ATE537142T1 - Übergangsmetallkatalysierte synthese von n- aminoindolen - Google Patents

Übergangsmetallkatalysierte synthese von n- aminoindolen

Info

Publication number: ATE537142T1
Authority: AT; Austria
Prior art keywords: transition metal; metal catalyzed; aminoindoles; formula; catalyzed synthesis
Prior art date: 2007-04-13

Application number

AT08734883T

Other languages

English (en)

Inventor

Nis Halland

M Nazare

Andreas Lindenschmidt

Omar Rkyek

Matthias Urmann

Jorge Alonso

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-04-13

Filing date

2008-03-29

Publication date

2011-12-15

2008-03-29 Application filed by Sanofi Sa filed Critical Sanofi Sa

2011-12-15 Application granted granted Critical

2011-12-15 Publication of ATE537142T1 publication Critical patent/ATE537142T1/de

Links

230000015572 biosynthetic process Effects 0.000 title abstract 2
238000003786 synthesis reaction Methods 0.000 title abstract 2
229910052723 transition metal Inorganic materials 0.000 title abstract 2
150000003624 transition metals Chemical class 0.000 title abstract 2
238000000034 method Methods 0.000 abstract 2
HDIJHZHDOMXSQS-UHFFFAOYSA-N 2-ethynylbenzenesulfonic acid Chemical class OS(=O)(=O)C1=CC=CC=C1C#C HDIJHZHDOMXSQS-UHFFFAOYSA-N 0.000 abstract 1
-1 N,N-disubstituted hydrazines Chemical class 0.000 abstract 1
230000000895 acaricidal effect Effects 0.000 abstract 1
239000000642 acaricide Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000000032 diagnostic agent Substances 0.000 abstract 1
229940039227 diagnostic agent Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000000855 fungicidal effect Effects 0.000 abstract 1
239000004009 herbicide Substances 0.000 abstract 1
ZWUUZXDACSQYMI-UHFFFAOYSA-N indazol-1-amine Chemical class C1=CC=C2N(N)N=CC2=C1 ZWUUZXDACSQYMI-UHFFFAOYSA-N 0.000 abstract 1
VUSYGSNEEYEGGX-UHFFFAOYSA-N indol-1-amine Chemical compound C1=CC=C2N(N)C=CC2=C1 VUSYGSNEEYEGGX-UHFFFAOYSA-N 0.000 abstract 1
239000002917 insecticide Substances 0.000 abstract 1
239000004973 liquid crystal related substance Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
230000001069 nematicidal effect Effects 0.000 abstract 1
230000000590 parasiticidal effect Effects 0.000 abstract 1
239000002297 parasiticide Substances 0.000 abstract 1
229920000642 polymer Polymers 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Indole Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT08734883T 2007-04-13 2008-03-29 Übergangsmetallkatalysierte synthese von n- aminoindolen ATE537142T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP07007585		2007-04-13
PCT/EP2008/002519 WO2008125207A1 (en)	2007-04-13	2008-03-29	A transition metal catalyzed synthesis of n-aminoindoles

Publications (1)

Publication Number	Publication Date
ATE537142T1 true ATE537142T1 (de)	2011-12-15

Family

ID=38457866

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT08734883T ATE537142T1 (de)	2007-04-13	2008-03-29	Übergangsmetallkatalysierte synthese von n- aminoindolen

Country Status (12)

