ATE536405T1 - Hämatopoetische stammzellen und verfahren zur behandlung von neovaskulären augenerkrankungen damit - Google Patents

Hämatopoetische stammzellen und verfahren zur behandlung von neovaskulären augenerkrankungen damit

Info

Publication number
ATE536405T1
ATE536405T1 AT03772195T AT03772195T ATE536405T1 AT E536405 T1 ATE536405 T1 AT E536405T1 AT 03772195 T AT03772195 T AT 03772195T AT 03772195 T AT03772195 T AT 03772195T AT E536405 T1 ATE536405 T1 AT E536405T1
Authority
AT
Austria
Prior art keywords
cells
stem cells
eye diseases
express
hematopoetic stem
Prior art date
Application number
AT03772195T
Other languages
English (en)
Inventor
Martin Friedlander
Atsushi Otani
Karen Dasilva
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Application granted granted Critical
Publication of ATE536405T1 publication Critical patent/ATE536405T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/069—Vascular Endothelial cells
    • C12N5/0692—Stem cells; Progenitor cells; Precursor cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Transplantation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT03772195T 2002-07-25 2003-07-25 Hämatopoetische stammzellen und verfahren zur behandlung von neovaskulären augenerkrankungen damit ATE536405T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39852202P 2002-07-25 2002-07-25
US46705103P 2003-05-02 2003-05-02
PCT/US2003/024839 WO2004010959A2 (en) 2002-07-25 2003-07-25 Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith

Publications (1)

Publication Number Publication Date
ATE536405T1 true ATE536405T1 (de) 2011-12-15

Family

ID=31191212

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03772195T ATE536405T1 (de) 2002-07-25 2003-07-25 Hämatopoetische stammzellen und verfahren zur behandlung von neovaskulären augenerkrankungen damit

Country Status (17)

Country Link
US (2) US7153501B2 (de)
EP (1) EP1542536B1 (de)
JP (2) JP2005538742A (de)
KR (2) KR20110102961A (de)
CN (1) CN1307300C (de)
AT (1) ATE536405T1 (de)
AU (1) AU2003259687B2 (de)
BR (1) BR0312920A (de)
CA (1) CA2493122C (de)
DK (1) DK1542536T3 (de)
ES (1) ES2376866T3 (de)
MX (1) MXPA05000972A (de)
PL (1) PL216193B1 (de)
PT (1) PT1542536E (de)
RU (1) RU2331669C2 (de)
WO (2) WO2004010959A2 (de)
ZA (1) ZA200500682B (de)

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WO2006031467A2 (en) * 2002-07-25 2006-03-23 The Scripps Research Institute Isolated lineage negative hematopoietic stem cells and methods of treatment therewith
US20060104963A1 (en) * 2002-07-25 2006-05-18 The Scripps Research Institute Treatment of cone cell degeneration with transfected lineage negative hematopoietic stem cells
US20060104962A1 (en) * 2002-07-25 2006-05-18 The Scripps Research Institute Transfected hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith
CA2524063C (en) * 2003-05-02 2015-02-17 The Scripps Research Institute Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith
WO2005042731A1 (en) * 2003-10-31 2005-05-12 Children's Medical Center Corporation Methods for purifying hematopoietic stem cells
RU2279886C2 (ru) * 2004-06-10 2006-07-20 Московский научно-исследовательский институт глазных болезней им. Гельмгольца Минздрава РФ Способ улучшения функциональной активности сетчатки при ее патологии различного генеза
US8282921B2 (en) 2004-08-02 2012-10-09 Paul Glidden tRNA synthetase fragments
CA2574186A1 (en) * 2004-08-13 2006-02-23 Medtronic, Inc. Isolation of endothelial progenitor cell subsets and methods for their use
CA2579292A1 (en) * 2004-09-03 2006-03-23 The Scripps Research Institute Isolated lineage negative hematopoietic stem cells and methods of treatment therewith
DE102004055615A1 (de) * 2004-11-16 2006-05-18 Universitätsklinikum Hamburg-Eppendorf In vitro aus Knochenmarkstammzellen differenzierte Retina-spezifische Zellen, ihre Herstellung und Verwendung
US20080317721A1 (en) * 2005-02-24 2008-12-25 The Scripps Research Institute Method for the Treatment of Retinopathy of Prematurity and Related Retinopathic Diseases
US20070231306A1 (en) * 2005-02-24 2007-10-04 The Scripps Research Institute Isolated myeloid-like cell populations and methods of treatment therewith
BRPI0608272A2 (pt) * 2005-02-24 2009-12-08 Scripps Research Inst método para promover revascularização fisiológica benéfica de tecido retinal isquêmico e método de triagem para identificar e avaliar a eficácia terapêutica de agentes terapêuticos potenciais para tratar doenças neovasculares retinais
CA2598029A1 (en) * 2005-02-24 2006-10-05 The Scripps Research Institute Isolated myeloid-like bone marrow cell populations and methods of treatment therewith
JP4734636B2 (ja) * 2005-11-02 2011-07-27 国立大学法人 鹿児島大学 免疫染色法、及び当該免疫染色法を利用した細胞の評価方法
US8637005B2 (en) 2005-11-07 2014-01-28 Amorcyte, Inc. Compositions and methods of vascular injury repair
EP1951864B1 (de) 2005-11-07 2014-05-07 Amorcyte, Inc. Zusammensetzungen und verfahren zur reparatur von gefässverletzungen
US20110076255A1 (en) 2005-11-07 2011-03-31 Pecora Andrew L Compositions and methods for treating progressive myocardial injury due to a vascular insufficiency
JP5649786B2 (ja) 2006-03-07 2015-01-07 ギータ シュロフ ヒト胚性幹細胞およびそれらの誘導体を含む組成物、使用方法、ならびに調製方法
KR100757265B1 (ko) * 2006-04-27 2007-09-10 (주) 차바이오텍 제대혈 유래 줄기 세포를 포함하는 요실금 치료용 조성물
WO2008006168A1 (en) * 2006-07-12 2008-01-17 Angioblast Systems, Inc. Treatment of excessive neovascularization
JP5372764B2 (ja) * 2006-11-07 2013-12-18 シャイア リジェネラティブ メディシン， インコーポレイテッド 血管形成関連疾患の治療および管理のための材料および方法
US20100098675A1 (en) * 2008-05-30 2010-04-22 Nikolai Tankovich Methods for reducing the side effects of ophthalmic laser surgery
EP2331679B1 (de) * 2008-09-12 2017-04-19 Cryopraxis Criobiologia LTDA. Ischämische gewebezellentherapie
RU2497532C2 (ru) 2008-12-03 2013-11-10 Эморсайт, Инк. Композиции, улучшающие перфузию в области инфаркта и способы восстановления сосудистого повреждения
RU2428956C2 (ru) * 2009-07-13 2011-09-20 Александр Дмитриевич Ромащенко Способ лечения атрофии зрительного нерва посредством трансплантации аутологичных стволовых клеток
WO2012005763A1 (en) 2010-07-06 2012-01-12 The Scripps Research Institute Use of myeloid-like progenitor cell populations to treat tumors
CA2853379C (en) 2011-10-27 2020-11-24 Wellstat Ophthalmics Corporation Vectors encoding rod-derived cone viability factor
EP2838995A4 (de) * 2012-04-16 2016-01-06 Univ California Augentherapeutika mit mikrovesikeln aus embryonalen stammzellen
KR102254082B1 (ko) 2012-08-24 2021-05-18 고쿠리쓰 겐큐 가이하쓰 호징 리가가쿠 겐큐소 망막 색소 상피 세포 시트의 제조 방법
WO2020172854A1 (en) * 2019-02-28 2020-09-03 Shenzhen University Use of endothelial progenitor cells (epcs) in rejuvenating microvasculature, preventing aging and treating age-related diseases
CN121550400A (zh) * 2026-01-26 2026-02-24 天津医科大学眼科医院 Crybb2重组蛋白在治疗和/或预防糖尿病性视网膜病变中的应用

