2009-04-02 2016-02-24 ジーイー・ヘルスケア・リミテッド 炎症又は感染の検出のための過分極１３ｃピルビン酸塩を含む磁気共鳴造影媒体の使用
SG10201405591YA (en) 2009-09-10 2014-10-30 Ge Healthcare Ltd 13c-mr detection using hyperpolarised 13c-fructose
US8722420B2 (en) 2009-10-29 2014-05-13 Kyushu University, National University Corporation Method for detecting an endogenous biomolecule
EP2348327B1 (de) 2010-01-18 2013-11-27 Bruker BioSpin AG Verfahren zur NMR-Messung in Lösung unter Verwendung von dynamischer Kernpolarisation (DNP) mit Einfangen von freien Radikalen
CN102892434B (zh) 2010-04-08 2014-11-19 伯拉考成像股份公司 制备超极化底物的方法和mri方法
CN102858377B (zh) 2010-05-03 2015-04-15 通用电气健康护理有限公司 测定ldh活性的超极化的乳酸盐造影剂
US20140328766A1 (en) * 2010-08-24 2014-11-06 Ge Healthcare Limited Composition and method for generating a metabolic profile using 13c-mr detection
US9738686B2 (en) 2011-07-18 2017-08-22 The Trustees of the California State University Electron spin labeled ice binding compounds used for carrying paramagnetic centers for dynamic nuclear polarization
WO2013053839A1 (en) 2011-10-12 2013-04-18 Bracco Imaging Spa Process for the preparation of hyperpolarized derivatives for use in mri analysis
EP2788035B1 (de) 2011-12-05 2016-03-09 Bracco Imaging S.p.A Zusammensetzung mit essigsäureanhydrid und einem gadoliniumkomplex und verfahren zur verwendung in der hyperpolarisations-mri-analyse
US9925280B2 (en) 2012-04-02 2018-03-27 Bracco Imaging S.P.A. Hyperpolarized amino acids
EP2847591A1 (de) 2012-05-07 2015-03-18 Albeda Innovation ApS Intraoperative krebsdiagnose auf basis eines hyperpolarisierten markers
WO2014139573A1 (en) * 2013-03-14 2014-09-18 Ecole Polytechnique Federale De Lausanne (Epfl) Method for the generation of radicals for dynamic nuclear polarization and uses thereof for nmr, mrs and mri
US20160296645A1 (en) 2013-07-01 2016-10-13 Bracco Imaging S.P.A Hyperpolarized 1-13c-1,1-bis(acetoxy(methyl))-2,2'-cyclopropane as metabolic marker for mr
US9642924B2 (en) 2013-08-29 2017-05-09 Duke University Contrast agents based on long-lived nuclear singlet states and related methods
EP2891500B1 (de) 2014-01-07 2018-08-01 Cambridge Enterprise Limited Kontrastmittel zur Bestimmung von Aldehyd-Dehydrogenase-(ALDH)-Aktivität
EP3101012A1 (de) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft Neue gadoliniumchelat-verbindung zur verwendung in der magnetresonanzbildgebung
CN110035996B (zh) 2016-11-28 2022-08-09 拜耳医药股份公司 用于磁共振成像的新型高弛豫性钆螯合物
EP3883613A1 (de) 2018-11-23 2021-09-29 Bayer Aktiengesellschaft Formulierung für kontrastmittel und verfahren zur herstellung davon
CN120574245B (zh) * 2025-08-04 2025-12-02 中国科学院精密测量科学与技术创新研究院 一种含氟三苯甲基自由基化合物及其制备方法和应用