Country	Link
US (1)	US8026375B2 (de)
EP (1)	EP2134682B1 (de)
JP (1)	JP5412422B2 (de)
KR (1)	KR20100015546A (de)
CN (1)	CN101657422A (de)
AT (1)	ATE537142T1 (de)
AU (1)	AU2008238379A1 (de)
BR (1)	BRPI0810199A2 (de)
CA (1)	CA2683578A1 (de)
IL (1)	IL201253A0 (de)
MX (1)	MX2009010536A (de)
WO (1)	WO2008125207A1 (de)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9512125B2 (en)	2004-11-19	2016-12-06	The Regents Of The University Of California	Substituted pyrazolo[3.4-D] pyrimidines as anti-inflammatory agents
KR101499783B1 (ko)	2006-04-04	2015-03-09	더 리젠트스 오브 더 유니이버시티 오브 캘리포니아	키나제 길항물질
US20110160232A1 (en)	2007-10-04	2011-06-30	Pingda Ren	Certain chemical entities and therapeutic uses thereof
US8193182B2 (en)	2008-01-04	2012-06-05	Intellikine, Inc.	Substituted isoquinolin-1(2H)-ones, and methods of use thereof
AU2009204483B2 (en)	2008-01-04	2014-03-13	Intellikine, Llc	Certain chemical entities, compositions and methods
JP5547099B2 (ja)	2008-03-14	2014-07-09	インテリカイン，エルエルシー	キナーゼ阻害剤および使用方法
US8993580B2 (en)	2008-03-14	2015-03-31	Intellikine Llc	Benzothiazole kinase inhibitors and methods of use
US20110224223A1 (en)	2008-07-08	2011-09-15	The Regents Of The University Of California, A California Corporation	MTOR Modulators and Uses Thereof
MX2011000216A (es)	2008-07-08	2011-03-29	Intellikine Inc	Inhibidores de cinasa y metodos para su uso.
WO2010036380A1 (en)	2008-09-26	2010-04-01	Intellikine, Inc.	Heterocyclic kinase inhibitors
WO2010045542A2 (en)	2008-10-16	2010-04-22	The Regents Of The University Of California	Fused ring heteroaryl kinase inhibitors
US8476431B2 (en)	2008-11-03	2013-07-02	Itellikine LLC	Benzoxazole kinase inhibitors and methods of use
WO2010129816A2 (en)	2009-05-07	2010-11-11	Intellikine, Inc.	Heterocyclic compounds and uses thereof
WO2011047384A2 (en)	2009-10-16	2011-04-21	The Regents Of The University Of California	Methods of inhibiting ire1
JP5951600B2 (ja)	2010-05-21	2016-07-13	インフィニティーファーマシューティカルズ，インコーポレイテッド	キナーゼ調節のための、化合物、組成物および方法
US8901133B2 (en)	2010-11-10	2014-12-02	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
KR20180080358A (ko)	2011-01-10	2018-07-11	인피니티 파마슈티칼스, 인코포레이티드	이소퀴놀린온 및 이의 고체 형태의 제조 방법
CN102093334B (zh) *	2011-02-22	2013-05-08	郑州大学	一组稠环噻吩类化合物的合成方法
JP6130305B2 (ja)	2011-02-23	2017-05-17	インテリカイン，エルエルシー	キナーゼ阻害剤の組み合わせおよびそれらの使用
EP2734530A1 (de)	2011-07-19	2014-05-28	Infinity Pharmaceuticals, Inc.	Heterocyclische verbindungen und ihre verwendung
CN103930422A (zh)	2011-07-19	2014-07-16	无限药品股份有限公司	杂环化合物及其用途
CN103998442B (zh)	2011-08-29	2016-09-14	无限药品股份有限公司	杂环化合物及其用途
MX370814B (es)	2011-09-02	2020-01-08	Univ California	Pirazolo[3,4-d]pirimidinas sustituidas y usos de las mismas.
US8940742B2 (en)	2012-04-10	2015-01-27	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
US8828998B2 (en)	2012-06-25	2014-09-09	Infinity Pharmaceuticals, Inc.	Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
WO2014052669A1 (en)	2012-09-26	2014-04-03	The Regents Of The University Of California	Modulation of ire1
IL291945B2 (en)	2012-11-01	2025-11-01	Infinity Pharmaceuticals Inc	Treatment of cancers using pi3 kinase isoform modulators
US9481667B2 (en)	2013-03-15	2016-11-01	Infinity Pharmaceuticals, Inc.	Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
MX389256B (es)	2013-10-04	2025-03-20	Infinity Pharmaceuticals Inc	Compuestos heterociclicos y usos de los mismos.
WO2015051241A1 (en)	2013-10-04	2015-04-09	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
CN103755621B (zh) *	2014-01-23	2015-08-05	清华大学	由芳基肼和炔烃制备多取代吲哚的方法
EP4066834A1 (de)	2014-03-19	2022-10-05	Infinity Pharmaceuticals, Inc.	Heterocyclische verbindungen zur verwendung in der behandlung von pi3k-gamma-vermittelten erkrankungen
US20150320755A1 (en)	2014-04-16	2015-11-12	Infinity Pharmaceuticals, Inc.	Combination therapies
WO2016054491A1 (en)	2014-10-03	2016-04-07	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
US10285824B2 (en)	2014-10-28	2019-05-14	Spectrum Spine Ip Holdings, Llc	Expandable, adjustable inter-body fusion devices and methods
CN108349985A (zh)	2015-09-14	2018-07-31	无限药品股份有限公司	异喹啉酮的固体形式、其制备方法、包含其的组合物及其使用方法
US10759806B2 (en)	2016-03-17	2020-09-01	Infinity Pharmaceuticals, Inc.	Isotopologues of isoquinolinone and quinazolinone compounds and uses thereof as PI3K kinase inhibitors
WO2017214269A1 (en)	2016-06-08	2017-12-14	Infinity Pharmaceuticals, Inc.	Heterocyclic compounds and uses thereof
CA3028718A1 (en)	2016-06-24	2017-12-28	Infinity Pharmaceuticals, Inc.	Combination therapies
KR102038977B1 (ko) *	2016-12-30	2019-11-01	사빅 에스케이 넥슬렌 컴퍼니 피티이 엘티디	신규한 시클로펜타[ｂ]티오펜일 전이금속 화합물, 이를 포함하는 전이금속 촉매 조성물, 및 이를 이용한 에틸렌 단독중합체 또는 에틸렌과 α-올레핀의 공중합체의 제조방법
TW202039481A (zh)	2018-12-21	2020-11-01	美商西建公司	Ripk2之噻吩并吡啶抑制劑
SG11202106115WA (en) *	2018-12-21	2021-07-29	Dow Global Technologies Llc	Heterocycle-heterocycle-based group iv transition metal catalysts for olefin polymerization
CN116813522A (zh) *	2023-05-04	2023-09-29	广州方中化工有限公司	一种含吲哚的苯磺酰脲类化合物的制备方法与应用
CN118638038B (zh) *	2024-06-05	2024-12-03	常州大学	一种n-n轴手性吲哚酰胺类化合物及其合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE115143T1 (de) *	1987-04-24	1994-12-15	Hoechst Roussel Pharma	N-(pyridinyl)-1h-indol-1-amine, verfahren zu deren herstellung und ihre verwendung als arzneimittel.
US4983608A (en)	1989-09-05	1991-01-08	Hoechst-Roussell Pharmaceuticals, Inc.	N-substituted-4-pyrimidinamines and pyrimidinediamines
DE60016068T2 (de)	1999-03-10	2005-11-03	Tosoh Corp., Shinnanyo	Verfahren zur Herstellung Stickstoffheterocyclischer Verbindungen
FR2842196B1 (fr) *	2002-07-15	2006-01-13	Rhodia Polyamide Intermediates	Procede de fabrication de composes nitriles a partir de composes a insaturation ethylenique
US20080317767A1 (en)	2004-04-08	2008-12-25	Tobias Braxmeier	Tripartitle Raftophilic Strutures and their Use

