ATE536347T1 - Effiziente herstellung heterologer proteine unter verwendung von mannosyltransferaseinhibitoren - Google Patents

Effiziente herstellung heterologer proteine unter verwendung von mannosyltransferaseinhibitoren

Info

Publication number: ATE536347T1
Authority: AT; Austria
Prior art keywords: inhibitors; heterologue; transferas; mannosyl; proteins
Prior art date: 2008-05-20

Application number

AT09751270T

Other languages

English (en)

Inventor

Ranjit Desai

Lihu Yang

Original Assignee

Merck Sharp & Dohme

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-05-20

Filing date

2009-05-18

Publication date

2011-12-15

2009-05-18 Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme

2011-12-15 Application granted granted Critical

2011-12-15 Publication of ATE536347T1 publication Critical patent/ATE536347T1/de

Links

108090000623 proteins and genes Proteins 0.000 title abstract 3
102000004169 proteins and genes Human genes 0.000 title abstract 3
239000003112 inhibitor Substances 0.000 title abstract 2
230000004989 O-glycosylation Effects 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
SGIZECXZFLAGBW-UHFFFAOYSA-N 5-benzylidene-1,3-thiazolidine-2,4-dione Chemical class S1C(=O)NC(=O)C1=CC1=CC=CC=C1 SGIZECXZFLAGBW-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/36—Sulfur atoms
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Wood Science & Technology (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Thiazole And Isothizaole Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Enzymes And Modification Thereof (AREA)

AT09751270T 2008-05-20 2009-05-18 Effiziente herstellung heterologer proteine unter verwendung von mannosyltransferaseinhibitoren ATE536347T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US12825108P	2008-05-20	2008-05-20
PCT/US2009/044297 WO2009143041A1 (en)	2008-05-20	2009-05-18	Efficient production of heterologous proteins using mannosyl transferase inhibitors

Publications (1)

Publication Number	Publication Date
ATE536347T1 true ATE536347T1 (de)	2011-12-15

Family

ID=40929664

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT09751270T ATE536347T1 (de)	2008-05-20	2009-05-18	Effiziente herstellung heterologer proteine unter verwendung von mannosyltransferaseinhibitoren

Country Status (9)

Country	Link
US (2)	US8309325B2 (de)
EP (1)	EP2300446B1 (de)
JP (2)	JP5411929B2 (de)
CN (1)	CN102036974B (de)
AT (1)	ATE536347T1 (de)
AU (1)	AU2009249314A1 (de)
CA (1)	CA2721459A1 (de)
MX (1)	MX2010012626A (de)
WO (1)	WO2009143041A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8206949B2 (en) *	2005-11-15	2012-06-26	Glycofi, Inc.	Production of glycoproteins with reduced O-glycosylation
WO2009143041A1 (en) *	2008-05-20	2009-11-26	Merck & Co., Inc.	Efficient production of heterologous proteins using mannosyl transferase inhibitors
CN103764837A (zh)	2011-02-25	2014-04-30	默沙东公司	用于生产具有修饰的o-糖基化的蛋白的酵母菌株
WO2015001049A1 (en)	2013-07-04	2015-01-08	Novartis Ag	O-mannosyltransferase deficient filamentous fungal cells and methods of use thereof
SG11201700446XA (en)	2014-07-21	2017-02-27	Glykos Finland Oy	Production of glycoproteins with mammalian-like n-glycans in filamentous fungi

