ATE544757T1 - Regioselektive, palladiumkatalysierte synthese von benzimidazolen und azabenzimidazolen - Google Patents
Regioselektive, palladiumkatalysierte synthese von benzimidazolen und azabenzimidazolenInfo
- Publication number
- ATE544757T1 ATE544757T1 AT07764976T AT07764976T ATE544757T1 AT E544757 T1 ATE544757 T1 AT E544757T1 AT 07764976 T AT07764976 T AT 07764976T AT 07764976 T AT07764976 T AT 07764976T AT E544757 T1 ATE544757 T1 AT E544757T1
- Authority
- AT
- Austria
- Prior art keywords
- azabenzimidazoles
- benzimidazoles
- regioselective
- catalyzed synthesis
- formula
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 150000001556 benzimidazoles Chemical class 0.000 title 1
- -1 N-substituted benzimidazoles Chemical class 0.000 abstract 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000032 diagnostic agent Substances 0.000 abstract 1
- 229940039227 diagnostic agent Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000855 fungicidal effect Effects 0.000 abstract 1
- 239000004009 herbicide Substances 0.000 abstract 1
- 239000002917 insecticide Substances 0.000 abstract 1
- 239000004973 liquid crystal related substance Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000001069 nematicidal effect Effects 0.000 abstract 1
- 229910052763 palladium Inorganic materials 0.000 abstract 1
- 230000000590 parasiticidal effect Effects 0.000 abstract 1
- 239000002297 parasiticide Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/10—Radicals substituted by halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06014789A EP1878724A1 (de) | 2006-07-15 | 2006-07-15 | Regioselektive, Palladium-katalysierte Synthese von Benzimidazolen und Azabenzimidazolen |
| PCT/EP2007/005816 WO2008009348A1 (en) | 2006-07-15 | 2007-06-30 | A regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE544757T1 true ATE544757T1 (de) | 2012-02-15 |
Family
ID=37564112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07764976T ATE544757T1 (de) | 2006-07-15 | 2007-06-30 | Regioselektive, palladiumkatalysierte synthese von benzimidazolen und azabenzimidazolen |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US8188282B2 (de) |
| EP (2) | EP1878724A1 (de) |
| JP (1) | JP5271264B2 (de) |
| KR (1) | KR20090029267A (de) |
| CN (1) | CN101490014B (de) |
| AT (1) | ATE544757T1 (de) |
| AU (1) | AU2007276514A1 (de) |
| BR (1) | BRPI0714202A2 (de) |
| CA (1) | CA2657717A1 (de) |
| IL (1) | IL196431A0 (de) |
| MX (1) | MX2009000276A (de) |
| NO (1) | NO20090264L (de) |
| WO (1) | WO2008009348A1 (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8507473B2 (en) | 2008-09-11 | 2013-08-13 | Arena Pharmaceuticals, Inc. | 3H-imidazo[4,5-b]pyridin-5-ol derivatives useful in the treatment of GPR81 receptor disorders |
| US8394969B2 (en) | 2008-09-26 | 2013-03-12 | Merck Sharp & Dohme Corp. | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
| EP2348857B1 (de) | 2008-10-22 | 2016-02-24 | Merck Sharp & Dohme Corp. | Neue cyclische benzimidazolderivate als antidiabetika |
| EP2352374B1 (de) | 2008-10-29 | 2014-09-24 | Merck Sharp & Dohme Corp. | Neue cyclische benzimidazolderivate als antidiabetika |
| US8329914B2 (en) | 2008-10-31 | 2012-12-11 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
| JP2013520502A (ja) | 2010-02-25 | 2013-06-06 | メルク・シャープ・エンド・ドーム・コーポレイション | 有用な抗糖尿病薬である新規な環状ベンズイミダゾール誘導体 |
| MY170236A (en) | 2010-10-06 | 2019-07-11 | Glaxosmithkline Llc | Benzimidazole derivatives as pi3 kinase inhibitors |
| US8952177B2 (en) | 2013-03-15 | 2015-02-10 | Janssen Pharmaceutica Nv | 1,2,6-substituted benzimidazoles as FLAP modulators |
| US9682971B2 (en) | 2013-03-15 | 2017-06-20 | Janssen Pharmaceutica Nv | 1,2,5-Substituted benzimidazoles as flap modulators |
| CN105017257B (zh) * | 2014-04-30 | 2017-05-24 | 华东理工大学 | 四氢茚并吡咯并咪唑的衍生物及其制备方法和用途 |
| US10385048B2 (en) | 2014-12-31 | 2019-08-20 | Syngenta Participation Ag | Pesticidally active polycyclic derivatives with sulfur containing substituents |
| BR112017019326B1 (pt) * | 2015-03-12 | 2022-04-26 | Fmc Corporation | Composto, composição e método para controlar uma praga invertebrada |