2008
- 2008-03-29 KR KR1020097021379A patent/KR20100015546A/ko not_active Withdrawn
- 2008-03-29 CN CN200880011689A patent/CN101657422A/zh active Pending
- 2008-03-29 CA CA002683578A patent/CA2683578A1/en not_active Abandoned
- 2008-03-29 AT AT08734883T patent/ATE537142T1/de active
- 2008-03-29 EP EP08734883A patent/EP2134682B1/de not_active Not-in-force
- 2008-03-29 MX MX2009010536A patent/MX2009010536A/es active IP Right Grant
- 2008-03-29 JP JP2010502442A patent/JP5412422B2/ja not_active Expired - Fee Related
- 2008-03-29 WO PCT/EP2008/002519 patent/WO2008125207A1/en not_active Ceased
- 2008-03-29 BR BRPI0810199-0A2A patent/BRPI0810199A2/pt not_active IP Right Cessation
- 2008-03-29 AU AU2008238379A patent/AU2008238379A1/en not_active Abandoned
2009
- 2009-09-30 IL IL201253A patent/IL201253A0/en unknown
- 2009-10-09 US US12/576,339 patent/US8026375B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR20100015546A (ko)	2010-02-12
JP5412422B2 (ja)	2014-02-12
EP2134682A1 (de)	2009-12-23
CN101657422A (zh)	2010-02-24
MX2009010536A (es)	2009-10-22
EP2134682B1 (de)	2011-12-14
AU2008238379A1 (en)	2008-10-23
US8026375B2 (en)	2011-09-27
JP2010523605A (ja)	2010-07-15
WO2008125207A1 (en)	2008-10-23
CA2683578A1 (en)	2008-10-23
IL201253A0 (en)	2010-05-31
BRPI0810199A2 (pt)	2014-10-14
US20100168429A1 (en)	2010-07-01

