PL1954321T3 - Sposób dynamicznej polaryzacji jądrowej (DNP) przy użyciu rodnika tritylowego oraz jonu metalu paramagnetycznego - Google Patents

Sposób dynamicznej polaryzacji jądrowej (DNP) przy użyciu rodnika tritylowego oraz jonu metalu paramagnetycznego

Info

Publication number
PL1954321T3
PL1954321T3 PL06824360T PL06824360T PL1954321T3 PL 1954321 T3 PL1954321 T3 PL 1954321T3 PL 06824360 T PL06824360 T PL 06824360T PL 06824360 T PL06824360 T PL 06824360T PL 1954321 T3 PL1954321 T3 PL 1954321T3
Authority
PL
Poland
Prior art keywords
dnp
metal ion
paramagnetic metal
dynamic nuclear
trityl radical
Prior art date
Application number
PL06824360T
Other languages
English (en)
Inventor
Mikkel Thaning
Rolf Servin
Original Assignee
Ge Healthcare As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from NO20055681A external-priority patent/NO20055681D0/no
Priority claimed from NO20055705A external-priority patent/NO20055705D0/no
Application filed by Ge Healthcare As filed Critical Ge Healthcare As
Publication of PL1954321T3 publication Critical patent/PL1954321T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/20—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
PL06824360T 2005-12-01 2006-12-01 Sposób dynamicznej polaryzacji jądrowej (DNP) przy użyciu rodnika tritylowego oraz jonu metalu paramagnetycznego PL1954321T3 (pl)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
NO20055681A NO20055681D0 (no) 2005-12-01 2005-12-01 Method of dynamic nuclear polarisation
NO20055705A NO20055705D0 (no) 2005-12-02 2005-12-02 Method of dynamic nuclear polarisation
NO20063119 2006-07-05
EP06824360A EP1954321B1 (en) 2005-12-01 2006-12-01 Method of dynamic nuclear polarisation (dnp) using a trityl radical and a paramagnetic metal ion
PCT/NO2006/000449 WO2007064226A2 (en) 2005-12-01 2006-12-01 Method of dynamic nuclear polarisation (dnp) using a trityl radical and a paramagnetic metal ion

Publications (1)

Publication Number Publication Date
PL1954321T3 true PL1954321T3 (pl) 2012-04-30

Family

ID=38092667

Family Applications (1)

Application Number Title Priority Date Filing Date
PL06824360T PL1954321T3 (pl) 2005-12-01 2006-12-01 Sposób dynamicznej polaryzacji jądrowej (DNP) przy użyciu rodnika tritylowego oraz jonu metalu paramagnetycznego

Country Status (10)