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI896234A0 (fi) 1987-06-23 1989-12-22 Hafslund Nycomed Innovation Foerbaettringar i och angaoende magnetisk resonansavbildning.
GB8817137D0 (en) 1988-07-19 1988-08-24 Nycomed As Compositions
US5314681A (en) * 1988-12-23 1994-05-24 Nycomed Innovation Ab Composition of positive and negative contrast agents for electron spin resonance enhanced magnetic resonance imaging
GB8830215D0 (en) 1988-12-23 1989-02-22 Hafslund Nycomed Innovation Method
US4969184A (en) 1989-02-02 1990-11-06 Alphanet Technology Corporation Data transmission arrangement
ATE126707T1 (de) 1990-02-12 1995-09-15 Nycomed Innovation Ab Triarylmethyl-radikale und die anwendung von inerten kohlenstofffreien radikalen in mri.
US5368840A (en) * 1990-04-10 1994-11-29 Imarx Pharmaceutical Corp. Natural polymers as contrast media for magnetic resonance imaging
GB9024528D0 (en) * 1990-11-12 1991-01-02 Instrumentarium Corp Improvements in and relating to magnetic resonance imaging
WO1993002711A1 (en) 1991-08-09 1993-02-18 Nycomed Innovation Ab Use of persistent free-radicals in magnetic resonance imaging
GB9704669D0 (en) 1997-03-06 1997-04-23 Nycomed Imaging As Free radicals
US5728370A (en) 1993-04-02 1998-03-17 Nycomed Imaging As Free Radicals
CZ66998A3 (cs) 1995-09-08 1998-07-15 Nycomed Imaging A/S Způsob stanovení koncentrace kyslíku ve vzorku
EP0966414B1 (de) * 1997-03-06 2003-06-04 Amersham Health AS Triarylmethylfreie radikale als bildverbesserungsmittel
AU8119298A (en) 1997-06-19 1999-01-04 Nycomed Imaging As Overhauser magnetic resonance imaging (ormi) method comprising ex vivo polarization of a magnetic resonance (mr) imaging agent
US6278893B1 (en) 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
GB0014463D0 (en) 2000-06-14 2000-08-09 Nycomed Amersham Plc NMR Method
DK1330659T3 (da) 2000-11-03 2006-12-18 Amersham Health As Fremgangsmåde og indretning til oplösning af hyperpolariseret, fast materiale til NMR-analyser
NO20023357D0 (no) 2002-04-19 2002-07-11 Amersham Health As Blanding
NO20025738D0 (no) 2002-11-29 2002-11-29 Amersham Health As Metode
US7351402B2 (en) * 2003-08-21 2008-04-01 Massachusetts Institute Of Technology Polarizing agents for dynamic nuclear polarization
US20050063491A1 (en) 2003-09-19 2005-03-24 Siemens Vdo Automotive Corporation Radio frequency signal discrimination method and system
JP2007523504A (ja) 2004-02-04 2007-08-16 松下電器産業株式会社 データ伝送用のパケット・フレームの生成方法及び装置
JP5535435B2 (ja) 2004-07-30 2014-07-02 ジーイー・ヘルスケア・アクスイェ・セルスカプ ラジカル及び、ｄｎｐ処理における常磁性試薬としてのその使用
WO2006011809A1 (en) 2004-07-30 2006-02-02 Ge Healthcare As Method of producing a composition, composition and its use
CN101031811A (zh) 2004-07-30 2007-09-05 通用电气医疗集团股份有限公司 肿瘤成像方法
CN101506179B (zh) * 2006-08-30 2012-08-22 通用电气医疗集团股份有限公司 动态核极化(dnp)的方法及用于所述方法的化合物和组合物

Also Published As

Publication number Publication date
US8951502B2 (en) 2015-02-10
JP2009517688A (ja) 2009-04-30
US20080260649A1 (en) 2008-10-23
WO2007064226A2 (en) 2007-06-07
EP1954321B1 (de) 2011-11-23
KR20130116383A (ko) 2013-10-23
ES2375089T3 (es) 2012-02-24
WO2007064226A3 (en) 2007-10-18
AU2006321057B2 (en) 2012-11-01
PL1954321T3 (pl) 2012-04-30
EP1954321A2 (de) 2008-08-13
KR20080072692A (ko) 2008-08-06
KR101372173B1 (ko) 2014-03-07
JP5475995B2 (ja) 2014-04-16
CA2628539C (en) 2014-04-29
CA2628539A1 (en) 2007-06-07
AU2006321057A1 (en) 2007-06-07

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