ATE536420T1 - Verbesserte verfahren für beaming - Google Patents

Verbesserte verfahren für beaming

Info

Publication number
ATE536420T1
ATE536420T1 AT06817236T AT06817236T ATE536420T1 AT E536420 T1 ATE536420 T1 AT E536420T1 AT 06817236 T AT06817236 T AT 06817236T AT 06817236 T AT06817236 T AT 06817236T AT E536420 T1 ATE536420 T1 AT E536420T1
Authority
AT
Austria
Prior art keywords
beaming
improved methods
permitted
increase
rare
Prior art date
Application number
AT06817236T
Other languages
English (en)
Inventor
Bert Vogelstein
Frank Diehl
Kenneth Kinzler
Ming Li
Original Assignee
Univ Johns Hopkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins filed Critical Univ Johns Hopkins
Application granted granted Critical
Publication of ATE536420T1 publication Critical patent/ATE536420T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6858Allele-specific amplification
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R31/00Arrangements for testing electric properties; Arrangements for locating electric faults; Arrangements for electrical testing characterised by what is being tested not provided for elsewhere
    • G01R31/327Testing of circuit interrupters, switches or circuit-breakers
    • G01R31/3277Testing of circuit interrupters, switches or circuit-breakers of low voltage devices, e.g. domestic or industrial devices, such as motor protections, relays, rotation switches
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R31/00Arrangements for testing electric properties; Arrangements for locating electric faults; Arrangements for electrical testing characterised by what is being tested not provided for elsewhere
    • G01R31/50Testing of electric apparatus, lines, cables or components for short-circuits, continuity, leakage current or incorrect line connections
    • G01R31/52Testing for short-circuits, leakage current or ground faults
    • HELECTRICITY
    • H02GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02HEMERGENCY PROTECTIVE CIRCUIT ARRANGEMENTS
    • H02H1/00Details of emergency protective circuit arrangements
    • H02H1/0007Details of emergency protective circuit arrangements concerning the detecting means
    • H02H1/0015Using arc detectors
    • HELECTRICITY
    • H02GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02HEMERGENCY PROTECTIVE CIRCUIT ARRANGEMENTS
    • H02H3/00Emergency protective circuit arrangements for automatic disconnection directly responsive to an undesired change from normal electric working condition with or without subsequent reconnection ; integrated protection
    • H02H3/26Emergency protective circuit arrangements for automatic disconnection directly responsive to an undesired change from normal electric working condition with or without subsequent reconnection ; integrated protection responsive to difference between voltages or between currents; responsive to phase angle between voltages or between currents
    • H02H3/32Emergency protective circuit arrangements for automatic disconnection directly responsive to an undesired change from normal electric working condition with or without subsequent reconnection ; integrated protection responsive to difference between voltages or between currents; responsive to phase angle between voltages or between currents involving comparison of the voltage or current values at corresponding points in different conductors of a single system, e.g. of currents in go and return conductors
    • H02H3/33Emergency protective circuit arrangements for automatic disconnection directly responsive to an undesired change from normal electric working condition with or without subsequent reconnection ; integrated protection responsive to difference between voltages or between currents; responsive to phase angle between voltages or between currents involving comparison of the voltage or current values at corresponding points in different conductors of a single system, e.g. of currents in go and return conductors using summation current transformers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Power Engineering (AREA)
  • Urology & Nephrology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Nanotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT06817236T 2005-10-24 2006-10-20 Verbesserte verfahren für beaming ATE536420T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72923505P 2005-10-24 2005-10-24
PCT/US2006/041115 WO2007050465A2 (en) 2005-10-24 2006-10-20 Improved methods for beaming

Publications (1)

Publication Number Publication Date
ATE536420T1 true ATE536420T1 (de) 2011-12-15

Family

ID=37968413

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06817236T ATE536420T1 (de) 2005-10-24 2006-10-20 Verbesserte verfahren für beaming

Country Status (10)