Country Link
US (1) US8951502B2 (pl)
EP (1) EP1954321B1 (pl)
JP (1) JP5475995B2 (pl)
KR (2) KR20130116383A (pl)
AT (1) ATE534407T1 (pl)
AU (1) AU2006321057B2 (pl)
CA (1) CA2628539C (pl)
ES (1) ES2375089T3 (pl)
PL (1) PL1954321T3 (pl)
WO (1) WO2007064226A2 (pl)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2393750T3 (es) * 2005-12-16 2012-12-27 Ge Healthcare As Procedimiento para producir carbosilatos hiperpolarizados de aminas orgánicas
JP5269791B2 (ja) 2006-08-30 2013-08-21 ジーイー・ヘルスケア・アクスイェ・セルスカプ 動的核分極（ｄｎｐ）方法並びに該方法で使用するための化合物及び組成物
WO2008086534A1 (en) * 2007-01-11 2008-07-17 Huntington Medical Research Institutes Imaging agents and methods of use thereof
GB0713074D0 (en) * 2007-07-05 2007-08-15 Univ London A method of hyperpolarising a magnetic resonance agent
US20100196283A1 (en) * 2007-07-26 2010-08-05 Lerche Matilde H Method and imaging medium for use in the method
ES2375083T3 (es) * 2007-08-27 2012-02-24 Ge Healthcare Limited Medio de formación de imagen que comprende 13c-acetat-hiperpolarizado y uso del mismo.
EP2072061A1 (en) 2007-12-19 2009-06-24 GE Healthcare Limited Composition and method for generating a metabolic profile using 13C-MR detection
EP2222346B1 (en) * 2007-12-21 2012-02-08 GE Healthcare Limited Mr imaging agent, imaging medium and methods of imaging wherein such an imaging medium is used
JP2011514313A (ja) * 2008-02-04 2011-05-06 ジーイー・ヘルスケア・リミテッド 過分極アミノ酸及びアミノスルホン酸の製造方法
WO2009098192A1 (en) * 2008-02-04 2009-08-13 Ge Healthcare Limited Mr imaging agent or medium compressing hzperpolarised 13c alanine and methods of imaging wherein such an imaging medium is used
WO2009150211A1 (en) * 2008-06-13 2009-12-17 Ge Healthcare Limited Dnp polariser and method of producing a hyperpolarised selected material
WO2010014893A2 (en) * 2008-07-31 2010-02-04 Duke University Magnetic resonance imaging and/or spectroscopy contrast agents and methods of use thereof
US8697034B2 (en) * 2008-10-10 2014-04-15 The Board Of Regents Of The University Of Texas System Hyperpolarized 89-yttrium and methods relating thereto
CN102388317B (zh) 2009-04-02 2015-11-25 通用电气健康护理有限公司 包含超极化13c丙酮酸盐的磁共振成像介质用于检测炎症或感染的用途
US8968703B2 (en) 2009-09-10 2015-03-03 Ge Healthcare Limited 13C-MR detection using hyperpolarised 13C-fructose
JP5150822B2 (ja) 2009-10-29 2013-02-27 国立大学法人九州大学 生体内因性分子の検出方法
EP2348327B1 (en) 2010-01-18 2013-11-27 Bruker BioSpin AG Method for NMR measurements using dissolution dynamic nuclear polarization (DNP) with elimination of free radicals
WO2011124672A1 (en) 2010-04-08 2011-10-13 Bracco Imaging Spa Process for preparing hyperpolarized substrates and method for mri
WO2011138269A1 (en) 2010-05-03 2011-11-10 Ge Healthcare Limited Hyperpolarized lactate contrast agent for determination of ldh activity
US20140328766A1 (en) * 2010-08-24 2014-11-06 Ge Healthcare Limited Composition and method for generating a metabolic profile using 13c-mr detection
US9738686B2 (en) 2011-07-18 2017-08-22 The Trustees of the California State University Electron spin labeled ice binding compounds used for carrying paramagnetic centers for dynamic nuclear polarization
US9511154B2 (en) 2011-10-12 2016-12-06 Bracco Imaging S.P.A. Process for the preparation of hyperpolarized derivatives for use in MRI analysis
US9693828B2 (en) 2011-12-05 2017-07-04 Bracco Imaging S.P.A. Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation in MRI analysis
US9925280B2 (en) 2012-04-02 2018-03-27 Bracco Imaging S.P.A. Hyperpolarized amino acids
WO2013167587A1 (en) 2012-05-07 2013-11-14 Albeda Innovation Aps Intra-operative cancer diagnosis based on a hyperpolarized marker
EP2972441B1 (en) * 2013-03-14 2016-11-30 Ecole Polytechnique Fédérale de Lausanne (EPFL) Method for the generation of radicals for dynamic nuclear polarization and uses thereof for nmr, mrs and mri
WO2015000838A1 (en) 2013-07-01 2015-01-08 Bracco Imaging Spa Hyperpolarized 1-13c-1,1-bis(acetoxy(methyl))-2,2'-cyclopropane as metabolic marker for mr
US9642924B2 (en) 2013-08-29 2017-05-09 Duke University Contrast agents based on long-lived nuclear singlet states and related methods
EP2891500B1 (en) 2014-01-07 2018-08-01 Cambridge Enterprise Limited Contrast agent for determination of aldehyde dehydrogenase (ALDH) activity
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
ES2814555T3 (es) 2016-11-28 2021-03-29 Bayer Pharma AG Compuestos de quelato de gadolinio con alta relaxividad para usar en la obtención de imágenes por resonancia magnética
EP3883613A1 (en) 2018-11-23 2021-09-29 Bayer Aktiengesellschaft Formulation of contrast media and process of preparation thereof
CN120574245B (zh) * 2025-08-04 2025-12-02 中国科学院精密测量科学与技术创新研究院 一种含氟三苯甲基自由基化合物及其制备方法和应用