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US6103501A (en) *	1997-11-17	2000-08-15	Washington University	Single chain glycoprotein hormones comprising two β and one α subunits and recombinant production thereof
FR2804113B1 (fr) *	2000-01-26	2004-06-18	Lipha	Derives animes de dihydro-1,3,5-triazine et leurs applications en therapeutique
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AU2001249310A1 (en) *	2000-03-21	2001-10-03	Uab Research Foundation	Prevention and/or treatment of diabetes mellitus by pharmacologically inhibitingpancreatic beta-cell o-linked protin glycosylation and/or pancreatic beta-cell p135 o-glycosylation
US20030186948A1 (en) *	2000-03-21	2003-10-02	Jeffrey Kudlow	O-linked N-acetylglucosamine pathway in the pathogenesis of neurodegeneration and diabetes
GB0021419D0 (en) *	2000-08-31	2000-10-18	Oxford Glycosciences Uk Ltd	Compounds
GB0021421D0 (en) *	2000-08-31	2000-10-18	Oxford Glycosciences Uk Ltd	Compounds
JP2005513026A (ja) *	2001-11-15	2005-05-12	インサイトサンディエゴインコーポレイテッド	高コレステロール血症、異脂肪血症および他の代謝障害；癌、および他の疾患を治療するｎ−置換複素環
GB0204252D0 (en) *	2002-02-23	2002-04-10	Oxford Glycosciences Uk Ltd	Novel compounds
AU2003205907A1 (en)	2002-02-23	2003-09-09	Oxford Glycosciences (Uk) Ltd	Thiazolidine antifungal agents
US7102000B2 (en) *	2002-03-08	2006-09-05	Incyte San Diego Inc.	Heterocyclic amide derivatives for the treatment of diabetes and other diseases
AU2002953533A0 (en) *	2002-12-24	2003-01-16	Arthron Limited	Fc receptor modulating compounds and compositions
US7781464B2 (en) *	2003-01-17	2010-08-24	Bexel Pharmaceuticals, Inc.	Heterocyclic diphenyl ethers
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JP2007045946A (ja)	2005-08-10	2007-02-22	Shipro Kasei Kaisha Ltd	チアゾリジン誘導体を用いた有機色素
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US8206949B2 (en) *	2005-11-15	2012-06-26	Glycofi, Inc.	Production of glycoproteins with reduced O-glycosylation
EP1834642A3 (de) *	2006-03-08	2007-10-03	National Institute of Immunology	2-thioxothiazolidin-4-on-Verbindungen und -Zusammensetzungen als antimikrobielle und Antimalaria-Mittel zum Targeting der Enoyl-ACP-Reduktase des Syntheseweges von Fettsäure Typ 2 und anderer Zellwachstumswege
AU2007250735A1 (en) *	2006-05-16	2007-11-22	Daiichi Sankyo Company, Limited	Method for high-level secretory production of protein
CA2659956C (en) *	2006-08-04	2016-01-05	Lewis C. Cantley	Inhibitors of pyruvate kinase and methods of treating disease
WO2009143041A1 (en) *	2008-05-20	2009-11-26	Merck & Co., Inc.	Efficient production of heterologous proteins using mannosyl transferase inhibitors

2009
- 2009-05-18 WO PCT/US2009/044297 patent/WO2009143041A1/en not_active Ceased
- 2009-05-18 US US12/993,716 patent/US8309325B2/en active Active
- 2009-05-18 AT AT09751270T patent/ATE536347T1/de active
- 2009-05-18 EP EP09751270A patent/EP2300446B1/de active Active
- 2009-05-18 CN CN200980118628.9A patent/CN102036974B/zh not_active Expired - Fee Related
- 2009-05-18 JP JP2011510611A patent/JP5411929B2/ja not_active Expired - Fee Related
- 2009-05-18 MX MX2010012626A patent/MX2010012626A/es active IP Right Grant
- 2009-05-18 AU AU2009249314A patent/AU2009249314A1/en not_active Abandoned
- 2009-05-18 CA CA2721459A patent/CA2721459A1/en not_active Abandoned
2012
- 2012-08-17 US US13/588,022 patent/US8765409B2/en active Active
2013
- 2013-11-08 JP JP2013231654A patent/JP2014055157A/ja active Pending

Also Published As

Publication number	Publication date
US8765409B2 (en)	2014-07-01
US8309325B2 (en)	2012-11-13
EP2300446A1 (de)	2011-03-30
US20110076721A1 (en)	2011-03-31
CN102036974B (zh)	2014-07-23
AU2009249314A1 (en)	2009-11-26
WO2009143041A1 (en)	2009-11-26
JP2011520968A (ja)	2011-07-21
JP2014055157A (ja)	2014-03-27
EP2300446B1 (de)	2011-12-07
CN102036974A (zh)	2011-04-27
MX2010012626A (es)	2011-02-22
US20130316398A1 (en)	2013-11-28
CA2721459A1 (en)	2009-11-26
JP5411929B2 (ja)	2014-02-12

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