ATE535537T1 - 2-o-(-d-glucopyranosyl)ascorbinsäure, verfahren zu ihrer herstellung , sowie lebensmittel und kosmetika, die diese umfassende zusammensetzungen enthalten - Google Patents

2-o-(-d-glucopyranosyl)ascorbinsäure, verfahren zu ihrer herstellung , sowie lebensmittel und kosmetika, die diese umfassende zusammensetzungen enthalten

Info

Publication number: ATE535537T1
Authority: AT; Austria
Prior art keywords: glucopyranosyl; ascorbic acid; food; production; compositions
Prior art date: 2001-12-28

Application number

AT02793462T

Other languages

English (en)

Inventor

Mitsuru Maeda

Masahiro Nakao

Harukazu Fukami

Original Assignee

Suntory Holdings Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-12-28

Filing date

2002-12-27

Publication date

2011-12-15

2002-12-27 Application filed by Suntory Holdings Ltd filed Critical Suntory Holdings Ltd

2011-12-15 Application granted granted Critical

2011-12-15 Publication of ATE535537T1 publication Critical patent/ATE535537T1/de

Links

239000000203 mixture Substances 0.000 title abstract 4
150000001875 compounds Chemical class 0.000 title abstract 2
239000002537 cosmetic Substances 0.000 title abstract 2
235000013305 food Nutrition 0.000 title abstract 2
MLSJBGYKDYSOAE-BEVZWNRGSA-N (2r)-2-[(1s)-1,2-dihydroxyethyl]-3-hydroxy-4-[(3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2h-furan-5-one Chemical compound OC[C@H](O)[C@H]1OC(=O)C(OC2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=C1O MLSJBGYKDYSOAE-BEVZWNRGSA-N 0.000 title 1
MLSJBGYKDYSOAE-DNYNHWTLSA-N (2r)-2-[(1s)-1,2-dihydroxyethyl]-3-hydroxy-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2h-furan-5-one Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=C1O MLSJBGYKDYSOAE-DNYNHWTLSA-N 0.000 abstract 5
MLSJBGYKDYSOAE-UHFFFAOYSA-N L-ascorbyl 2-glucoside Natural products OCC(O)C1OC(=O)C(OC2C(C(O)C(O)C(CO)O2)O)=C1O MLSJBGYKDYSOAE-UHFFFAOYSA-N 0.000 abstract 5
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 2
230000002035 prolonged effect Effects 0.000 abstract 2
ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 abstract 1
241000196324 Embryophyta Species 0.000 abstract 1
MLSJBGYKDYSOAE-DCWMUDTNSA-N L-Ascorbic acid-2-glucoside Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)=C1O MLSJBGYKDYSOAE-DCWMUDTNSA-N 0.000 abstract 1
150000000996 L-ascorbic acids Chemical class 0.000 abstract 1
244000241838 Lycium barbarum Species 0.000 abstract 1
235000015459 Lycium barbarum Nutrition 0.000 abstract 1
244000241872 Lycium chinense Species 0.000 abstract 1
235000015468 Lycium chinense Nutrition 0.000 abstract 1
229930003268 Vitamin C Natural products 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
235000019154 vitamin C Nutrition 0.000 abstract 1
239000011718 vitamin C Substances 0.000 abstract 1
-1 α-D-glucopyranosyl Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
- C07H1/08—Separation; Purification from natural products
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Nutrition Science (AREA)
Molecular Biology (AREA)
Birds (AREA)
Polymers & Plastics (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Mycology (AREA)
Food Science & Technology (AREA)
Immunology (AREA)
Botany (AREA)
Toxicology (AREA)
Diabetes (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Hematology (AREA)

AT02793462T 2001-12-28 2002-12-27 2-o-(-d-glucopyranosyl)ascorbinsäure, verfahren zu ihrer herstellung , sowie lebensmittel und kosmetika, die diese umfassende zusammensetzungen enthalten ATE535537T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP2001400258		2001-12-28
PCT/JP2002/013857 WO2003057707A1 (en)	2001-12-28	2002-12-27	2-o-( -d-glucopyranosyl)ascorbic acid, process for its production, and foods and cosmetics containing compositions comprising it

Publications (1)

Publication Number	Publication Date
ATE535537T1 true ATE535537T1 (de)	2011-12-15

Family

ID=19189590

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02793462T ATE535537T1 (de)	2001-12-28	2002-12-27	2-o-(-d-glucopyranosyl)ascorbinsäure, verfahren zu ihrer herstellung , sowie lebensmittel und kosmetika, die diese umfassende zusammensetzungen enthalten

Country Status (10)

Country	Link
US (3)	US7566698B2 (de)
EP (1)	EP1461347B8 (de)
JP (1)	JP4713832B2 (de)
KR (3)	KR20040071764A (de)
CN (1)	CN1314696C (de)
AT (1)	ATE535537T1 (de)
AU (1)	AU2002359000B2 (de)
CA (1)	CA2472114C (de)
TW (1)	TWI331610B (de)
WO (1)	WO2003057707A1 (de)