| JP6662901B2 (ja) * | 2015-03-27 | 2020-03-11 | シンジェンタ パーティシペーションズ アーゲー | 殺微生物性二環式複素環式誘導体 |
| DE102016000837A1 (de) | 2016-01-27 | 2017-07-27 | Giesecke & Devrient Gmbh | Verfahren und Vorrichtung zur Untersuchung von Wertdokumenten |
| GB201617630D0 (en) | 2016-10-18 | 2016-11-30 | Cellcentric Ltd | Pharmaceutical compounds |
| EP3562306B1 (de) | 2016-12-29 | 2025-02-26 | Ji Xing Pharmaceuticals Hong Kong Limited | Metalloenzym-inhibitor-verbindungen |
| JP7227157B2 (ja) | 2016-12-29 | 2023-02-21 | フェーズバイオ ファーマシューティカルズ，インコーポレイテッド | 金属酵素阻害剤化合物 |
| MX388196B (es) | 2017-04-26 | 2025-03-19 | Basilea Pharm Int Ag | Procesos para la preparacion de furazanobencimidazoles y formas cristalinas de estos. |
| TWI795440B (zh) | 2017-09-15 | 2023-03-11 | 美商佛瑪治療公司 | 作為ＣＢＰ／ｐ３００抑制劑之四氫─咪唑並喹啉化合物 |
| GB201806320D0 (en) | 2018-04-18 | 2018-05-30 | Cellcentric Ltd | Process |
| US10870648B2 (en) | 2018-06-29 | 2020-12-22 | Forma Therapeutics, Inc. | Inhibiting CREB binding protein (CBP) |
| MX2021003904A (es) | 2018-10-05 | 2021-10-26 | Annapurna Bio Inc | Compuestos y composiciones para el tratamiento de afecciones asociadas con la actividad del receptor apj. |
| JP2022516969A (ja) | 2019-01-08 | 2022-03-03 | フェーズバイオ ファーマシューティカルズ，インコーポレイテッド | 金属酵素阻害剤化合物 |
| WO2020190791A1 (en) | 2019-03-15 | 2020-09-24 | Forma Therapeutics, Inc. | Inhibiting cyclic amp-responsive element-binding protein (creb) |
| US11801243B2 (en) | 2020-09-23 | 2023-10-31 | Forma Therapeutics, Inc. | Bromodomain inhibitors for androgen receptor-driven cancers |
| US11795168B2 (en) | 2020-09-23 | 2023-10-24 | Forma Therapeutics, Inc. | Inhibiting cyclic amp-responsive element-binding protein (CREB) binding protein (CBP) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA9610745B (en) * | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
| TWI245068B (en) * | 2003-11-18 | 2005-12-11 | Chi Mei Optoelectronics Corp | Iridium complex as light emitting material and organic light emitting diode device |
| US7371743B2 (en) * | 2004-02-28 | 2008-05-13 | Boehringer Ingelheim International Gmbh | Carboxylic acid amides, the preparation thereof and their use as medicaments |
| EP1695971A1 (de) * | 2004-12-30 | 2006-08-30 | Laboratorios Del Dr. Esteve, S.A. | Substituierte Phenylpiparazinverbindungen, deren Herstellung und Verwendung in Medikamenten |
-
2006
- 2006-07-15 EP EP06014789A patent/EP1878724A1/de not_active Withdrawn
-
2007
- 2007-06-30 CN CN2007800268865A patent/CN101490014B/zh not_active Expired - Fee Related
- 2007-06-30 WO PCT/EP2007/005816 patent/WO2008009348A1/en not_active Ceased
- 2007-06-30 KR KR1020097000869A patent/KR20090029267A/ko not_active Withdrawn
- 2007-06-30 AU AU2007276514A patent/AU2007276514A1/en not_active Abandoned
- 2007-06-30 BR BRPI0714202-1A patent/BRPI0714202A2/pt not_active IP Right Cessation
- 2007-06-30 JP JP2009519817A patent/JP5271264B2/ja not_active Expired - Fee Related
- 2007-06-30 EP EP07764976A patent/EP2044033B1/de not_active Not-in-force
- 2007-06-30 AT AT07764976T patent/ATE544757T1/de active
- 2007-06-30 CA CA002657717A patent/CA2657717A1/en not_active Abandoned
- 2007-08-07 MX MX2009000276A patent/MX2009000276A/es active IP Right Grant
-
2009
- 2009-01-11 IL IL196431A patent/IL196431A0/en unknown
- 2009-01-14 US US12/353,271 patent/US8188282B2/en not_active Expired - Fee Related
- 2009-01-16 NO NO20090264A patent/NO20090264L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP2044033A1 (de) | 2009-04-08 |
| WO2008009348A1 (en) | 2008-01-24 |
| EP2044033B1 (de) | 2012-02-08 |
| IL196431A0 (en) | 2009-09-22 |
| EP1878724A1 (de) | 2008-01-16 |
| MX2009000276A (es) | 2009-01-26 |
| CN101490014B (zh) | 2011-12-14 |
| US8188282B2 (en) | 2012-05-29 |
| CN101490014A (zh) | 2009-07-22 |
| US20090203912A1 (en) | 2009-08-13 |
| CA2657717A1 (en) | 2008-01-24 |
| JP2009544589A (ja) | 2009-12-17 |
| AU2007276514A1 (en) | 2008-01-24 |
| NO20090264L (no) | 2009-03-25 |
| KR20090029267A (ko) | 2009-03-20 |
| BRPI0714202A2 (pt) | 2013-02-19 |
| JP5271264B2 (ja) | 2013-08-21 |
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