Publication	Publication Date	Title
ATE537142T1 (de)	2011-12-15	Übergangsmetallkatalysierte synthese von n- aminoindolen
MX2009013753A (es)	2010-01-26	Una sintesis regioselectiva catalizada por cobre de bencimidazoles y azabencimidazoles.
MX2009014203A (es)	2010-01-28	Una sintesis de 2h-indazoles catalizada por un metal de transicion.
ATE544757T1 (de)	2012-02-15	Regioselektive, palladiumkatalysierte synthese von benzimidazolen und azabenzimidazolen
NO20072605L (no)	2007-09-05	Nytt antranilinsyrederivat eller et salt derav
MY150379A (en)	2013-12-31	Fused heterocyclic derivative and use thereof
TW200617009A (en)	2006-06-01	Organic compounds
BRPI0813273A2 (pt)	2014-12-30	Síntese catalisada por metal regiosseletivo de benzimidazóis e azabenzimidazóis anelados
TNSN08372A1 (en)	2009-12-29	Heterocyclic amides for use as pharmaceuticals
TW200732335A (en)	2007-09-01	Organic compounds
DE602008002843D1 (de)	2010-11-11	Neue antimikrobielle verbindungen, ihre synthese und ihre verwendung zur behandlung von säugetierinfektionen
MX2009007713A (es)	2009-07-29	Derivados de piridazina, procedimientos para su preparacion y su uso como fungicidas.
TW200635921A (en)	2006-10-16	Organic compounds
MX2009013738A (es)	2010-01-25	Un procedimiento catalizado por paladio para el acoplamiento de alquinos terminales con tosilatos de arilo.
SE0400850D0 (sv)	2004-03-31	Novel Compounds
GB0508318D0 (en)	2005-06-01	Organic compounds
TW200638930A (en)	2006-11-16	Acetylene derivatives
TW200732337A (en)	2007-09-01	Organic compounds
EP1740674A4 (de)	2009-09-09	Verfahren zur herstellung von hoch lumineszierend dotierten metallnitridpulvern
WO2008156102A1 (ja)	2008-12-24	ピラゾロン誘導体及びそれらを有効成分とするｐｄｅ阻害剤
TW200744996A (en)	2007-12-16	Improved process for the production of nitroisourea derivative
MY151461A (en)	2014-05-30	A process for the palladium-catalyzed coupling of terminal alkynes with heteroayl tosylates and heteroaryl benzenesulfonates
TW200716521A (en)	2007-05-01	Substituted aryl oximes
MX2007007554A (es)	2007-07-20	Oxiarenos sustituidos.
TW200621693A (en)	2006-07-01	Ortho-substituted pentafluorosulfanylbenzenes, process for their preparation and their use as synthetic intermediates