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE61448B1 (en) 1987-06-23 1994-11-02 Hafslund Nycomed Innovation Improvements in and relating to magnetic resonance imaging
GB8817137D0 (en) 1988-07-19 1988-08-24 Nycomed As Compositions
US5314681A (en) * 1988-12-23 1994-05-24 Nycomed Innovation Ab Composition of positive and negative contrast agents for electron spin resonance enhanced magnetic resonance imaging
GB8830215D0 (en) 1988-12-23 1989-02-22 Hafslund Nycomed Innovation Method
US4969184A (en) * 1989-02-02 1990-11-06 Alphanet Technology Corporation Data transmission arrangement
DK0515458T3 (da) 1990-02-12 1995-09-25 Nycomed Innovation Ab Triarylmethylradikaler og anvendelse af inerte, frie carbon-radikaler ved MRI
US5368840A (en) * 1990-04-10 1994-11-29 Imarx Pharmaceutical Corp. Natural polymers as contrast media for magnetic resonance imaging
GB9024528D0 (en) * 1990-11-12 1991-01-02 Instrumentarium Corp Improvements in and relating to magnetic resonance imaging
ES2114566T3 (es) 1991-08-09 1998-06-01 Nycomed Innovation Ab Uso de radicales libres persistentes en formacion de imagenes por resonancia magnetica nuclear.
GB9704669D0 (en) 1997-03-06 1997-04-23 Nycomed Imaging As Free radicals
US5728370A (en) * 1993-04-02 1998-03-17 Nycomed Imaging As Free Radicals
ES2175123T3 (es) 1995-09-08 2002-11-16 Nycomed Imaging As Procedimiento que sirve para determinar la concentracion de oxigeno enuna muestra.
ES2201462T3 (es) 1997-03-06 2004-03-16 Amersham Health As Radicales libres de triarilmetilo como agentes mejoradores de la imagen.
EP0990168A1 (en) * 1997-06-19 2000-04-05 Nycomed Imaging As Overhauser magnetic resonance imaging (ormi) method comprising ex vivo polarization of a magnetic resonance (mr) imaging agent
US6278893B1 (en) 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
GB0014463D0 (en) 2000-06-14 2000-08-09 Nycomed Amersham Plc NMR Method
IL155476A0 (en) 2000-11-03 2003-11-23 Amersham Health As Methods and devices for dissolving hyperpolarised material for nmr analyses
NO20023357D0 (no) 2002-04-19 2002-07-11 Amersham Health As Blanding
NO20025738D0 (no) 2002-11-29 2002-11-29 Amersham Health As Metode
US7351402B2 (en) * 2003-08-21 2008-04-01 Massachusetts Institute Of Technology Polarizing agents for dynamic nuclear polarization
US20050063491A1 (en) 2003-09-19 2005-03-24 Siemens Vdo Automotive Corporation Radio frequency signal discrimination method and system
JP2007523504A (ja) 2004-02-04 2007-08-16 松下電器産業株式会社 データ伝送用のパケット・フレームの生成方法及び装置
NZ552898A (en) * 2004-07-30 2011-02-25 Ge Healthcare As Method of producing a composition, composition and its use
JP5535435B2 (ja) * 2004-07-30 2014-07-02 ジーイー・ヘルスケア・アクスイェ・セルスカプ ラジカル及び、ｄｎｐ処理における常磁性試薬としてのその使用
ES2372058T3 (es) 2004-07-30 2012-01-13 Ge Healthcare As Procedimiento de visualización de imágenes rm para la discriminación entre tejido sano y tumoral.
JP5269791B2 (ja) * 2006-08-30 2013-08-21 ジーイー・ヘルスケア・アクスイェ・セルスカプ 動的核分極（ｄｎｐ）方法並びに該方法で使用するための化合物及び組成物

Also Published As

Publication number Publication date
AU2006321057A1 (en) 2007-06-07
KR20130116383A (ko) 2013-10-23
US8951502B2 (en) 2015-02-10
CA2628539A1 (en) 2007-06-07
EP1954321B1 (en) 2011-11-23
CA2628539C (en) 2014-04-29
ES2375089T3 (es) 2012-02-24
US20080260649A1 (en) 2008-10-23
AU2006321057B2 (en) 2012-11-01
WO2007064226A2 (en) 2007-06-07
JP2009517688A (ja) 2009-04-30
WO2007064226A3 (en) 2007-10-18
KR101372173B1 (ko) 2014-03-07
ATE534407T1 (de) 2011-12-15
KR20080072692A (ko) 2008-08-06
JP5475995B2 (ja) 2014-04-16
EP1954321A2 (en) 2008-08-13

Similar Documents

Publication Publication Date Title
PL1954321T3 (pl) Sposób dynamicznej polaryzacji jądrowej (DNP) przy użyciu rodnika tritylowego oraz jonu metalu paramagnetycznego
MY142334A (en) Fertilizer-compatible composition
TW200738263A (en) ANG2 and VEGF inhibitor combinations
MX2009008511A (es) Reduccion de efectos secundarios de tramadol.
EP1904290A4 (en) MICRO BEADS ON ALUMINUM PHOSPHATE BASE
MY160041A (en) Compositions and methods for treating parasitic infections
MX2010010209A (es) 4-hidroxipirimidina-5-carboxamidas sustituidas.
MX2011010390A (es) Conjugados, particulas, composiciones de agentes polimericos y metodos relacionados de uso.
TW200700092A (en) Tigecycline compositions and methods of preparation
MX2012000396A (es) Metodos y composiciones para uso en tartamientos celulares.
WO2008036317A3 (en) Systems and methods for pathogen detection and response
WO2008085064A3 (en) Hydroxypyridinone chelating agents, their metal complexes and their use as mri contrast agents
MX2008012035A (es) Material cementoso.
WO2007143211A3 (en) Methods for identifying agents and their use for the prevention of restenosis
MX2010008875A (es) Agonistas nicotinicos alfa 7 y antipsicoticos.
WO2007069909A3 (en) Method to produce hyperpolarised carboxylates of organic amines
NZ628148A (en) Mitigation of alternate bearing
NZ580533A (en) Cell lines, compositions comprising them for the treatment of melanomas, procedures to prepare the compositions, and treatment methods
WO2009120700A3 (en) Inhibition of dcps
BRPI0513880A (pt) método para a polarização nuclear dinámica de um composto, radicais, uso de radicais, e, composição
PL2052273T3 (pl) Obrazowanie lub spektroskopia metodą rezonansu magnetycznego 13C śmierci komórkowej
MX2008015142A (es) Composicion de limpieza.
MXPA05011501A (es) Combinacion terapeutica de un inhibidor de cox-2 y un inhibidor de aromatasa.
MD307Y (en) Inhibitor of steel corrosion in the water
MX2009004633A (es) Composicion solida para tratamiento de agua.