Country Link
US (4) US9360526B2 (de)
EP (2) EP1948816B1 (de)
AT (1) ATE536420T1 (de)
CY (1) CY1112525T1 (de)
DK (1) DK1948816T3 (de)
ES (2) ES2381204T3 (de)
PL (1) PL1948816T3 (de)
PT (1) PT1948816E (de)
SI (1) SI1948816T1 (de)
WO (1) WO2007050465A2 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
EP1712639B1 (de) 2005-04-06 2008-08-27 Maurice Stroun Methode zur Krebsdiagnose mittels Nachweis von DNA und RNA im Kreislauf
ES2381204T3 (es) 2005-10-24 2012-05-24 The Johns Hopkins University Métodos mejorados para BEAMING
WO2007081385A2 (en) 2006-01-11 2007-07-19 Raindance Technologies, Inc. Microfluidic devices and methods of use in the formation and control of nanoreactors
EP2530167A1 (de) 2006-05-11 2012-12-05 Raindance Technologies, Inc. Mikrofluidische Vorrichtungen
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
WO2008097559A2 (en) 2007-02-06 2008-08-14 Brandeis University Manipulation of fluids and reactions in microfluidic systems
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
GB2453173A (en) 2007-09-28 2009-04-01 Dxs Ltd Polynucleotide primers
US12038438B2 (en) 2008-07-18 2024-07-16 Bio-Rad Laboratories, Inc. Enzyme quantification
EP4047367A1 (de) 2008-07-18 2022-08-24 Bio-Rad Laboratories, Inc. Verfahren zum nachweis von zielanalyten unter verwendung von tropfenbibliotheken
US20100041048A1 (en) * 2008-07-31 2010-02-18 The Johns Hopkins University Circulating Mutant DNA to Assess Tumor Dynamics
WO2010028288A2 (en) 2008-09-05 2010-03-11 Aueon, Inc. Methods for stratifying and annotating cancer drug treatment options
WO2010111231A1 (en) 2009-03-23 2010-09-30 Raindance Technologies, Inc. Manipulation of microfluidic droplets
EP4484577A3 (de) 2010-02-12 2025-03-26 Bio-Rad Laboratories, Inc. Digitale analytanalyse
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
EP2619329B1 (de) 2010-09-24 2019-05-22 The Board of Trustees of The Leland Stanford Junior University Direkte erfassung, amplifikation und sequenzierung einer ziel-dna unter verwendung immobilisierter primer
EP3412778A1 (de) 2011-02-11 2018-12-12 Raindance Technologies, Inc. Verfahren zur bildung gemischter tröpfchen
WO2012112804A1 (en) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions and methods for molecular labeling
EP3216872B1 (de) 2011-06-02 2020-04-01 Bio-Rad Laboratories, Inc. Enzymquantifizierung
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
US9376715B2 (en) * 2011-12-09 2016-06-28 Roche Molecular Systems, Inc Methods for detecting mutations in the catalytic subunit of the phosphoinositol-3 kinase (PIK3CA) gene
US20130309667A1 (en) * 2012-05-15 2013-11-21 Anthony P. Shuber Primers for analyzing methylated sequences and methods of use thereof
GB2525568B (en) 2013-03-15 2020-10-14 Abvitro Llc Single cell barcoding for antibody discovery
DE102013211113A1 (de) * 2013-06-14 2014-12-18 Siemens Aktiengesellschaft Verfahren zur kombinierten Quantifizierung und Sequenzierung von mindestens einer Ziel-Nukleinsäure
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
EP3950944A1 (de) 2014-09-15 2022-02-09 AbVitro LLC Nukleotidbibliotheksequenzierung mit hohem durchsatz
US10399074B2 (en) * 2015-03-24 2019-09-03 Hitachi Metals, Ltd. Ceramic honeycomb structure
WO2016170179A1 (en) * 2015-04-24 2016-10-27 Qiagen Gmbh Method for immobilizing a nucleic acid molecule on solid support
US11085073B2 (en) 2015-04-24 2021-08-10 Qiagen Gmbh Method for immobilizing a nucleic acid molecule on a solid support
US9938572B1 (en) 2015-09-08 2018-04-10 Raindance Technologies, Inc. System and method for forming an emulsion
CN106929598B (zh) * 2017-05-04 2019-07-05 湖南融健基因生物科技有限公司 一种乳液中进行滚环扩增的数字核酸分析方法
EP3700543A4 (de) 2017-10-24 2021-08-25 Elani, Dalia Verfahren zur behandlung einer ischämischen erkrankung
WO2020060994A1 (en) 2018-09-17 2020-03-26 The University Of North Carolina At Chapel Hill Method for quantifying dna fragments in a sample by size
US11474109B2 (en) 2018-11-16 2022-10-18 Scintimetrics, Inc. Compositions and methods for controllably merging emulsion droplets and sample analysis
EP3725894A1 (de) 2019-04-16 2020-10-21 Blod Diagnostik GmbH Vorrichtung und verfahren zur nukleinsäurezielanreicherung, -suspension und -quantifizierung
EP4058763A4 (de) * 2019-11-15 2023-11-29 Scintimetrics, Inc. Zusammensetzungen und verfahren basierend auf der diffusion von fluorophoren