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UA27055C2 (uk) * 1993-12-14 2000-02-28 Центр Ембріональних Тканин "Емселл" Лікарський препарат імуhозаміhhої дії hа осhові клітиhhої суспеhзії та спосіб лікуваhhя сиhдрому hабутого імуhодефіциту (віл-іhфекції) з використаhhям цього препарату
US6908763B1 (en) * 1997-08-22 2005-06-21 The Board Of Trustees Of The Leland Stanford Junior University Mammalian common lymphoid progenitor cell
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US6767737B1 (en) * 1998-08-31 2004-07-27 New York University Stem cells bearing an FGF receptor on the cell surface
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US20020061587A1 (en) * 2000-07-31 2002-05-23 Piero Anversa Methods and compositions for the repair and/or regeneration of damaged myocardium
ATE420653T1 (de) * 2001-02-23 2009-01-15 Scripps Research Inst Von tryptophanyl-trna-synthetase stammende polypeptide zur regulierung der angiogenese
EP1490107A4 (de) * 2002-03-21 2005-11-09 Univ Florida Modulation der angiogenese
WO2004005531A2 (en) * 2002-07-05 2004-01-15 Roger Williams Medical Center Targeting and tracking of cells to specific organs and tissues in vivo

Also Published As

Publication number Publication date
PL374868A1 (en) 2005-11-14
RU2331669C2 (ru) 2008-08-20
JP2010285434A (ja) 2010-12-24
RU2005105065A (ru) 2005-09-10
US20040197902A1 (en) 2004-10-07
US7153501B2 (en) 2006-12-26
KR101095287B1 (ko) 2011-12-16
EP1542536A2 (de) 2005-06-22
KR20050027132A (ko) 2005-03-17
AU2003259687A1 (en) 2004-02-16
KR20110102961A (ko) 2011-09-19
MXPA05000972A (es) 2005-09-12
ES2376866T3 (es) 2012-03-20
EP1542536A4 (de) 2007-05-16
CA2493122A1 (en) 2004-02-05
JP5385219B2 (ja) 2014-01-08
WO2004098499A3 (en) 2005-10-06
BR0312920A (pt) 2007-07-10
ZA200500682B (en) 2006-07-26
AU2003259687B2 (en) 2009-10-29
WO2004098499A2 (en) 2004-11-18
CN1307300C (zh) 2007-03-28
US20070116685A1 (en) 2007-05-24
CN1688196A (zh) 2005-10-26
WO2004010959A2 (en) 2004-02-05
PT1542536E (pt) 2012-02-14
CA2493122C (en) 2012-11-27
JP2005538742A (ja) 2005-12-22
WO2004010959A3 (en) 2005-04-07
EP1542536B1 (de) 2011-12-07
DK1542536T3 (da) 2012-01-23
PL216193B1 (pl) 2014-03-31

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