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CA2472114C (en) *	2001-12-28	2011-03-29	Suntory Limited	2-o-(.beta.-d-glucopyranosyl) ascorbic acid, process for its production, and foods and cosmetics containing compositons comprising it
TWI329024B (en) *	2003-06-26	2010-08-21	Suntory Holdings Ltd	Composition for skin, kit for skin and skin permeation enhancer
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CN102942606B (zh) *	2012-12-11	2015-05-06	上海诺德生物实业有限公司	一种制备高纯枸杞酸的方法
KR101505311B1 (ko)	2013-07-29	2015-03-24	건양대학교산학협력단	당 결합 단백질의 특성을 이용하여 구기자 추출물로부터 식물성 아스코르빈산-2-글루코사이드를 분리 및 정제하는 방법
TW201629077A (zh) *	2014-10-21	2016-08-16	Suntory Holdings Ltd	抗壞血酸衍生物及使用該衍生物的配醣體之製造方法
CN104370977B (zh) *	2014-11-28	2017-05-24	山东师范大学	一种2‑O‑(2,3,4,6‑四‑O‑乙酰基‑β‑D‑吡喃葡萄糖基)‑3‑O‑苄基‑5,6‑O‑异亚丙基‑抗血酸的制备方法
CN105267231B (zh) *	2015-10-22	2018-04-17	华中农业大学	L‑抗坏血酸基糖苷类化合物在制备α‑葡萄糖苷酶抑制剂中的应用
CN109476693A (zh) *	2016-07-29	2019-03-15	佳里多控股公司	2-O-α-D-糖基-L-抗坏血酸金属盐、其作为抗氧化剂的用途及其粉末的制造方法
CN106380498B (zh) *	2016-08-12	2018-11-23	上海诺德生物实业有限公司	枸杞酸的制备方法
KR102354282B1 (ko) *	2017-05-17	2022-01-21	주식회사 엘지생활건강	에리소르빈산을 포함하는 화장료 조성물
CN120360921A (zh)	2018-03-23	2025-07-25	玫琳凯有限公司	局部用组合物和方法
JP7378469B2 (ja) *	2018-10-03	2023-11-13	ラボラトリーコーポレイションオブアメリカホールディングス	アスコルビン酸を測定するための方法およびシステム
JP7220457B2 (ja) *	2018-12-14	2023-02-10	丸善製薬株式会社	ヒアルロン酸産生促進剤、関節機能改善剤、及び経口用組成物
CN109731005A (zh) *	2019-02-19	2019-05-10	珠海壮元健康研究院有限公司	2-O-β-D-单糖基-L-抗坏血酸在防治神经退行性疾病药物中的应用
CN110734945A (zh) *	2019-10-30	2020-01-31	安徽泰格生物技术股份有限公司	一种合成l-抗坏血酸-2-葡萄糖苷的方法
EP4129282A4 (de)	2020-03-31	2024-05-01	Natural Medicine Institute Of Zhejiang Yangshengtang Co., Ltd.	Pharmazeutische kombination und verwendung davon
CN115361945B (zh)	2020-03-31	2024-11-12	浙江养生堂天然药物研究所有限公司	药物组合及其用途
CN115397411B (zh)	2020-04-23	2025-08-22	浙江养生堂天然药物研究所有限公司	药物组合及其用途
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2002
- 2002-12-27 CA CA2472114A patent/CA2472114C/en not_active Expired - Fee Related
- 2002-12-27 EP EP02793462A patent/EP1461347B8/de not_active Expired - Lifetime
- 2002-12-27 US US10/500,334 patent/US7566698B2/en not_active Expired - Fee Related
- 2002-12-27 KR KR10-2004-7010257A patent/KR20040071764A/ko not_active Ceased
- 2002-12-27 KR KR1020097021962A patent/KR101147947B1/ko not_active Expired - Fee Related
- 2002-12-27 AT AT02793462T patent/ATE535537T1/de active
- 2002-12-27 JP JP2003558021A patent/JP4713832B2/ja not_active Expired - Lifetime
- 2002-12-27 AU AU2002359000A patent/AU2002359000B2/en not_active Ceased
- 2002-12-27 WO PCT/JP2002/013857 patent/WO2003057707A1/en not_active Ceased
- 2002-12-27 KR KR1020107024545A patent/KR101092269B1/ko not_active Expired - Fee Related
- 2002-12-27 CN CNB028263170A patent/CN1314696C/zh not_active Expired - Fee Related
- 2002-12-30 TW TW091137876A patent/TWI331610B/zh not_active IP Right Cessation
2006
- 2006-08-09 US US11/501,074 patent/US7943583B2/en not_active Expired - Fee Related
2007
- 2007-09-10 US US11/898,121 patent/US8017587B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
TW200301259A (en)	2003-07-01
CN1610691A (zh)	2005-04-27
KR20090115820A (ko)	2009-11-06
CA2472114A1 (en)	2003-07-17
US20070065380A1 (en)	2007-03-22
KR20040071764A (ko)	2004-08-12
US8017587B2 (en)	2011-09-13
KR20100121709A (ko)	2010-11-18
EP1461347B1 (de)	2011-11-30
TWI331610B (en)	2010-10-11
KR101147947B1 (ko)	2012-05-29
JP4713832B2 (ja)	2011-06-29
US20050113312A1 (en)	2005-05-26
CN1314696C (zh)	2007-05-09
AU2002359000B2 (en)	2009-07-02
EP1461347A1 (de)	2004-09-29
US7943583B2 (en)	2011-05-17
KR101092269B1 (ko)	2011-12-13
WO2003057707A1 (en)	2003-07-17
EP1461347B8 (de)	2012-08-15
JP2005518401A (ja)	2005-06-23
CA2472114C (en)	2011-03-29
AU2002359000A1 (en)	2003-07-24
US20080070983A1 (en)	2008-03-20
US7566698B2 (en)	2009-07-28

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