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5888778A (en) * 1997-06-16 1999-03-30 Exact Laboratories, Inc. High-throughput screening method for identification of genetic mutations or disease-causing microorganisms using segmented primers
GB9900298D0 (en) * 1999-01-07 1999-02-24 Medical Res Council Optical sorting method
US6355431B1 (en) * 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
DE10048797A1 (de) * 2000-10-02 2002-04-18 Bayer Ag Wirkstoffhaltige Emulsionen
AUPS298102A0 (en) 2002-06-13 2002-07-04 Nucleics Pty Ltd Method for performing chemical reactions
CA2513899C (en) * 2003-01-29 2013-03-26 454 Corporation Methods of amplifying and sequencing nucleic acids
US8048627B2 (en) * 2003-07-05 2011-11-01 The Johns Hopkins University Method and compositions for detection and enumeration of genetic variations
US7927797B2 (en) * 2004-01-28 2011-04-19 454 Life Sciences Corporation Nucleic acid amplification with continuous flow emulsion
NZ582558A (en) * 2004-05-13 2012-06-29 Anita Goel Nano-PCR: Methods and devices for nucleic acid amplification and detection
US20060228721A1 (en) * 2005-04-12 2006-10-12 Leamon John H Methods for determining sequence variants using ultra-deep sequencing
ES2381204T3 (es) 2005-10-24 2012-05-24 The Johns Hopkins University Métodos mejorados para BEAMING
US20080242560A1 (en) * 2006-11-21 2008-10-02 Gunderson Kevin L Methods for generating amplified nucleic acid arrays

Also Published As

Publication number Publication date
EP2428579B1 (de) 2013-05-29
PT1948816E (pt) 2012-03-19
PL1948816T3 (pl) 2012-07-31
CY1112525T1 (el) 2015-12-09
DK1948816T3 (da) 2012-04-02
US10837050B2 (en) 2020-11-17
US10150991B2 (en) 2018-12-11
US20200123600A1 (en) 2020-04-23
US20120014879A1 (en) 2012-01-19
EP1948816B1 (de) 2011-12-07
ES2426031T3 (es) 2013-10-18
US20130040300A9 (en) 2013-02-14
US20160376645A1 (en) 2016-12-29
EP1948816A2 (de) 2008-07-30
HK1121193A1 (en) 2009-04-17
WO2007050465A3 (en) 2007-10-25
US9360526B2 (en) 2016-06-07
US20110059435A1 (en) 2011-03-10
ES2381204T3 (es) 2012-05-24
SI1948816T1 (sl) 2012-04-30
EP1948816A4 (de) 2009-11-04
EP2428579A1 (de) 2012-03-14
WO2007050465A2 (en) 2007-05-03

Similar Documents

Publication Publication Date Title
ATE536420T1 (de) Verbesserte verfahren für beaming
EA200702203A1 (ru) Способы и нуклеиновые кислоты для анализов клеточных пролиферативных нарушений
ATE496142T1 (de) Verfahren zur diagnose von nicht-kleinzelligem lungenkrebs
IL181131A0 (en) USE OF C3a AND DERIVATIVES THEREOF AS A BIOMARKER FOR COLORECTAL ADEMONA AND/OR CARCINOMA; DIAGNOSIS METHOD AND TEST SYSTEM USING THE SAME
WO2006073811A3 (en) Fluorescence detection system
DE60333295D1 (de) Verfahren zum nachweis abnormal methylierter nukleinsäure in heterogenen biologischen proben
WO2004030511A3 (en) Prostate cancer biomarkers
EA200970695A1 (ru) Способы и нуклеиновые кислоты для анализов нарушений клеточной пролиферации
EP2212700B8 (de) Verfahren zur beurteilung von kolorektalem krebs anhand einer stuhlprobe durch verwendung einer marker-kombination aus calprotectin und einem hämoglobin/haptoglobin-komplex
JP2009537798A5 (de)
WO2006110599A3 (en) Cacna1e in cancer diagnosis, detection and treatment
DE60315715D1 (de) Verwendung von nicotinamide n-methyltransferase zur diagnose von kolorektalem krebs
WO2006007403A3 (en) Methods for identifying and measuring s-nitrosothiol bonds in heme-containing cells and molecules
ATE494390T1 (de) Verfahren und nukleinsäuren zur analyse von störungen der proliferation von kolonzellen
GB2437545B (en) Dextrin-containing reagents for detecting and quantifying proteins
ATE551605T1 (de) Verfahren und vorrichtungen zur erkennung von biofilmen
ATE504833T1 (de) Verfahren zur bestimmung des phänotyps von zellen
WO2006110587A3 (en) Ddr2 in cancer diagnosis, detection and treatment
IL189185A0 (en) Use of an endoplasmin fragment and derivatives thereof as a biomarker for colorectal adenoma and/or carcinoma; method for detection and test system
DE60323677D1 (de) Verfahren zur bestimmung des wiederauftretens von prostata krebs
MXPA05009162A (es) Metodos para determinar un regimen quimioterapeutico basado en la perdida de heterocigosidad en la posicion de sintasa de timidilato.
WO2006110583A3 (en) Adam10 in cancer diagnosis, detection and treatment
WO2004071267A3 (en) Diagnosis of colorectal cancer by detection of nicotinamide n-methyltransferase in a stool sample
DE60329224D1 (de) Verfahren zur Bestimmung von zirkulierender DNS in Plasma und zum Nachweis von Krebs
CY1115206T1 (el) Διαγνωστικη δοκιμη για ευαισθησια σε αναστολεις της b-raf κινασης